| | This journal provides immediate access to some articles. Editorials PNAS policy on publication of sensitive material in the life sciences Nicholas R. Cozzarelli PMCID: PMC149849 Uncensored exchange of scientific results Journal Editors and Authors Group PMCID: PMC149850 Commentaries Insights into mRNA transport in neurons Fabrice Roegiers PMCID: PMC149851 Ecological food webs: High-quality data facilitate theoretical unification James H. Brown and James F. Gillooly PMCID: PMC149852 Seeds of understanding of plant diversity H. C. Muller-Landau PMCID: PMC149853 Mechanosensation through integrins: Cells act locally but think globally Donald E. Ingber PMCID: PMC149854 Perspective Regulatory gene networks and the properties of the developmental process Eric H. Davidson, David R. McClay, and Leroy Hood PMCID: PMC149855 Physical Sciences Applied Mathematics Transfer of a passive additive in a turbulent boundary layer at very large Reynolds numbers G. I. Barenblatt PMCID: PMC149856 Applied Physical Sciences From the Cover:
Cells lying on a bed of microneedles: An approach to isolate mechanical force John L. Tan, Joe Tien, Dana M. Pirone, Darren S. Gray, Kiran Bhadriraju, and Christopher S. Chen PMCID: PMC149857 Chemistry Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens Paul Wentworth, Jr., Anita D. Wentworth, Xueyong Zhu, Ian A. Wilson, Kim D. Janda, Albert Eschenmoser, and Richard A. Lerner PMCID: PMC149858 Experimental test of a method for determining causal connectivities of species in reactions Antonio S. Torralba, Kristine Yu, Peidong Shen, Peter J. Oefner, and John Ross PMCID: PMC149859 Engineering Gray-scale photolithography using microfluidic photomasks Chihchen Chen, Danny Hirdes, and Albert Folch PMCID: PMC149860 Geophysics Impacts of anthropogenic and natural NOx sources over the U.S. on tropospheric chemistry Renyi Zhang, Xuexi Tie, and Donald W. Bond PMCID: PMC149861 Mathematics Negative specific heat of a magnetically self-confined plasma torus Michael K.-H. Kiessling and Thomas Neukirch PMCID: PMC149862 Physics The origin of the boson peak and thermal conductivity plateau in low-temperature glasses Vassiliy Lubchenko and Peter G. Wolynes PMCID: PMC149863 Biological Sciences Agricultural Sciences Long-term regional suppression of pink bollworm by Bacillus thuringiensis cotton Yves Carrière, Christa Ellers-Kirk, Mark Sisterson, Larry Antilla, Mike Whitlow, Timothy J. Dennehy, and Bruce E. Tabashnik PMCID: PMC149864 Anthropology From the Cover:
Direct chemical evidence for widespread dairying in prehistoric Britain M. S. Copley, R. Berstan, S. N. Dudd, G. Docherty, A. J. Mukherjee, V. Straker, S. Payne, and R. P. Evershed PMCID: PMC149865 Applied Biological Sciences Uptake and antifungal activity of oligonucleotides in Candida albicans Matthew D. Disney, Constantine G. Haidaris, and Douglas H. Turner PMCID: PMC149866 Biochemistry Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens Paul Wentworth, Jr., Anita D. Wentworth, Xueyong Zhu, Ian A. Wilson, Kim D. Janda, Albert Eschenmoser, and Richard A. Lerner PMCID: PMC149858 Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners Assen Marintchev, Victoria G. Kolupaeva, Tatyana V. Pestova, and Gerhard Wagner PMCID: PMC149867 PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin Bertolt Gust, Greg L. Challis, Kay Fowler, Tobias Kieser, and Keith F. Chater PMCID: PMC149868 Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis David E. Cane and Rory M. Watt PMCID: PMC149869 The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase Annette Cronin, Sherry Mowbray, Heike Dürk, Shirli Homburg, Ingrid Fleming, Beate Fisslthaler, Franz Oesch, and Michael Arand PMCID: PMC149870 The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity John W. Newman, Christophe Morisseau, Todd R. Harris, and Bruce D. Hammock PMCID: PMC149871 Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells Antoine Kichler, Christian Leborgne, Josefine März, Olivier Danos, and Burkhard Bechinger PMCID: PMC149872 DNA duplex–quadruplex exchange as the basis for a nanomolecular machine Patrizia Alberti and Jean-Louis Mergny PMCID: PMC149873 Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme Prashanth Rangan, Benoît Masquida, Eric Westhof, and Sarah A. Woodson PMCID: PMC149874 Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus László G. Puskás, Klára Kitajka, Csaba Nyakas, Gwendolyn Barcelo-Coblijn, and Tibor Farkas PMCID: PMC149875 The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: Studies on the mechanisms of the reactions catalyzed by IspG and IspH protein Felix Rohdich, Ferdinand Zepeck, Petra Adam, Stefan Hecht, Johannes Kaiser, Ralf Laupitz, Tobias Gräwert, Sabine Amslinger, Wolfgang Eisenreich, Adelbert Bacher, and Duilio Arigoni PMCID: PMC149876 Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding Francesco Trapasso, Agnieszka Krakowiak, Rossano Cesari, Jeffrey Arkles, Sai Yendamuri, Hideshi Ishii, Andrea Vecchione, Tamotsu Kuroki, Pawel Bieganowski, Helen C. Pace, Kay Huebner, Carlo M. Croce, and Charles Brenner PMCID: PMC149877 Coordinate inhibition of expression of several genes for protein subunits of human nuclear RNase P Elizaveta Kovrigina, Donna Wesolowski, and Sidney Altman PMCID: PMC149878 Binding of small molecules to an adaptive protein–protein interface Michelle R. Arkin, Mike Randal, Warren L. DeLano, Jennifer Hyde, Tinh N. Luong, Johan D. Oslob, Darren R. Raphael, Lisa Taylor, Jun Wang, Robert S. McDowell, James A. Wells, and Andrew C. Braisted PMCID: PMC149879 Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex Xuejun Huang Parsons, Sandra N. Garcia, Lorraine Pillus, and James T. Kadonaga PMCID: PMC149880 Repression of the HIV-1 5′ LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors Lindsey Reynolds, Christopher Ullman, Michael Moore, Mark Isalan, Michelle J. West, Paul Clapham, Aaron Klug, and Yen Choo PMCID: PMC149881 Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors Monika Papworth, Michael Moore, Mark Isalan, Michal Minczuk, Yen Choo, and Aaron Klug PMCID: PMC149882 Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) Hewang Li, Ronald Adamik, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan PMCID: PMC149883 Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro Vladimir P. Bermudez, Laura A. Lindsey-Boltz, Anthony J. Cesare, Yoshimasa Maniwa, Jack D. Griffith, Jerard Hurwitz, and Aziz Sancar PMCID: PMC149884 Exonucleolytic degradation of double-stranded RNA by an activity in Xenopus laevis germinal vesicles Paolo Fruscoloni, Michela Zamboni, M. Irene Baldi, and Glauco P. Tocchini-Valentini PMCID: PMC149885 Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation Mark A. McCoy, Jennifer J. Gesell, Mary M. Senior, and Daniel F. Wyss PMCID: PMC149886 Crystal structure of a photoactive yellow protein from a sensor histidine kinase: Conformational variability and signal transduction Sudarshan Rajagopal and Keith Moffat PMCID: PMC149887 Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes P. J. Rothwell, S. Berger, O. Kensch, S. Felekyan, M. Antonik, B. M. Wöhrl, T. Restle, R. S. Goody, and C. A. M. Seidel PMCID: PMC149888 Crystal structure of the plasmid maintenance system ![[var epsilon]](corehtml/pmc/pmcents/epsiv.gif) /ζ: Functional mechanism of toxin ζ and inactivation by 2ζ 2 complex formation Anton Meinhart, Juan C. Alonso, Norbert Sträter, and Wolfram Saenger PMCID: PMC149889 The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions Oded Lewinson, Julia Adler, Gerrit J. Poelarends, Piotr Mazurkiewicz, Arnold J. M. Driessen, and Eitan Bibi PMCID: PMC149890 Biophysics The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases Satwik Kamtekar, W. Dexter Kennedy, Jimin Wang, Constantinos Stathopoulos, Dieter Söll, and Thomas A. Steitz PMCID: PMC149891 Associative memory Hamiltonians for structure prediction without homology: α/β proteins Corey Hardin, Michael P. Eastwood, Michael C. Prentiss, Zadia Luthey-Schulten, and Peter G. Wolynes PMCID: PMC149892 Single-cell nonphotochemical hole burning of ovarian surface epithelial carcinoma and normal cells R. J. Walsh, S. Matsuzaki, T. Reinot, J. M. Hayes, K. R. Kalli, L. C. Hartmann, and G. J. Small PMCID: PMC149893 Nanodissection and high-resolution imaging of the Rhodopseudomonas viridis photosynthetic core complex in native membranes by AFM Simon Scheuring, Jérôme Seguin, Sergio Marco, Daniel Lévy, Bruno Robert, and Jean-Louis Rigaud PMCID: PMC149894 DNA unzipped under a constant force exhibits multiple metastable intermediates Claudia Danilowicz, Vincent W. Coljee, Cedric Bouzigues, David K. Lubensky, David R. Nelson, and Mara Prentiss PMCID: PMC149895 Designed to be stable: Crystal structure of a consensus ankyrin repeat protein Andreas Kohl, H. Kaspar Binz, Patrik Forrer, Michael T. Stumpp, Andreas Plückthun, and Markus G. Grütter PMCID: PMC149896 Packing helices in proteins by global optimization of a potential energy function Marian Nanias, Maurizio Chinchio, Jarosław Pillardy, Daniel R. Ripoll, and Harold A. Scheraga PMCID: PMC149897 Cell Biology Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5 Michael P. Czubryt, John McAnally, Glenn I. Fishman, and Eric N. Olson PMCID: PMC149898 The strategy for coupling the RanGTP gradient to nuclear protein export Attila Becskei and Iain W. Mattaj PMCID: PMC149899 Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice Scott H. Soderling, Lorene K. Langeberg, Jacquelyn A. Soderling, Stephen M. Davee, Richard Simerly, Jacob Raber, and John D. Scott PMCID: PMC149900 JNK-interacting protein-1 promotes transcription of Aβ protein precursor but not Aβ precursor-like proteins, mechanistically different than Fe65 Meir H. Scheinfeld, Shuji Matsuda, and Luciano D'Adamio PMCID: PMC149901 MyoD is functionally linked to the silencing of a muscle-specific regulatory gene prior to skeletal myogenesis Asoke Mal and Marian L. Harter PMCID: PMC149902 Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference Seungkirl Ahn, Christopher D. Nelson, Tiffany Runyan Garrison, William E. Miller, and Robert J. Lefkowitz PMCID: PMC149903 GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors Bin Zheng, Christopher P. Berrie, Daniela Corda, and Marilyn G. Farquhar PMCID: PMC149904 Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion Dilprit Bagga, Ling Wang, Robin Farias-Eisner, John A. Glaspy, and Srinivasa T. Reddy PMCID: PMC149905 Developmental Biology Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain Elaine E. Storm, John L. R. Rubenstein, and Gail R. Martin PMCID: PMC149906 Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice Julien Vermot, Karen Niederreither, Jean-Marie Garnier, Pierre Chambon, and Pascal Dollé PMCID: PMC149907 Tadpole skin dies autonomously in response to thyroid hormone at metamorphosis Alexander M. Schreiber and Donald D. Brown PMCID: PMC149908 Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats Christopher C. Oakes, Dominic J. Smiraglia, Christoph Plass, Jacquetta M. Trasler, and Bernard Robaire PMCID: PMC149909 Ecology From the Cover:
Ecological community description using the food web, species abundance, and body size Joel E. Cohen, Tomas Jonsson, and Stephen R. Carpenter PMCID: PMC149910 From the Cover:
Matchmaking and species marriage: A game-theory model of community assembly María Uriarte and Hudson Kern Reeve PMCID: PMC149911 Evolution Patterns of DNA sequence polymorphism at Sod vicinities in Drosophila melanogaster: Unraveling the footprint of a recent selective sweep Alberto G. Sáez, Andrey Tatarenkov, Eladio Barrio, Nelsson H. Becerra, and Francisco J. Ayala PMCID: PMC149912 Social exploitation of vitellogenin Gro V. Amdam, Kari Norberg, Arne Hagen, and Stig W. Omholt PMCID: PMC149913 Facultative bacterial symbionts in aphids confer resistance to parasitic wasps Kerry M. Oliver, Jacob A. Russell, Nancy A. Moran, and Martha S. Hunter PMCID: PMC149914 Drosophila pigmentation evolution: Divergent genotypes underlying convergent phenotypes Patricia J. Wittkopp, Barry L. Williams, Jayne E. Selegue, and Sean B. Carroll PMCID: PMC149915 Genetics kep1 interacts genetically with dredd/Caspase-8, and kep1 mutants alter the balance of dredd isoforms Marco Di Fruscio, Sylvia Styhler, Eva Wikholm, Marie-Chloé Boulanger, Paul Lasko, and Stéphane Richard PMCID: PMC149916 Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation Huck Hui Ng, David N. Ciccone, Katrina B. Morshead, Marjorie A. Oettinger, and Kevin Struhl PMCID: PMC149917 Phenotype variation in two-locus mouse models of Hirschsprung disease: Tissue-specific interaction between Ret and Ednrb Andrew S. McCallion, Erine Stames, Ronald A. Conlon, and Aravinda Chakravarti PMCID: PMC149918 Tracking an embryonic L1 retrotransposition event Eline T. Luning Prak, Allen W. Dodson, Evan A. Farkash, and Haig H. Kazazian, Jr. PMCID: PMC149919 Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations Elizabeth Mambo, Xiangqun Gao, Yoram Cohen, Zhongmin Guo, Paul Talalay, and David Sidransky PMCID: PMC149920 A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA Gustavo Tiscornia, Oded Singer, Masahito Ikawa, and Inder M. Verma PMCID: PMC149921 Immunology Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by β-d-glucosylceramide synthase deficiency Aleksandar K. Stanic, A. Dharshan De Silva, Jang-June Park, Venkataraman Sriram, Shinichi Ichikawa, Yoshio Hirabyashi, Kyoko Hayakawa, Luc Van Kaer, Randy R. Brutkiewicz, and Sebastian Joyce PMCID: PMC149922 Boosting immunity by antiviral drug therapy: A simple relationship among timing, efficacy, and success Natalia L. Komarova, Eleanor Barnes, Paul Klenerman, and Dominik Wodarz PMCID: PMC149923 Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC Marianne M. Martinic, Thomas Rülicke, Alana Althage, Bernhard Odermatt, Matthias Höchli, Alain Lamarre, Tilman Dumrese, Daniel E. Speiser, Diego Kyburz, Hans Hengartner, and Rolf M. Zinkernagel PMCID: PMC149924 Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination Rosetta Pedotti, Jason J. DeVoss, Sawsan Youssef, Dennis Mitchell, Jochen Wedemeyer, Rami Madanat, Hideki Garren, Paulo Fontoura, Mindy Tsai, Stephen J. Galli, Raymond A. Sobel, and Lawrence Steinman PMCID: PMC149925 Structure and allosteric regulation of the αXβ2 integrin I domain Thomas Vorup-Jensen, Christian Ostermeier, Motomu Shimaoka, Ulrich Hommel, and Timothy A. Springer PMCID: PMC149926 STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity Thomas Welte, Samuel S. M. Zhang, Tian Wang, Zhiyuan Zhang, David G. T. Hesslein, Zhinan Yin, Arihiro Kano, Yoshiki Iwamoto, En Li, Joseph E. Craft, Alfred L. M. Bothwell, Erol Fikrig, Pandelakis A. Koni, Richard A. Flavell, and Xin-Yuan Fu PMCID: PMC149927 Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines Amanda E. I. Proudfoot, Tracy M. Handel, Zoë Johnson, Elaine K. Lau, Patricia LiWang, Ian Clark-Lewis, Frédéric Borlat, Timothy N. C. Wells, and Marie H. Kosco-Vilbois PMCID: PMC149928 Medical Sciences Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts Meili Zhang, Zhuo Zhang, Kayhan Garmestani, Jody Schultz, Donald B. Axworthy, Carolyn K. Goldman, Martin W. Brechbiel, Jorge A. Carrasquillo, and Thomas A. Waldmann PMCID: PMC149929 Individuality and variation in gene expression patterns in human blood Adeline R. Whitney, Maximilian Diehn, Stephen J. Popper, Ash A. Alizadeh, Jennifer C. Boldrick, David A. Relman, and Patrick O. Brown PMCID: PMC149930 Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB Kazuhiro Ohmi, David S. Greenberg, Kavitha S. Rajavel, Sergey Ryazantsev, Hong Hua Li, and Elizabeth F. Neufeld PMCID: PMC149931 Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals Tae-Wook Chun, J. Shawn Justement, Richard A. Lempicki, Jun Yang, Glynn Dennis, Jr., Claire W. Hallahan, Christina Sanford, Punita Pandya, Shuying Liu, Mary McLaughlin, Linda A. Ehler, Susan Moir, and Anthony S. Fauci PMCID: PMC149932 Identification of frame-shift intermediate mutant cells Christoph Gasche, Christina L. Chang, Loki Natarajan, Ajay Goel, Jennifer Rhees, Dennis J. Young, Christian N. Arnold, and C. Richard Boland PMCID: PMC149933 A mechanism converting psychosocial stress into mononuclear cell activation Angelika Bierhaus, Jutta Wolf, Martin Andrassy, Nicolas Rohleder, Per M. Humpert, Dimitri Petrov, Roman Ferstl, Maximilian von Eynatten, Thoralf Wendt, Gottfried Rudofsky, Martina Joswig, Michael Morcos, Markus Schwaninger, Bruce McEwen, Clemens Kirschbaum, and Peter P. Nawroth PMCID: PMC149934 Variation in gene expression patterns in follicular lymphoma and the response to rituximab Sean P. Bohen, Olga G. Troyanskaya, Orly Alter, Roger Warnke, David Botstein, Patrick O. Brown, and Ronald Levy PMCID: PMC149935 PUMA mediates the apoptotic response to p53 in colorectal cancer cells Jian Yu, Zhenghe Wang, Kenneth W. Kinzler, Bert Vogelstein, and Lin Zhang PMCID: PMC149936 Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia Lynda S. Ostedgaard, Christoph Randak, Tatiana Rokhlina, Philip Karp, Daniel Vermeer, Katherine J. Ashbourne Excoffon, and Michael J. Welsh PMCID: PMC149937 Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor M. Anders, R. Hansen, R.-X. Ding, K. A. Rauen, M. J. Bissell, and W. Michael Korn PMCID: PMC149938 Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection Fadie T. Coleman, Simone Mueschenborn, Gloria Meluleni, Christopher Ray, Vincent J. Carey, Sara O. Vargas, Carolyn L. Cannon, Frederick M. Ausubel, and Gerald B. Pier PMCID: PMC149939 Insights into glutamate transport regulation in human astrocytes: Cloning of the promoter for excitatory amino acid transporter 2 (EAAT2) Zao-zhong Su, Magdalena Leszczyniecka, Dong-chul Kang, Devanand Sarkar, Wei Chao, David J. Volsky, and Paul B. Fisher PMCID: PMC149940 Using temporal context to improve biosurveillance Ben Y. Reis, Marcello Pagano, and Kenneth D. Mandl PMCID: PMC149941 Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection Richard Malley, Philipp Henneke, Sarah C. Morse, Michael J. Cieslewicz, Marc Lipsitch, Claudette M. Thompson, Evelyn Kurt-Jones, James C. Paton, Michael R. Wessels, and Douglas T. Golenbock PMCID: PMC149942 Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes Vladimir P. Torchilin, Tatyana S. Levchenko, Ram Rammohan, Natalia Volodina, Brigitte Papahadjopoulos-Sternberg, and Gerard G. M. D'Souza PMCID: PMC149943 Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding Marco Cattaneo, Maddalena L. Zighetti, Rossana Lombardi, Constantino Martinez, Anna Lecchi, Pamela B. Conley, Jerry Ware, and Zaverio M. Ruggeri PMCID: PMC149944 Microbiology Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription Ning Liu, Ru Tian, and Daniel D. Loeb PMCID: PMC149945 Complete genome sequence of Lactobacillus plantarum WCFS1 Michiel Kleerebezem, Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos, and Roland J. Siezen PMCID: PMC149946 Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes Jovanka M. Voyich, Daniel E. Sturdevant, Kevin R. Braughton, Scott D. Kobayashi, Benfang Lei, Kimmo Virtaneva, David W. Dorward, James M. Musser, and Frank R. DeLeo PMCID: PMC149947 Selective incorporation of influenza virus RNA segments into virions Yutaka Fujii, Hideo Goto, Tokiko Watanabe, Tetsuya Yoshida, and Yoshihiro Kawaoka PMCID: PMC149948 Chemosensory regulation of developmental gene expression in Myxococcus xanthus John R. Kirby and David R. Zusman PMCID: PMC149949 Interference of hepatitis C virus RNA replication by short interfering RNAs Sharookh B. Kapadia, Amy Brideau-Andersen, and Francis V. Chisari PMCID: PMC149950 Neuroscience Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly Antonio Convit, Oliver T. Wolf, Chaim Tarshish, and Mony J. de Leon PMCID: PMC149951 Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology Frédérique Bard, Robin Barbour, Catherine Cannon, Robert Carretto, Michael Fox, Dora Games, Teresa Guido, Kathleen Hoenow, Kang Hu, Kelly Johnson-Wood, Karen Khan, Dora Kholodenko, Celeste Lee, Mike Lee, Ruth Motter, Minh Nguyen, Amanda Reed, Dale Schenk, Pearl Tang, Nicki Vasquez, Peter Seubert, and Ted Yednock PMCID: PMC149952 cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1 A. Soren Leonard, Olena Yermolaieva, Alesia Hruska-Hageman, Candice C. Askwith, Margaret P. Price, John A. Wemmie, and Michael J. Welsh PMCID: PMC149953 In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine Graziano Pinna, Erbo Dong, Kinzo Matsumoto, Erminio Costa, and Alessandro Guidotti PMCID: PMC149954 Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease Emma Hockly, Victoria M. Richon, Benjamin Woodman, Donna L. Smith, Xianbo Zhou, Eddie Rosa, Kirupa Sathasivam, Shabnam Ghazi-Noori, Amarbirpal Mahal, Philip A. S. Lowden, Joan S. Steffan, J. Lawrence Marsh, Leslie M. Thompson, Cathryn M. Lewis, Paul A. Marks, and Gillian P. Bates PMCID: PMC149955 Tissue transglutaminase-induced aggregation of α-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies Eunsung Junn, Ruben D. Ronchetti, Martha M. Quezado, Soo-Youl Kim, and M. Maral Mouradian PMCID: PMC149956 Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons Marisa Roberto, Samuel G. Madamba, Scott D. Moore, Melanie K. Tallent, and George R. Siggins PMCID: PMC149957 Nicotine activates immature “silent” connections in the developing hippocampus Laura Maggi, Corentin Le Magueresse, Jean-Pierre Changeux, and Enrico Cherubini PMCID: PMC149958 Communication between neocortex and hippocampus during sleep in rodents Anton Sirota, Jozsef Csicsvari, Derek Buhl, and György Buzsáki PMCID: PMC149959 Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells Justin W. Taraska, David Perrais, Mica Ohara-Imaizumi, Shinya Nagamatsu, and Wolfhard Almers PMCID: PMC149960 Gain control of firing rate by shunting inhibition: Roles of synaptic noise and dendritic saturation Steven A. Prescott and Yves De Koninck PMCID: PMC149961 Visualization of synaptotagmin I oligomers assembled onto lipid monolayers Yi Wu, Yuhong He, Jihong Bai, Shang-Rong Ji, Ward C. Tucker, Edwin R. Chapman, and Sen-Fang Sui PMCID: PMC149962 Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains James M. Weimann, Carol A. Charlton, Timothy R. Brazelton, Robert C. Hackman, and Helen M. Blau PMCID: PMC149963 Operant behavior can be triggered by the position of the rat relative to objects rotating on an inaccessible platform E. Pastalkova, E. Kelemen, and J. Bureš PMCID: PMC149964 From the Cover:
Isolation and characterization of Staufen-containing ribonucleoprotein particles from rat brain Massimo Mallardo, Anke Deitinghoff, Juliane Müller, Bernhard Goetze, Paolo Macchi, Christopher Peters, and Michael A. Kiebler PMCID: PMC149965 An α-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain Mahmood Amiry-Moghaddam, Takashi Otsuka, Patricia D. Hurn, Richard J. Traystman, Finn-Mogens Haug, Stanley C. Froehner, Marvin E. Adams, John D. Neely, Peter Agre, Ole Petter Ottersen, and Anish Bhardwaj PMCID: PMC149966 Pharmacology Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet Claudio Napoli, Ines Martin-Padura, Filomena de Nigris, Marco Giorgio, Gelsomina Mansueto, Pasquale Somma, Mario Condorelli, Giacomo Sica, Gaetano De Rosa, and PierGiuseppe Pelicci PMCID: PMC149967 In vivo activation of a mutant μ-opioid receptor by antagonist: Future direction for opiate pain treatment paradigm that lacks undesirable side effects Ping-Yee Law, Jesse W. Yang, Xiaohong Guo, and Horace H. Loh PMCID: PMC149968 Physiology Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel Junko Kurokawa, Lei Chen, and Robert S. Kass PMCID: PMC149969 Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance Lei Liu, Wayne A. Johnson, and Michael J. Welsh PMCID: PMC149970 The effect of anandamide on prolactin secretion is modulated by estrogen Camila Scorticati, Claudia Mohn, Andrea De Laurentiis, Paula Vissio, Javier Fernández Solari, Adriana Seilicovich, Samuel M. McCann, and Valeria Rettori PMCID: PMC149971 Plant Biology Regulation of photoperiodic flowering by Arabidopsis photoreceptors Todd Mockler, Hongyun Yang, XuHong Yu, Dhavan Parikh, Ying-chia Cheng, Sarah Dolan, and Chentao Lin PMCID: PMC149972 Dynamic recruitment of dynamin for final mitochondrial severance in a primitive red alga Keiji Nishida, Manabu Takahara, Shin-ya Miyagishima, Haruko Kuroiwa, Motomichi Matsuzaki, and Tsuneyoshi Kuroiwa PMCID: PMC149973 Arabidopsis LEAFY COTYLEDON1 represents a functionally specialized subunit of the CCAAT binding transcription factor Hyeseung Lee, Robert L. Fischer, Robert B. Goldberg, and John J. Harada PMCID: PMC149974 Social Sciences Psychology Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories Lila Davachi, Jason P. Mitchell, and Anthony D. Wagner PMCID: PMC149975 Corrections Proc Natl Acad Sci U S A. 2003 February 18; 100(4): 2163. Published online 2003 February 13. doi: 10.1073/pnas.0538065100.PMCID: PMC149846 Corrects: Thomas M. McIntyre, et al. From the Cover:
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist. Proc Natl Acad Sci U S A. 2003 January 7; 100(1): 131–136. Proc Natl Acad Sci U S A. 2003 February 18; 100(4): 2163. Published online 2003 February 13. doi: 10.1073/pnas.0530200100.PMCID: PMC149847 Corrects: Achim A. Jungbluth, et al. A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor. Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 639–644. Proc Natl Acad Sci U S A. 2003 February 18; 100(4): 2163. Published online 2003 February 13. doi: 10.1073/pnas.0630447100.PMCID: PMC149848 Corrects: Ping-Yee Law, et al. In vivo activation of a mutant μ-opioid receptor by antagonist: Future direction for opiate pain treatment paradigm that lacks undesirable side effects. Proc Natl Acad Sci U S A. 2003 February 18; 100(4): 2117–2121. |
