| | This journal provides immediate access to some articles. Commentaries Polyglutamine fibrillogenesis: The pathway unfolds Christopher A. Ross, Michelle A. Poirier, Erich E. Wanker, and Mario Amzel PMCID: PMC140861 Role of ABC transporters in secretion of cholesterol from liver into bile Donald M. Small PMCID: PMC140863 Trypanosomatid transcription factors: Waiting for Godot Scott M. Landfear PMCID: PMC140865 Physical Sciences Chemistry Photoisomerization of a rotaxane hydrogen bonding template: Light-induced acceleration of a large amplitude rotational motion Francesco G. Gatti, Salvador León, Jenny K. Y. Wong, Giovanni Bottari, Andrea Altieri, M. Angeles Farran Morales, Simon J. Teat, Céline Frochot, David A. Leigh, Albert M. Brouwer, and Francesco Zerbetto PMCID: PMC140866 Quantum-mechanical calculations of the stabilities of fluxional isomers of C 4H  in solution Joseph Casanova, David R. Kent, IV, William A. Goddard, III, and John D. Roberts PMCID: PMC140868 Insufficiently dehydrated hydrogen bonds as determinants of protein interactions Ariel Fernández and Harold A. Scheraga PMCID: PMC140898 Computer Sciences Genome-based peptide fingerprint scanning Michael C. Giddings, Atul A. Shah, Ray Gesteland, and Barry Moore PMCID: PMC140871 Geology Formation and character of an ancient 19-m ice cover and underlying trapped brine in an “ice-sealed” east Antarctic lake Peter T. Doran, Christian H. Fritsen, Christopher P. McKay, John C. Priscu, and Edward E. Adams PMCID: PMC140872 Biological Sciences Biochemistry Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins Irina Dulubova, Tomohiro Yamaguchi, Demet Araç, Hongmei Li, Iryna Huryeva, Sang-Won Min, Josep Rizo, and Thomas C. Südhof PMCID: PMC140874 Crystal structure of saposin B reveals a dimeric shell for lipid binding Victoria E. Ahn, Kym F. Faull, Julian P. Whitelegge, Arvan L. Fluharty, and Gilbert G. Privé PMCID: PMC140876 Mitotic clonal expansion: A synchronous process required for adipogenesis Qi-Qun Tang, Tamara C. Otto, and M. Daniel Lane PMCID: PMC140878 Optimal alignment for enzymatic proton transfer: Structure of the Michaelis complex of triosephosphate isomerase at 1.2-Å resolution Gerwald Jogl, Sharon Rozovsky, Ann E. McDermott, and Liang Tong PMCID: PMC140880 Addition of the keto functional group to the genetic code of Escherichia coli Lei Wang, Zhiwen Zhang, Ansgar Brock, and Peter G. Schultz PMCID: PMC140882 Catalysis of electron transfer during activation of O2 by the flavoprotein glucose oxidase Justine P. Roth and Judith P. Klinman PMCID: PMC404145 Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase Niu Huang, Nilesh K. Banavali, and Alexander D. MacKerell, Jr. PMCID: PMC140885 From the Cover:
Structural basis and prediction of substrate specificity in protein serine/threonine kinases Ross I. Brinkworth, Robert A. Breinl, and Bostjan Kobe PMCID: PMC140887 From the Cover:
RNA polymerase II-dependent transcription in trypanosomes is associated with a SNAP complex-like transcription factor Anish Das and Vivian Bellofatto PMCID: PMC140888 INAUGURAL ARTICLE by a Recently Elected Academy Member: UDP-Glc:glycoprotein glucosyltransferase recognizes structured and solvent accessible hydrophobic patches in molten globule-like folding intermediates Julio J. Caramelo, Olga A. Castro, Leonardo G. Alonso, Gonzalo de Prat-Gay, and Armando J. Parodi PMCID: PMC140890 Biophysics From the Cover:
Flexibility and molecular recognition in the immune system Ralph Jimenez, Georgina Salazar, Kim K. Baldridge, and Floyd E. Romesberg PMCID: PMC140891 Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-Å resolution Nobuo Kamiya and Jian-Ren Shen PMCID: PMC140893 Substructure synthesis method for simulating large molecular complexes Dengming Ming, Yifei Kong, Yinghao Wu, and Jianpeng Ma PMCID: PMC140894 Imaging whole Escherichia coli bacteria by using single-particle x-ray diffraction Jianwei Miao, Keith O. Hodgson, Tetsuya Ishikawa, Carolyn A. Larabell, Mark A. LeGros, and Yoshinori Nishino PMCID: PMC140897 Insufficiently dehydrated hydrogen bonds as determinants of protein interactions Ariel Fernández and Harold A. Scheraga PMCID: PMC140898 Automatic classification of protein structure by using Gauss integrals Peter Røgen and Boris Fain PMCID: PMC140900 Cell Biology Genome-based peptide fingerprint scanning Michael C. Giddings, Atul A. Shah, Ray Gesteland, and Barry Moore PMCID: PMC140871 IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor α from T cells Gianluca Toraldo, Cristiana Roggia, Wei-Ping Qian, Roberto Pacifici, and M. Neale Weitzmann PMCID: PMC140902 From the Cover:
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist Thomas M. McIntyre, Aaron V. Pontsler, Adriana R. Silva, Andy St. Hilaire, Yong Xu, Jerald C. Hinshaw, Guy A. Zimmerman, Kotaro Hama, Junken Aoki, Hiroyuki Arai, and Glenn D. Prestwich PMCID: PMC140905 Asymmetry of the central apparatus defines the location of active microtubule sliding in Chlamydomonas flagella Matthew J. Wargo and Elizabeth F. Smith PMCID: PMC140907 Nitric oxide-induced cellular stress and p53 activation in chronic inflammation Lorne J. Hofseth, Shin'ichi Saito, S. Perwez Hussain, Michael G. Espey, Katrina M. Miranda, Yuzuru Araki, Chamelli Jhappan, Yuichiro Higashimoto, Peijun He, Steven P. Linke, Martha M. Quezado, Irit Zurer, Varda Rotter, David A. Wink, Ettore Appella, and Curtis C. Harris PMCID: PMC140909 Store-operated calcium channel regulates the chemotactic behavior of ascidian sperm Manabu Yoshida, Makiko Ishikawa, Hiroko Izumi, Rosaria De Santis, and Masaaki Morisawa PMCID: PMC140910 Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis Julie Guillermet, Nathalie Saint-Laurent, Philippe Rochaix, Olivier Cuvillier, Thierry Levade, Andrew V. Schally, Lucien Pradayrol, Louis Buscail, Christiane Susini, and Corinne Bousquet PMCID: PMC140912 β-Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of β2 adrenergic receptor Gαs signaling in 3T3-L1 adipocytes Christopher J. Hupfeld, Stephane Dalle, and Jerrold M. Olefsky PMCID: PMC140914 Ecology Formation and character of an ancient 19-m ice cover and underlying trapped brine in an “ice-sealed” east Antarctic lake Peter T. Doran, Christian H. Fritsen, Christopher P. McKay, John C. Priscu, and Edward E. Adams PMCID: PMC140872 Warmer paleotemperatures for terrestrial ecosystems Elizabeth A. Kowalski and David L. Dilcher PMCID: PMC140915 Evolution Natural selection shaped regional mtDNA variation in humans Dan Mishmar, Eduardo Ruiz-Pesini, Pawel Golik, Vincent Macaulay, Andrew G. Clark, Seyed Hosseini, Martin Brandon, Kirk Easley, Estella Chen, Michael D. Brown, Rem I. Sukernik, Antonel Olckers, and Douglas C. Wallace PMCID: PMC140917 Genetics Color and genomic ancestry in Brazilians Flavia C. Parra, Roberto C. Amado, José R. Lambertucci, Jorge Rocha, Carlos M. Antunes, and Sérgio D. J. Pena PMCID: PMC140919 Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 Xiao-Feng Qin, Dong Sung An, Irvin S. Y. Chen, and David Baltimore PMCID: PMC140921 Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans Benjamin P. Lewis, Richard E. Green, and Steven E. Brenner PMCID: PMC140922 RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast Ira M. Hall, Ken-ichi Noma, and Shiv I. S. Grewal PMCID: PMC140924 Sequence variations in the public human genome data reflect a bottlenecked population history Gabor Marth, Greg Schuler, Raymond Yeh, Ruth Davenport, Richa Agarwala, Deanna Church, Sarah Wheelan, Jonathan Baker, Ming Ward, Michael Kholodov, Lon Phan, Eva Czabarka, Janos Murvai, David Cutler, Stephen Wooding, Alan Rogers, Aravinda Chakravarti, Henry C. Harpending, Pui-Yan Kwok, and Stephen T. Sherry PMCID: PMC140982 Immunology The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development Daniela Finke, Sanjiv A. Luther, and Hans Acha-Orbea PMCID: PMC140926 Medical Sciences Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 Xiao-Feng Qin, Dong Sung An, Irvin S. Y. Chen, and David Baltimore PMCID: PMC140921 Characterization of mouse clonogenic megakaryocyte progenitors Thanyaphong Na Nakorn, Toshihiro Miyamoto, and Irving L. Weissman PMCID: PMC140928 Absence of p16INK4a and truncation of ARF tumor suppressors in chickens Soo-Hyun Kim, Michael Mitchell, Hideta Fujii, Susana Llanos, and Gordon Peters PMCID: PMC140929 Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines Ingo Drexler, Caroline Staib, Wolfgang Kastenmüller, Stefan Stevanović, Burkhard Schmidt, François A. Lemonnier, Hans-Georg Rammensee, Dirk H. Busch, Helga Bernhard, Volker Erfle, and Gerd Sutter PMCID: PMC140931 Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor Bryan Goodwin, Karine C. Gauthier, Michihisa Umetani, Michael A. Watson, Matthew I. Lochansky, Jon L. Collins, Eran Leitersdorf, David J. Mangelsdorf, Steven A. Kliewer, and Joyce J. Repa PMCID: PMC140933 Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion Takahiro Fujino, Hiroshi Asaba, Man-Jong Kang, Yukio Ikeda, Hideyuki Sone, Shinji Takada, Dong-Ho Kim, Ryoichi X. Ioka, Masao Ono, Hiroko Tomoyori, Minoru Okubo, Toshio Murase, Akihisa Kamataki, Joji Yamamoto, Kenta Magoori, Sadao Takahashi, Yoshiharu Miyamoto, Hisashi Oishi, Masato Nose, Mitsuyo Okazaki, Shinichi Usui, Katsumi Imaizumi, Masashi Yanagisawa, Juro Sakai, and Tokuo T. Yamamoto PMCID: PMC140935 Microbiology Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs Glenn Randall, Arash Grakoui, and Charles M. Rice PMCID: PMC140937 Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence Lanbo Shi, Yu-Jin Jung, Sanjay Tyagi, Maria Laura Gennaro, and Robert J. North PMCID: PMC140939 Identification of pathogen-specific and conserved genes expressed in vivo by an avian pathogenic Escherichia coli strain Charles M. Dozois, France Daigle, and Roy Curtiss, III PMCID: PMC140941 Neuroscience Functional connectivity in the resting brain: A network analysis of the default mode hypothesis Michael D. Greicius, Ben Krasnow, Allan L. Reiss, and Vinod Menon PMCID: PMC140943 Positive and negative regulation of APP amyloidogenesis by sumoylation Yonghong Li, Hui Wang, Su Wang, Diana Quon, Yu-Wang Liu, and Barbara Cordell PMCID: PMC140945 Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus Kiyohiro Fujino and Donata Oertel PMCID: PMC140946 Contribution of GIRK2-mediated postsynaptic signaling to opiate and α2-adrenergic analgesia and analgesic sex differences Igor Mitrovic, Marta Margeta-Mitrovic, Semon Bader, Markus Stoffel, Lily Y. Jan, and Allan I. Basbaum PMCID: PMC140949 A pervasive mechanism for analgesia: Activation of GIRK2 channels Y. A. Blednov, M. Stoffel, H. Alva, and R. A. Harris PMCID: PMC140950 Interaction of “readthrough” acetylcholinesterase with RACK1 and PKCβII correlates with intensified fear-induced conflict behavior Klara R. Birikh, Ella H. Sklan, Shai Shoham, and Hermona Soreq PMCID: PMC140952 From the Cover:
Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth Yuji Ozeki, Toshifumi Tomoda, John Kleiderlein, Atsushi Kamiya, Lyuda Bord, Kumiko Fujii, Masako Okawa, Naoto Yamada, Mary E. Hatten, Solomon H. Snyder, Christopher A. Ross, and Akira Sawa PMCID: PMC140954 Arachidonic acid mediates muscarinic inhibition and enhancement of N-type Ca2+ current in sympathetic neurons Liwang Liu and Ann R. Rittenhouse PMCID: PMC140955 Phenotypic effects of familial amyotrophic lateral sclerosis mutant Sod alleles in transgenic Drosophila Robin J. Mockett, Svetlana N. Radyuk, Judith J. Benes, William C. Orr, and Rajindar S. Sohal PMCID: PMC140958 Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel β4 subunit H. Hibino, R. Pironkova, O. Onwumere, M. Rousset, P. Charnet, A. J. Hudspeth, and F. Lesage PMCID: PMC140959 Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients Phil Ok Koh, Ashiwel S. Undie, Nadine Kabbani, Robert Levenson, Patricia S. Goldman-Rakic, and Michael S. Lidow PMCID: PMC140961 Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: Evidence from high-density oligonucleotide arrays and in situ hybridization Jessica A. Mong, Nino Devidze, Donald E. Frail, Lawrence T. O'Connor, Manjo Samuel, Elena Choleris, Sonoko Ogawa, and Donald W. Pfaff PMCID: PMC140964 Invariant representations of visual patterns in a temporal population code Reto Wyss, Peter König, and Paul F. M. J. Verschure PMCID: PMC140966 Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways Gal Bitan, Marina D. Kirkitadze, Aleksey Lomakin, Sabrina S. Vollers, George B. Benedek, and David B. Teplow PMCID: PMC140968 Physiology Chemical nature of nitric oxide storage forms in rat vascular tissue Juan Rodriguez, Ronald E. Maloney, Tienush Rassaf, Nathan S. Bryan, and Martin Feelisch PMCID: PMC140970 A macromolecular complex of β2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA Anjaparavanda P. Naren, Bryan Cobb, Chunying Li, Koushik Roy, David Nelson, Ghanshyam D. Heda, Jie Liao, Kevin L. Kirk, Eric J. Sorscher, John Hanrahan, and John P. Clancy PMCID: PMC140971 Block of Shaker potassium channels by external calcium ions Froylan Gomez-Lagunas, Alexey Melishchuk, and Clay M. Armstrong PMCID: PMC140973 Plant Biology Canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission Wuyi Wang, Anne E. Hall, Ronan O'Malley, and Anthony B. Bleecker PMCID: PMC140975 NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants Haejeong Moon, Boyoung Lee, Giltsu Choi, Dongjin Shin, D. Theertha Prasad, Oksun Lee, Sang-Soo Kwak, Doh Hoon Kim, Jaesung Nam, Jeongdong Bahk, Jong Chan Hong, Sang Yeol Lee, Moo Je Cho, Chae Oh Lim, and Dae-Jin Yun PMCID: PMC140977 Genetically engineered stem rust resistance in barley using the Rpg1 gene Henriette Horvath, Nils Rostoks, Robert Brueggeman, Brian Steffenson, Diter von Wettstein, and Andris Kleinhofs PMCID: PMC140979 Proteomics gives insight into the regulatory function of chloroplast thioredoxins Yves Balmer, Antonius Koller, Gregorio del Val, Wanda Manieri, Peter Schürmann, and Bob B. Buchanan PMCID: PMC140980 Social Sciences Anthropology Sequence variations in the public human genome data reflect a bottlenecked population history Gabor Marth, Greg Schuler, Raymond Yeh, Ruth Davenport, Richa Agarwala, Deanna Church, Sarah Wheelan, Jonathan Baker, Ming Ward, Michael Kholodov, Lon Phan, Eva Czabarka, Janos Murvai, David Cutler, Stephen Wooding, Alan Rogers, Aravinda Chakravarti, Henry C. Harpending, Pui-Yan Kwok, and Stephen T. Sherry PMCID: PMC140982 Retraction Proc Natl Acad Sci U S A. 2003 January 7; 100(1): 382. Published online 2002 December 26. doi: 10.1073/pnas.0234540100.PMCID: PMC140860 Retracts: M Garnier, et al. Functional characterization of a nonclassical nicotine receptor associated with inositolphospholipid breakdown and mobilization of intracellular calcium pools. Proc Natl Acad Sci U S A. 1994 November 22; 91(24): 11743–11747. |
