| | This journal provides immediate access to some articles. Commentaries Do SNARE proteins confer specificity for vesicle fusion? Mingshan Xue and Bing Zhang PMCID: PMC129673 Chemotherapeutic hope on the horizon for Plasmodium vivax malaria? Robert G. Ridley PMCID: PMC129674 The discovery of susceptibility genes for mental disorders C. Robert Cloninger PMCID: PMC129675 Mechanism for saltational shifts in pheromone communication systems Thomas C. Baker PMCID: PMC129676 Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum? Timothy D. Warner and Jane A. Mitchell PMCID: PMC129677 Error catastrophe and antiviral strategy Manfred Eigen PMCID: PMC129678 Interruption of antiretroviral therapy to augment immune control of chronic HIV-1 infection: Risk without reward Ume L. Abbas and John W. Mellors PMCID: PMC129679 Climate, changing phenology, and other life history traits: Nonlinearity and match–mismatch to the environment Nils Chr. Stenseth and Atle Mysterud PMCID: PMC129680 Physical Sciences Applied Physical Sciences Modeling the Internet's large-scale topology Soon-Hyung Yook, Hawoong Jeong, and Albert-László Barabási PMCID: PMC129681 Chemistry Structures and stabilities of higher coordinate onium-boronium dications (X+BH3+ and X+BH5+; X = NH3, PH3, H2O, and H2S) Golam Rasul, G. K. Surya Prakash, and George A. Olah PMCID: PMC129682 Critical points in charged membranes containing cholesterol Arun Radhakrishnan and Harden M. McConnell PMCID: PMC129683 Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering William A. Barton, John B. Biggins, Jiqing Jiang, Jon S. Thorson, and Dimitar B. Nikolov PMCID: PMC129684 Physics Increased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro Ralf Kemkemer, Stephanie Schrank, Walther Vogel, Hans Gruler, and Dieter Kaufmann PMCID: PMC129775 Biological Sciences Biochemistry An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP Randy L. Luciano and Angus C. Wilson PMCID: PMC129685 Structure and function in rhodopsin: Asymmetric reconstitution of rhodopsin in liposomes Li Niu, Jong-Myoung Kim, and H. Gobind Khorana PMCID: PMC129686 Structure and function in rhodopsin: A tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants Philip J. Reeves, Jong-Myoung Kim, and H. Gobind Khorana PMCID: PMC129687 Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line Philip J. Reeves, Nico Callewaert, Roland Contreras, and H. Gobind Khorana PMCID: PMC129688 Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes Sara S. Hook, Amir Orian, Shaun M. Cowley, and Robert N. Eisenman PMCID: PMC129689 The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast Roy M. Williams, Michael Primig, Brian K. Washburn, Elizabeth A. Winzeler, Michel Bellis, Cyril Sarrauste de Menthière, Ronald W. Davis, and Rochelle E. Esposito PMCID: PMC129690 X-ray structure of a bifunctional protein kinase in complex with its protein substrate HPr Sonia Fieulaine, Solange Morera, Sandrine Poncet, Ivan Mijakovic, Anne Galinier, Joël Janin, Josef Deutscher, and Sylvie Nessler PMCID: PMC129691 Pyrophosphate-producing protein dephosphorylation by HPr kinase/phosphorylase: A relic of early life? Ivan Mijakovic, Sandrine Poncet, Anne Galinier, Vicente Monedero, Sonia Fieulaine, Joël Janin, Sylvie Nessler, José Antonio Marquez, Klaus Scheffzek, Sonja Hasenbein, Wolfgang Hengstenberg, and Josef Deutscher PMCID: PMC129692 Subunit rotation of ATP synthase embedded in membranes: a or β subunit rotation relative to the c subunit ring Kazuaki Nishio, Atsuko Iwamoto-Kihara, Akitsugu Yamamoto, Yoh Wada, and Masamitsu Futai PMCID: PMC129693 Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum Shane R. Wilkinson, Samson O. Obado, Isabel L. Mauricio, and John M. Kelly PMCID: PMC129694 Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor Mircea Ivan, Thomas Haberberger, David C. Gervasi, Kristen S. Michelson, Volkmar Günzler, Keiichi Kondo, Haifeng Yang, Irina Sorokina, Ronald C. Conaway, Joan W. Conaway, and William G. Kaelin, Jr. PMCID: PMC129695 Protonation of non-Watson–Crick base pairs and encapsidation of turnip yellow mosaic virus RNA Hugo H. J. Bink, Koen Hellendoorn, Jannes van der Meulen, and Cornelis W. A. Pleij PMCID: PMC129696 Adaptation to famine: A family of stationary-phase genes revealed by microarray analysis Travis H. Tani, Arkady Khodursky, Robert M. Blumenthal, Patrick O. Brown, and Rowena G. Matthews PMCID: PMC129697 Structural analysis of the RSC chromatin-remodeling complex Francisco J. Asturias, Wen-Hsiang Chung, Roger D. Kornberg, and Yahli Lorch PMCID: PMC129698 Interaction of dihydrofolate reductase with methotrexate: Ensemble and single-molecule kinetics P. T. Ravi Rajagopalan, Zhiquan Zhang, Lynn McCourt, Mary Dwyer, Stephen J. Benkovic, and Gordon G. Hammes PMCID: PMC129699 A potent analog of 1α,25-dihydroxyvitamin D3 selectively induces bone formation Nirupama K. Shevde, Lori A. Plum, Margaret Clagett-Dame, Hironori Yamamoto, J. Wesley Pike, and Hector F. DeLuca PMCID: PMC129700 Structure of the single-strand annealing domain of human RAD52 protein Martin R. Singleton, Lois M. Wentzell, Yilun Liu, Stephen C. West, and Dale B. Wigley PMCID: PMC129701 Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues Shuyuan Yeh, Meng-Yin Tsai, Qingquan Xu, Xiao-Min Mu, Henry Lardy, Ko-En Huang, Hank Lin, Shauh-Der Yeh, Saleh Altuwaijri, Xinchang Zhou, Lianping Xing, Brendan F. Boyce, Min-Chi Hung, Su Zhang, Lin Gan, and Chawnshang Chang PMCID: PMC129702 Small heat-shock proteins regulate membrane lipid polymorphism Nelly M. Tsvetkova, Ibolya Horváth, Zsolt Török, Willem F. Wolkers, Zsolt Balogi, Natalia Shigapova, Lois M. Crowe, Fern Tablin, Elizabeth Vierling, John H. Crowe, and László Vígh PMCID: PMC129703 Helix–hairpin–helix motifs confer salt resistance and processivity on chimeric DNA polymerases Andrey R. Pavlov, Galina I. Belova, Sergei A. Kozyavkin, and Alexei I. Slesarev PMCID: PMC129704 A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity Subrata Adak, Manisha Sharma, Abigail L. Meade, and Dennis J. Stuehr PMCID: PMC129705 Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin Lei Jin and Stephen C. Harrison PMCID: PMC129706 S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase James Leiper, Judith Murray-Rust, Neil McDonald, and Patrick Vallance PMCID: PMC129707 Biophysics Critical points in charged membranes containing cholesterol Arun Radhakrishnan and Harden M. McConnell PMCID: PMC129683 Lipid–protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy César Fernández, Christian Hilty, Gerhard Wider, and Kurt Wüthrich PMCID: PMC129708 Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior Karen Adelman, Arthur La Porta, Thomas J. Santangelo, John T. Lis, Jeffrey W. Roberts, and Michelle D. Wang PMCID: PMC129709 A two-state kinetic model for the unfolding of single molecules by mechanical force F. Ritort, C. Bustamante, and I. Tinoco, Jr. PMCID: PMC129710 Combinatorial mutagenesis to restrict amino acid usage in an enzyme to a reduced set Satoshi Akanuma, Takanori Kigawa, and Shigeyuki Yokoyama PMCID: PMC129711 Folding free energy function selects native-like protein sequences in the core but not on the surface Alfonso Jaramillo, Lorenz Wernisch, Stéphanie Héry, and Shoshana J. Wodak PMCID: PMC129712 Solution structure and dynamics of the outer membrane enzyme PagP by NMR Peter M. Hwang, Wing-Yiu Choy, Eileen I. Lo, Lu Chen, Julie D. Forman-Kay, Christian R. H. Raetz, Gilbert G. Privé, Russell E. Bishop, and Lewis E. Kay PMCID: PMC129713 Recognition of the DNA sequence by an inorganic crystal surface Beatrice Sampaolese, Anna Bergia, Anita Scipioni, Giampaolo Zuccheri, Maria Savino, Bruno Samorì, and Pasquale De Santis PMCID: PMC129714 Cell Biology Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling Andrew R. Tee, Diane C. Fingar, Brendan D. Manning, David J. Kwiatkowski, Lewis C. Cantley, and John Blenis PMCID: PMC129715 Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo Bing Song, Min Zhao, John V. Forrester, and Colin D. McCaig PMCID: PMC129716 Higher order arrangement of the eukaryotic nuclear bodies I-Fan Wang, Narsa M. Reddy, and C.-K. James Shen PMCID: PMC129717 Developmental Biology An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β,17β-diol, and CYP7B1, regulates prostate growth Zhang Weihua, Richard Lathe, Margaret Warner, and Jan-Åke Gustafsson PMCID: PMC129718 Ecology Predicting the effects of climate change on avian life-history traits David W. Winkler, Peter O. Dunn, and Charles E. McCulloch PMCID: PMC129719 The functional integrity of normally forested landscapes: A proposal for an index of environmental capital George M. Woodwell PMCID: PMC129720 Evolution Natural alleles at a tomato fruit size quantitative trait locus differ by heterochronic regulatory mutations Bin Cong, Jiping Liu, and Steven D. Tanksley PMCID: PMC129721 Molecular evidence for ecological speciation in tropical habitats Rob Ogden and Roger S. Thorpe PMCID: PMC129722 Linkage limits the power of natural selection in Drosophila Andrea J. Betancourt and Daven C. Presgraves PMCID: PMC129723 From the Cover:
Evolution of moth sex pheromones via ancestral genes Wendell L. Roelofs, Weitian Liu, Guixia Hao, Hongmei Jiao, Alejandro P. Rooney, and Charles E. Linn, Jr. PMCID: PMC129724 The hidden duplication past of Arabidopsis thaliana Cedric Simillion, Klaas Vandepoele, Marc C. E. Van Montagu, Marc Zabeau, and Yves Van de Peer PMCID: PMC129725 Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels Roy J. Britten PMCID: PMC129726 Remarkable compartmentalization of transposable elements and pseudogenes in the heterochromatin of the Tetraodon nigroviridis genome Corinne Dasilva, Hajer Hadji, Catherine Ozouf-Costaz, Sophie Nicaud, Olivier Jaillon, Jean Weissenbach, and Hugues Roest Crollius PMCID: PMC129727 Genetics Computer assisted cloning of human neutral α-glucosidase C (GANC): A new paralog in the glycosyl hydrolase gene family 31 R. Hirschhorn, M. L. Huie, and J. S. Kasper PMCID: PMC129728 DBC2, a candidate for a tumor suppressor gene involved in breast cancer Masaaki Hamaguchi, Jennifer L. Meth, Christine von Klitzing, Wen Wei, Diane Esposito, Linda Rodgers, Tom Walsh, Piri Welcsh, Mary-Claire King, and Michael H. Wigler PMCID: PMC129730 SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria Patrick Onyango, Ivana Celic, J. Michael McCaffery, Jef D. Boeke, and Andrew P. Feinberg PMCID: PMC129731 Two regulatory levels of transcriptional gene silencing in Arabidopsis Ortrun Mittelsten Scheid, Aline V. Probst, Karin Afsar, and Jerzy Paszkowski PMCID: PMC129733 Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse Lee G. Fradkin, Jessica T. Kamphorst, Aaron DiAntonio, Corey S. Goodman, and Jasprina N. Noordermeer PMCID: PMC129735 Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage John R. Vance and Thomas E. Wilson PMCID: PMC129737 Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia Ilya Chumakov, Marta Blumenfeld, Oxana Guerassimenko, Laurent Cavarec, Marta Palicio, Hadi Abderrahim, Lydie Bougueleret, Caroline Barry, Hiroaki Tanaka, Philippe La Rosa, Anne Puech, Nadia Tahri, Annick Cohen-Akenine, Sylvain Delabrosse, Sébastien Lissarrague, Françoise-Pascaline Picard, Karelle Maurice, Laurent Essioux, Philippe Millasseau, Pascale Grel, Virginie Debailleul, Anne-Marie Simon, Dominique Caterina, Isabelle Dufaure, Kattayoun Malekzadeh, Maria Belova, Jian-Jian Luan, Michel Bouillot, Jean-Luc Sambucy, Gwenael Primas, Martial Saumier, Nadia Boubkiri, Sandrine Martin-Saumier, Myriam Nasroune, Hélène Peixoto, Arnaud Delaye, Virginie Pinchot, Mariam Bastucci, Sophie Guillou, Magali Chevillon, Ricardo Sainz-Fuertes, Said Meguenni, Joan Aurich-Costa, Dorra Cherif, Anne Gimalac, Cornelia Van Duijn, Denis Gauvreau, Gail Ouelette, Isabel Fortier, John Realson, Tatiana Sherbatich, Nadejda Riazanskaia, Evgeny Rogaev, Peter Raeymaekers, Jeroen Aerssens, Frank Konings, Walter Luyten, Fabio Macciardi, Pak C. Sham, Richard E. Straub, Daniel R. Weinberger, Nadine Cohen, and Daniel Cohen PMCID: PMC129739 Immunology Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium Heidrun Koebernick, Leander Grode, John R. David, Wolfgang Rohde, Michael S. Rolph, Hans-Willi Mittrücker, and Stefan H. E. Kaufmann PMCID: PMC129741 A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex Masanori Kasahara, Yutaka Watanabe, Motoko Sumasu, and Taeko Nagata PMCID: PMC129743 The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression Jie Zhou, Nasrin Ashouian, Marc Delepine, Fumihiko Matsuda, Christophe Chevillard, Roy Riblet, Carl L. Schildkraut, and Barbara K. Birshtein PMCID: PMC129745 On the power of chemical synthesis: Immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines Govindaswami Ragupathi, Don M. Coltart, Lawrence J. Williams, Fusataka Koide, Ella Kagan, Jennifer Allen, Christina Harris, Peter W. Glunz, Philip O. Livingston, and Samuel J. Danishefsky PMCID: PMC129747 Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae Aya Takehana, Tomonori Katsuyama, Tamaki Yano, Yoshiteru Oshima, Haruhiko Takada, Toshiro Aigaki, and Shoichiro Kurata PMCID: PMC129750 B cells develop in the zebrafish pancreas Nadia Danilova and Lisa A. Steiner PMCID: PMC129751 Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes Giovanni Sitia, Masanori Isogawa, Kazuhiro Kakimi, Stefan F. Wieland, Francis V. Chisari, and Luca G. Guidotti PMCID: PMC129753 A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity Philip Bufler, Tania Azam, Fabia Gamboni-Robertson, Leonid L. Reznikov, Sanjay Kumar, Charles A. Dinarello, and Soo-Hyun Kim PMCID: PMC129755 Soluble peptide–MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules Qing Ge, Jennifer D. Stone, M. Todd Thompson, Jennifer R. Cochran, Mia Rushe, Herman N. Eisen, Jianzhu Chen, and Lawrence J. Stern PMCID: PMC129758 Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules Eckart Schott, Nicolas Bertho, Qing Ge, Madelon M. Maurice, and Hidde L. Ploegh PMCID: PMC129760 CD1d and invariant NKT cells at the human maternal–fetal interface Jonathan E. Boyson, Basya Rybalov, Louise A. Koopman, Mark Exley, Steven P. Balk, Frederick K. Racke, Frederick Schatz, Rachel Masch, S. Brian Wilson, and Jack L. Strominger PMCID: PMC129762 Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection Annette Oxenius, David A. Price, Huldrych F. Günthard, Sara J. Dawson, Catherine Fagard, Luc Perrin, Marek Fischer, Rainer Weber, Montserrat Plana, Felipe García, Bernard Hirschel, Angela McLean, and Rodney E. Phillips PMCID: PMC129766 Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice Michele P. Marron, Robert T. Graser, Harold D. Chapman, and David V. Serreze PMCID: PMC129768 IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes Hai-Hui Xue, Panu E. Kovanen, Cynthia A. Pise-Masison, Maria Berg, Michael F. Radovich, John N. Brady, and Warren J. Leonard PMCID: PMC129770 Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides Chikara Ohyama, Satoru Kanto, Kazunori Kato, Osamu Nakano, Yoichi Arai, Tetsuro Kato, Shihao Chen, Michiko N. Fukuda, and Minoru Fukuda PMCID: PMC129776 Medical Sciences From the Cover:
Bystander effect produced by radiolabeled tumor cells in vivo Lanny Y. Xue, Nicholas J. Butler, G. Mike Makrigiorgos, S. James Adelstein, and Amin I. Kassis PMCID: PMC129772 APC-dependent suppression of colon carcinogenesis by PPARγ Geoffrey D. Girnun, Wendy M. Smith, Stavit Drori, Pasha Sarraf, Elisabetta Mueller, Charis Eng, Prashant Nambiar, Daniel W. Rosenberg, Roderick T. Bronson, Winfried Edelmann, Raju Kucherlapati, Frank J. Gonzalez, and Bruce M. Spiegelman PMCID: PMC129773 Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer Hiroshi Takahashi, Yukihiko Hirai, Makoto Migita, Yoshihiko Seino, Yuh Fukuda, Hitoshi Sakuraba, Ryoichi Kase, Toshihide Kobayashi, Yasuhiro Hashimoto, and Takashi Shimada PMCID: PMC129774 Increased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro Ralf Kemkemer, Stephanie Schrank, Walther Vogel, Hans Gruler, and Dieter Kaufmann PMCID: PMC129775 Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides Chikara Ohyama, Satoru Kanto, Kazunori Kato, Osamu Nakano, Yoichi Arai, Tetsuro Kato, Shihao Chen, Michiko N. Fukuda, and Minoru Fukuda PMCID: PMC129776 From the Cover:
HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels Enrique Gonzalez, Brad H. Rovin, Luisa Sen, Glen Cooke, Rahul Dhanda, Srinivas Mummidi, Hemant Kulkarni, Michael J. Bamshad, Vanessa Telles, Stephanie A. Anderson, Elizabeth A. Walter, Kevin T. Stephan, Michael Deucher, Andrea Mangano, Rosa Bologna, Seema S. Ahuja, Matthew J. Dolan, and Sunil K. Ahuja PMCID: PMC129777 Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR) Junichiro Sonoda, Wen Xie, John M. Rosenfeld, Joyce L. Barwick, Philip S. Guzelian, and Ronald M. Evans PMCID: PMC129778 Microbiology Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon James W. Wilson, Rajee Ramamurthy, Steffen Porwollik, Michael McClelland, Timothy Hammond, Pat Allen, C. Mark Ott, Duane L. Pierson, and Cheryl A. Nickerson PMCID: PMC129779 Amino acid deletions are introduced into the V2 region of gp120 during independent pathogenic simian immunodeficiency virus/HIV chimeric virus (SHIV) infections of rhesus monkeys generating variants that are macrophage tropic Hiromi Imamichi, Tatsuhiko Igarashi, Tomozumi Imamichi, Olivia K. Donau, Yasuyuki Endo, Yoshiaki Nishimura, Ronald L. Willey, Anthony F. Suffredini, H. Clifford Lane, and Malcolm A. Martin PMCID: PMC129780 Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT-1 and NF-κB) complexes by antibody-dependent enhancement of macrophage infection by Ross River virus Surendran Mahalingam and Brett A. Lidbury PMCID: PMC129781 Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection Priscilla L. Yang, Alana Althage, Josan Chung, and Francis V. Chisari PMCID: PMC129782 Identification of a localization factor for the polar positioning of bacterial structural and regulatory proteins Patrick H. Viollier, Nitzan Sternheim, and Lucy Shapiro PMCID: PMC129783 Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses Erika Geimonen, Sherry Neff, Tracy Raymond, Salih S. Kocer, Irina N. Gavrilovskaya, and Erich R. Mackow PMCID: PMC129784 A dominant block to HIV-1 replication at reverse transcription in simian cells Carsten Münk, Stephanie M. Brandt, Ginger Lucero, and Nathaniel R. Landau PMCID: PMC129785 Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus Terrence M. Tumpey, Adolfo García-Sastre, Andrea Mikulasova, Jeffery K. Taubenberger, David E. Swayne, Peter Palese, and Christopher F. Basler PMCID: PMC129786 Virulence control in group A Streptococcus by a two-component gene regulatory system: Global expression profiling and in vivo infection modeling Morag R. Graham, Laura M. Smoot, Cristi A. Lux Migliaccio, Kimmo Virtaneva, Daniel E. Sturdevant, Stephen F. Porcella, Michael J. Federle, Gerald J. Adams, June R. Scott, and James M. Musser PMCID: PMC129787 Innate recognition of bacteria by a macrophage cytosolic surveillance pathway Mary O'Riordan, Caroline H. Yi, Ramona Gonzales, Kyung-Dall Lee, and Daniel A. Portnoy PMCID: PMC129788 Neuroscience From the Cover:
Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability Sharmila Bhattacharya, Bryan A. Stewart, Barbara A. Niemeyer, Robert W. Burgess, Brian D. McCabe, Peter Lin, Gabrielle Boulianne, Cahir J. O'Kane, and Thomas L. Schwarz PMCID: PMC129789 Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals David Weinshenker, Nicole S. Miller, Katherine Blizinsky, Marc L. Laughlin, and Richard D. Palmiter PMCID: PMC129790 Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration Ling Wang, Gertrud U. Schuster, Kjell Hultenby, Qinghong Zhang, Sandra Andersson, and Jan-Åke Gustafsson PMCID: PMC129791 Reciprocal developmental regulation of presynaptic ionotropic receptors Rostislav Turecek and Laurence O. Trussell PMCID: PMC129792 Temporal expression of seven clock genes in the suprachiasmatic nucleus and the pars tuberalis of the sheep: Evidence for an internal coincidence timer Gerald Lincoln, Sophie Messager, Håkan Andersson, and David Hazlerigg PMCID: PMC129793 Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau Yoshitaka Tatebayashi, Tomohiro Miyasaka, De-Hua Chui, Takumi Akagi, Ken-ichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Kentaro Tanemura, Miyuki Murayama, Koichi Ishiguro, Emmanuel Planel, Shinji Sato, Tsutomu Hashikawa, and Akihiko Takashima PMCID: PMC129794 Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number Eric Schnell, Max Sizemore, Siavash Karimzadegan, Lu Chen, David S. Bredt, and Roger A. Nicoll PMCID: PMC129795 Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation Benno Roozendaal, Kristen L. Brunson, Brian L. Holloway, James L. McGaugh, and Tallie Z. Baram PMCID: PMC129796 Activity patterns in human motion-sensitive areas depend on the interpretation of global motion Miguel Castelo-Branco, Elia Formisano, Walter Backes, Friedhelm Zanella, Sergio Neuenschwander, Wolf Singer, and Rainer Goebel PMCID: PMC129797 The function of bursts of spikes during visual fixation in the awake primate lateral geniculate nucleus and primary visual cortex Susana Martinez-Conde, Stephen L. Macknik, and David H. Hubel PMCID: PMC129798 Pharmacology From the Cover:
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression N. V. Chandrasekharan, Hu Dai, K. Lamar Turepu Roos, Nathan K. Evanson, Joshua Tomsik, Terry S. Elton, and Daniel L. Simmons PMCID: PMC129799 Transport of nitrated albumin across continuous vascular endothelium Dan Predescu, Sanda Predescu, and Asrar B. Malik PMCID: PMC129800 Plant Biology The tomato fer gene encoding a bHLH protein controls iron-uptake responses in roots Hong-Qing Ling, Petra Bauer, Zsolt Bereczky, Beat Keller, and Martin Ganal PMCID: PMC129801 Three semidominant barley mutants with single amino acid substitutions in the smallest magnesium chelatase subunit form defective AAA+ hexamers A. Hansson, R. D. Willows, T. H. Roberts, and M. Hansson PMCID: PMC129802 Population Biology Natural radioactivity and human mitochondrial DNA mutations Lucy Forster, Peter Forster, Sabine Lutz-Bonengel, Horst Willkomm, and Bernd Brinkmann PMCID: PMC129803 Social Sciences Psychology Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood Tracey J. Shors and George Miesegaes PMCID: PMC129804 Corrections Proc Natl Acad Sci U S A. 2002 October 15; 99(21): 13961. Published online 2002 October 3. doi: 10.1073/pnas.222559599.PMCID: PMC129670 Corrects: C. Kiong Ho, et al. Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains. Proc Natl Acad Sci U S A. 2002 October 1; 99(20): 12709–12714. Proc Natl Acad Sci U S A. 2002 October 15; 99(21): 13961. Published online 2002 October 2. doi: 10.1073/pnas.222515499.PMCID: PMC129671 Corrects: Yoonseong Park, et al. Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc Natl Acad Sci U S A. 2002 August 20; 99(17): 11423–11428. Proc Natl Acad Sci U S A. 2002 October 15; 99(21): 13961. Published online 2002 October 2. doi: 10.1073/pnas.222439799.PMCID: PMC129672 Corrects: T. P. Dinh, et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci U S A. 2002 August 6; 99(16): 10819–10824. |
