| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 February 22; 102(8): 2673–2674. doi: 10.1073/iti0805102.PMCID: PMC549503 Commentaries Cholesterol detoxification by the nuclear pregnane X receptor Steven A. Kliewer PMCID: PMC549480 Phosphatase and tensin homologue growth suppression without phosphatase David Stokoe and Joseph F. Costello PMCID: PMC549471 Endocytosis of membrane receptors: Two pathways are better than one Rubén Claudio Aguilar and Beverly Wendland PMCID: PMC549498 Eukaryotic-like signaling and gene regulation in a prokaryote that undergoes multicellular development Lee Kroos PMCID: PMC549479 The community-wide dilemma of hospital-acquired drug resistance Leslie A. Real PMCID: PMC549469 Physical Sciences Engineering Uncovering transcriptional regulation of metabolism by using metabolic network topology Kiran Raosaheb Patil and Jens Nielsen PMCID: PMC549453 Mathematics From the Cover:
Combinatorial theory of Macdonald polynomials I: Proof of Haglund's formula J. Haglund, M. Haiman, and N. Loehr PMCID: PMC549509 Biological Sciences Applied Biological Sciences Tailored catalysts for plant cell-wall degradation: Redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A Mark R. Proctor, Edward J. Taylor, Didier Nurizzo, Johan P. Turkenburg, Ruth M. Lloyd, Maria Vardakou, Gideon J. Davies, and Harry J. Gilbert PMCID: PMC549454 Biochemistry From the Cover:
Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor Koichi Okumura, Mujun Zhao, Ronald A. DePinho, Frank B. Furnari, and Webster K. Cavenee PMCID: PMC549467 A critical role of helix 3–helix 5 interaction in steroid hormone receptor function Junhui Zhang, Jessica Simisky, Francis T. F. Tsai, and David S. Geller PMCID: PMC549476 Sulfide binding is mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin Jason F. Flores, Charles R. Fisher, Susan L. Carney, Brian N. Green, John K. Freytag, Stephen W. Schaeffer, and William E. Royer, Jr. PMCID: PMC549462 Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor Elizabeth Buck and James A. Wells PMCID: PMC549436 Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon–glial interactions Tadashi Yamashita, Yun-Ping Wu, Roger Sandhoff, Norbert Werth, Hiroki Mizukami, Jessica M. Ellis, Jeffrey L. Dupree, Rudolf Geyer, Konrad Sandhoff, and Richard L. Proia PMCID: PMC549464 Inorganic polyphosphate in Dictyostelium discoideum: Influence on development, sporulation, and predation Haiyu Zhang, María R. Gómez-García, Michael R. W. Brown, and Arthur Kornberg PMCID: PMC549442 Biophysics Surviving heat shock: Control strategies for robustness and performance H. El-Samad, H. Kurata, J. C. Doyle, C. A. Gross, and M. Khammash PMCID: PMC549435 The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path J. P. Johnson, Jr. and William N. Zagotta PMCID: PMC549449 Specific collapse followed by slow hydrogen-bond formation of β-sheet in the folding of single-chain monellin Tetsunari Kimura, Takanori Uzawa, Koichiro Ishimori, Isao Morishima, Satoshi Takahashi, Takashi Konno, Shuji Akiyama, and Tetsuro Fujisawa PMCID: PMC549438 Polyproline and the “spectroscopic ruler” revisited with single-molecule fluorescence Benjamin Schuler, Everett A. Lipman, Peter J. Steinbach, Michael Kumke, and William A. Eaton PMCID: PMC549440 Cell Biology From the Cover:
Clathrin-independent endocytosis of ubiquitinated cargos Sara Sigismund, Tanja Woelk, Claudia Puri, Elena Maspero, Carlo Tacchetti, Pietro Transidico, Pier Paolo Di Fiore, and Simona Polo PMCID: PMC549482 From the Cover:
The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin Hong Chen and Pietro De Camilli PMCID: PMC549477 Cryo-electron tomography of vaccinia virus Marek Cyrklaff, Cristina Risco, Jose Jesús Fernández, Maria Victoria Jiménez, Mariano Estéban, Wolfgang Baumeister, and José L. Carrascosa PMCID: PMC549483 Nucleoplasmin regulates chromatin condensation during apoptosis Zhigang Lu, Chuanmao Zhang, and Zhonghe Zhai PMCID: PMC549441 Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70 Kai-Feng Xu, Xiaoyan Shen, Hewang Li, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan PMCID: PMC549493 β-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform Elöd Z. Szabó, Masayuki Numata, Viktoria Lukashova, Pietro Iannuzzi, and John Orlowski PMCID: PMC549460 Mouse Na+/K+-ATPase β1-subunit has a K+-dependent cell adhesion activity for β-GlcNAc-terminating glycans Noriaki Kitamura, Masahiko Ikekita, Takeshi Sato, Yoshihiro Akimoto, Yasumaru Hatanaka, Hayato Kawakami, Mitsushi Inomata, and Kiyoshi Furukawa PMCID: PMC549466 Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis Qinghong Zhang, Amanda Nottke, and Richard H. Goodman PMCID: PMC549470 Developmental Biology Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis Igor Martianov, Stefano Brancorsini, Raffaella Catena, Anne Gansmuller, Noora Kotaja, Martti Parvinen, Paolo Sassone-Corsi, and Irwin Davidson PMCID: PMC549447 Early onset of puberty and early ovarian failure in CYP7B1 knockout mice Yoko Omoto, Richard Lathe, Margaret Warner, and Jan-Åke Gustafsson PMCID: PMC549492 Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2 Ching-Wei Luo, Elizabeth M. Dewey, Satoko Sudo, John Ewer, Sheau Yu Hsu, Hans-Willi Honegger, and Aaron J. W. Hsueh PMCID: PMC549504 Ecology Ecosystem recovery after climatic extremes enhanced by genotypic diversity Thorsten B. H. Reusch, Anneli Ehlers, August Hämmerli, and Boris Worm PMCID: PMC549506 Evolution Positive selection of primate TRIM5α identifies a critical species-specific retroviral restriction domain Sara L. Sawyer, Lily I. Wu, Michael Emerman, and Harmit S. Malik PMCID: PMC549489 Heritability and genetic constraints of life-history trait evolution in preindustrial humans Jenni E. Pettay, Loeske E. B. Kruuk, Jukka Jokela, and Virpi Lummaa PMCID: PMC549452 Synthesis and degradation of dinoflagellate plastid-encoded psbA proteins are light-regulated, not circadian-regulated Yunling Wang, Lene Jensen, Peter Højrup, and David Morse PMCID: PMC549448 Genetics Uncovering transcriptional regulation of metabolism by using metabolic network topology Kiran Raosaheb Patil and Jens Nielsen PMCID: PMC549453 Identification and analysis of alternative splicing events conserved in human and mouse Gene W. Yeo, Eric Van Nostrand, Dirk Holste, Tomaso Poggio, and Christopher B. Burge PMCID: PMC548664 Multiple homeostatic mechanisms in the control of P1 plasmid replication Nilangshu Das, Majda Valjavec-Gratian, Ashish N. Basuray, Richard A. Fekete, Peter P. Papp, Johan Paulsson, and Dhruba K. Chattoraj PMCID: PMC549481 Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica Igor Zwir, Dongwoo Shin, Akinori Kato, Kunihiko Nishino, Tammy Latifi, Felix Solomon, Janelle M. Hare, Henry Huang, and Eduardo A. Groisman PMCID: PMC548500 Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice Jackie Haines, Victoria Johnson, Kevin Pack, Nirosha Suraweera, Predrag Slijepcevic, Erik Cabuy, Margaret Coster, Mohammad Ilyas, Jennifer Wilding, Oliver Sieber, Walter Bodmer, Ian Tomlinson, and Andrew Silver PMCID: PMC549446 Immunology TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs Julia Hauer, Stephanie Püschner, Parameswaran Ramakrishnan, Ute Simon, Martina Bongers, Christine Federle, and Hartmut Engelmann PMCID: PMC549490 Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization Mansour Mohamadzadeh, Scott Olson, Warren V. Kalina, Gordon Ruthel, Gretchen L. Demmin, Kelly L. Warfield, Sina Bavari, and Todd R. Klaenhammer PMCID: PMC549474 Characterization of CD56–/CD16+ natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals Domenico Mavilio, Gabriella Lombardo, Janet Benjamin, Diana Kim, Dean Follman, Emanuela Marcenaro, M. Angeline O'Shea, Audrey Kinter, Colin Kovacs, Alessandro Moretta, and Anthony S. Fauci PMCID: PMC549494 The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles Jörg H. W. Distler, Astrid Jüngel, Lars C. Huber, Christian A. Seemayer, Charles F. Reich, III, Renate E. Gay, Beat A. Michel, Adriano Fontana, Steffen Gay, David S. Pisetsky, and Oliver Distler PMCID: PMC548330 T cells from epicutaneously immunized mice are prone to T cell receptor revision Margaret S. Bynoe, Christophe Viret, Richard A. Flavell, and Charles A. Janeway, Jr. PMCID: PMC549496 T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells Bozidar Purtic, Lisa A. Pitcher, Nicolai S. C. van Oers, and Christoph Wülfing PMCID: PMC549456 Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells Kavita M. Dhodapkar, Jacob L. Kaufman, Marc Ehlers, Devi K. Banerjee, Ezio Bonvini, Scott Koenig, Ralph M. Steinman, Jeffrey V. Ravetch, and Madhav V. Dhodapkar PMCID: PMC549508 Medical Sciences Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats Tammara Watts, Irene Berti, Anna Sapone, Tania Gerarduzzi, Tarcisio Not, Ronald Zielke, and Alessio Fasano PMCID: PMC549484 Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging P. Peter Ghoroghchian, Paul R. Frail, Kimihiro Susumu, Dana Blessington, Aaron K. Brannan, Frank S. Bates, Britton Chance, Daniel A. Hammer, and Michael J. Therien PMCID: PMC549472 Embryonic pig liver, pancreas, and lung as a source for transplantation: Optimal organogenesis without teratoma depends on distinct time windows Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh, Benjamin Dekel, Enrique Freud, and Yair Reisner PMCID: PMC548800 Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors Malin Sund, Yuki Hamano, Hikaru Sugimoto, Akulapalli Sudhakar, Mary Soubasakos, Udaya Yerramalla, Laura E. Benjamin, Jack Lawler, Mark Kieran, Amish Shah, and Raghu Kalluri PMCID: PMC549486 Vaccinia viruses with a serpin gene deletion and expressing IFN-γ induce potent immune responses without detectable replication in vivo Fatema A. Legrand, Paulo H. Verardi, Kenneth S. Chan, Yue Peng, Leslie A. Jones, and Tilahun D. Yilma PMCID: PMC548597 Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration Jeffrey A. Spencer, Shelby L. Hacker, Elaine C. Davis, Robert P. Mecham, Russ H. Knutsen, Dean Y. Li, Robert D. Gerard, James A. Richardson, Eric N. Olson, and Hiromi Yanagisawa PMCID: PMC549459 A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia Lynda S. Ostedgaard, Tatiana Rokhlina, Philip H. Karp, Philip Lashmit, Sandra Afione, Michael Schmidt, Joseph Zabner, Mark F. Stinski, Jay A. Chiorini, and Michael J. Welsh PMCID: PMC549485 Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro Jeffrey H. Fair, Bruce A. Cairns, Michael A. LaPaglia, Montserrat Caballero, W. Andrew Pleasant, Seigo Hatada, Hyung-suk Kim, Tong Gui, Larysa Pevny, Anthony A. Meyer, Darrel W. Stafford, Oliver Smithies, and Jeffrey A. Frelinger PMCID: PMC548326 Karyotypic “state” as a potential determinant for anticancer drug discovery Anna V. Roschke, Samir Lababidi, Giovanni Tonon, Kristen S. Gehlhaus, Kimberly Bussey, John N. Weinstein, and Ilan R. Kirsch PMCID: PMC549443 Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice Naoko Niho, Michihiro Mutoh, Mami Takahashi, Kazuhiko Tsutsumi, Takashi Sugimura, and Keiji Wakabayashi PMCID: PMC549478 Syndromic patent ductus arteriosus: Evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder Arya Mani, Jayaram Radhakrishnan, Anita Farhi, Khary S. Carew, Carole A. Warnes, Carol Nelson-Williams, Ronald W. Day, Barbara Pober, Matthew W. State, and Richard P. Lifton PMCID: PMC549488 Microbiology Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators Markus Meissner, Efrosinia Krejany, Paul R. Gilson, Tania F. de Koning-Ward, Dominique Soldati, and Brendan S. Crabb PMCID: PMC548799 Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling Eileen Foy, Kui Li, Rhea Sumpter, Jr., Yueh-Ming Loo, Cynthia L. Johnson, Chunfu Wang, Penny Mar Fish, Mitsutoshi Yoneyama, Takashi Fujita, Stanley M. Lemon, and Michael Gale, Jr. PMCID: PMC549461 Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF Kui Li, Eileen Foy, Josephine C. Ferreon, Mitsuyasu Nakamura, Allan C. M. Ferreon, Masanori Ikeda, Stuart C. Ray, Michael Gale, Jr., and Stanley M. Lemon PMCID: PMC548795 Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein Angela R. Brannon, Julia A. Maresca, Jef D. Boeke, Munira A. Basrai, and Alison A. McBride PMCID: PMC549465 Complete genome sequence of Vibrio fischeri: A symbiotic bacterium with pathogenic congeners E. G. Ruby, M. Urbanowski, J. Campbell, A. Dunn, M. Faini, R. Gunsalus, P. Lostroh, C. Lupp, J. McCann, D. Millikan, A. Schaefer, E. Stabb, A. Stevens, K. Visick, C. Whistler, and E. P. Greenberg PMCID: PMC549501 Enhancer-binding proteins with a forkhead-associated domain and the σ54 regulon in Myxococcus xanthus fruiting body development Lars Jelsbak, Michael Givskov, and Dale Kaiser PMCID: PMC549468 Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli Mario F. Feldman, Michael Wacker, Marcela Hernandez, Paul G. Hitchen, Cristina L. Marolda, Michael Kowarik, Howard R. Morris, Anne Dell, Miguel A. Valvano, and Markus Aebi PMCID: PMC549450 Plasmodium liver stage developmental arrest by depletion of a protein at the parasite–host interface Ann-Kristin Mueller, Nelly Camargo, Karine Kaiser, Cathy Andorfer, Ute Frevert, Kai Matuschewski, and Stefan H. I. Kappe PMCID: PMC548321 Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner Deborah T. Hung and John J. Mekalanos PMCID: PMC549475 Neuroscience β-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids Amyaouch Bradaïa, Frédérique Berton, Serge Ferrari, and Christian Lüscher PMCID: PMC549451 Honey bees navigate according to a map-like spatial memory Randolf Menzel, Uwe Greggers, Alan Smith, Sandra Berger, Robert Brandt, Sascha Brunke, Gesine Bundrock, Sandra Hülse, Tobias Plümpe, Frank Schaupp, Elke Schüttler, Silke Stach, Jan Stindt, Nicola Stollhoff, and Sebastian Watzl PMCID: PMC549458 Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease Salvatore Oddo, Antonella Caccamo, Kim N. Green, Kevin Liang, Levina Tran, Yiling Chen, Frances M. Leslie, and Frank M. LaFerla PMCID: PMC549455 Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain Takayoshi Ubuka, George E. Bentley, Kazuyoshi Ukena, John C. Wingfield, and Kazuyoshi Tsutsui PMCID: PMC549437 Amyloid-β neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity Nikolay L. Malinin, Sarah Wright, Peter Seubert, Dale Schenk, and Irene Griswold-Prenner PMCID: PMC549444 Transcellular induction of neuropeptide Y expression by NT4 and BDNF Marcus J. Wirth, Silke Patz, and Petra Wahle PMCID: PMC549439 Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats Giulia D'Intino, Michela Paradisi, Mercedes Fernandez, Alessandro Giuliani, Luigi Aloe, Luciana Giardino, and Laura Calzà PMCID: PMC548798 Shared and specific muscle synergies in natural motor behaviors Andrea d'Avella and Emilio Bizzi PMCID: PMC549495 Pharmacology Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: Modes of ligand binding and dimerization Sergio E. Martinez, Sandra Bruder, Anita Schultz, Ning Zheng, Joachim E. Schultz, Joseph A. Beavo, and Jürgen U. Linder PMCID: PMC549502 The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites Sandra Bruder, Jürgen U. Linder, Sergio E. Martinez, Ning Zheng, Joseph A. Beavo, and Joachim E. Schultz PMCID: PMC549505 CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids Mohab M. Ibrahim, Frank Porreca, Josephine Lai, Phillip J. Albrecht, Frank L. Rice, Alla Khodorova, Gudarz Davar, Alexandros Makriyannis, Todd W. Vanderah, Heriberto P. Mata, and T. Philip Malan, Jr. PMCID: PMC549497 Physiology Ca2+ blinks: Rapid nanoscopic store calcium signaling Didier X. P. Brochet, Dongmei Yang, Alessandro Di Maio, W. Jonathan Lederer, Clara Franzini-Armstrong, and Heping Cheng PMCID: PMC548797 Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands Susan J. Broughton, Matthew D. W. Piper, Tomoatsu Ikeya, Timothy M. Bass, Jake Jacobson, Yasmine Driege, Pedro Martinez, Ernst Hafen, Dominic J. Withers, Sally J. Leevers, and Linda Partridge PMCID: PMC549445 Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals Hongnian Guo, Judy McKinley Brewer, Ameya Champhekar, Ruth B. S. Harris, and Eric L. Bittman PMCID: PMC548796 Plant Biology Control of seed mass and seed yield by the floral homeotic gene APETALA2 K. Diane Jofuku, Pamela K. Omidyar, Zorana Gee, and Jack K. Okamuro PMCID: PMC549499 Control of seed mass by APETALA2 Masa-aki Ohto, Robert L. Fischer, Robert B. Goldberg, Kenzo Nakamura, and John J. Harada PMCID: PMC549491 Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis Xinhua Dai, Ken-ichiro Hayashi, Hiroshi Nozaki, Youfa Cheng, and Yunde Zhao PMCID: PMC549487 Recruitment and interaction dynamics of plant penetration resistance components in a plasma membrane microdomain Riyaz A. Bhat, Marco Miklis, Elmon Schmelzer, Paul Schulze-Lefert, and Ralph Panstruga PMCID: PMC549507 Antioxidants and photoprotection in a lichen as compared with its isolated symbiotic partners Ilse Kranner, W. John Cram, Margret Zorn, Sabine Wornik, Isao Yoshimura, Edith Stabentheiner, and Hartwig W. Pfeifhofer PMCID: PMC549463 Root-knot nematodes and bacterial Nod factors elicit common signal transduction events in Lotus japonicus Ravisha R. Weerasinghe, David McK. Bird, and Nina S. Allen PMCID: PMC549434 Population Biology From the Cover:
Strategic interactions in multi-institutional epidemics of antibiotic resistance David L. Smith, Simon A. Levin, and Ramanan Laxminarayan PMCID: PMC549473 Psychology Symmetry activates extrastriate visual cortex in human and nonhuman primates Yuka Sasaki, Wim Vanduffel, Tamara Knutsen, Christopher Tyler, and Roger Tootell PMCID: PMC549500 Past trials influence perception of ambiguous motion quartets through pattern completion L. T. Maloney, M. F. Dal Martello, C. Sahm, and L. Spillmann PMCID: PMC549457 |
