| | This journal provides immediate access to some articles. Commentaries Creating a niche in the cytoskeleton: Actin reorganization by a
protein kinase Paul A. Janmey Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14745–14747. doi: 10.1073/pnas.011601598.PMCID: PMC64925 Can engineered bacteria help control cancer? Rakesh K. Jain and Neil S. Forbes Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14748–14750. doi: 10.1073/pnas.261606598.PMCID: PMC64926 Feedback regulation of iron-sulfur cluster biosynthesis Jeverson Frazzon and Dennis R. Dean Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14751–14753. doi: 10.1073/pnas.011579098.PMCID: PMC64927 Genetic diversity and disease: Opportunities and challenge John M. Scott Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14754–14756. doi: 10.1073/pnas.011601398.PMCID: PMC64928 Progress in transthyretin fibrillogenesis research strengthens
the amyloid hypothesis Avijit Chakrabartty Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14757–14759. doi: 10.1073/pnas.261596398.PMCID: PMC64929 Does amoeboid reasoning explain the evolution and maintenance
of virulence factors in
Cryptococcus neoformans? Stuart M. Levitz Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14760–14762. doi: 10.1073/pnas.261612398.PMCID: PMC64930 Tumor suppressors on 3p: A neoclassic quartet Kay Huebner Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14763–14765. doi: 10.1073/pnas.261586598.PMCID: PMC64931 How many ways to craft a cofactor? Judith P. Klinman Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14766–14768. doi: 10.1073/pnas.011602498.PMCID: PMC64932 Physical Sciences Chemistry Building highly sensitive dye assemblies for biosensing from
molecular building blocks Robert M. Jones, Liangde Lu, Roger Helgeson, Troy S. Bergstedt, Duncan W. McBranch, and David G. Whitten Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14769–14772. Published online 2001 December 11. doi: 10.1073/pnas.251555298.PMCID: PMC64933 Identification of a small molecule inhibitor of Sir2p Antonio Bedalov, Tonibelle Gatbonton, William P. Irvine, Daniel E. Gottschling, and Julian A. Simon Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15113–15118. doi: 10.1073/pnas.261574398.PMCID: PMC64992 Engineering Prediction of disclinations in nematic elastomers Eliot Fried and Russell E. Todres Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14773–14777. doi: 10.1073/pnas.261395098.PMCID: PMC64934 Geophysics Trends of measured climate forcing agents James E. Hansen and Makiko Sato Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14778–14783. doi: 10.1073/pnas.261553698.PMCID: PMC64935 A large carbon sink in the woody biomass of
Northern forests R. B. Myneni, J. Dong, C. J. Tucker, R. K. Kaufmann, P. E. Kauppi, J. Liski, L. Zhou, V. Alexeyev, and M. K. Hughes Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14784–14789. Published online 2001 December 11. doi: 10.1073/pnas.261555198.PMCID: PMC64936 Biological Sciences Biochemistry Structural basis for the activation of human procaspase-7 Stefan J. Riedl, Pablo Fuentes-Prior, Martin Renatus, Norman Kairies, Stephan Krapp, Robert Huber, Guy S. Salvesen, and Wolfram Bode Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14790–14795. doi: 10.1073/pnas.221580098.PMCID: PMC64937 Combining multiple structure and sequence alignments to improve
sequence detection and alignment: Application to the SH2 domains of Janus kinases Bissan Al-Lazikani, Felix B. Sheinerman, and Barry Honig Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14796–14801. doi: 10.1073/pnas.011577898.PMCID: PMC64938 The remarkable structural and functional organization of the
eukaryotic pyruvate dehydrogenase complexes Z. Hong Zhou, Diane B. McCarthy, Catherine M. O'Connor, Lester J. Reed, and James K. Stoops Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14802–14807. doi: 10.1073/pnas.011597698.PMCID: PMC64939 Crystal structure of the macrocycle-forming thioesterase domain
of the erythromycin polyketide synthase: Versatility from a
unique substrate channel Shiou-Chuan Tsai, Larry J. W. Miercke, Jolanta Krucinski, Rajesh Gokhale, Julian C.-H. Chen, Paul G. Foster, David E. Cane, Chaitan Khosla, and Robert M. Stroud Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14808–14813. doi: 10.1073/pnas.011399198.PMCID: PMC64940 Extension of the Drosophila lifespan by
overexpression of a protein repair methyltransferase David A. Chavous, F. Rob Jackson, and Clare M. O'Connor Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14814–14818. Published online 2001 December 11. doi: 10.1073/pnas.251446498.PMCID: PMC64941 betawrap: Successful prediction of parallel
β-helices from primary sequence reveals an association with many
microbial pathogens Phil Bradley, Lenore Cowen, Matthew Menke, Jonathan King, and Bonnie Berger Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14819–14824. doi: 10.1073/pnas.251267298.PMCID: PMC64942 Side-chain repacking calculations for predicting structures and
stabilities of heterodimeric coiled coils Amy E. Keating, Vladimir N. Malashkevich, Bruce Tidor, and Peter S. Kim Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14825–14830. doi: 10.1073/pnas.261563398.PMCID: PMC64943 RNase P-mediated inhibition of cytomegalovirus protease
expression and viral DNA encapsidation by oligonucleotide external
guide sequences Walter Dunn, Phong Trang, Umair Khan, Jiaming Zhu, and Fenyong Liu Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14831–14836. Published online 2001 December 11. doi: 10.1073/pnas.261560598.PMCID: PMC64944 Studies on the nonmevalonate pathway to terpenes: The role of the
GcpE (IspG) protein Stefan Hecht, Wolfgang Eisenreich, Petra Adam, Sabine Amslinger, Klaus Kis, Adelbert Bacher, Duilio Arigoni, and Felix Rohdich Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14837–14842. doi: 10.1073/pnas.201399298.PMCID: PMC64945 Partial purification and identification of GDP-mannose
3",5"-epimerase of Arabidopsis thaliana, a key enzyme of
the plant vitamin C pathway Beata A. Wolucka, Geert Persiau, Jan Van Doorsselaere, Mark W. Davey, Hans Demol, Joël Vandekerckhove, Marc Van Montagu, Marc Zabeau, and Wout Boerjan Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14843–14848. doi: 10.1073/pnas.011578198.PMCID: PMC64946 A “master” in base unpairing during isomerization of a
promoter upon RNA polymerase binding Heon Man Lim, Hee Jung Lee, Siddhartha Roy, and Sankar Adhya Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14849–14852. Published online 2001 December 4. doi: 10.1073/pnas.261517398.PMCID: PMC64947 Effects of common polymorphisms on the properties of
recombinant human methylenetetrahydrofolate reductase Kazuhiro Yamada, Zhoutao Chen, Rima Rozen, and Rowena G. Matthews Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14853–14858. Published online 2001 December 11. doi: 10.1073/pnas.261469998.PMCID: PMC64948 The temperature-signaling cascade in sponges involves a
heat-gated cation channel, abscisic acid, and
cyclic ADP-ribose Elena Zocchi, Armando Carpaneto, Carlo Cerrano, Giorgio Bavestrello, Marco Giovine, Santina Bruzzone, Lucrezia Guida, Luisa Franco, and Cesare Usai Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14859–14864. doi: 10.1073/pnas.261448698.PMCID: PMC64949 From the Cover: The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two
F-actin-binding domains to bundle F-actin Yinxiang Wang, Ann L. Miller, Mark S. Mooseker, and Anthony J. Koleske Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14865–14870. doi: 10.1073/pnas.251249298.PMCID: PMC64950 Arp2/3 complex requires hydrolyzable ATP for nucleation of new
actin filaments Mark J. Dayel, Elizabeth A. Holleran, and R. Dyche Mullins Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14871–14876. doi: 10.1073/pnas.261419298.PMCID: PMC64951 Oligomeric structure of virion-associated and soluble forms of
the simian immunodeficiency virus envelope protein in the prefusion
activated conformation Rob J. Center, Peter Schuck, Richard D. Leapman, Larry O. Arthur, Patricia L. Earl, Bernard Moss, and Jacob Lebowitz Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14877–14882. doi: 10.1073/pnas.261573898.PMCID: PMC64952 DNA supercoiling allows enhancer action over a large
distance Ye Liu, Vladimir Bondarenko, Alexander Ninfa, and Vasily M. Studitsky Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14883–14888. Published online 2001 December 11. doi: 10.1073/pnas.261477898.PMCID: PMC64953 β-Arrestin1 modulates lymphoid enhancer factor transcriptional
activity through interaction with phosphorylated dishevelled proteins Wei Chen, Liaoyuan A. Hu, Mikhail V. Semenov, Shinichi Yanagawa, Akira Kikuchi, Robert J. Lefkowitz, and William E. Miller Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14889–14894. Published online 2001 December 11. doi: 10.1073/pnas.211572798.PMCID: PMC64954 From the Cover: IscR, an Fe-S cluster-containing transcription factor, represses
expression of Escherichia coli genes encoding Fe-S
cluster assembly proteins Christopher J. Schwartz, Jennifer L. Giel, Thomas Patschkowski, Christopher Luther, Frank J. Ruzicka, Helmut Beinert, and Patricia J. Kiley Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14895–14900. Published online 2001 December 11. doi: 10.1073/pnas.251550898.PMCID: PMC64955 Glycopeptide antibiotic biosynthesis: Enzymatic assembly of the
dedicated amino acid
monomer (S)-3,5-dihydroxyphenylglycine Huawei Chen, Claire C. Tseng, Brian K. Hubbard, and Christopher T. Walsh Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14901–14906. doi: 10.1073/pnas.221582098.PMCID: PMC64956 Biophysics Cell behavior in traveling wave patterns of myxobacteria Roy Welch and Dale Kaiser Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14907–14912. doi: 10.1073/pnas.261574598.PMCID: PMC64957 Pattern formation and traveling waves in myxobacteria: Theory and
modeling Oleg A. Igoshin, Alex Mogilner, Roy D. Welch, Dale Kaiser, and George Oster Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14913–14918. doi: 10.1073/pnas.221579598.PMCID: PMC64958 Multiparticle adhesive dynamics: Hydrodynamic recruitment of
rolling leukocytes Michael R. King and Daniel A. Hammer Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14919–14924. doi: 10.1073/pnas.261272498.PMCID: PMC64959 From the Cover: Cryoelectron microscopy of λ phage DNA condensates in vitreous
ice: The fine structure of DNA toroids Nicholas V. Hud and Kenneth H. Downing Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14925–14930. Published online 2001 December 4. doi: 10.1073/pnas.261560398.PMCID: PMC64960 The free energy landscape for β hairpin folding in
explicit water Ruhong Zhou, Bruce J. Berne, and Robert Germain Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14931–14936. doi: 10.1073/pnas.201543998.PMCID: PMC64961 Computational study of protein specificity: The molecular basis
of HIV-1 protease drug resistance Wei Wang and Peter A. Kollman Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14937–14942. doi: 10.1073/pnas.251265598.PMCID: PMC64962 The V122I cardiomyopathy variant of transthyretin increases the
velocity of rate-limiting tetramer dissociation, resulting in
accelerated amyloidosis Xin Jiang, Joel N. Buxbaum, and Jeffery W. Kelly Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14943–14948. doi: 10.1073/pnas.261419998.PMCID: PMC64963 Mapping the actin filament with myosin Walter Steffen, David Smith, Robert Simmons, and John Sleep Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14949–14954. Published online 2001 December 4. doi: 10.1073/pnas.261560698.PMCID: PMC64964 Cell Biology Wild-type PrP and a mutant associated with prion disease are
subject to retrograde transport and proteasome degradation Jiyan Ma and Susan Lindquist Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14955–14960. Published online 2001 December 11. doi: 10.1073/pnas.011578098.PMCID: PMC64965 Gαi3 binding to calnuc on Golgi membranes in living cells
monitored by fluorescence resonance energy transfer of green
fluorescent protein fusion proteins Thomas S. Weiss, Chester E. Chamberlain, Tetsuro Takeda, Ping Lin, Klaus M. Hahn, and Marilyn Gist Farquhar Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14961–14966. doi: 10.1073/pnas.261572098.PMCID: PMC64966 Tumor induction by an Lck-MyrAkt transgene is delayed by
mechanisms controlling the size of the thymus Scott Malstrom, Esmerina Tili, Dietmar Kappes, Jeffrey D. Ceci, and Philip N. Tsichlis Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14967–14972. doi: 10.1073/pnas.231467698.PMCID: PMC64967 Elevated expression of axin2 and
hnkd mRNA provides evidence that
Wnt/β-catenin signaling is activated in human
colon tumors Dong Yan, Marion Wiesmann, Michael Rohan, Vivien Chan, Ann B. Jefferson, Lida Guo, Doreen Sakamoto, Roger H. Caothien, John H. Fuller, Christoph Reinhard, Pablo D. Garcia, Filippo M. Randazzo, Jaime Escobedo, Wendy J. Fantl, and Lewis T. Williams Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14973–14978. doi: 10.1073/pnas.261574498.PMCID: PMC64968 The γ-secretase-cleaved C-terminal fragment of amyloid
precursor protein mediates signaling to the nucleus Yuehua Gao and Sanjay W. Pimplikar Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14979–14984. Published online 2001 December 11. doi: 10.1073/pnas.261463298.PMCID: PMC64969 Granzyme B can cause mitochondrial depolarization and cell death
in the absence of BID, BAX, and BAK Dori A. Thomas, Luca Scorrano, Girish V. Putcha, Stanley J. Korsmeyer, and Timothy J. Ley Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14985–14990. doi: 10.1073/pnas.261581498.PMCID: PMC64970 A genetic screen identifies a cellular regulator of
adeno-associated virus Toni Cathomen, Travis H. Stracker, Luz Beatriz Gilbert, and Matthew D. Weitzman Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14991–14996. Published online 2001 December 4. doi: 10.1073/pnas.261567198.PMCID: PMC64971 Genetically encoded reporters of protein kinase A activity reveal
impact of substrate tethering Jin Zhang, Yuliang Ma, Susan S. Taylor, and Roger Y. Tsien Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14997–15002. doi: 10.1073/pnas.211566798.PMCID: PMC64972 Genetically encoded fluorescent reporters of protein tyrosine
kinase activities in living cells Alice Y. Ting, Kristin H. Kain, Richard L. Klemke, and Roger Y. Tsien Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15003–15008. doi: 10.1073/pnas.211564598.PMCID: PMC64973 Direct real-time observation of actin filament branching mediated
by Arp2/3 complex using total internal reflection fluorescence microscopy Kurt J. Amann and Thomas D. Pollard Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15009–15013. Published online 2001 December 11. doi: 10.1073/pnas.211556398.PMCID: PMC64974 Developmental Biology Cell behavior in traveling wave patterns of myxobacteria Roy Welch and Dale Kaiser Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 14907–14912. doi: 10.1073/pnas.261574598.PMCID: PMC64957 neurogenin2 elicits the genesis of retinal neurons
from cultures of nonneural cells Run-Tao Yan, Wen-Xin Ma, and Shu-Zhen Wang Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15014–15019. doi: 10.1073/pnas.261455698.PMCID: PMC64975 PDK1 regulates growth through Akt and S6K
in Drosophila Felix Rintelen, Hugo Stocker, George Thomas, and Ernst Hafen Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15020–15025. doi: 10.1073/pnas.011318098.PMCID: PMC64976 Ecology Regular exposure to rabies virus and lack of symptomatic disease
in Serengeti spotted hyenas Marion L. East, Heribert Hofer, James H. Cox, Ulrich Wulle, Harald Wiik, and Christian Pitra Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15026–15031. Published online 2001 December 11. doi: 10.1073/pnas.261411898.PMCID: PMC64977 Evolution A receptor tyrosine kinase from choanoflagellates: Molecular
insights into early animal evolution Nicole King and Sean B. Carroll Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15032–15037. doi: 10.1073/pnas.261477698.PMCID: PMC64978 Antigen polymorphism in Borrelia hermsii, a clonal
pathogenic bacterium Stephen M. Rich, Stanley A. Sawyer, and Alan G. Barbour Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15038–15043. Published online 2001 December 11. doi: 10.1073/pnas.071042098.PMCID: PMC64979 Genetics Gene expression in papillary thyroid carcinoma reveals highly
consistent profiles Ying Huang, Manju Prasad, William J. Lemon, Heather Hampel, Fred A. Wright, Karl Kornacker, Virginia LiVolsi, Wendy Frankel, Richard T. Kloos, Charis Eng, Natalia S. Pellegata, and Albert de la Chapelle Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15044–15049. doi: 10.1073/pnas.251547398.PMCID: PMC64980 A protein trap strategy to detect GFP-tagged proteins expressed
from their endogenous loci
in Drosophila Xavier Morin, Richard Daneman, Michael Zavortink, and William Chia Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15050–15055. Published online 2001 December 11. doi: 10.1073/pnas.261408198.PMCID: PMC64981 Recombination and mutation during long-term gastric colonization
by Helicobacter pylori: Estimates of clock rates,
recombination size, and minimal age Daniel Falush, Christian Kraft, Nancy S. Taylor, Pelayo Correa, James G. Fox, Mark Achtman, and Sebastian Suerbaum Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15056–15061. Published online 2001 December 11. doi: 10.1073/pnas.251396098.PMCID: PMC64982 Inadequate lung development and bronchial hyperplasia in mice
with a targeted deletion in the
Dutt1/Robo1 gene Jian Xian, Katherine J. Clark, Rosalyn Fordham, Richard Pannell, Terence H. Rabbitts, and Pamela H. Rabbitts Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15062–15066. Published online 2001 December 4. doi: 10.1073/pnas.251407098.PMCID: PMC64983 Siah-1 binds and regulates the function of Numb Laurent Susini, Brent J. Passer, Nathalie Amzallag-Elbaz, Tamar Juven-Gershon, Sylvie Prieur, Nicolas Privat, Marcel Tuynder, Marie-Claude Gendron, Alain Israël, Robert Amson, Moshe Oren, and Adam Telerman Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15067–15072. doi: 10.1073/pnas.261571998.PMCID: PMC64984 The expression of human α-like globin genes in transgenic mice
mediated by bacterial artificial chromosome Dong-Xiao Feng, De-Pei Liu, Yue Huang, Lin Wu, Tie-Chang Li, Min Wu, Xiao-Bin Tang, and Chih-Chuan Liang Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15073–15077. Published online 2001 December 11. doi: 10.1073/pnas.251550598.PMCID: PMC64985 The double par locus of virulence factor pB171:
DNA segregation is correlated with oscillation of ParA Gitte Ebersbach and Kenn Gerdes Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15078–15083. doi: 10.1073/pnas.261569598.PMCID: PMC64986 DNA-PKcs is critical for telomere capping David Gilley, Hiromi Tanaka, M. Prakash Hande, Akihiro Kurimasa, Gloria C. Li, Mitsuo Oshimura, and David J. Chen Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15084–15088. Published online 2001 December 11. doi: 10.1073/pnas.261574698.PMCID: PMC64987 Insight into hepatocellular carcinogenesis at transcriptome level
by comparing gene expression profiles of hepatocellular carcinoma
with those of corresponding noncancerous liver Xiang-Ru Xu, Jian Huang, Zhi-Gang Xu, Bin-Zhi Qian, Zhi-Dong Zhu, Qing Yan, Ting Cai, Xin Zhang, Hua-Sheng Xiao, Jian Qu, Feng Liu, Qiu-Hua Huang, Zhi-Hong Cheng, Neng-Gan Li, Jian-Jun Du, Wei Hu, Kun-Tang Shen, Gang Lu, Gang Fu, Ming Zhong, Shu-Hua Xu, Wen-Yi Gu, Wei Huang, Xin-Tai Zhao, Geng-Xi Hu, Jian-Ren Gu, Zhu Chen, and Ze-Guang Han Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15089–15094. doi: 10.1073/pnas.241522398.PMCID: PMC64988 A targeted dominant negative mutation of the thyroid hormone α1
receptor causes increased mortality, infertility, and dwarfism in mice Masahiro Kaneshige, Hideyo Suzuki, Kumiko Kaneshige, Jun Cheng, Heather Wimbrow, Carrolee Barlow, Mark C. Willingham, and Sheue-yann Cheng Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15095–15100. Published online 2001 December 4. doi: 10.1073/pnas.261565798.PMCID: PMC64989 Evolution of IESs and scrambling in the actin I gene in
hypotrichous ciliates Daniel J. Hogan, Elizabeth A. Hewitt, Kindra E. Orr, David M. Prescott, and Kirsten M. Müller Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15101–15106. Published online 2001 December 11. doi: 10.1073/pnas.011578598.PMCID: PMC64990 Functional significance of concomitant inactivation of
hMLH1 and hMSH6 in tumor cells of the
microsatellite mutator phenotype Svetlana Baranovskaya, Jose Luis Soto, Manuel Perucho, and Sergei R. Malkhosyan Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15107–15112. Published online 2001 December 11. doi: 10.1073/pnas.251234498.PMCID: PMC64991 Identification of a small molecule inhibitor of Sir2p Antonio Bedalov, Tonibelle Gatbonton, William P. Irvine, Daniel E. Gottschling, and Julian A. Simon Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15113–15118. doi: 10.1073/pnas.261574398.PMCID: PMC64992 Immunology A genome-wide analysis of immune responses in Drosophila Phil Irving, Laurent Troxler, Timothy S. Heuer, Marcia Belvin, Casey Kopczynski, Jean-Marc Reichhart, Jules A. Hoffmann, and Charles Hetru Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15119–15124. Published online 2001 December 11. doi: 10.1073/pnas.261573998.PMCID: PMC64993 INAUGURAL ARTICLE by a Recently Elected Academy Member: Viperin (cig5), an IFN-inducible antiviral protein directly
induced by human cytomegalovirus Keh-Chuang Chin and Peter Cresswell Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15125–15130. doi: 10.1073/pnas.011593298.PMCID: PMC64994 Age and stage dependency of estrogen receptor expression by
lymphocyte precursors Hideya Igarashi, Taku Kouro, Takafumi Yokota, Phillip C. Comp, and Paul W. Kincade Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15131–15136. doi: 10.1073/pnas.011513098.PMCID: PMC64995 T-bet is rapidly induced by interferon-γ in lymphoid and
myeloid cells Andre A. Lighvani, David M. Frucht, Dragana Jankovic, Hidehiro Yamane, Julio Aliberti, Bruce D. Hissong, Bai V. Nguyen, Massimo Gadina, Alan Sher, William E. Paul, and John J. O'Shea Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15137–15142. doi: 10.1073/pnas.261570598.PMCID: PMC64996 Circulating thioredoxin suppresses lipopolysaccharide-induced
neutrophil chemotaxis Hajime Nakamura, Leonore A. Herzenberg, Jie Bai, Shinichi Araya, Norihiko Kondo, Yumiko Nishinaka, Leonard A. Herzenberg, and Junji Yodoi Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15143–15148. Published online 2001 December 11. doi: 10.1073/pnas.191498798.PMCID: PMC64997 Medical Sciences Multiclass cancer diagnosis using tumor gene
expression signatures Sridhar Ramaswamy, Pablo Tamayo, Ryan Rifkin, Sayan Mukherjee, Chen-Hsiang Yeang, Michael Angelo, Christine Ladd, Michael Reich, Eva Latulippe, Jill P. Mesirov, Tomaso Poggio, William Gerald, Massimo Loda, Eric S. Lander, and Todd R. Golub Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15149–15154. Published online 2001 December 11. doi: 10.1073/pnas.211566398.PMCID: PMC64998 Combination bacteriolytic therapy for the treatment of
experimental tumors Long H. Dang, Chetan Bettegowda, David L. Huso, Kenneth W. Kinzler, and Bert Vogelstein Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15155–15160. Published online 2001 November 27. doi: 10.1073/pnas.251543698.PMCID: PMC64999 Short-cycle structured intermittent treatment of chronic HIV
infection with highly active antiretroviral therapy: Effects on
virologic, immunologic, and toxicity parameters Mark Dybul, Tae-Wook Chun, Christian Yoder, Bertha Hidalgo, Michael Belson, Kurt Hertogs, Brendan Larder, Robin L. Dewar, Cecil H. Fox, Claire W. Hallahan, J. Shawn Justement, Stephen A. Migueles, Julia A. Metcalf, Richard T. Davey, Marybeth Daucher, Punita Pandya, Michael Baseler, Douglas J. Ward, and Anthony S. Fauci Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15161–15166. Published online 2001 December 4. doi: 10.1073/pnas.261568398.PMCID: PMC65000 Quantification of intrinsic residual viral replication in treated
HIV-infected patients Christophe Fraser, Neil M. Ferguson, and Roy M. Anderson Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15167–15172. Published online 2001 December 11. doi: 10.1073/pnas.261283598.PMCID: PMC65001 Vaccination with a Nogo-A-derived peptide after incomplete
spinal-cord injury promotes recovery via a T-cell-mediated
neuroprotective response: Comparison with other myelin antigens Ehud Hauben, Antonio Ibarra, Tal Mizrahi, Rina Barouch, Eugenia Agranov, and Michal Schwartz Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15173–15178. doi: 10.1073/pnas.011585298.PMCID: PMC65002 Histone deacetylase inhibitors reduce polyglutamine toxicity Alexander McCampbell, Addis A. Taye, Leslie Whitty, Ellen Penney, Joan S. Steffan, and Kenneth H. Fischbeck Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15179–15184. Published online 2001 December 11. doi: 10.1073/pnas.261400698.PMCID: PMC65003 From the Cover: Delayed-onset ataxia in mice lacking α-tocopherol transfer
protein: Model for neuronal degeneration caused by chronic
oxidative stress Takanori Yokota, Keiji Igarashi, Toshiki Uchihara, Kou-ichi Jishage, Hiroshi Tomita, Akira Inaba, Yi Li, Makoto Arita, Hiroshi Suzuki, Hidehiro Mizusawa, and Hiroyuki Arai Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15185–15190. doi: 10.1073/pnas.261456098.PMCID: PMC65004 The coxsackievirus and adenovirus receptor is a transmembrane
component of the tight junction Christopher J. Cohen, Joseph T. C. Shieh, Raymond J. Pickles, Takatsugu Okegawa, Jer-Tsong Hsieh, and Jeffrey M. Bergelson Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15191–15196. Published online 2001 December 4. doi: 10.1073/pnas.261452898.PMCID: PMC65005 Estrogen receptors and proliferation markers in primary and
recurrent breast cancer Elwood V. Jensen, Guojun Cheng, Carlo Palmieri, Shigehira Saji, Sari Mäkelä, Susan Van Noorden, Torsten Wahlström, Margaret Warner, R. Charles Coombes, and Jan-Åke Gustafsson Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15197–15202. Published online 2001 December 4. doi: 10.1073/pnas.211556298.PMCID: PMC65006 Molecular characteristics of non-small cell lung cancer Mariana Nacht, Tatiana Dracheva, Yuhong Gao, Takeshi Fujii, Yidong Chen, Audrey Player, Viatcheslav Akmaev, Brian Cook, Michael Dufault, Mindy Zhang, Wen Zhang, MingZhou Guo, John Curran, Sean Han, David Sidransky, Kenneth Buetow, Stephen L. Madden, and Jin Jen Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15203–15208. doi: 10.1073/pnas.261414598.PMCID: PMC65007 Aberrant expression of homeobox gene HOXA7 is
associated with müllerian-like differentiation of epithelial
ovarian tumors and the generation of a specific autologous
antibody response Honami Naora, Fredrick J. Montz, Chee-Yin Chai, and Richard B. S. Roden Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15209–15214. Published online 2001 December 11. doi: 10.1073/pnas.011503998.PMCID: PMC65008 Oxygen radical inhibition of nitric oxide-dependent
vascular function in sickle cell disease Mutay Aslan, Thomas M. Ryan, Brian Adler, Tim M. Townes, Dale A. Parks, J. Anthony Thompson, Albert Tousson, Mark T. Gladwin, Rakesh P. Patel, Margaret M. Tarpey, Ines Batinic-Haberle, C. Roger White, and Bruce A. Freeman Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15215–15220. doi: 10.1073/pnas.221292098.PMCID: PMC65009 Powerful and prolonged protection of human retinal pigment
epithelial cells, keratinocytes, and mouse leukemia cells against
oxidative damage: The indirect antioxidant effects of sulforaphane Xiangqun Gao, Albena T. Dinkova-Kostova, and Paul Talalay Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15221–15226. doi: 10.1073/pnas.261572998.PMCID: PMC65010 Microbiology The role of the third β strand in gp120 conformation and
neutralization sensitivity of the HIV-1 primary isolate DH012 Chong-Bin Zhu, Lei Zhu, Sonia Holz-Smith, Thomas J. Matthews, and Chin Ho Chen Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15227–15232. Published online 2001 December 4. doi: 10.1073/pnas.261359098.PMCID: PMC65011 Epstein–Barr virus nuclear antigen 1 activates transcription
from episomal but not integrated DNA and does not alter
lymphocyte growth Myung-Soo Kang, Siu Chun Hung, and Elliott Kieff Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15233–15238. Published online 2001 December 4. doi: 10.1073/pnas.211556598.PMCID: PMC65012 Efficient assembly of an HIV-1/MLV Gag-chimeric virus in
murine cells Benjamin K. Chen, Itay Rousso, Sung Shim, and Peter S. Kim Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15239–15244. Published online 2001 December 11. doi: 10.1073/pnas.261563198.PMCID: PMC65013 From the Cover: Cryptococcus neoformans interactions with amoebae
suggest an explanation for its virulence and intracellular pathogenic
strategy in macrophages J. N. Steenbergen, H. A. Shuman, and A. Casadevall Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15245–15250. Published online 2001 December 11. doi: 10.1073/pnas.261418798.PMCID: PMC65014 PAS-A domain of phosphorelay sensor kinase A: A catalytic
ATP-binding domain involved in the initiation of development in
Bacillus subtilis Keith Stephenson and James A. Hoch Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15251–15256. Published online 2001 December 4. doi: 10.1073/pnas.251408398.PMCID: PMC65015 Genetic control of manno(fructo)kinase activity in
Escherichia coli Andrew A. Sproul, Linda T. M. Lambourne, Jims Jean-Jacques D, and Hans L. Kornberg Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15257–15259. Published online 2001 December 11. doi: 10.1073/pnas.211569798.PMCID: PMC65016 Evidence that the cell wall of Bacillus subtilis
is protonated during respiration H. G. Calamita, W. D. Ehringer, A. L. Koch, and R. J. Doyle Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15260–15263. doi: 10.1073/pnas.261483798.PMCID: PMC65017 Epitope tagging of chromosomal genes
in Salmonella Sergio Uzzau, Nara Figueroa-Bossi, Salvatore Rubino, and Lionello Bossi Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15264–15269. Published online 2001 December 11. doi: 10.1073/pnas.261348198.PMCID: PMC65018 Recombinant hepatitis E virus genomes infectious for primates:
Importance of capping and discovery of a cis-reactive element S. U. Emerson, M. Zhang, X.-J. Meng, H. Nguyen, M. St. Claire, S. Govindarajan, Y. K. Huang, and R. H. Purcell Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15270–15275. Published online 2001 December 11. doi: 10.1073/pnas.251555098.PMCID: PMC65019 Neisseria gonorrhoeae PilV, a type
IV pilus-associated protein essential to human epithelial cell
adherence Hanne C. Winther-Larsen, Finn Terje Hegge, Matthew Wolfgang, Stanley F. Hayes, Jos P. M. van Putten, and Michael Koomey Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15276–15281. doi: 10.1073/pnas.261574998.PMCID: PMC65020 Neurobiology Calcium influx selects the fast mode of endocytosis in the
synaptic terminal of retinal bipolar cells Guilherme Neves, Ana Gomis, and Leon Lagnado Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15282–15287. Published online 2001 December 4. doi: 10.1073/pnas.261311698.PMCID: PMC65021 Doppel-induced cerebellar degeneration in transgenic mice Richard C. Moore, Peter Mastrangelo, Essia Bouzamondo, Cornelia Heinrich, Giuseppe Legname, Stanley B. Prusiner, Leroy Hood, David Westaway, Stephen J. DeArmond, and Patrick Tremblay Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15288–15293. Published online 2001 December 4. doi: 10.1073/pnas.251550798.PMCID: PMC65022 Different responses of astrocytes and neurons to nitric oxide:
The role of glycolytically generated ATP in astrocyte protection Angeles Almeida, Julia Almeida, Juan P. Bolaños, and Salvador Moncada Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15294–15299. Published online 2001 December 11. doi: 10.1073/pnas.261560998.PMCID: PMC65023 A role for phospholipase D1 in neurotransmitter release Yann Humeau, Nicolas Vitale, Sylvette Chasserot-Golaz, Jean-Luc Dupont, Guangwei Du, Michael A. Frohman, Marie-France Bader, and Bernard Poulain Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15300–15305. doi: 10.1073/pnas.261358698.PMCID: PMC65024 Neuroglobin is up-regulated by and protects neurons from
hypoxic-ischemic injury Yunjuan Sun, Kunlin Jin, Xiao Ou Mao, Yonghua Zhu, and David A. Greenberg Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15306–15311. Published online 2001 December 11. doi: 10.1073/pnas.251466698.PMCID: PMC65025 Hyperactivity, elevated dopaminergic transmission, and response
to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice David J. Gerber, Tatyana D. Sotnikova, Raul R. Gainetdinov, Shu Ying Huang, Marc G. Caron, and Susumu Tonegawa Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15312–15317. doi: 10.1073/pnas.261583798.PMCID: PMC65026 BID mediates neuronal cell death after oxygen/ glucose
deprivation and focal cerebral ischemia Nikolaus Plesnila, Sandra Zinkel, Dean A. Le, Sepideh Amin-Hanjani, Yonqin Wu, Jianhua Qiu, Alberto Chiarugi, Sunu S. Thomas, Daniel S. Kohane, Stanley J. Korsmeyer, and Michael A. Moskowitz Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15318–15323. Published online 2001 December 11. doi: 10.1073/pnas.261323298.PMCID: PMC65027 Sulfhydryl modification of V449C in the glutamate transporter
EAAT1 abolishes substrate transport but not the substrate-gated
anion conductance Rebecca P. Seal, Yasushi Shigeri, Scott Eliasof, Barbara H. Leighton, and Susan G. Amara Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15324–15329. doi: 10.1073/pnas.011400198.PMCID: PMC65028 Thalamic bursting in rats during different awake
behavioral states Erika E. Fanselow, Koichi Sameshima, Luiz A. Baccala, and Miguel A. L. Nicolelis Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15330–15335. doi: 10.1073/pnas.261273898.PMCID: PMC65029 A central neural circuit for experience-independent olfactory and
courtship behavior in Drosophila melanogaster Gertrud Heimbeck, Véronique Bugnon, Nanaë Gendre, Andreas Keller, and Reinhard F. Stocker Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15336–15341. Published online 2001 December 11. doi: 10.1073/pnas.011314898.PMCID: PMC65030 Calmodulin priming: Nuclear translocation of a
calmodulin complex and the memory of prior
neuronal activity Paul G. Mermelstein, Karl Deisseroth, Neela Dasgupta, Ann L. Isaksen, and Richard W. Tsien Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15342–15347. Published online 2001 December 11. doi: 10.1073/pnas.211563998.PMCID: PMC65031 Role of the C-terminal domain in inactivation of brain and
cardiac sodium channels Massimo Mantegazza, Frank H. Yu, William A. Catterall, and Todd Scheuer Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15348–15353. Published online 2001 December 11. doi: 10.1073/pnas.211563298.PMCID: PMC65032 Physiology Alkalinization by chloride/bicarbonate pathway in larval
mosquito midgut Dmitri Y. Boudko, Leonid L. Moroz, William R. Harvey, and Paul J. Linser Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15354–15359. Published online 2001 December 11. doi: 10.1073/pnas.261253998.PMCID: PMC65033 Plant Biology Tetrahydrofolate biosynthesis in plants: Molecular and functional
characterization of dihydrofolate synthetase and three isoforms of
folylpolyglutamate synthetase in
Arabidopsis thaliana Stéphane Ravanel, Hélène Cherest, Samuel Jabrin, Didier Grunwald, Yolande Surdin-Kerjan, Roland Douce, and Fabrice Rébeillé Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15360–15365. doi: 10.1073/pnas.261585098.PMCID: PMC65034 Medicago truncatula plants overexpressing the early nodulin gene enod40 exhibit accelerated
mycorrhizal colonization and enhanced formation of arbuscules Christian Staehelin, Celine Charon, Thomas Boller, Martin Crespi, and Ádám Kondorosi Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15366–15371. doi: 10.1073/pnas.251491698.PMCID: PMC65035 Genetic analysis of Nicotiana pollen-part mutants
is consistent with the presence of an S-ribonuclease
inhibitor at the S locus John F. Golz, Hae-Young Oh, Vanessa Su, Makoto Kusaba, and Ed Newbigin Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15372–15376. doi: 10.1073/pnas.261571598.PMCID: PMC65036 A domain unique to plant RanGAP is responsible for its targeting
to the plant nuclear rim Annkatrin Rose and Iris Meier Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15377–15382. doi: 10.1073/pnas.261459698.PMCID: PMC65037 Population Biology Explaining mortality rate plateaus Joshua S. Weitz and Hunter B. Fraser Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15383–15386. doi: 10.1073/pnas.261228098.PMCID: PMC65038 Social Sciences Psychology Can race be erased? Coalitional computation and
social categorization Robert Kurzban, John Tooby, and Leda Cosmides Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15387–15392. Published online 2001 December 11. doi: 10.1073/pnas.251541498.PMCID: PMC65039 Corrections Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. PMCID: PMC64916 Corrects: Trissa Miller, et al. COMPASS: A complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12902–12907. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. Published online 2001 December 11. PMCID: PMC64917 Corrects: Jing X. Kang, et al. Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoicacid. Proc Natl Acad Sci U S A. 1997 December 9; 94(25): 13671–13676. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. Published online 2001 December 11. PMCID: PMC64918 Corrects: Percy H. Carter, et al. Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α. Proc Natl Acad Sci U S A. 2001 October 9; 98(21): 11879–11884. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. Published online 2001 December 11. PMCID: PMC64919 Corrects: Olimpia Meucci, et al. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A. 2000 July 5; 97(14): 8075–8080. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. Published online 2001 December 11. PMCID: PMC64920 Corrects: David R. Sherman, et al. Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin. Proc Natl Acad Sci U S A. 2001 June 19; 98(13): 7534–7539. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. Published online 2001 December 11. PMCID: PMC64921 Corrects: Frédéric Knoflach, et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13402–13407. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. Published online 2001 December 11. PMCID: PMC64922 Corrects: James M. Allan, et al. Polymorphism in glutathione S-transferase P1 is
associated with susceptibility to chemotherapy-induced leukemia. Proc Natl Acad Sci U S A. 2001 September 25; 98(20): 11592–11597. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. Published online 2001 December 11. PMCID: PMC64923 Corrects: Gregory Pearce, et al. RALF, a 5-kDa ubiquitous polypeptide in plants, arrests root growth and development. Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12843–12847. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15393. Published online 2001 December 11. PMCID: PMC64924 Corrects: Phillip Colella, et al. Numerical simulation of incompressible viscous flow in deforming domains. Proc Natl Acad Sci U S A. 1999 May 11; 96(10): 5378–5381. |