| | This journal provides immediate access to some articles. Letters Orbital origin of field-induced “quantum criticality” in overdoped Tl2Ba2CuO6+x M. M. J. French and N. E. Hussey Proc Natl Acad Sci U S A. 2008 September 16; 105(37): E58. doi: 10.1073/pnas.0805887105.PMCID: PMC2656354 Reply to French and Hussey: Evidence against orbital origin of field-induced quantum criticality in Tl2Ba2CuO6+x superconductors Takasada Shibauchi, Lia Krusin-Elbaum, and Yuji Matsuda Proc Natl Acad Sci U S A. 2008 September 16; 105(37): E59. doi: 10.1073/pnas.0806589105.PMCID: PMC2544608 This Week in PNAS Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13697–13698. doi: 10.1073/iti3708105.PMCID: PMC2544512 Commentaries Proofreading optimizes iodotyrosine insertion into the genetic code Tamara L. Hendrickson Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13699–13700. doi: 10.1073/pnas.0807442105.PMCID: PMC2544513 Detecting multiple origins of domesticated crops Kenneth M. Olsen and Briana L. Gross Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13701–13702. doi: 10.1073/pnas.0807439105.PMCID: PMC2544514 Sortases make pili from three ingredients So-Young Oh, Jonathan M. Budzik, and Olaf Schneewind Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13703–13704. doi: 10.1073/pnas.0807334105.PMCID: PMC2544515 Environmental estrogens impact primate brain John H. Morrison Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13705–13706. doi: 10.1073/pnas.0807272105.PMCID: PMC2544516 Physical Sciences Applied Physical Sciences Characterization of reconnecting vortices in superfluid helium Gregory P. Bewley, Matthew S. Paoletti, Katepalli R. Sreenivasan, and Daniel P. Lathrop Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13707–13710. doi: 10.1073/pnas.0806002105.PMCID: PMC2544517 Hierarchies of networked phases induced by multiple liquid–liquid critical points Chia Wei Hsu, Julio Largo, Francesco Sciortino, and Francis W. Starr Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13711–13715. doi: 10.1073/pnas.0804854105.PMCID: PMC2544518 Three-dimensional analysis of tokamaks and stellarators Paul R. Garabedian Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13716–13719. doi: 10.1073/pnas.0806354105.PMCID: PMC2544519 Chemistry Calculated interactions of a nitro group with aromatic rings of crystalline picryl bromide Lulu Huang, Lou Massa, and Jerome Karle Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13720–13723. doi: 10.1073/pnas.0807218105.PMCID: PMC2544520 Diffusive reaction dynamics on invariant free energy profiles Sergei V. Krivov and Martin Karplus Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13841–13846. doi: 10.1073/pnas.0800228105.PMCID: PMC2544541 Computer Sciences From the Cover: Experience versus talent shapes the structure of the Web Joseph S. Kong, Nima Sarshar, and Vwani P. Roychowdhury Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13724–13729. doi: 10.1073/pnas.0805921105.PMCID: PMC2544521 Engineering Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum YongKeun Park, Monica Diez-Silva, Gabriel Popescu, George Lykotrafitis, Wonshik Choi, Michael S. Feld, and Subra Suresh Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13730–13735. doi: 10.1073/pnas.0806100105.PMCID: PMC2529332 Geology A scale of greatness and causal classification of mass extinctions: Implications for mechanisms A. M. Celâl Şengör, Saniye Atayman, and Sinan Özeren Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13736–13740. doi: 10.1073/pnas.0805482105.PMCID: PMC2544523 Global synchronous changes in the carbon isotopic composition of carbonate sediments unrelated to changes in the global carbon cycle Peter K. Swart Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13741–13745. doi: 10.1073/pnas.0802841105.PMCID: PMC2544524 Mathematics On the best possible remaining term in the Hardy inequality Nassif Ghoussoub and Amir Moradifam Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13746–13751. doi: 10.1073/pnas.0803703105.PMCID: PMC2544525 Physics An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis Jian Liu, Arshad Desai, José N. Onuchic, and Terence Hwa Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13752–13757. doi: 10.1073/pnas.0807007105.PMCID: PMC2544526 Development of input connections in neural cultures Jordi Soriano, María Rodríguez Martínez, Tsvi Tlusty, and Elisha Moses Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13758–13763. doi: 10.1073/pnas.0707492105.PMCID: PMC2544527 Biological Sciences Anthropology From the Cover: Neanderthal brain size at birth provides insights into the evolution of human life history Marcia S. Ponce de León, Lubov Golovanova, Vladimir Doronichev, Galina Romanova, Takeru Akazawa, Osamu Kondo, Hajime Ishida, and Christoph P. E. Zollikofer Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13764–13768. doi: 10.1073/pnas.0803917105.PMCID: PMC2533682 Applied Biological Sciences Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield A. Joe Shaw, Kara K. Podkaminer, Sunil G. Desai, John S. Bardsley, Stephen R. Rogers, Philip G. Thorne, David A. Hogsett, and Lee R. Lynd Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13769–13774. doi: 10.1073/pnas.0801266105.PMCID: PMC2544529 A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells Emmanouil D. Karagiannis and Aleksander S. Popel Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13775–13780. doi: 10.1073/pnas.0803241105.PMCID: PMC2544530 Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors Keiichiro Suzuki, Kaoru Mitsui, Emi Aizawa, Kouichi Hasegawa, Eihachiro Kawase, Toshiyuki Yamagishi, Yoshihiko Shimizu, Hirofumi Suemori, Norio Nakatsuji, and Kohnosuke Mitani Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13781–13786. doi: 10.1073/pnas.0806976105.PMCID: PMC2544531 Biochemistry Effects of local mRNA structure on posttranscriptional gene silencing Stephen I. Rudnick, Jyothishmathi Swaminathan, Marina Sumaroka, Stephen Liebhaber, and Alan M. Gewirtz Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13787–13792. doi: 10.1073/pnas.0805781105.PMCID: PMC2544532 Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc Zihao Wang, Marjan Gucek, and Gerald W. Hart Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13793–13798. doi: 10.1073/pnas.0806216105.PMCID: PMC2544533 Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis Florian C. Kurschus, Edward Fellows, Elisabeth Stegmann, and Dieter E. Jenne Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13799–13804. doi: 10.1073/pnas.0801724105.PMCID: PMC2544534 STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis Aurel Betz, Hyung Don Ryoo, Hermann Steller, and James E. Darnell, Jr Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13805–13810. doi: 10.1073/pnas.0806291105.PMCID: PMC2544535 Oleic acid content is responsible for the reduction in blood pressure induced by olive oil S. Terés, G. Barceló-Coblijn, M. Benet, R. Álvarez, R. Bressani, J. E. Halver, and P. V. Escribá Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13811–13816. doi: 10.1073/pnas.0807500105.PMCID: PMC2544536 Crystal structure of the β-finger domain of Prp8 reveals analogy to ribosomal proteins Kui Yang, Lingdi Zhang, Tao Xu, Annie Heroux, and Rui Zhao Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13817–13822. doi: 10.1073/pnas.0805960105.PMCID: PMC2544537 Periplasmic orientation of nascent lipid A in the inner membrane of an Escherichia coli LptA mutant Bing Ma, C. Michael Reynolds, and Christian R. H. Raetz Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13823–13828. doi: 10.1073/pnas.0807028105.PMCID: PMC2544538 Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection Sarah M. Sullivan and Todd Holyoak Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13829–13834. doi: 10.1073/pnas.0805364105.PMCID: PMC2544539 The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain Leslie A. Piggott, Andrea L. Bauman, John D. Scott, and Carmen W. Dessauer Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13835–13840. doi: 10.1073/pnas.0712100105.PMCID: PMC2544540 Biophysics An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis Jian Liu, Arshad Desai, José N. Onuchic, and Terence Hwa Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13752–13757. doi: 10.1073/pnas.0807007105.PMCID: PMC2544526 Diffusive reaction dynamics on invariant free energy profiles Sergei V. Krivov and Martin Karplus Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13841–13846. doi: 10.1073/pnas.0800228105.PMCID: PMC2544541 Flow induces loop-to-β-hairpin transition on the β-switch of platelet glycoprotein Ibα Jizhong Lou and Cheng Zhu Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13847–13852. doi: 10.1073/pnas.0801965105.PMCID: PMC2544542 Single-molecule studies of group II intron ribozymes Miriam Steiner, Krishanthi S. Karunatilaka, Roland K. O. Sigel, and David Rueda Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13853–13858. doi: 10.1073/pnas.0804034105.PMCID: PMC2544543 Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR Takanori Uzawa, Chiaki Nishimura, Shuji Akiyama, Koichiro Ishimori, Satoshi Takahashi, H. Jane Dyson, and Peter E. Wright Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13859–13864. doi: 10.1073/pnas.0804033105.PMCID: PMC2544544 Cooperativity, connectivity, and folding pathways of multidomain proteins Kazuhito Itoh and Masaki Sasai Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13865–13870. doi: 10.1073/pnas.0804512105.PMCID: PMC2544545 Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1 Michaeleen Doucleff and G. Marius Clore Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13871–13876. doi: 10.1073/pnas.0805050105.PMCID: PMC2544546 On the relationship between folding and chemical landscapes in enzyme catalysis Maite Roca, Benjamin Messer, Donald Hilvert, and Arieh Warshel Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13877–13882. doi: 10.1073/pnas.0803405105.PMCID: PMC2544547 Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase Lenong Li, Zhenzhan Chang, Zhiqiang Pan, Zheng-Qing Fu, and Xiaoqiang Wang Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13883–13888. doi: 10.1073/pnas.0804099105.PMCID: PMC2533679 Cell Biology Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum YongKeun Park, Monica Diez-Silva, Gabriel Popescu, George Lykotrafitis, Wonshik Choi, Michael S. Feld, and Subra Suresh Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13730–13735. doi: 10.1073/pnas.0806100105.PMCID: PMC2529332 Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload John A. Muraski, Kimberlee M. Fischer, Weitao Wu, Christopher T. Cottage, Pearl Quijada, Matt Mason, Shabana Din, Natalie Gude, Roberto Alvarez, Jr, Marcello Rota, Jan Kajstura, Zeping Wang, Erik Schaefer, Xiongen Chen, Scott MacDonnel, Nancy Magnuson, Stephen R. Houser, Piero Anversa, and Mark A. Sussman Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13889–13894. doi: 10.1073/pnas.0709135105.PMCID: PMC2544549 A system for Cre-regulated RNA interference in vivo Patrick Stern, Sophie Astrof, Stefan J. Erkeland, Joshua Schustak, Phillip A. Sharp, and Richard O. Hynes Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13895–13900. doi: 10.1073/pnas.0806907105.PMCID: PMC2532697 A fluorescent reporter of caspase activity for live imaging Pierre-Luc Bardet, Golnar Kolahgar, Anita Mynett, Irene Miguel-Aliaga, James Briscoe, Pascal Meier, and Jean-Paul Vincent Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13901–13905. doi: 10.1073/pnas.0806983105.PMCID: PMC2544551 A microRNA signature for a BMP2-induced osteoblast lineage commitment program Zhaoyong Li, Mohammad Q. Hassan, Stefano Volinia, Andre J. van Wijnen, Janet L. Stein, Carlo M. Croce, Jane B. Lian, and Gary S. Stein Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13906–13911. doi: 10.1073/pnas.0804438105.PMCID: PMC2544552 Developmental Biology Mating induces an immune response and developmental switch in the Drosophila oviduct Anat Kapelnikov, Einat Zelinger, Yuval Gottlieb, Kahn Rhrissorrakrai, Kristin C. Gunsalus, and Yael Heifetz Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13912–13917. doi: 10.1073/pnas.0710997105.PMCID: PMC2544553 Transmission of Y chromosomes from XY female mice was made possible by the replacement of cytoplasm during oocyte maturation Yayoi Obata, Michele Villemure, Tomohiro Kono, and Teruko Taketo Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13918–13923. doi: 10.1073/pnas.0802680105.PMCID: PMC2544554 Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart Kari Baker, Nathalia G. Holtzman, and Rebecca D. Burdine Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13924–13929. doi: 10.1073/pnas.0802159105.PMCID: PMC2544555 Ecology Stage-specific predator species help each other to persist while competing for a single prey A. M. De Roos, T. Schellekens, T. Van Kooten, and L. Persson Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13930–13935. doi: 10.1073/pnas.0803834105.PMCID: PMC2532698 When to stop managing or surveying cryptic threatened species Iadine Chadès, Eve McDonald-Madden, Michael A. McCarthy, Brendan Wintle, Matthew Linkie, and Hugh P. Possingham Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13936–13940. doi: 10.1073/pnas.0805265105.PMCID: PMC2544557 Environmental Sciences Middle East coastal ecosystem response to middle-to-late Holocene abrupt climate changes D. Kaniewski, E. Paulissen, E. Van Campo, M. Al-Maqdissi, J. Bretschneider, and K. Van Lerberghe Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13941–13946. doi: 10.1073/pnas.0803533105.PMCID: PMC2544558 Evolution A scale of greatness and causal classification of mass extinctions: Implications for mechanisms A. M. Celâl Şengör, Saniye Atayman, and Sinan Özeren Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13736–13740. doi: 10.1073/pnas.0805482105.PMCID: PMC2544523 Multiple deleterious effects of experimentally aged sperm in a monogamous bird Joël White, Richard H. Wagner, Fabrice Helfenstein, Scott A. Hatch, Hervé Mulard, Liliana C. Naves, and Etienne Danchin Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13947–13952. doi: 10.1073/pnas.0803067105.PMCID: PMC2544559 Molecular signatures of ribosomal evolution Elijah Roberts, Anurag Sethi, Jonathan Montoya, Carl R. Woese, and Zaida Luthey-Schulten Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13953–13958. doi: 10.1073/pnas.0804861105.PMCID: PMC2528867 The hearing gene Prestin reunites echolocating bats Gang Li, Jinhong Wang, Stephen J. Rossiter, Gareth Jones, James A. Cotton, and Shuyi Zhang Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13959–13964. doi: 10.1073/pnas.0802097105.PMCID: PMC2544561 Demography and weak selection drive patterns of transposable element diversity in natural populations of Arabidopsis lyrata Steven Lockton, Jeffrey Ross-Ibarra, and Brandon S. Gaut Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13965–13970. doi: 10.1073/pnas.0804671105.PMCID: PMC2544562 The short-sequence designs of isochores from the human genome Maria Costantini and Giorgio Bernardi Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13971–13976. doi: 10.1073/pnas.0803916105.PMCID: PMC2532971 Accelerated evolution of resistance in multidrug environments Matthew Hegreness, Noam Shoresh, Doris Damian, Daniel Hartl, and Roy Kishony Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13977–13981. doi: 10.1073/pnas.0805965105.PMCID: PMC2544564 From the Cover: The genetic expectations of a protracted model for the origins of domesticated crops Robin G. Allaby, Dorian Q. Fuller, and Terence A. Brown Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13982–13986. doi: 10.1073/pnas.0803780105.PMCID: PMC2544565 Genetics FOXO3A genotype is strongly associated with human longevity Bradley J. Willcox, Timothy A. Donlon, Qimei He, Randi Chen, John S. Grove, Katsuhiko Yano, Kamal H. Masaki, D. Craig Willcox, Beatriz Rodriguez, and J. David Curb Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13987–13992. doi: 10.1073/pnas.0801030105.PMCID: PMC2544566 Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q Ivana Marinovic-Terzic, Atsuko Yoshioka-Yamashita, Hideki Shimodaira, Elena Avdievich, Irina C. Hunton, Richard D. Kolodner, Winfried Edelmann, and Jean Y. J. Wang Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13993–13998. doi: 10.1073/pnas.0806435105.PMCID: PMC2528866 A powerful method combining homologous recombination and site-specific recombination for targeted mutagenesis in Drosophila Guanjun Gao, Conor McMahon, Jie Chen, and Yikang S. Rong Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13999–14004. doi: 10.1073/pnas.0805843105.PMCID: PMC2529331 Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats Carola Rintisch, Jacqueline Ameri, Peter Olofsson, Holger Luthman, and Rikard Holmdahl Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14005–14010. doi: 10.1073/pnas.0803956105.PMCID: PMC2544569 Immunology Transcriptional impact of Aire varies with cell type Mireia Guerau-de-Arellano, Diane Mathis, and Christophe Benoist Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14011–14016. doi: 10.1073/pnas.0806616105.PMCID: PMC2544570 Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria Nathan W. Schmidt, Rebecca L. Podyminogin, Noah S. Butler, Vladimir P. Badovinac, Brad J. Tucker, Keith S. Bahjat, Peter Lauer, Arturo Reyes-Sandoval, Claire L. Hutchings, Anne C. Moore, Sarah C. Gilbert, Adrian V. Hill, Lyric C. Bartholomay, and John T. Harty Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14017–14022. doi: 10.1073/pnas.0805452105.PMCID: PMC2544571 TGF-β and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3 Arabinda Samanta, Bin Li, Xiaomin Song, Kathryn Bembas, Geng Zhang, Makoto Katsumata, Sandra J. Saouaf, Qiang Wang, Wayne W. Hancock, Yuan Shen, and Mark I. Greene Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14023–14027. doi: 10.1073/pnas.0806726105.PMCID: PMC2544572 IL-21 signaling is critical for the development of type I diabetes in the NOD mouse Rosanne Spolski, Mohit Kashyap, Constance Robinson, Zuxi Yu, and Warren J. Leonard Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14028–14033. doi: 10.1073/pnas.0804358105.PMCID: PMC2544573 Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice Francesca Menconi, Maria C. Monti, David A. Greenberg, Taiji Oashi, Roman Osman, Terry F. Davies, Yoshiyuki Ban, Eric M. Jacobson, Erlinda S. Concepcion, Cheuk Wun Li, and Yaron Tomer Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14034–14039. doi: 10.1073/pnas.0806584105.PMCID: PMC2544574 Crosspresentation by nonhematopoietic and direct presentation by hematopoietic cells induce central tolerance to myelin basic protein Antoine Perchellet, Thea Brabb, and Joan M. Goverman Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14040–14045. doi: 10.1073/pnas.0804970105.PMCID: PMC2544575 MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus Vijay G. Bhoj, Qinmiao Sun, Elizabeth J. Bhoj, Cynthia Somers, Xiang Chen, Juan-Pablo Torres, Asuncion Mejias, Ana M. Gomez, Hasan Jafri, Octavio Ramilo, and Zhijian J. Chen Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14046–14051. doi: 10.1073/pnas.0804717105.PMCID: PMC2532974 Medical Sciences Peripheral Aβ subspecies as risk biomarkers of Alzheimer's disease Nicole Schupf, Ming X. Tang, Hide Fukuyama, Jennifer Manly, Howard Andrews, Pankaj Mehta, Jeffery Ravetch, and Richard Mayeux Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14052–14057. doi: 10.1073/pnas.0805902105.PMCID: PMC2544577 The neutrophil gelatinase-associated lipocalin (NGAL), a NF-κB-regulated gene, is a survival factor for thyroid neoplastic cells Alessio Iannetti, Francesco Pacifico, Renato Acquaviva, Alfonso Lavorgna, Elvira Crescenzi, Carlo Vascotto, Gianluca Tell, Anna Maria Salzano, Andrea Scaloni, Emilia Vuttariello, Gennaro Chiappetta, Silvestro Formisano, and Antonio Leonardi Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14058–14063. doi: 10.1073/pnas.0710846105.PMCID: PMC2544578 Loss of PIP5KIβ demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J. Stalker, Takehiko Sasaki, Lawrence F. Brass, John K. Choi, John H. Hartwig, and Charles S. Abrams Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14064–14069. doi: 10.1073/pnas.0804139105.PMCID: PMC2544579 Making insulin-deficient type 1 diabetic rodents thrive without insulin Xinxin Yu, Byung-Hyun Park, May-Yun Wang, Zhao V. Wang, and Roger H. Unger Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14070–14075. doi: 10.1073/pnas.0806993105.PMCID: PMC2544580 Cell type-specific DNA methylation patterns in the human breast Noga Bloushtain-Qimron, Jun Yao, Eric L. Snyder, Michail Shipitsin, Lauren L. Campbell, Sendurai A. Mani, Min Hu, Haiyan Chen, Vadim Ustyansky, Jessica E. Antosiewicz, Pedram Argani, Marc K. Halushka, James A. Thomson, Paul Pharoah, Angel Porgador, Saraswati Sukumar, Ramon Parsons, Andrea L. Richardson, Martha R. Stampfer, Rebecca S. Gelman, Tatiana Nikolskaya, Yuri Nikolsky, and Kornelia Polyak Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14076–14081. doi: 10.1073/pnas.0805206105.PMCID: PMC2532972 Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis Yajaira Suárez, Carlos Fernández-Hernando, Jun Yu, Scott A. Gerber, Kenneth D. Harrison, Jordan S. Pober, M. Luisa Iruela-Arispe, Matthias Merkenschlager, and William C. Sessa Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14082–14087. doi: 10.1073/pnas.0804597105.PMCID: PMC2544582 Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell Yang Jo Chung, Chul Won Choi, Christopher Slape, Terry Fry, and Peter D. Aplan Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14088–14093. doi: 10.1073/pnas.0804507105.PMCID: PMC2544583 High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma Erik Fredlund, Markus Ringnér, John M. Maris, and Sven Påhlman Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14094–14099. doi: 10.1073/pnas.0804455105.PMCID: PMC2544584 Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines Cameron Rink, Greg Christoforidis, Amir Abduljalil, Marinos Kontzialis, Valerie Bergdall, Sashwati Roy, Savita Khanna, Andrew Slivka, Michael Knopp, and Chandan K. Sen Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14100–14105. doi: 10.1073/pnas.0806678105.PMCID: PMC2544585 Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease Stefanie Krick, Shaolin Shi, Wenjun Ju, Christian Faul, Su-yi Tsai, Peter Mundel, and Erwin P. Böttinger Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14106–14111. doi: 10.1073/pnas.0801146105.PMCID: PMC2529330 Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS Udayan Guha, Raghothama Chaerkady, Arivusudar Marimuthu, A. Scott Patterson, Manoj K. Kashyap, H. C. Harsha, Mitsuo Sato, Joel S. Bader, Alex E. Lash, John D. Minna, Akhilesh Pandey, and Harold E. Varmus Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14112–14117. doi: 10.1073/pnas.0806158105.PMCID: PMC2531065 Microbiology HCMV gH/gL/UL128–131 interferes with virus entry into epithelial cells: Evidence for cell type-specific receptors Brent J. Ryckman, Marie C. Chase, and David C. Johnson Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14118–14123. doi: 10.1073/pnas.0804365105.PMCID: PMC2544588 Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections Charles Y. Chiu, Alexander L. Greninger, Kimberly Kanada, Thomas Kwok, Kael F. Fischer, Charles Runckel, Janice K. Louie, Carol A. Glaser, Shigeo Yagi, David P. Schnurr, Tom D. Haggerty, Julie Parsonnet, Don Ganem, and Joseph L. DeRisi Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14124–14129. doi: 10.1073/pnas.0805968105.PMCID: PMC2528868 Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus Ulrich Nübel, Philippe Roumagnac, Mirjam Feldkamp, Jae-Hoon Song, Kwan Soo Ko, Yhu-Chering Huang, Geoffrey Coombs, Margaret Ip, Henrik Westh, Robert Skov, Marc J. Struelens, Richard V. Goering, Birgit Strommenger, Annette Weller, Wolfgang Witte, and Mark Achtman Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14130–14135. doi: 10.1073/pnas.0804178105.PMCID: PMC2544590 Spatial organization of a replicating bacterial chromosome Idit Anna Berlatzky, Alex Rouvinski, and Sigal Ben-Yehuda Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14136–14140. doi: 10.1073/pnas.0804982105.PMCID: PMC2544591 The Salmonella virulence protein SifA is a G protein antagonist Laurie K. Jackson, Parwez Nawabi, Cristiana Hentea, Everett A. Roark, and Kasturi Haldar Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14141–14146. doi: 10.1073/pnas.0801872105.PMCID: PMC2544592 Neuroscience Development of input connections in neural cultures Jordi Soriano, María Rodríguez Martínez, Tsvi Tlusty, and Elisha Moses Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13758–13763. doi: 10.1073/pnas.0707492105.PMCID: PMC2544527 Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans Hasse Walum, Lars Westberg, Susanne Henningsson, Jenae M. Neiderhiser, David Reiss, Wilmar Igl, Jody M. Ganiban, Erica L. Spotts, Nancy L. Pedersen, Elias Eriksson, and Paul Lichtenstein Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14153–14156. doi: 10.1073/pnas.0803081105.PMCID: PMC2533683 Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain Regina L. Faulkner, Mi-Hyeon Jang, Xiao-Bo Liu, Xin Duan, Kurt A. Sailor, Ju Young Kim, Shaoyu Ge, Edward G. Jones, Guo-li Ming, Hongjun Song, and Hwai-Jong Cheng Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14157–14162. doi: 10.1073/pnas.0806658105.PMCID: PMC2544594 Rules of engagement for NMDA receptor subunits Maximilian H. Ulbrich and Ehud Y. Isacoff Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14163–14168. doi: 10.1073/pnas.0802075105.PMCID: PMC2544595 The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice Fabio Pibiri, Alan P. Kozikowski, Graziano Pinna, James Auta, Bashkim Kadriu, Erminio Costa, and Alessandro Guidotti Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14169–14174. doi: 10.1073/pnas.0807172105.PMCID: PMC2544596 C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity Erica A. Fradinger, Bernhard H. Monien, Brigita Urbanc, Aleksey Lomakin, Miao Tan, Huiyuan Li, Sean M. Spring, Margaret M. Condron, Luis Cruz, Cui-Wei Xie, George B. Benedek, and Gal Bitan Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14175–14180. doi: 10.1073/pnas.0807163105.PMCID: PMC2544597 Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons Dao-Qi Zhang, Kwoon Y. Wong, Patricia J. Sollars, David M. Berson, Gary E. Pickard, and Douglas G. McMahon Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14181–14186. doi: 10.1073/pnas.0803893105.PMCID: PMC2544598 From the Cover: Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates Csaba Leranth, Tibor Hajszan, Klara Szigeti-Buck, Jeremy Bober, and Neil J. MacLusky Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14187–14191. doi: 10.1073/pnas.0806139105.PMCID: PMC2544599 Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission Lucia Carvelli, Randy D. Blakely, and Louis J. DeFelice Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14192–14197. doi: 10.1073/pnas.0802214105.PMCID: PMC2528871 Physiology The guanylate kinase domain of the β-subunit of voltage-gated calcium channels suffices to modulate gating Giovanni Gonzalez-Gutierrez, Erick Miranda-Laferte, Doreen Nothmann, Silke Schmidt, Alan Neely, and Patricia Hidalgo Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14198–14203. doi: 10.1073/pnas.0806558105.PMCID: PMC2544601 Plant Biology Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin Hikaru Seki, Kiyoshi Ohyama, Satoru Sawai, Masaharu Mizutani, Toshiyuki Ohnishi, Hiroshi Sudo, Tomoyoshi Akashi, Toshio Aoki, Kazuki Saito, and Toshiya Muranaka Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14204–14209. doi: 10.1073/pnas.0803876105.PMCID: PMC2532699 A transcript profiling approach reveals an epicatechin-specific glucosyltransferase expressed in the seed coat of Medicago truncatula Yongzhen Pang, Gregory J. Peel, Shashi B. Sharma, Yuhong Tang, and Richard A. Dixon Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14210–14215. doi: 10.1073/pnas.0805954105.PMCID: PMC2544603 Population Biology Benefits of using multiple first-line therapies against malaria Maciej F. Boni, David L. Smith, and Ramanan Laxminarayan Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14216–14221. doi: 10.1073/pnas.0804628105.PMCID: PMC2544604 Psychology The neonate brain detects speech structure Judit Gervain, Francesco Macagno, Silvia Cogoi, Marcela Peña, and Jacques Mehler Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14222–14227. doi: 10.1073/pnas.0806530105.PMCID: PMC2544605 Neural correlates of access to short-term memory Derek Evan Nee and John Jonides Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14228–14233. doi: 10.1073/pnas.0802081105.PMCID: PMC2544606 Social Sciences Environmental Sciences Middle East coastal ecosystem response to middle-to-late Holocene abrupt climate changes D. Kaniewski, E. Paulissen, E. Van Campo, M. Al-Maqdissi, J. Bretschneider, and K. Van Lerberghe Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13941–13946. doi: 10.1073/pnas.0803533105.PMCID: PMC2544558 Social Sciences From the Cover: Experience versus talent shapes the structure of the Web Joseph S. Kong, Nima Sarshar, and Vwani P. Roychowdhury Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13724–13729. doi: 10.1073/pnas.0805921105.PMCID: PMC2544521 Correction Correction for Gongora et al., Indo-European and Asian origins for Chilean and Pacific chickens revealed by mtDNA Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 14234. doi: 10.1073/pnas.0807512105.PMCID: PMC2544607 Corrects: Jaime Gongora, et al. From the Cover: Indo-European and Asian origins for Chilean and Pacific chickens revealed by mtDNA. Proc Natl Acad Sci U S A. 2008 July 29; 105(30): 10308–10313. |