| | This journal provides immediate access to some articles. Applied Physical Sciences Chemistry Lévy strategies in intermittent search processes are advantageous Michael A. Lomholt, Koren Tal, Ralf Metzler, and Klafter Joseph PMCID: PMC2516217 Letters Binaural jitter with cochlear implants, improved interaural time-delay sensitivity, and normal hearing Richard J. M. van Hoesel PMCID: PMC2516228 Reply to van Hoesel: Binaural jitter with cochlear implants, improved interaural time-delay sensitivity, and normal hearing Bernhard Laback and Piotr Majdak PMCID: PMC2516242 This Week in PNAS Proc Natl Acad Sci U S A. 2008 August 12; 105(32): 11033–11034. doi: 10.1073/iti03208105.PMCID: PMC2516280 Commentaries Metallic helium in massive planets David J. Stevenson PMCID: PMC2516209 Vitamin C and cancer revisited Balz Frei and Stephen Lawson PMCID: PMC2516245 Phosphorus control is critical to mitigating eutrophication Stephen R. Carpenter PMCID: PMC2516213 PINK1 in mitochondrial function Helene Plun-Favreau and John Hardy PMCID: PMC2516263 Perspective Aminoacyl tRNA synthetases and their connections to disease Sang Gyu Park, Paul Schimmel, and Sunghoon Kim PMCID: PMC2516211 Physical Sciences Applied Physical Sciences Experimental quantum coding against qubit loss error Chao-Yang Lu, Wei-Bo Gao, Jin Zhang, Xiao-Qi Zhou, Tao Yang, and Jian-Wei Pan PMCID: PMC2516277 Chemistry Silicon–Carbon bond cleavage reactions of Ansa tungstenocene compounds: The [Me2Si] bridge as a site for metallocene functionalization Cary E. Zachmanoglou, Hyosun Lee, Seung Ho Jang, Keliang Pang, and Gerard Parkin PMCID: PMC2516221 Influence of nonlinear electrostatics on transfer energies between liquid phases: Charge burial is far less expensive than Born model Haipeng Gong, Glen Hocky, and Karl F. Freed PMCID: PMC2516240 Single molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins Yi Cao, Teri Yoo, and Hongbin Li PMCID: PMC2516265 Engineering Large-scale, heterogeneous integration of nanowire arrays for image sensor circuitry Zhiyong Fan, Johnny C. Ho, Zachery A. Jacobson, Haleh Razavi, and Ali Javey PMCID: PMC2516247 Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes Yi Duan, Nanami Gotoh, Qingshang Yan, Zhaopeng Du, Alan M. Weinstein, Tong Wang, and Sheldon Weinbaum PMCID: PMC2516248 Geophysics From the Cover:
Fluid helium at conditions of giant planetary interiors Lars Stixrude and Raymond Jeanloz PMCID: PMC2497461 Statistics Statistical analysis of the National Institutes of Health peer review system Valen E. Johnson PMCID: PMC2488382 Sustainability Science Warming of the Indian Ocean threatens eastern and southern African food security but could be mitigated by agricultural development Chris Funk, Michael D. Dettinger, Joel C. Michaelsen, James P. Verdin, Molly E. Brown, Mathew Barlow, and Andrew Hoell PMCID: PMC2497460 Biological Sciences Anthropology The oldest Asian record of Anthropoidea Sunil Bajpai, Richard F. Kay, Blythe A. Williams, Debasis P. Das, Vivesh V. Kapur, and B. N. Tiwari PMCID: PMC2516236 Applied Biological Sciences Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy–cell transplantation approach Ehsan Jabbarzadeh, Trevor Starnes, Yusuf M. Khan, Tao Jiang, Anthony J. Wirtel, Meng Deng, Qing Lv, Lakshmi S. Nair, Steven B. Doty, and Cato T. Laurencin PMCID: PMC2516212 Biochemistry From the Cover:
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice Qi Chen, Michael Graham Espey, Andrew Y. Sun, Chaya Pooput, Kenneth L. Kirk, Murali C. Krishna, Deena Beneda Khosh, Jeanne Drisko, and Mark Levine PMCID: PMC2516281 Structural basis for induced formation of the inflammatory mediator prostaglandin E2 Caroline Jegerschöld, Sven-Christian Pawelzik, Pasi Purhonen, Priyaranjan Bhakat, Karina Roxana Gheorghe, Nobuhiko Gyobu, Kaoru Mitsuoka, Ralf Morgenstern, Per-Johan Jakobsson, and Hans Hebert PMCID: PMC2516235 Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp Roxana E. Georgescu, Olga Yurieva, Seung-Sup Kim, John Kuriyan, Xiang-Peng Kong, and Mike O'Donnell PMCID: PMC2495014 Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro Sjoerd Wanrooij, Javier Miralles Fusté, Géraldine Farge, Yonghong Shi, Claes M. Gustafsson, and Maria Falkenberg PMCID: PMC2516254 Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis Michael F. Freeman, Kristos A. Moshos, Micah J. Bodner, Rongfeng Li, and Craig A. Townsend PMCID: PMC2516261 Specific mutations within the AT-rich region of a plasmid replication origin affect either origin opening or helicase loading Magdalena Rajewska, Lukasz Kowalczyk, Grazyna Konopa, and Igor Konieczny PMCID: PMC2516259 Extracellular loop C of NPC1L1 is important for binding to ezetimibe Adam B. Weinglass, Martin Kohler, Uwe Schulte, Jessica Liu, Emmanuel O. Nketiah, Anu Thomas, William Schmalhofer, Brande Williams, Wolfgang Bildl, Daniel R. McMasters, Kevin Dai, Lindsey Beers, Margaret E. McCann, Gregory J. Kaczorowski, and Maria L. Garcia PMCID: PMC2516253 Biophysics Influence of nonlinear electrostatics on transfer energies between liquid phases: Charge burial is far less expensive than Born model Haipeng Gong, Glen Hocky, and Karl F. Freed PMCID: PMC2516240 Single molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins Yi Cao, Teri Yoo, and Hongbin Li PMCID: PMC2516265 Conserved residues modulate copper release in human copper chaperone Atox1 Faiza Hussain, John S. Olson, and Pernilla Wittung-Stafshede PMCID: PMC2516206 Capillarity-like growth of protein folding nuclei Xianghong Qi and John J. Portman PMCID: PMC2516257 Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners Orly Dym, Shira Albeck, Tamar Unger, Jossef Jacobovitch, Anna Branzburg, Yigal Michael, Daphna Frenkiel-Krispin, Sharon Grayer Wolf, and Michael Elbaum PMCID: PMC2516231 Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids Asif Iqbal, Sinan Arslan, Burak Okumus, Timothy J. Wilson, Gerard Giraud, David G. Norman, Taekjip Ha, and David M. J. Lilley PMCID: PMC2516210 Dynamic energy landscape view of coupled binding and protein conformational change: Induced-fit versus population-shift mechanisms Kei-ichi Okazaki and Shoji Takada PMCID: PMC2516237 Experimental approaches to kinetics of gas diffusion in hydrogenase Fanny Leroux, Sébastien Dementin, Bénédicte Burlat, Laurent Cournac, Anne Volbeda, Stéphanie Champ, Lydie Martin, Bruno Guigliarelli, Patrick Bertrand, Juan Fontecilla-Camps, Marc Rousset, and Christophe Léger PMCID: PMC2516266 Ion permeation through a Cl−-selective channel designed from a CLC Cl−/H+ exchanger Hariharan Jayaram, Alessio Accardi, Fang Wu, Carole Williams, and Christopher Miller PMCID: PMC2516207 Cell Biology MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks Liming Wu, Kuntian Luo, Zhenkun Lou, and Junjie Chen PMCID: PMC2516250 AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53 Jung Min Han, Bum-Joon Park, Sang Gyu Park, Young Sun Oh, So Jung Choi, Sang Won Lee, Soon-Kyung Hwang, Seung-Hee Chang, Myung-Haing Cho, and Sunghoon Kim PMCID: PMC2516205 The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity Sara Farrah Heuss, Delphine Ndiaye-Lobry, Emmanuelle M. Six, Alain Israël, and Frédérique Logeat PMCID: PMC2516222 A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators Peter Stoilov, Chia-Ho Lin, Robert Damoiseaux, Julia Nikolic, and Douglas L. Black PMCID: PMC2516208 Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2 Malin Åkerfelt, Eva Henriksson, Asta Laiho, Anniina Vihervaara, Karoliina Rautoma, Noora Kotaja, and Lea Sistonen PMCID: PMC2496887 DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1 R. A. M. de Bruin, T. I. Kalashnikova, A. Aslanian, J. Wohlschlegel, C. Chahwan, J. R. Yates, III, P. Russell, and C. Wittenberg PMCID: PMC2516226 Apoptosis leads to a degradation of vital components of active nuclear transport and a dissociation of the nuclear lamina A. Kramer, I. Liashkovich, H. Oberleithner, S. Ludwig, I. Mazur, and V. Shahin PMCID: PMC2516273 Developmental Biology Pitx2 regulates gonad morphogenesis Joaquín Rodríguez-León, Concepción Rodríguez Esteban, Mercè Martí, Belén Santiago-Josefat, Ilir Dubova, Xavier Rubiralta, and Juan Carlos Izpisúa Belmonte PMCID: PMC2516275 Ecology Lévy strategies in intermittent search processes are advantageous Michael A. Lomholt, Koren Tal, Ralf Metzler, and Klafter Joseph PMCID: PMC2516217 Hydraulic integration and shrub growth form linked across continental aridity gradients H. Jochen Schenk, Susana Espino, Christine M. Goedhart, Marisa Nordenstahl, Hugo I. Martinez Cabrera, and Cynthia S. Jones PMCID: PMC2516251 Environmental Sciences From the Cover:
Eutrophication of lakes cannot be controlled by reducing nitrogen input: Results of a 37-year whole-ecosystem experiment David W. Schindler, R. E. Hecky, D. L. Findlay, M. P. Stainton, B. R. Parker, M. J. Paterson, K. G. Beaty, M. Lyng, and S. E. M. Kasian PMCID: PMC2491484 Evolution Novelties of the flowering plant pollen tube underlie diversification of a key life history stage Joseph H. Williams PMCID: PMC2516219 Genetics Excessive genomic DNA copy number variation in the Li–Fraumeni cancer predisposition syndrome Adam Shlien, Uri Tabori, Christian R. Marshall, Malgorzata Pienkowska, Lars Feuk, Ana Novokmet, Sonia Nanda, Harriet Druker, Stephen W. Scherer, and David Malkin PMCID: PMC2516272 Immunology CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis Erin E. McCandless, Bo Zhang, Michael S. Diamond, and Robyn S. Klein PMCID: PMC2495012 Immunochemical termination of self-tolerance Jan Grünewald, Meng-Lin Tsao, Roshan Perera, Liqun Dong, Frank Niessen, Ben G. Wen, Diane M. Kubitz, Vaughn V. Smider, Wolfram Ruf, Marc Nasoff, Richard A. Lerner, and Peter G. Schultz PMCID: PMC2516224 Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation David L. Hava, Nicole van der Wel, Nadia Cohen, Christopher C. Dascher, Diane Houben, Luis León, Sandeep Agarwal, Masahiko Sugita, Maaike van Zon, Sally C. Kent, Homayoun Shams, Peter J. Peters, and Michael B. Brenner PMCID: PMC2516216 Diverse cytokine production by NKT cell subsets and identification of an IL-17–producing CD4−NK1.1− NKT cell population Jonathan M. Coquet, Sumone Chakravarti, Konstantinos Kyparissoudis, Finlay W. McNab, Lauren A. Pitt, Brent S. McKenzie, Stuart P. Berzins, Mark J. Smyth, and Dale I. Godfrey PMCID: PMC2516267 Medical Sciences Impact of enhanced tuberculosis diagnosis in South Africa: A mathematical model of expanded culture and drug susceptibility testing David W. Dowdy, Richard E. Chaisson, Gary Maartens, Elizabeth L. Corbett, and Susan E. Dorman PMCID: PMC2516234 Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease Hong Jiang, Eric Schiffer, Zhangfa Song, Jianwei Wang, Petra Zürbig, Kathrin Thedieck, Suzette Moes, Heike Bantel, Nadja Saal, Justyna Jantos, Meiken Brecht, Paul Jenö, Michael N. Hall, Klaus Hager, Michael P. Manns, Hartmut Hecker, Arnold Ganser, Konstanze Döhner, Andrzej Bartke, Christoph Meissner, Harald Mischak, Zhenyu Ju, and K. Lenhard Rudolph PMCID: PMC2516278 Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro Kaustabh Ghosh, Charles K. Thodeti, Andrew C. Dudley, Akiko Mammoto, Michael Klagsbrun, and Donald E. Ingber PMCID: PMC2516246 An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes Masanori Onda, Richard Beers, Laiman Xiang, Satoshi Nagata, Qing-cheng Wang, and Ira Pastan PMCID: PMC2516223 Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist Ailsa J. Frew, Ralph K. Lindemann, Ben P. Martin, Christopher J. P. Clarke, Janelle Sharkey, Desiree A. Anthony, Kellie-Marie Banks, Nicole M. Haynes, Pradnya Gangatirkar, Kym Stanley, Jessica E. Bolden, Kazuyoshi Takeda, Hideo Yagita, J. Paul Secrist, Mark J. Smyth, and Ricky W. Johnstone PMCID: PMC2516269 Microbiology Effects of colonization, luminescence, and autoinducer on host transcription during development of the squid-vibrio association Carlene K. Chun, Joshua V. Troll, Irina Koroleva, Bartley Brown, Liliana Manzella, Einat Snir, Hakeem Almabrazi, Todd E. Scheetz, Maria de Fatima Bonaldo, Thomas L. Casavant, M. Bento Soares, Edward G. Ruby, and Margaret J. McFall-Ngai PMCID: PMC2516268 Deciphering the genetic determinants for aerobic nicotinic acid degradation: The nic cluster from Pseudomonas putida KT2440 José I. Jiménez, Ángeles Canales, Jesús Jiménez-Barbero, Krzysztof Ginalski, Leszek Rychlewski, José L. García, and Eduardo Díaz PMCID: PMC2516282 Herpesvirus tegument protein activates NF-κB signaling through the TRAF6 adaptor protein XueQiao Liu, Katherine Fitzgerald, Evelyn Kurt-Jones, Robert Finberg, and David M. Knipe PMCID: PMC2516262 Architecture and inherent robustness of a bacterial cell-cycle control system Xiling Shen, Justine Collier, David Dill, Lucy Shapiro, Mark Horowitz, and Harley H. McAdams PMCID: PMC2516238 A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea Chinping Chng, Amy M. Lum, Jonathan A. Vroom, and Camilla M. Kao PMCID: PMC2516264 Neuroscience Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus Eri Segi-Nishida, Jennifer L. Warner-Schmidt, and Ronald S. Duman PMCID: PMC2516270 Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis Rina Aharoni, Avia Herschkovitz, Raya Eilam, Michal Blumberg-Hazan, Michael Sela, Wolfgang Bruck, and Ruth Arnon PMCID: PMC2516229 From the Cover:
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress Clement A. Gautier, Tohru Kitada, and Jie Shen PMCID: PMC2516271 Polarized microtubule arrays in apical dendrites and axons Alex C. Kwan, Daniel A. Dombeck, and Watt W. Webb PMCID: PMC2496886 T current potentiation increases the occurrence and temporal fidelity of synaptically evoked burst firing in sensory thalamic neurons Thomas Bessaïh, Nathalie Leresche, and Régis C. Lambert PMCID: PMC2516279 The Fezf2–Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex Bin Chen, Song S. Wang, Alexis M. Hattox, Helen Rayburn, Sacha B. Nelson, and Susan K. McConnell PMCID: PMC2495013 Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation Yunlei Yang, Xiao-bin Wang, Matthew Frerking, and Qiang Zhou PMCID: PMC2496888 Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation Tiina Kotti, Daphne D. Head, Charles E. McKenna, and David W. Russell PMCID: PMC2516227 Deletion of the mouse RegIIIβ (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons L. A. Tebar, S. M. Géranton, C. Parsons-Perez, A. S. Fisher, R. Bayne, A. J. H. Smith, M. Turmaine, S. Perez-Luz, A. Sheasby, C. De Felipe, C. Ruff, G. Raivich, and S. P. Hunt PMCID: PMC2516218 Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice Shuo Lin, Marcin Maj, Gabriela Bezakova, Josef P. Magyar, Hans Rudolf Brenner, and Markus A. Ruegg PMCID: PMC2497462 GABAA transmission is a critical step in the process of triggering homeostatic increases in quantal amplitude Jennifer C. Wilhelm and Peter Wenner PMCID: PMC2516260 Physiology Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes Yi Duan, Nanami Gotoh, Qingshang Yan, Zhaopeng Du, Alan M. Weinstein, Tong Wang, and Sheldon Weinbaum PMCID: PMC2516248 Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression Pawan Gupta, Ping-Chih Ho, MD Mostaqul Huq, Sung Gil Ha, Sung Wook Park, Amjad Ali Khan, Nien-Pei Tsai, and Li-Na Wei PMCID: PMC2516243 Nitric oxide promotes distant organ protection: Evidence for an endocrine role of nitric oxide John W. Elrod, John W. Calvert, Susheel Gundewar, Nathan S. Bryan, and David J. Lefer PMCID: PMC2516252 Plant Biology From the Cover:
A triallelic system of S5 is a major regulator of the reproductive barrier and compatibility of indica–japonica hybrids in rice Jiongjiong Chen, Jihua Ding, Yidan Ouyang, Hongyi Du, Jiangyi Yang, Ke Cheng, Jie Zhao, Shuqing Qiu, Xuelian Zhang, Jialing Yao, Kede Liu, Lei Wang, Caiguo Xu, Xianghua Li, Yongbiao Xue, Mian Xia, Qing Ji, Jufei Lu, Mingliang Xu, and Qifa Zhang PMCID: PMC2516230 Psychology Electrophysiological evidence of illusory audiovisual speech percept in human infants Elena Kushnerenko, Tuomas Teinonen, Agnes Volein, and Gergely Csibra PMCID: PMC2516214 Sustainability Science Cost-effective priorities for global mammal conservation Josie Carwardine, Kerrie A. Wilson, Gerardo Ceballos, Paul R. Ehrlich, Robin Naidoo, Takuya Iwamura, Stefan A. Hajkowicz, and Hugh P. Possingham PMCID: PMC2495010 Social Sciences Psychology Statistical analysis of the National Institutes of Health peer review system Valen E. Johnson PMCID: PMC2488382 The functional basis of face evaluation Nikolaas N. Oosterhof and Alexander Todorov PMCID: PMC2516255 Correction Correction for Kyrylyuk and van der Schoot, Continuum percolation of carbon nanotubes in polymeric and colloidal media PMCID: PMC2516225 Corrects: Andriy V. Kyrylyuk, et al. Continuum percolation of carbon nanotubes in polymeric and colloidal media. Proc Natl Acad Sci U S A. 2008 June 17; 105(24): 8221–8226. |
