| | This journal provides immediate access to some articles. Editorial Liberalization of PNAS copyright policy: Noncommercial use freely allowed Nicholas R. Cozzarelli, Kenneth R. Fulton, and Diane M. Sullenberger PMCID: PMC515072 Commentary Playing scales in the methane cycle: From microbial ecology to the globe Joshua Schimel PMCID: PMC515073 Physical Sciences Applied Physical Sciences Emissions pathways, climate change, and impacts on California Katharine Hayhoe, Daniel Cayan, Christopher B. Field, Peter C. Frumhoff, Edwin P. Maurer, Norman L. Miller, Susanne C. Moser, Stephen H. Schneider, Kimberly Nicholas Cahill, Elsa E. Cleland, Larry Dale, Ray Drapek, R. Michael Hanemann, Laurence S. Kalkstein, James Lenihan, Claire K. Lunch, Ronald P. Neilson, Scott C. Sheridan, and Julia H. Verville PMCID: PMC514653 From the Cover:
Fabricating complex three-dimensional nanostructures with high-resolution conformable phase masks Seokwoo Jeon, Jang-Ung Park, Ray Cirelli, Shu Yang, Carla E. Heitzman, Paul V. Braun, Paul J. A. Kenis, and John A. Rogers PMCID: PMC515078 Dynamic control of liquid-core/liquid-cladding optical waveguides Daniel B. Wolfe, Richard S. Conroy, Piotr Garstecki, Brian T. Mayers, Michael A. Fischbach, Kateri E. Paul, Mara Prentiss, and George M. Whitesides PMCID: PMC515079 Environmental Sciences From the Cover:
Sulfur pollution suppression of the wetland methane source in the 20th and 21st centuries Vincent Gauci, Elaine Matthews, Nancy Dise, Bernadette Walter, Dorothy Koch, Gunnar Granberg, and Melanie Vile PMCID: PMC515100 Physics Cell mechanosensitivity controls the anisotropy of focal adhesions Alice Nicolas, Benjamin Geiger, and Samuel A. Safran PMCID: PMC515090 Biological Sciences Biochemistry Creating ribosomes with an all-RNA 30S subunit P site Lee Hoang, Kurt Fredrick, and Harry F. Noller PMCID: PMC515080 Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor V. A. Streltsov, J. N. Varghese, J. A. Carmichael, R. A. Irving, P. J. Hudson, and S. D. Nuttall PMCID: PMC515081 An aminoacyl-tRNA synthetase that specifically activates pyrrolysine Carla Polycarpo, Alexandre Ambrogelly, Amélie Bérubé, SusAnn M. Winbush, James A. McCloskey, Pamela F. Crain, John L. Wood, and Dieter Söll PMCID: PMC515082 Structure of adeno-associated virus type 2 Rep40–ADP complex: Insight into nucleotide recognition and catalysis by superfamily 3 helicases J. Anson James, Aneel K. Aggarwal, R. Michael Linden, and Carlos R. Escalante PMCID: PMC515083 Discovery of an allosteric site in the caspases Jeanne A. Hardy, Joni Lam, Jack T. Nguyen, Tom O'Brien, and James A. Wells PMCID: PMC514654 Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition Frederic A. Fellouse, Christian Wiesmann, and Sachdev S. Sidhu PMCID: PMC515084 Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain Nobutaka Ohgami, Dennis C. Ko, Matthew Thomas, Matthew P. Scott, Catherine C. Y. Chang, and Ta-Yuan Chang PMCID: PMC514655 A tagging-via-substrate technology for detection and proteomics of farnesylated proteins Yoonjung Kho, Sung Chan Kim, Chen Jiang, Deb Barma, Sung Won Kwon, Jinke Cheng, Janis Jaunbergs, Carolyn Weinbaum, Fuyuhiko Tamanoi, John Falck, and Yingming Zhao PMCID: PMC515085 Carbon dioxide mediates Mn(II)-catalyzed decomposition of hydrogen peroxide and peroxidation reactions Stefan I. Liochev and Irwin Fridovich PMCID: PMC515086 Biophysics Random-coil behavior and the dimensions of chemically unfolded proteins Jonathan E. Kohn, Ian S. Millett, Jaby Jacob, Bojan Zagrovic, Thomas M. Dillon, Nikolina Cingel, Robin S. Dothager, Soenke Seifert, P. Thiyagarajan, Tobin R. Sosnick, M. Zahid Hasan, Vijay S. Pande, Ingo Ruczinski, Sebastian Doniach, and Kevin W. Plaxco PMCID: PMC515087 Reassessing random-coil statistics in unfolded proteins Nicholas C. Fitzkee and George D. Rose PMCID: PMC514656 Single-molecule recognition imaging microscopy C. Stroh, H. Wang, R. Bash, B. Ashcroft, J. Nelson, H. Gruber, D. Lohr, S. M. Lindsay, and P. Hinterdorfer PMCID: PMC514657 Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge Jong-Myoung Kim, Christian Altenbach, Masahiro Kono, Daniel D. Oprian, Wayne L. Hubbell, and H. Gobind Khorana PMCID: PMC515088 Nonspecific hydrophobic interactions stabilize an equilibrium intermediate of apomyoglobin at a key position within the AGH region Angela M. Bertagna and Doug Barrick PMCID: PMC515089 Cell mechanosensitivity controls the anisotropy of focal adhesions Alice Nicolas, Benjamin Geiger, and Samuel A. Safran PMCID: PMC515090 Cell Biology From the Cover:
Rho overexpression leads to mitosis-associated detachment of cells from epithelial sheets: A link to the mechanism of cancer dissemination J. M. Vasiliev, T. Omelchenko, I. M. Gelfand, H. H. Feder, and E. M. Bonder PMCID: PMC515091 Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest Keita Ohsumi, Ayako Koyanagi, Tomomi M. Yamamoto, Tetsuya Gotoh, and Takeo Kishimoto PMCID: PMC515092 Cotranslational integration and initial sorting at the endoplasmic reticulum translocon of proteins destined for the inner nuclear membrane Suraj Saksena, Yuanlong Shao, Sharon C. Braunagel, Max D. Summers, and Arthur E. Johnson PMCID: PMC515093 Developmental Biology From the Cover:
Derivation of midbrain dopamine neurons from human embryonic stem cells Anselme L. Perrier, Viviane Tabar, Tiziano Barberi, Maria E. Rubio, Juan Bruses, Norbert Topf, Neil L. Harrison, and Lorenz Studer PMCID: PMC515094 The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome Sibylle Jäger, Hillel T. Schwartz, H. Robert Horvitz, and Barbara Conradt PMCID: PMC515095 A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis Veraragavan P. Eswarakumar, Mark C. Horowitz, Rachel Locklin, Gillian M. Morriss-Kay, and Peter Lonai PMCID: PMC515096 Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling Pilar Sanchez, Ana Maria Hernández, Barbara Stecca, Andrea J. Kahler, Amy M. DeGueme, Andrea Barrett, Mercedes Beyna, Milton W. Datta, Sumana Datta, and Ariel Ruiz i Altaba PMCID: PMC514658 A myocardin-related transcription factor regulates activity of serum response factor in Drosophila Zhe Han, Xiumin Li, Jiang Wu, and Eric N. Olson PMCID: PMC515097 GATA4 is essential for formation of the proepicardium and regulates cardiogenesis Alistair J. Watt, Michele A. Battle, Jixuan Li, and Stephen A. Duncan PMCID: PMC515098 Ecology Emissions pathways, climate change, and impacts on California Katharine Hayhoe, Daniel Cayan, Christopher B. Field, Peter C. Frumhoff, Edwin P. Maurer, Norman L. Miller, Susanne C. Moser, Stephen H. Schneider, Kimberly Nicholas Cahill, Elsa E. Cleland, Larry Dale, Ray Drapek, R. Michael Hanemann, Laurence S. Kalkstein, James Lenihan, Claire K. Lunch, Ronald P. Neilson, Scott C. Sheridan, and Julia H. Verville PMCID: PMC514653 Economic value of tropical forest to coffee production Taylor H. Ricketts, Gretchen C. Daily, Paul R. Ehrlich, and Charles D. Michener PMCID: PMC515099 Environmental Sciences From the Cover:
Sulfur pollution suppression of the wetland methane source in the 20th and 21st centuries Vincent Gauci, Elaine Matthews, Nancy Dise, Bernadette Walter, Dorothy Koch, Gunnar Granberg, and Melanie Vile PMCID: PMC515100 Evolution Tissue-specific codon usage and the expression of human genes Joshua B. Plotkin, Harlan Robins, and Arnold J. Levine PMCID: PMC515101 Genetics INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Jeffrey L. Bennetzen Emma Hitt PMCID: PMC515074 INAUGURAL ARTICLE by a Recently Elected Academy Member: Rapid recent growth and divergence of rice nuclear genomes Jianxin Ma and Jeffrey L. Bennetzen PMCID: PMC515075 A mechanical basis for chromosome function Nancy Kleckner, Denise Zickler, Gareth H. Jones, Job Dekker, Ruth Padmore, Jim Henle, and John Hutchinson PMCID: PMC515102 The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis Jessica L. Flint, Joseph C. Kowalski, Pavan K. Karnati, and Keith M. Derbyshire PMCID: PMC515103 Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia Michael F. Egan, Richard E. Straub, Terry E. Goldberg, Imtiaz Yakub, Joseph H. Callicott, Ahmad R. Hariri, Venkata S. Mattay, Alessandro Bertolino, Thomas M. Hyde, Cynthia Shannon-Weickert, Mayada Akil, Jeremy Crook, Radha Krishna Vakkalanka, Rishi Balkissoon, Richard A. Gibbs, Joel E. Kleinman, and Daniel R. Weinberger PMCID: PMC515104 Multiple-stress analysis for isolation of Drosophila longevity genes Horng-Dar Wang, Parsa Kazemi-Esfarjani, and Seymour Benzer PMCID: PMC515105 Role of the yeast acetyltransferase Mpr1 in oxidative stress: Regulation of oxygen reactive species caused by a toxic proline catabolism intermediate Michiyo Nomura and Hiroshi Takagi PMCID: PMC515106 Immunology Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells Maria Shnyreva, William M. Weaver, Mathieu Blanchette, Scott L. Taylor, Martin Tompa, David R. Fitzpatrick, and Christopher B. Wilson PMCID: PMC515107 Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjögren's syndrome Gil-Jin Shim, Margaret Warner, Hyun-Jin Kim, Sandra Andersson, Lining Liu, Jenny Ekman, Otabek Imamov, Margaret E. Jones, Evan R. Simpson, and Jan-Åke Gustafsson PMCID: PMC515108 Imaging inflammation of the pancreatic islets in type 1 diabetes Maria C. Denis, Umar Mahmood, Christophe Benoist, Diane Mathis, and Ralph Weissleder PMCID: PMC515109 Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis Roberta Castriconi, Alessandra Dondero, Raffaella Augugliaro, Claudia Cantoni, Barbara Carnemolla, Angela Rita Sementa, Francesca Negri, Romana Conte, Maria Valeria Corrias, Lorenzo Moretta, Alessandro Moretta, and Cristina Bottino PMCID: PMC515110 Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene Malin Hultqvist, Peter Olofsson, Jens Holmberg, B. Thomas Bäckström, Jesper Tordsson, and Rikard Holmdahl PMCID: PMC515111 Mycobacterium tuberculosis (Mtb) isocitrate dehydrogenases show strong B cell response and distinguish vaccinated controls from TB patients Sharmistha Banerjee, Ashok Nandyala, Raviprasad Podili, V. M. Katoch, K. J. R. Murthy, and Seyed E. Hasnain PMCID: PMC514659 Medical Sciences Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier Akihiko Urayama, Jeffrey H. Grubb, William S. Sly, and William A. Banks PMCID: PMC515112 Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification Loen M. Hansford, Wayne D. Thomas, Joanna M. Keating, Catherine A. Burkhart, Anne E. Peaston, Murray D. Norris, Michelle Haber, Patricia J. Armati, William A. Weiss, and Glenn M. Marshall PMCID: PMC515113 Insulin resistance in skeletal muscles of caveolin-3-null mice Jin Oshikawa, Koji Otsu, Yoshiyuki Toya, Takashi Tsunematsu, Raleigh Hankins, Jun-ichi Kawabe, Susumu Minamisawa, Satoshi Umemura, Yasuko Hagiwara, and Yoshihiro Ishikawa PMCID: PMC515114 Metabonomic investigations in mice infected with Schistosoma mansoni: An approach for biomarker identification Yulan Wang, Elaine Holmes, Jeremy K. Nicholson, Olivier Cloarec, Jacques Chollet, Marcel Tanner, Burton H. Singer, and Jürg Utzinger PMCID: PMC515115 A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription Katayoon H. Emami, Cu Nguyen, Hong Ma, Dae Hoon Kim, Kwang Won Jeong, Masakatsu Eguchi, Randall T. Moon, Jia-Ling Teo, Se Wong Oh, Hak Yeop Kim, Sung Hwan Moon, Jong Ryul Ha, and Michael Kahn PMCID: PMC515116 Microbiology INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Patricia G. Spear Liza Q. Bundesen PMCID: PMC515076 INAUGURAL ARTICLE by a Recently Elected Academy Member: Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism Sharmila Manoj, Cheryl R. Jogger, Dawn Myscofski, Miri Yoon, and Patricia G. Spear PMCID: PMC515077 High-resolution structure of a picornaviral internal cis-acting RNA replication element (cre) Varatharasa Thiviyanathan, Yan Yang, Kumaralal Kaluarachchi, Rene Rijnbrand, David G. Gorenstein, and Stanley M. Lemon PMCID: PMC515117 Major genetic marker of nidoviruses encodes a replicative endoribonuclease Konstantin A. Ivanov, Tobias Hertzig, Mikhail Rozanov, Sonja Bayer, Volker Thiel, Alexander E. Gorbalenya, and John Ziebuhr PMCID: PMC514660 Neuroscience Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo Robin A. de Graaf, Graeme F. Mason, Anant B. Patel, Douglas L. Rothman, and Kevin L. Behar PMCID: PMC515118 Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain Mohammed A. Nassar, L. Caroline Stirling, Greta Forlani, Mark D. Baker, Elizabeth A. Matthews, Anthony H. Dickenson, and John N. Wood PMCID: PMC515119 Correlates of transsaccadic integration in the primary visual cortex of the monkey Paul S. Khayat, Henk Spekreijse, and Pieter R. Roelfsema PMCID: PMC515120 Spatial patterns of gene expression in the olfactory bulb David M. Lin, Yee Hwa Yang, Jonathan A. Scolnick, Lisa J. Brunet, Heather Marsh, Vivian Peng, Yasushi Okazaki, Yoshihide Hayashizaki, Terence P. Speed, and John Ngai PMCID: PMC515121 Modality maps within primate somatosensory cortex Robert M. Friedman, Li Min Chen, and Anna Wang Roe PMCID: PMC514661 Granulocyte-macrophage colony-stimulating factor-induced arteriogenesis reduces energy failure in hemodynamic stroke Edda Schneeloch, Günter Mies, Hans-Jörg Busch, Ivo R. Buschmann, and Konstantin-Alexander Hossmann PMCID: PMC514662 Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating γ-aminobutyric acid type A receptor membrane trafficking Josef T. Kittler, Philip Thomas, Verena Tretter, Yuri D. Bogdanov, Volker Haucke, Trevor G. Smart, and Stephen J. Moss PMCID: PMC515122 Y1 receptors regulate aggressive behavior by modulating serotonin pathways Tim Karl, Shu Lin, Christoph Schwarzer, Amanda Sainsbury, Michelle Couzens, Walter Wittmann, Dana Boey, Stephan von Hörsten, and Herbert Herzog PMCID: PMC515123 Physiology Evidence for conformational coupling between two calcium channels C. Paolini, James D. Fessenden, Isaac N. Pessah, and C. Franzini-Armstrong PMCID: PMC515124 Plant Biology From the Cover:
Arabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions Yukio Kurihara and Yuichiro Watanabe PMCID: PMC515125 Regulation of flowering time in Arabidopsis by K homology domain proteins Todd C. Mockler, Xuhong Yu, Dror Shalitin, Dhavan Parikh, Todd P. Michael, Jasmine Liou, Jie Huang, Zachery Smith, Jose M. Alonso, Joseph R. Ecker, Joanne Chory, and Chentao Lin PMCID: PMC515126 Mutations in ClpC2/Hsp100 suppress the requirement for FtsH in thylakoid membrane biogenesis Sungsoon Park and Steven R. Rodermel PMCID: PMC515127 Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY Lucia C. Strader, Siân Ritchie, Jonathan D. Soule, Karen M. McGinnis, and Camille M. Steber PMCID: PMC515128 Corrections Proc Natl Acad Sci U S A. 2004 August 24; 101(34): 12777. doi: 10.1073/pnas.0404931101.PMCID: PMC515129 Corrects: H. Peter Larsson, et al. Fluorometric measurements of conformational changes in glutamate transporters. Proc Natl Acad Sci U S A. 2004 March 16; 101(11): 3951–3956. Proc Natl Acad Sci U S A. 2004 August 24; 101(34): 12777. doi: 10.1073/pnas.0404696101.PMCID: PMC515130 Corrects: Fatma Eker, et al. Preferred peptide backbone conformations in the unfolded state revealed by the structure analysis of alanine-based (AXA) tripeptides in aqueous solution. Proc Natl Acad Sci U S A. 2004 July 6; 101(27): 10054–10059. Proc Natl Acad Sci U S A. 2004 August 24; 101(34): 12777. doi: 10.1073/pnas.0404699101.PMCID: PMC515131 Corrects: Kai Sun, et al. Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib. Proc Natl Acad Sci U S A. 2004 May 25; 101(21): 8120–8125. |
