| | This journal provides immediate access to some articles. Feature Articles From the Cover:
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig Arun Radhakrishnan, Yukio Ikeda, Hyock Joo Kwon, Michael S. Brown, and Joseph L. Goldstein PMCID: PMC1851665 From the Cover:
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins Li-Ping Sun, Joachim Seemann, Joseph L. Goldstein, and Michael S. Brown PMCID: PMC1851663 This Week in PNAS Proc Natl Acad Sci U S A. 2007 April 17; 104(16): 6493–6494. doi: 10.1073/iti1607104.PMCID: PMC1871810 Editorial Introducing Feature Articles in PNAS PMCID: PMC1871811 Commentaries How sterols regulate protein sorting and traffic Randy Schekman PMCID: PMC1871812 Organized structures, memory, and the decay of turbulence Thomas Y. Hou PMCID: PMC1871813 Conventional wisdom and climate history Steven M. Colman PMCID: PMC1871814 Visiting order on membrane proteins by using nanotechnology Charles R. Sanders PMCID: PMC1871815 Physical Sciences Applied Mathematics From the Cover:
Optimal prediction and the rate of decay for solutions of the Euler equations in two and three dimensions Ole H. Hald and Panagiotis Stinis PMCID: PMC1871819 Oscillation patterns in negative feedback loops Simone Pigolotti, Sandeep Krishna, and Mogens H. Jensen PMCID: PMC1871820 Chemistry A cationic host displaying positive cooperativity in water Andrew D. Hughes and Eric V. Anslyn PMCID: PMC1871821 Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe Percy H. Carter, Rui-Qin Liu, William R. Foster, Joseph A. Tamasi, Andrew J. Tebben, Margaret Favata, Ada Staal, Mary Ellen Cvijic, Michele H. French, Vanessa Dell, Donald Apanovitch, Ming Lei, Qihong Zhao, Mark Cunningham, Carl P. Decicco, James M. Trzaskos, and Jean H. M. Feyen PMCID: PMC1871873 Environmental Sciences Genesis of hexavalent chromium from natural sources in soil and groundwater Christopher Oze, Dennis K. Bird, and Scott Fendorf PMCID: PMC1871822 Combined climate and carbon-cycle effects of large-scale deforestation G. Bala, K. Caldeira, M. Wickett, T. J. Phillips, D. B. Lobell, C. Delire, and A. Mirin PMCID: PMC1871823 Geology From the Cover:
Geochemical proxies of North American freshwater routing during the Younger Dryas cold event Anders E. Carlson, Peter U. Clark, Brian A. Haley, Gary P. Klinkhammer, Kathleen Simmons, Edward J. Brook, and Katrin J. Meissner PMCID: PMC1871824 Statistics Algorithm for model validation: Theory and applications D. Sornette, A. B. Davis, K. Ide, K. R. Vixie, V. Pisarenko, and J. R. Kamm PMCID: PMC1871825 Sustainability Science Projected impacts of climate change on salmon habitat restoration James Battin, Matthew W. Wiley, Mary H. Ruckelshaus, Richard N. Palmer, Elizabeth Korb, Krista K. Bartz, and Hiroo Imaki PMCID: PMC1871852 Biological Sciences Anthropology From the Cover:
Gorilla-like anatomy on Australopithecus afarensis mandibles suggests Au. afarensis link to robust australopiths Yoel Rak, Avishag Ginzburg, and Eli Geffen PMCID: PMC1871826 An early modern human from Tianyuan Cave, Zhoukoudian, China Hong Shang, Haowen Tong, Shuangquan Zhang, Fuyou Chen, and Erik Trinkaus PMCID: PMC1871827 Applied Biological Sciences Combinatorial RNAi for quantitative protein network analysis Özgür Sahin, Christian Löbke, Ulrike Korf, Heribert Appelhans, Holger Sültmann, Annemarie Poustka, Stefan Wiemann, and Dorit Arlt PMCID: PMC1849961 Asymmetric binding of transferrin receptor to parvovirus capsids Susan Hafenstein, Laura M. Palermo, Victor A. Kostyuchenko, Chuan Xiao, Marc C. Morais, Christian D. S. Nelson, Valorie D. Bowman, Anthony J. Battisti, Paul R. Chipman, Colin R. Parrish, and Michael G. Rossmann PMCID: PMC1871829 Biochemistry From the Cover:
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig Arun Radhakrishnan, Yukio Ikeda, Hyock Joo Kwon, Michael S. Brown, and Joseph L. Goldstein PMCID: PMC1851665 From the Cover:
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins Li-Ping Sun, Joachim Seemann, Joseph L. Goldstein, and Michael S. Brown PMCID: PMC1851663 A cationic host displaying positive cooperativity in water Andrew D. Hughes and Eric V. Anslyn PMCID: PMC1871821 Direct and adaptor-mediated substrate recognition by an essential AAA+ protease Peter Chien, Barrett S. Perchuk, Michael T. Laub, Robert T. Sauer, and Tania A. Baker PMCID: PMC1871830 A conserved phosphatase cascade that regulates nuclear membrane biogenesis Youngjun Kim, Matthew S. Gentry, Thurl E. Harris, Sandra E. Wiley, John C. Lawrence, Jr, and Jack E. Dixon PMCID: PMC1871831 Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects Ji-Won Park, Chan-Hee Kim, Jung-Hyun Kim, Byung-Rok Je, Kyung-Baeg Roh, Su-Jin Kim, Hyeon-Hwa Lee, Ji-Hwan Ryu, Jae-Hong Lim, Byung-Ha Oh, Won-Jae Lee, Nam-Chul Ha, and Bok-Luel Lee PMCID: PMC1871832 Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110 Nikolaus S. Trede, Jan Medenbach, Andrey Damianov, Lee-Hsueh Hung, Gerhard J. Weber, Barry H. Paw, Yi Zhou, Candace Hersey, Agustin Zapata, Matthew Keefe, Bruce A. Barut, Andrew B. Stuart, Tammisty Katz, Chris T. Amemiya, Leonard I. Zon, and Albrecht Bindereif PMCID: PMC1871833 A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase Andrew A. Horwitz, El Bachir Affar, George F. Heine, Yang Shi, and Jeffrey D. Parvin PMCID: PMC1871834 Insertion of group II intron retroelements after intrinsic transcriptional terminators Aaron R. Robart, Wooseok Seo, and Steven Zimmerly PMCID: PMC1871835 Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2 Joshua L. Wheatley and Todd Holyoak PMCID: PMC1871836 High-affinity single-domain binding proteins with a binary-code interface Akiko Koide, Ryan N. Gilbreth, Kaori Esaki, Valentina Tereshko, and Shohei Koide PMCID: PMC1871837 SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK Yaron Bogin, Carmit Ainey, Dvora Beach, and Deborah Yablonski PMCID: PMC1871838 Biophysics From the Cover:
DNA-nanotube-induced alignment of membrane proteins for NMR structure determination Shawn M. Douglas, James J. Chou, and William M. Shih PMCID: PMC1871839 The alanine-rich XAO peptide adopts a heterogeneous population, including turn-like and polyproline II conformations Reinhard Schweitzer-Stenner and Thomas J. Measey PMCID: PMC1871840 H/ACA small nucleolar RNA pseudouridylation pockets bind substrate RNA to form three-way junctions that position the target U for modification Haihong Wu and Juli Feigon PMCID: PMC1871841 Symmetry matters for the electronic structure of core complexes from Rhodopseudomonas palustris and Rhodobacter sphaeroides PufX− M. F. Richter, J. Baier, T. Prem, S. Oellerich, F. Francia, G. Venturoli, D. Oesterhelt, J. Southall, R. J. Cogdell, and J. Köhler PMCID: PMC1871842 Tale of two spikes in bacteriophage PRD1 Juha T. Huiskonen, Violeta Manole, and Sarah J. Butcher PMCID: PMC1871843 Structural basis for reversible photobleaching of a green fluorescent protein homologue J. Nathan Henderson, Hui-wang Ai, Robert E. Campbell, and S. James Remington PMCID: PMC1871844 Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing Michael G. Malkowski, Erin Quartley, Alan E. Friedman, Julie Babulski, Yoshiko Kon, Jennifer Wolfley, Meriem Said, Joseph R. Luft, Eric M. Phizicky, George T. DeTitta, and Elizabeth J. Grayhack PMCID: PMC1850019 Cell Biology Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation Kathrin Kindsmüller, Peter Groitl, Barbara Härtl, Paola Blanchette, Joachim Hauber, and Thomas Dobner PMCID: PMC1871846 β-Arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo Vítězslav Bryja, Dietmar Gradl, Alexandra Schambony, Ernest Arenas, and Gunnar Schulte PMCID: PMC1871847 In vivo selection for metastasis promoting genes in the mouse Kiranmai Gumireddy, Fangxian Sun, Andres J. Klein-Szanto, Jonathan M. Gibbins, Phyllis A. Gimotty, Aleister J. Saunders, Peter G. Schultz, and Qihong Huang PMCID: PMC1871848 Enhanced EGFP-chromophore-assisted laser inactivation using deficient cells rescued with functional EGFP-fusion proteins Eric A. Vitriol, Andrea C. Uetrecht, Feimo Shen, Ken Jacobson, and James E. Bear PMCID: PMC1871849 Developmental Biology Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord Yasuyuki S. Kida, Takayuki Sato, Kota Y. Miyasaka, Asami Suto, and Toshihiko Ogura PMCID: PMC1871850 Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster Ai Khim Lim and Toshie Kai PMCID: PMC1871851 Ecology Projected impacts of climate change on salmon habitat restoration James Battin, Matthew W. Wiley, Mary H. Ruckelshaus, Richard N. Palmer, Elizabeth Korb, Krista K. Bartz, and Hiroo Imaki PMCID: PMC1871852 Evolution INAUGURAL ARTICLE by a Recently Elected Academy Member: Prevalence of positive selection among nearly neutral amino acid replacements in DrosophilaStanley A. Sawyer, John Parsch, Zhi Zhang, and Daniel L. Hartl PMCID: PMC1871816 Ancient DNA reveals lack of postglacial habitat tracking in the arctic fox Love Dalén, Veronica Nyström, Cristina Valdiosera, Mietje Germonpré, Mikhail Sablin, Elaine Turner, Anders Angerbjörn, Juan Luis Arsuaga, and Anders Götherström PMCID: PMC1871853 The species, sex, and stage specificity of a Caenorhabditis sex pheromone J. R. Chasnov, W. K. So, C. M. Chan, and K. L. Chow PMCID: PMC1871854 Group selection and kin selection: Two concepts but one process Laurent Lehmann, Laurent Keller, Stuart West, and Denis Roze PMCID: PMC1871855 Genetics Oscillation patterns in negative feedback loops Simone Pigolotti, Sandeep Krishna, and Mogens H. Jensen PMCID: PMC1871820 Lung metastasis genes couple breast tumor size and metastatic spread Andy J. Minn, Gaorav P. Gupta, David Padua, Paula Bos, Don X. Nguyen, Dimitry Nuyten, Bas Kreike, Yi Zhang, Yixin Wang, Hemant Ishwaran, John A. Foekens, Marc van de Vijver, and Joan Massagué PMCID: PMC1871856 A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy Stefan Krebs, Ivica Medugorac, Susanne Röther, Katja Strässer, and Martin Förster PMCID: PMC1868895 DNA demethylation in the Arabidopsis genome Jon Penterman, Daniel Zilberman, Jin Hoe Huh, Tracy Ballinger, Steven Henikoff, and Robert L. Fischer PMCID: PMC1847597 Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus Robert R. Graham, Chieko Kyogoku, Snaevar Sigurdsson, Irina A. Vlasova, Leela R. L. Davies, Emily C. Baechler, Robert M. Plenge, Thearith Koeuth, Ward A. Ortmann, Geoffrey Hom, Jason W. Bauer, Clarence Gillett, Noel Burtt, Deborah S. Cunninghame Graham, Robert Onofrio, Michelle Petri, Iva Gunnarsson, Elisabet Svenungsson, Lars Rönnblom, Gunnel Nordmark, Peter K. Gregersen, Kathy Moser, Patrick M. Gaffney, Lindsey A. Criswell, Timothy J. Vyse, Ann-Christine Syvänen, Paul R. Bohjanen, Mark J. Daly, Timothy W. Behrens, and David Altshuler PMCID: PMC1847749 Immunology SGT1 is essential for Nod1 activation Jean da Silva Correia, Yvonne Miranda, Nikki Leonard, and Richard Ulevitch PMCID: PMC1871859 Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis Scott J. Roberts, Bernice Y. Ng, Renata B. Filler, Julia Lewis, Earl J. Glusac, Adrian C. Hayday, Robert E. Tigelaar, and Michael Girardi PMCID: PMC1871860 HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype Asier Sáez-Cirión, Christine Lacabaratz, Olivier Lambotte, Pierre Versmisse, Alejandra Urrutia, Faroudy Boufassa, Françoise Barré-Sinoussi, Jean-François Delfraissy, Martine Sinet, Gianfranco Pancino, and Alain Venet PMCID: PMC1851664 Medical Sciences Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase Filippo Acconcia, Christopher J. Barnes, Rajesh R. Singh, Amjad H. Talukder, and Rakesh Kumar PMCID: PMC1871862 Analysis of PALB2/FANCN-associated breast cancer families Marc Tischkowitz, Bing Xia, Nelly Sabbaghian, Jorge S. Reis-Filho, Nancy Hamel, Guilan Li, Erik H. van Beers, Lili Li, Tayma Khalil, Louise A. Quenneville, Atilla Omeroglu, Aletta Poll, Pierre Lepage, Nora Wong, Petra M. Nederlof, Alan Ashworth, Patricia N. Tonin, Steven A. Narod, David M. Livingston, and William D. Foulkes PMCID: PMC1871863 Unrestrained erythroblast development in Nix−/− mice reveals a mechanism for apoptotic modulation of erythropoiesis Abhinav Diwan, Andrew G. Koesters, Amy M. Odley, Suvarnamala Pushkaran, Christopher P. Baines, Benjamin T. Spike, Diedre Daria, Anil G. Jegga, Hartmut Geiger, Bruce J. Aronow, Jeffery D. Molkentin, Kay F. Macleod, Theodosia A. Kalfa, and Gerald W. Dorn, II PMCID: PMC1849960 Inducible overexpression of wild-type prion protein in the muscles leads to a primary myopathy in transgenic mice Shenghai Huang, Jingjing Liang, Mengjie Zheng, Xinyi Li, Meiling Wang, Ping Wang, Difernando Vanegas, Di Wu, Bikram Chakraborty, Arthur P. Hays, Ken Chen, Shu G. Chen, Stephanie Booth, Mark Cohen, Pierluigi Gambetti, and Qingzhong Kong PMCID: PMC1871865 Microbiology Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene Daniel Grimm, Peter Staeheli, Martin Hufbauer, Iris Koerner, Luis Martínez-Sobrido, Alicia Solórzano, Adolfo García-Sastre, Otto Haller, and Georg Kochs PMCID: PMC1871866 Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef Massimo Pizzato, Anna Helander, Elena Popova, Arianna Calistri, Alessia Zamborlini, Giorgio Palù, and Heinrich G. Göttlinger PMCID: PMC1871867 Neuroscience A cortical potential reflecting cardiac function Marcus A. Gray, Peter Taggart, Peter M. Sutton, David Groves, Diana R. Holdright, David Bradbury, David Brull, and Hugo D. Critchley PMCID: PMC1871868 Identity of a pathway for saccadic suppression Psyche H. Lee, Thongchai Sooksawate, Yuchio Yanagawa, Kaoru Isa, Tadashi Isa, and William C. Hall PMCID: PMC1849959 Regulation of CNS synapses by neuronal MHC class I C. Alex Goddard, Daniel A. Butts, and Carla J. Shatz PMCID: PMC1871870 Genomic resources for songbird research and their use in characterizing gene expression during brain development XiaoChing Li, Xiu-Jie Wang, Jonathan Tannenhauser, Sheila Podell, Piali Mukherjee, Moritz Hertel, Jeremy Biane, Shoko Masuda, Fernando Nottebohm, and Terry Gaasterland PMCID: PMC1850020 Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine Marc Welter, Daniela Vallone, Tarek A. Samad, Hamid Meziane, Alessandro Usiello, and Emiliana Borrelli PMCID: PMC1871872 Pharmacology Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe Percy H. Carter, Rui-Qin Liu, William R. Foster, Joseph A. Tamasi, Andrew J. Tebben, Margaret Favata, Ada Staal, Mary Ellen Cvijic, Michele H. French, Vanessa Dell, Donald Apanovitch, Ming Lei, Qihong Zhao, Mark Cunningham, Carl P. Decicco, James M. Trzaskos, and Jean H. M. Feyen PMCID: PMC1871873 Physiology Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility Huili Zheng, Clifford J. Stratton, Kazuto Morozumi, Jingling Jin, Ryuzo Yanagimachi, and Wei Yan PMCID: PMC1871874 Quantifying the genetic influence on mammalian vascular tree structure Robb Glenny, Susan Bernard, Blazej Neradilek, and Nayak Polissar PMCID: PMC1871875 Plant Biology Smallpox subunit vaccine produced in planta confers protection in mice Maxim Golovkin, Sergei Spitsin, Vyacheslav Andrianov, Yuriy Smirnov, Yuhong Xiao, Natalia Pogrebnyak, Karen Markley, Robert Brodzik, Yuri Gleba, Stuart N. Isaacs, and Hilary Koprowski PMCID: PMC1871876 Social Sciences Anthropology Microfossil evidence for pre-Columbian maize dispersals in the neotropics from San Andrés, Tabasco, Mexico Mary E. D. Pohl, Dolores R. Piperno, Kevin O. Pope, and John G. Jones PMCID: PMC1871877 Corrections Correction for Narasimha Prasad et al., Characterization of capsaicin synthase and identification of its gene (csy1) for pungency factor capsaicin in pepper (Capsicum sp.) PMCID: PMC1871878 Corrects: B. C. Narasimha Prasad, et al. Characterization of capsaicin synthase and identification of its gene (csy1) for pungency factor capsaicin in pepper (Capsicum sp.). Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13315–13320. Correction for Galvan et al., Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664 PMCID: PMC1871879 Corrects: Veronica Galvan, et al. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A. 2006 May 2; 103(18): 7130–7135. |
