| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1443–1444. doi: 10.1073/iti0507104.PMCID: PMC1785265 Commentaries Transmembrane transporters: An open and closed case Robert M. Stroud Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1445–1446. Published online 2007 January 24. doi: 10.1073/pnas.0610349104.PMCID: PMC1785277 Chemical trails and the parasites that follow them Dickson D. Despommier Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1447–1448. Published online 2007 January 23. doi: 10.1073/pnas.0610778104.PMCID: PMC1785285 A new human retrovirus associated with prostate cancer Hung Fan Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1449–1450. Published online 2007 January 23. doi: 10.1073/pnas.0610912104.PMCID: PMC1785241 Physical Sciences Applied Physical Sciences From the Cover: Semiotic dynamics and collaborative tagging Ciro Cattuto, Vittorio Loreto, and Luciano Pietronero Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1461–1464. Published online 2007 January 23. doi: 10.1073/pnas.0610487104.PMCID: PMC1785269 Chemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: Connecting nitrogenase intermediates with the kinetic scheme for N 2 reduction by a relaxation protocol and identification of the N 2 binding state Dmitriy Lukoyanov, Brett M. Barney, Dennis R. Dean, Lance C. Seefeldt, and Brian M. Hoffman Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1451–1455. Published online 2007 January 24. doi: 10.1073/pnas.0610975104.PMCID: PMC1785236 Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV Ivaylo Ivanov, John A. Tainer, and J. Andrew McCammon Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1465–1470. Published online 2007 January 22. doi: 10.1073/pnas.0603468104.PMCID: PMC1780068 Chiral imine copper chloride-catalyzed enantioselective desymmetrization of 2-substituted 1,2,3-propanetriols Byunghyuck Jung and Sung Ho Kang Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1471–1475. Published online 2007 January 22. doi: 10.1073/pnas.0607865104.PMCID: PMC1785247 The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis Rebecca A. Butcher, Frank C. Schroeder, Michael A. Fischbach, Paul D. Straight, Roberto Kolter, Christopher T. Walsh, and Jon Clardy Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1506–1509. Published online 2007 January 18. doi: 10.1073/pnas.0610503104.PMCID: PMC1785240 Ligand configurational entropy and protein binding Chia-en A. Chang, Wei Chen, and Michael K. Gilson Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1534–1539. Published online 2007 January 22. doi: 10.1073/pnas.0610494104.PMCID: PMC1780070 Physics Superfluid transition of homogeneous and trapped two-dimensional Bose gases Markus Holzmann, Gordon Baym, Jean-Paul Blaizot, and Franck Laloë Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1476–1481. Published online 2007 January 23. doi: 10.1073/pnas.0609957104.PMCID: PMC1785267 Biological Sciences Applied Biological Sciences Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus Samuel K. Lai, D. Elizabeth O'Hanlon, Suzanne Harrold, Stan T. Man, Ying-Ying Wang, Richard Cone, and Justin Hanes Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1482–1487. Published online 2007 January 23. doi: 10.1073/pnas.0608611104.PMCID: PMC1785284 Large-scale phosphorylation analysis of mouse liver Judit Villén, Sean A. Beausoleil, Scott A. Gerber, and Steven P. Gygi Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1488–1493. Published online 2007 January 22. doi: 10.1073/pnas.0609836104.PMCID: PMC1785252 Biochemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: Connecting nitrogenase intermediates with the kinetic scheme for N 2 reduction by a relaxation protocol and identification of the N 2 binding state Dmitriy Lukoyanov, Brett M. Barney, Dennis R. Dean, Lance C. Seefeldt, and Brian M. Hoffman Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1451–1455. Published online 2007 January 24. doi: 10.1073/pnas.0610975104.PMCID: PMC1785236 Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine Roberta Leonardi, Charles O. Rock, Suzanne Jackowski, and Yong-Mei Zhang Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1494–1499. Published online 2007 January 22. doi: 10.1073/pnas.0607621104.PMCID: PMC1785270 From the Cover: Topological locking restrains replication fork reversal Marta Fierro-Fernández, Pablo Hernández, Dora B. Krimer, Andrzej Stasiak, and Jorge B. Schvartzman Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1500–1505. Published online 2007 January 22. doi: 10.1073/pnas.0609204104.PMCID: PMC1780069 The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis Rebecca A. Butcher, Frank C. Schroeder, Michael A. Fischbach, Paul D. Straight, Roberto Kolter, Christopher T. Walsh, and Jon Clardy Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1506–1509. Published online 2007 January 18. doi: 10.1073/pnas.0610503104.PMCID: PMC1785240 β-Sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange Xiaojun Lu, Patrick L. Wintrode, and Witold K. Surewicz Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1510–1515. Published online 2007 January 22. doi: 10.1073/pnas.0608447104.PMCID: PMC1785245 A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness R. Ficarella, F. Di Leva, M. Bortolozzi, S. Ortolano, F. Donaudy, M. Petrillo, S. Melchionda, A. Lelli, T. Domi, L. Fedrizzi, D. Lim, G. E. Shull, P. Gasparini, M. Brini, F. Mammano, and E. Carafoli Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1516–1521. Published online 2007 January 18. doi: 10.1073/pnas.0609775104.PMCID: PMC1785272 High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing Kara Juneau, Curtis Palm, Molly Miranda, and Ronald W. Davis Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1522–1527. Published online 2007 January 23. doi: 10.1073/pnas.0610354104.PMCID: PMC1780280 Biophysics Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations Kusai A. Merchant, Robert B. Best, John M. Louis, Irina V. Gopich, and William A. Eaton Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1528–1533. Published online 2007 January 24. doi: 10.1073/pnas.0607097104.PMCID: PMC1785253 Ligand configurational entropy and protein binding Chia-en A. Chang, Wei Chen, and Michael K. Gilson Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1534–1539. Published online 2007 January 22. doi: 10.1073/pnas.0610494104.PMCID: PMC1780070 Liposome reconstitution and modulation of recombinant N-methyl-d-aspartate receptor channels by membrane stretch Anna Kloda, Linda Lua, Rhonda Hall, David J. Adams, and Boris Martinac Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1540–1545. Published online 2007 January 22. doi: 10.1073/pnas.0609649104.PMCID: PMC1780071 Distortion product otoacoustic emissions measured as vibration on the eardrum of human subjects E. Dalhoff, D. Turcanu, H.-P. Zenner, and A. W. Gummer Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1546–1551. Published online 2007 January 22. doi: 10.1073/pnas.0610185103.PMCID: PMC1780065 Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry Janna G. Kiselar, Rachel Mahaffy, Thomas D. Pollard, Steven C. Almo, and Mark R. Chance Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1552–1557. Published online 2007 January 24. doi: 10.1073/pnas.0605380104.PMCID: PMC1785275 Cell Biology The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis Alison E. Meyer, Nai-Jung Hung, Peizhen Yang, Arlen W. Johnson, and Elizabeth A. Craig Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1558–1563. Published online 2007 January 22. doi: 10.1073/pnas.0610704104.PMCID: PMC1785244 AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells Diego Gravotta, Ami Deora, Emilie Perret, Claudia Oyanadel, Andrea Soza, Ryan Schreiner, Alfonso Gonzalez, and Enrique Rodriguez-Boulan Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1564–1569. Published online 2007 January 23. doi: 10.1073/pnas.0610700104.PMCID: PMC1785260 Developmental Biology Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1 Kirsten C. Sadler, Katherine N. Krahn, Naseem A. Gaur, and Chinweike Ukomadu Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1570–1575. Published online 2007 January 22. doi: 10.1073/pnas.0610774104.PMCID: PMC1785278 Evolution Biplane wing planform and flight performance of the feathered dinosaur Microraptor gui Sankar Chatterjee and R. Jack Templin Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1576–1580. Published online 2007 January 22. doi: 10.1073/pnas.0609975104.PMCID: PMC1780066 Context modulates signal meaning in primate communication Jessica C. Flack and Frans de Waal Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1581–1586. Published online 2007 January 23. doi: 10.1073/pnas.0603565104.PMCID: PMC1780279 Chromosome-wide linkage disequilibrium as a consequence of meiotic drive Kelly A. Dyer, Brian Charlesworth, and John Jaenike Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1587–1592. Published online 2007 January 22. doi: 10.1073/pnas.0605578104.PMCID: PMC1785283 Genetics Interaction of the Wiskott–Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells Karen Badour, Mary K. H. McGavin, Jinyi Zhang, Spencer Freeman, Claudia Vieira, Dominik Filipp, Michael Julius, Gordon B. Mills, and Katherine A. Siminovitch Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1593–1598. Published online 2007 January 22. doi: 10.1073/pnas.0610543104.PMCID: PMC1785243 Immunology Estimation of the rate of killing by cytotoxic T lymphocytes in vivo Roland R. Regoes, Daniel L. Barber, Rafi Ahmed, and Rustom Antia Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1599–1603. Published online 2007 January 22. doi: 10.1073/pnas.0508830104.PMCID: PMC1785271 MicroRNA-155 is induced during the macrophage inflammatory response Ryan M. O'Connell, Konstantin D. Taganov, Mark P. Boldin, Genhong Cheng, and David Baltimore Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1604–1609. Published online 2007 January 22. doi: 10.1073/pnas.0610731104.PMCID: PMC1780072 Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling Masayuki Tsuji, Reiko Shinkura, Kazuki Kuroda, Daisuke Yabe, and Tasuku Honjo Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1610–1615. Published online 2007 January 22. doi: 10.1073/pnas.0610520104.PMCID: PMC1785279 Medical Sciences Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice Ai Kotani, Naoki Kakazu, Tatsuaki Tsuruyama, Il-mi Okazaki, Masamichi Muramatsu, Kazuo Kinoshita, Hitoshi Nagaoka, Daisuke Yabe, and Tasuku Honjo Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1616–1620. Published online 2007 January 24. doi: 10.1073/pnas.0610732104.PMCID: PMC1785248 Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury Li Zhu, Wolfgang Bergmeier, Jie Wu, Hong Jiang, Timothy J. Stalker, Marcin Cieslak, Ran Fan, Laurence Boumsell, Atsushi Kumanogoh, Hitoshi Kikutani, Luca Tamagnone, Denisa D. Wagner, Marcos E. Milla, and Lawrence F. Brass Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1621–1626. Published online 2007 January 23. doi: 10.1073/pnas.0606344104.PMCID: PMC1785259 From the Cover: Urocanic acid is a major chemoattractant for the skin-penetrating parasitic nematode Strongyloides stercoralis Daniel Safer, Mario Brenes, Seth Dunipace, and Gerhard Schad Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1627–1630. Published online 2007 January 18. doi: 10.1073/pnas.0610193104.PMCID: PMC1785286 Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1 Zakir Hossain, Safiah Mohamed Ali, Hui Ling Ko, Jianliang Xu, Chee Peng Ng, Ke Guo, Zeng Qi, Sathivel Ponniah, Wanjin Hong, and Walter Hunziker Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1631–1636. Published online 2007 January 24. doi: 10.1073/pnas.0605266104.PMCID: PMC1785239 Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet β cell microchimerism J. Lee Nelson, Kathleen M. Gillespie, Nathalie C. Lambert, Anne M. Stevens, Laurence S. Loubiere, Joe C. Rutledge, Wendy M. Leisenring, Timothy D. Erickson, Zhen Yan, Meghan E. Mullarkey, Nick D. Boespflug, Polly J. Bingley, and Edwin A. M. Gale Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1637–1642. Published online 2007 January 23. doi: 10.1073/pnas.0606169104.PMCID: PMC1785262 Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair Maria Mirotsou, Zhongyan Zhang, Arjun Deb, Lunan Zhang, Massimiliano Gnecchi, Nicolas Noiseux, Hui Mu, Alok Pachori, and Victor Dzau Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1643–1648. Published online 2007 January 24. doi: 10.1073/pnas.0610024104.PMCID: PMC1785280 Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene Laëtitia Michou, Sandra Lasbleiz, Anne-Christine Rat, Paola Migliorini, Alejandro Balsa, René Westhovens, Pilar Barrera, Helena Alves, Céline Pierlot, Elodie Glikmans, Sophie Garnier, Jean Dausset, Carlos Vaz, Manuela Fernandes, Elisabeth Petit-Teixeira, Isabelle Lemaire, Dora Pascual-Salcedo, Stefano Bombardieri, Jan Dequeker, Timothy R. Radstake, Piet Van Riel, Leo van de Putte, Antonio Lopes-Vaz, Bernard Prum, Thomas Bardin, Philippe Dieudé, François Cornélis, and European Consortium on Rheumatoid Arthritis Families Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1649–1654. Published online 2007 January 19. doi: 10.1073/pnas.0610250104.PMCID: PMC1785249 Microbiology INAUGURAL ARTICLE by a Recently Elected Academy Member: Synthesis of Clostridium cellulovorans minicellulosomes by intercellular complementation Takamitsu Arai, Satoshi Matsuoka, Hee-Yeon Cho, Hideaki Yukawa, Masayuki Inui, Sui-Lam Wong, and Roy H. Doi Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1456–1460. Published online 2007 January 23. doi: 10.1073/pnas.0610740104.PMCID: PMC1785254 From the Cover: An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors Beihua Dong, Sanggu Kim, Seunghee Hong, Jaydip Das Gupta, Krishnamurthy Malathi, Eric A. Klein, Don Ganem, Joseph L. DeRisi, Samson A. Chow, and Robert H. Silverman Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1655–1660. Published online 2007 January 18. doi: 10.1073/pnas.0610291104.PMCID: PMC1776164 Critical role of PA28γ in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis Kohji Moriishi, Rika Mochizuki, Kyoji Moriya, Hironobu Miyamoto, Yoshio Mori, Takayuki Abe, Shigeo Murata, Keiji Tanaka, Tatsuo Miyamura, Tetsuro Suzuki, Kazuhiko Koike, and Yoshiharu Matsuura Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1661–1666. Published online 2007 January 18. doi: 10.1073/pnas.0607312104.PMCID: PMC1776165 RNaseE and the other constituents of the RNA degradosome are components of the bacterial cytoskeleton Aziz Taghbalout and Lawrence Rothfield Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1667–1672. Published online 2007 January 22. doi: 10.1073/pnas.0610491104.PMCID: PMC1785250 NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system Richard Bayliss, Richard Harris, Loic Coutte, Amy Monier, Remi Fronzes, Peter J. Christie, Paul C. Driscoll, and Gabriel Waksman Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1673–1678. Published online 2007 January 23. doi: 10.1073/pnas.0609535104.PMCID: PMC1785264 Neuroscience From the Cover: Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL Edwin C. T. Oh, Naheed Khan, Elena Novelli, Hemant Khanna, Enrica Strettoi, and Anand Swaroop Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1679–1684. Published online 2007 January 22. doi: 10.1073/pnas.0605934104.PMCID: PMC1780067 Corticothalamic feedback enhances stimulus response precision in the visual system Ian M. Andolina, Helen E. Jones, Wei Wang, and Adam M. Sillito Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1685–1690. Published online 2007 January 19. doi: 10.1073/pnas.0609318104.PMCID: PMC1785251 Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's disease Maria Becker, Vered Lavie, and Beka Solomon Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1691–1696. Published online 2007 January 22. doi: 10.1073/pnas.0610180104.PMCID: PMC1785268 Imaging synaptosomal calcium concentration microdomains and vesicle fusion by using total internal reflection fluorescent microscopy Yafell Serulle, Mutsuyuki Sugimori, and Rodolfo R. Llinás Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1697–1702. Published online 2007 January 22. doi: 10.1073/pnas.0610741104.PMCID: PMC1785242 Octopamine modulates honey bee dance behavior Andrew B. Barron, Ryszard Maleszka, Robert K. Vander Meer, and Gene E. Robinson Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1703–1707. Published online 2007 January 19. doi: 10.1073/pnas.0610506104.PMCID: PMC1779631 Plant Biology Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci Joost J. B. Keurentjes, Jingyuan Fu, Inez R. Terpstra, Juan M. Garcia, Guido van den Ackerveken, L. Basten Snoek, Anton J. M. Peeters, Dick Vreugdenhil, Maarten Koornneef, and Ritsert C. Jansen Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1708–1713. Published online 2007 January 19. doi: 10.1073/pnas.0610429104.PMCID: PMC1785256 RNAi-associated ssRNA-specific ribonucleases in Tombusvirus P19 mutant-infected plants and evidence for a discrete siRNA-containing effector complex Rustem T. Omarov, Jessica J. Ciomperlik, and Herman B. Scholthof Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1714–1719. Published online 2007 January 23. doi: 10.1073/pnas.0608117104.PMCID: PMC1785274 A Medicago truncatula phosphate transporter indispensable for the arbuscular mycorrhizal symbiosis Hélène Javot, R. Varma Penmetsa, Nadia Terzaghi, Douglas R. Cook, and Maria J. Harrison Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1720–1725. Published online 2007 January 22. doi: 10.1073/pnas.0608136104.PMCID: PMC1785290 Psychology Patients with hippocampal amnesia cannot imagine new experiences Demis Hassabis, Dharshan Kumaran, Seralynne D. Vann, and Eleanor A. Maguire Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1726–1731. Published online 2007 January 17. doi: 10.1073/pnas.0610561104.PMCID: PMC1773058 Corrections Correction for Wagoner and Baker, Assessing implicit models for nonpolar mean solvation forces: The importance of dispersion and volume terms Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1732. Published online 2007 January 18. doi: 10.1073/pnas.0610582103.PMCID: PMC1785276 Corrects: Jason A. Wagoner, et al. Assessing implicit models for nonpolar mean solvation forces: The importance of dispersion and volume terms. Proc Natl Acad Sci U S A. 2006 May 30; 103(22): 8331–8336. Correction for Scheuber et al., Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses Proc Natl Acad Sci U S A. 2007 January 30; 104(5): 1732–1733. Published online 2007 January 18. doi: 10.1073/pnas.0611561104.PMCID: PMC1785281 Corrects: Anita Scheuber, et al. Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16562–16567. |