| | This journal provides immediate access to some articles. Commentaries A conserved signaling cassette regulates hair patterning from Drosophila to man Thomas J. Klein and Marek Mlodzik PMCID: PMC438946 Linear ordering and dynamic segregation of the bacterial chromosome Adam M. Breier and Nicholas R. Cozzarelli PMCID: PMC438947 Hyperosmolality triggers oxidative damage in kidney cells Dietmar Kültz PMCID: PMC438948 Physical Sciences Applied Physical Sciences From the Cover:
Essential auditory contrast-sharpening is preneuronal R. Stoop and A. Kern PMCID: PMC438949 Astronomy Identification of diamino acids in the Murchison meteorite Uwe J. Meierhenrich, Guillermo M. Muñoz Caro, Jan Hendrik Bredehöft, Elmar K. Jessberger, and Wolfram H.-P. Thiemann PMCID: PMC438950 Geology Evidence for large methane releases to the atmosphere from deep-sea gas-hydrate dissociation during the last glacial episode Thibault de Garidel-Thoron, Luc Beaufort, Franck Bassinot, and Pierre Henry PMCID: PMC438951 Biological Sciences Applied Biological Sciences Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries Barrett R. Harvey, George Georgiou, Andrew Hayhurst, Ki Jun Jeong, Brent L. Iverson, and Geoffrey K. Rogers PMCID: PMC438952 Biochemistry Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice Michio Asahi, Kinya Otsu, Hiroyuki Nakayama, Shungo Hikoso, Toshihiro Takeda, Anthony O. Gramolini, Maria G. Trivieri, Gavin Y. Oudit, Takashi Morita, Yoichiro Kusakari, Shuta Hirano, Kenichi Hongo, Shinichi Hirotani, Osamu Yamaguchi, Alan Peterson, Peter H. Backx, Satoshi Kurihara, Masatsugu Hori, and David H. MacLennan PMCID: PMC438953 Protein tolerance to random amino acid change Haiwei H. Guo, Juno Choe, and Lawrence A. Loeb PMCID: PMC438954 Catalytic activation of multimeric RNase E and RNase G by 5′-monophosphorylated RNA Xunqing Jiang and Joel G. Belasco PMCID: PMC438955 Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail David L. Waning, Charles J. Russell, Theodore S. Jardetzky, and Robert A. Lamb PMCID: PMC438956 Biophysics Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex C. Kiel, T. Selzer, Y. Shaul, G. Schreiber, and C. Herrmann PMCID: PMC438957 Nature of structural inhomogeneities on folding a helix and their influence on spectral measurements S. Gnanakaran, Robin M. Hochstrasser, and Angel E. García PMCID: PMC438958 A simulation method for calculating the absolute entropy and free energy of fluids: Application to liquid argon and water Ronald P. White and Hagai Meirovitch PMCID: PMC438959 Simulation method for calculating the entropy and free energy of peptides and proteins Srinath Cheluvaraja and Hagai Meirovitch PMCID: PMC438960 Pattern formation by vascular mesenchymal cells Alan Garfinkel, Yin Tintut, Danny Petrasek, Kristina Boström, and Linda L. Demer PMCID: PMC438961 Cell Biology The topoisomerase IV ParC subunit colocalizes with the Caulobacter replisome and is required for polar localization of replication origins Sherry C. Wang and Lucy Shapiro PMCID: PMC438962 From the Cover:
Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication Patrick H. Viollier, Martin Thanbichler, Patrick T. McGrath, Lisandra West, Maliwan Meewan, Harley H. McAdams, and Lucy Shapiro PMCID: PMC438963 The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and β2-microglobulin-deficient hepatocytes Pauline Lee, Hongfan Peng, Terri Gelbart, and Ernest Beutler PMCID: PMC438964 Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion Li Ma, Vytautas P. Bindokas, Andrey Kuznetsov, Christopher Rhodes, Lori Hays, J. Michael Edwardson, Kazuya Ueda, Donald F. Steiner, and Louis H. Philipson PMCID: PMC438965 Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase Robert Drakas, Xiao Tu, and Renato Baserga PMCID: PMC438966 Developmental Biology From the Cover:
Frizzled6 controls hair patterning in mice Nini Guo, Charles Hawkins, and Jeremy Nathans PMCID: PMC438967 Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion Radhika R. Pochampally, Brian T. Neville, Emily J. Schwarz, Marilyn M. Li, and Darwin J. Prockop PMCID: PMC438968 Ecology From the Cover:
Spatial synchrony of local populations has increased in association with the recent Northern Hemisphere climate trend Eric Post and Mads C. Forchhammer PMCID: PMC438969 Comparative impacts of two major hurricane seasons on the Neuse River and western Pamlico Sound ecosystems JoAnn Burkholder, David Eggleston, Howard Glasgow, Cavell Brownie, Robert Reed, Gerald Janowitz, Martin Posey, Greg Melia, Carol Kinder, Reide Corbett, David Toms, Troy Alphin, Nora Deamer, and Jeffrey Springer PMCID: PMC438970 Exceptional record of mid-Pleistocene vertebrates helps differentiate climatic from anthropogenic ecosystem perturbations Anthony D. Barnosky, Christopher J. Bell, Steven D. Emslie, H. Thomas Goodwin, Jim I. Mead, Charles A. Repenning, Eric Scott, and Alan B. Shabel PMCID: PMC438971 Population effects of growth hormone transgenic coho salmon depend on food availability and genotype by environment interactions Robert H. Devlin, Mark D'Andrade, Mitchell Uh, and Carlo A. Biagi PMCID: PMC438972 Genetics Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression Daniel R. Rhodes, Jianjun Yu, K. Shanker, Nandan Deshpande, Radhika Varambally, Debashis Ghosh, Terrence Barrette, Akhilesh Pandey, and Arul M. Chinnaiyan PMCID: PMC438973 Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1 Neal Sugawara, Tamara Goldfarb, Barbara Studamire, Eric Alani, and James E. Haber PMCID: PMC438974 A detailed physical map of the horse Y chromosome Terje Raudsepp, Avni Santani, Barbara Wallner, Srinivas R. Kata, Chengwei Ren, Hong-Bin Zhang, James E. Womack, Loren C. Skow, and Bhanu P. Chowdhary PMCID: PMC438975 Selection–subtraction approach (SSA): A universal genetic screening technique that enables negative selection Aatur D. Singhi, Roman V. Kondratov, Nickolay Neznanov, Mikhail V. Chernov, and Andrei V. Gudkov PMCID: PMC438976 Suppression of tumorigenesis by the p53 target PUMA Michael T. Hemann, Jack T. Zilfou, Zhen Zhao, Darren J. Burgess, Gregory J. Hannon, and Scott W. Lowe PMCID: PMC438977 Immunology Detailed analysis of gene expression during development of T cell lineages in the thymus Nami McCarty, Mari L. Shinohara, Linrong Lu, and Harvey Cantor PMCID: PMC438978 CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes Catrin M. McGregor, Stephen P. Schoenberger, and E. Allison Green PMCID: PMC438979 Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells James P. O'Keefe, Kelly Blaine, Maria-Luisa Alegre, and Thomas F. Gajewski PMCID: PMC438980 IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory Derek C. Lenz, Sabine K. Kurz, Edward Lemmens, Stephen P. Schoenberger, Jonathan Sprent, Michael B. A. Oldstone, and Dirk Homann PMCID: PMC438981 Immunodominant CD4+ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant Qiyuan Chen, Heather Jackson, Phillip Parente, Tina Luke, Mark Rizkalla, Tsin Yee Tai, He-Cheng Zhu, Nicole A. Mifsud, Nektaria Dimopoulos, Kelly-Anne Masterman, Wendie Hopkins, Heather Goldie, Eugene Maraskovsky, Simon Green, Lena Miloradovic, James McCluskey, Lloyd J. Old, Ian D. Davis, Jonathan Cebon, and Weisan Chen PMCID: PMC438982 Multimerization and interaction of Toll and Spätzle in Drosophila Xiaodi Hu, Yoshimasa Yagi, Takahiro Tanji, Sili Zhou, and Y. Tony Ip PMCID: PMC438983 Medical Sciences Estrogen receptor β regulates epithelial cellular differentiation in the mouse ventral prostate Otabek Imamov, Andrea Morani, Gil-Jin Shim, Yoko Omoto, Christina Thulin-Andersson, Margaret Warner, and Jan-Åke Gustafsson PMCID: PMC438984 Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells Pirjo Laakkonen, Maria E. Åkerman, Hector Biliran, Meng Yang, Fernando Ferrer, Terhi Karpanen, Robert M. Hoffman, and Erkki Ruoslahti PMCID: PMC438985 TRPC3 channels confer cellular memory of recent neuromuscular activity Paul Rosenberg, April Hawkins, Jonathan Stiber, John M. Shelton, Kelley Hutcheson, Rhonda Bassel-Duby, Dong Min Shin, Zhen Yan, and R. Sanders Williams PMCID: PMC438986 HER-2 gene amplification can be acquired as breast cancer progresses Songdong Meng, Debasish Tripathy, Sanjay Shete, Raheela Ashfaq, Barbara Haley, Steve Perkins, Peter Beitsch, Amanullah Khan, David Euhus, Cynthia Osborne, Eugene Frenkel, Susan Hoover, Marilyn Leitch, Edward Clifford, Ellen Vitetta, Larry Morrison, Dorothee Herlyn, Leon W. M. M. Terstappen, Timothy Fleming, Tanja Fehm, Thomas Tucker, Nancy Lane, Jianqiang Wang, and Jonathan Uhr PMCID: PMC438987 Activation of alternative NF-κB pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1β-converting enzyme inhibitory protein (vFLIP) Hittu Matta and Preet M. Chaudhary PMCID: PMC438988 Microbiology Rabies virus nucleoprotein as a carrier for foreign antigens Martin L. Koser, James P. McGettigan, Gene S. Tan, Mary Ellen Smith, Hilary Koprowski, Bernhard Dietzschold, and Matthias J. Schnell PMCID: PMC438989 Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis Luca Benetti and Bernard Roizman PMCID: PMC438990 Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface Martine P. Bos, Boris Tefsen, Jeroen Geurtsen, and Jan Tommassen PMCID: PMC438991 TorI, a response regulator inhibitor of phage origin in Escherichia coli Mireille Ansaldi, Laurence Théraulaz, and Vincent Méjean PMCID: PMC438992 Identification of the amino acid sequence in Sindbis virus nsP4 that binds to the promoter for the synthesis of the subgenomic RNA Mei-Ling Li and Victor Stollar PMCID: PMC438993 Neuroscience Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease Eric J. Benner, R. Lee Mosley, Chris J. Destache, Travis B. Lewis, Vernice Jackson-Lewis, Santhi Gorantla, Craig Nemachek, Steven R. Green, Serge Przedborski, and Howard E. Gendelman PMCID: PMC438994 Synaptotagmin IV regulates glial glutamate release Qi Zhang, Mitsunori Fukuda, Elisabeth Van Bockstaele, Olivier Pascual, and Philip G. Haydon PMCID: PMC438995 Dynamical basis of intentions and expectations in a simple neuronal network Alex Proekt, Vladimir Brezina, and Klaudiusz R. Weiss PMCID: PMC438996 Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus Dong Ya Zhu, Lorraine Lau, Shu Hong Liu, Jian She Wei, and You Ming Lu PMCID: PMC438997 Involvement of Notch signaling in hippocampal synaptic plasticity Yue Wang, Sic L. Chan, Lucio Miele, Pamela J. Yao, Jennifer Mackes, Donald K. Ingram, Mark P. Mattson, and Katsutoshi Furukawa PMCID: PMC438998 Pharmacology Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel Andrew D. Levin, Neda Vukmirovic, Chao-Wei Hwang, and Elazer R. Edelman PMCID: PMC438999 Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model Hossein Tezval, Olaf Jahn, Cedomir Todorovic, Astrid Sasse, Klaus Eckart, and Joachim Spiess PMCID: PMC439000 Physiology Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency M. Sausbier, H. Hu, C. Arntz, S. Feil, S. Kamm, H. Adelsberger, U. Sausbier, C. A. Sailer, R. Feil, F. Hofmann, M. Korth, M. J. Shipston, H.-G. Knaus, D. P. Wolfer, C. M. Pedroarena, J. F. Storm, and P. Ruth PMCID: PMC439001 Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages Peter J. Hanley, Boris Musset, Vijay Renigunta, Sven H. Limberg, Alexander H. Dalpke, Rainer Sus, Klaus M. Heeg, Regina Preisig-Müller, and Jürgen Daut PMCID: PMC439002 Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport Huiren Zhao, Harn Shiue, Sara Palkon, Yingmin Wang, Patrick Cullinan, Janis K. Burkhardt, Mark W. Musch, Eugene B. Chang, and Jerrold R. Turner PMCID: PMC439003 From the Cover:
High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA Zheng Zhang, Natalia I. Dmitrieva, Jong-Hwan Park, Rodney L. Levine, and Maurice B. Burg PMCID: PMC439004 Plant Biology Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis Jan Zouhar, Glenn R. Hicks, and Natasha V. Raikhel PMCID: PMC439005 A plant plasma membrane Ca2+ pump is required for normal pollen tube growth and fertilization Morten Schiøtt, Shawn M. Romanowsky, Lone Bækgaard, Mia Kyed Jakobsen, Michael G. Palmgren, and Jeffrey F. Harper PMCID: PMC439006 Phospholipase Dα1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling Wenhua Zhang, Chunbo Qin, Jian Zhao, and Xuemin Wang PMCID: PMC439007 |
