| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3495–3496. doi: 10.1073/iti1006103.PMCID: PMC1450115 Commentaries Materials design of solid electrolytes Karlheinz Schwarz Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3497. Published online 2006 February 27. doi: 10.1073/pnas.0600327103.PMCID: PMC1533771 Multiplying myosins Holly V. Goodson and Scott C. Dawson Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3498–3499. Published online 2006 February 28. doi: 10.1073/pnas.0600045103.PMCID: PMC1533772 A milestone for hepatitis C virus research: A virus generated in cell
culture is fully viable in
vivo Jens Bukh and Robert H. Purcell Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3500–3501. Published online 2006 February 27. doi: 10.1073/pnas.0600551103.PMCID: PMC1533773 Physical Sciences Applied Physical Sciences From the Cover: Optimization of ionic conductivity in doped ceria David A. Andersson, Sergei I. Simak, Natalia V. Skorodumova, Igor A. Abrikosov, and Börje Johansson Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3518–3521. Published online 2006 February 14. doi: 10.1073/pnas.0509537103.PMCID: PMC1450116 Chemistry Chiral N-salicylidene vanadyl carboxylate-catalyzed enantioselective aerobic oxidation of α-hydroxy esters and amides Shiue-Shien Weng, Mei-Wen Shen, Jun-Qi Kao, Yogesh S. Munot, and Chien-Tien Chen Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3522–3527. Published online 2006 February 24. doi: 10.1073/pnas.0511021103.PMCID: PMC1382168 Picosecond dynamics of a membrane protein revealed by 2D IR Prabuddha Mukherjee, Itamar Kass, Isaiah T. Arkin, and Martin T. Zanni Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3528–3533. Published online 2006 February 27. doi: 10.1073/pnas.0508833103.PMCID: PMC1383493 X-ray diffraction “fingerprinting” of DNA structure in solution for quantitative evaluation of molecular dynamics simulation Xiaobing Zuo, Guanglei Cui, Kenneth M. Merz, Jr., Ligang Zhang, Frederick D. Lewis, and David M. Tiede Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3534–3539. Published online 2006 February 27. doi: 10.1073/pnas.0600022103.PMCID: PMC1383498 Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress Xinhe Wang, Beena Thomas, Rakesh Sachdeva, Linnea Arterburn, Lucy Frye, Patrick G. Hatcher, David G. Cornwell, and Jiyan Ma Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3604–3609. Published online 2006 February 27. doi: 10.1073/pnas.0510962103.PMCID: PMC1450130 Electron trap for DNA-bound repair enzymes: A strategy for DNA-mediated signaling Eylon Yavin, Eric D. A. Stemp, Valerie L. O’Shea, Sheila S. David, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3610–3614. Published online 2006 February 27. doi: 10.1073/pnas.0600239103.PMCID: PMC1450131 Engineering Initiation of shape-memory effect by inductive heating of magnetic nanoparticles in thermoplastic polymers R. Mohr, K. Kratz, T. Weigel, M. Lucka-Gabor, M. Moneke, and A. Lendlein Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3540–3545. Published online 2006 February 28. doi: 10.1073/pnas.0600079103.PMCID: PMC1383650 Environmental Sciences Heterotrophic Archaea dominate sedimentary subsurface ecosystems off Peru Jennifer F. Biddle, Julius S. Lipp, Mark A. Lever, Karen G. Lloyd, Ketil B. Sørensen, Rika Anderson, Helen F. Fredricks, Marcus Elvert, Timothy J. Kelly, Daniel P. Schrag, Mitchell L. Sogin, Jean E. Brenchley, Andreas Teske, Christopher H. House, and Kai-Uwe Hinrichs Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3846–3851. Published online 2006 February 27. doi: 10.1073/pnas.0600035103.PMCID: PMC1533785 Biological Sciences Agricultural Sciences High-amylose wheat generated by RNA interference improves indices of large-bowel health in rats Ahmed Regina, Anthony Bird, David Topping, Sarah Bowden, Judy Freeman, Tina Barsby, Behjat Kosar-Hashemi, Zhongyi Li, Sadequr Rahman, and Matthew Morell Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3546–3551. Published online 2006 February 28. doi: 10.1073/pnas.0510737103.PMCID: PMC1450120 Anthropology Body size, body proportions, and encephalization in a Middle Pleistocene archaic human from northern China Karen R. Rosenberg, Lü Zuné, and Christopher B. Ruff Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3552–3556. Published online 2006 February 27. doi: 10.1073/pnas.0508681103.PMCID: PMC1450121 Applied Biological Sciences Human antibodies for immunotherapy development generated via a human B cell hybridoma technology Jian Li, Tao Sai, Marc Berger, Qimin Chao, Diane Davidson, Gaurav Deshmukh, Brian Drozdowski, Wolfgang Ebel, Stephen Harley, Marianne Henry, Sara Jacob, Brad Kline, Ella Lazo, Frank Rotella, Eric Routhier, Kathryn Rudolph, Jeaneen Sage, Paul Simon, Jun Yao, Yuhong Zhou, Mani Kavuru, Tracey Bonfield, Mary Jane Thomassen, Philip M. Sass, Nicholas C. Nicolaides, and Luigi Grasso Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3557–3562. Published online 2006 February 27. doi: 10.1073/pnas.0511285103.PMCID: PMC1383494 Biochemistry X-ray diffraction “fingerprinting” of DNA structure in solution for quantitative evaluation of molecular dynamics simulation Xiaobing Zuo, Guanglei Cui, Kenneth M. Merz, Jr., Ligang Zhang, Frederick D. Lewis, and David M. Tiede Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3534–3539. Published online 2006 February 27. doi: 10.1073/pnas.0600022103.PMCID: PMC1383498 Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase Weiru Wang, Adhirai Marimuthu, James Tsai, Abhinav Kumar, Heike I. Krupka, Chao Zhang, Ben Powell, Yoshihisa Suzuki, Hoa Nguyen, Maryam Tabrizizad, Catherine Luu, and Brian L. West Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3563–3568. Published online 2006 February 28. doi: 10.1073/pnas.0600048103.PMCID: PMC1450123 A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone Sabine Mohr, Manabu Matsuura, Philip S. Perlman, and Alan M. Lambowitz Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3569–3574. Published online 2006 February 27. doi: 10.1073/pnas.0600332103.PMCID: PMC1450124 An elongated spine of buried core residues necessary for in vivo folding of the parallel β-helix of P22 tailspike adhesin Ryan Simkovsky and Jonathan King Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3575–3580. Published online 2006 February 27. doi: 10.1073/pnas.0509087103.PMCID: PMC1383501 Cofactor-containing antibodies: Crystal structure of the original yellow antibody Xueyong Zhu, Paul Wentworth, Jr., Robert A. Kyle, Richard A. Lerner, and Ian A. Wilson Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3581–3585. Published online 2006 February 28. doi: 10.1073/pnas.0600251103.PMCID: PMC1450126 Mutational unmasking of a tRNA-dependent pathway for preventing genetic code ambiguity Amy M. Williams and Susan A. Martinis Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3586–3591. Published online 2006 February 27. doi: 10.1073/pnas.0507362103.PMCID: PMC1383500 Calcium-dependent regulation of the voltage-gated sodium channel hH1: Intrinsic and extrinsic sensors use a common molecular switch Vikas N. Shah, Tammy L. Wingo, Kevin L. Weiss, Christina K. Williams, Jeffrey R. Balser, and Walter J. Chazin Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3592–3597. Published online 2006 February 27. doi: 10.1073/pnas.0507397103.PMCID: PMC1450128 Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide Luis Rogelio Cruz-Vera, Ming Gong, and Charles Yanofsky Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3598–3603. Published online 2006 February 27. doi: 10.1073/pnas.0600082103.PMCID: PMC1450129 Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress Xinhe Wang, Beena Thomas, Rakesh Sachdeva, Linnea Arterburn, Lucy Frye, Patrick G. Hatcher, David G. Cornwell, and Jiyan Ma Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3604–3609. Published online 2006 February 27. doi: 10.1073/pnas.0510962103.PMCID: PMC1450130 Electron trap for DNA-bound repair enzymes: A strategy for DNA-mediated signaling Eylon Yavin, Eric D. A. Stemp, Valerie L. O’Shea, Sheila S. David, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3610–3614. Published online 2006 February 27. doi: 10.1073/pnas.0600239103.PMCID: PMC1450131 Biophysics Structural determinants of selective α-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP Chris Ulens, Ronald C. Hogg, Patrick H. Celie, Daniel Bertrand, Victor Tsetlin, August B. Smit, and Titia K. Sixma Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3615–3620. Published online 2006 February 27. doi: 10.1073/pnas.0507889103.PMCID: PMC1450132 Structural basis for rodlet assembly in fungal hydrophobins A. H. Y. Kwan, R. D. Winefield, M. Sunde, J. M. Matthews, R. G. Haverkamp, M. D. Templeton, and J. P. Mackay Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3621–3626. Published online 2006 February 28. doi: 10.1073/pnas.0505704103.PMCID: PMC1533775 Projection structure of the human copper transporter CTR1 at 6-Å resolution reveals a compact trimer with a novel channel-like architecture Stephen G. Aller and Vinzenz M. Unger Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3627–3632. Published online 2006 February 24. doi: 10.1073/pnas.0509929103.PMCID: PMC1450133 Cell Biology Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane Francisca Vazquez, Satomi Matsuoka, William R. Sellers, Toshio Yanagida, Masahiro Ueda, and Peter N. Devreotes Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3633–3638. Published online 2006 February 28. doi: 10.1073/pnas.0510570103.PMCID: PMC1450134 Neutrophil polarization: Spatiotemporal dynamics of RhoA activity support a self-organizing mechanism Kit Wong, Olivier Pertz, Klaus Hahn, and Henry Bourne Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3639–3644. Published online 2006 February 28. doi: 10.1073/pnas.0600092103.PMCID: PMC1450135 Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16INK4a Isil Guney, Shirley Wu, and John M. Sedivy Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3645–3650. Published online 2006 February 28. doi: 10.1073/pnas.0600069103.PMCID: PMC1450136 Developmental Biology Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression Yukuto Yasuhiko, Seiki Haraguchi, Satoshi Kitajima, Yu Takahashi, Jun Kanno, and Yumiko Saga Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3651–3656. Published online 2006 February 27. doi: 10.1073/pnas.0508238103.PMCID: PMC1450137 Ecology From the Cover: DNA barcodes reveal cryptic host-specificity within the presumed polyphagous members of a genus of parasitoid flies (Diptera: Tachinidae) M. Alex Smith, Norman E. Woodley, Daniel H. Janzen, Winnie Hallwachs, and Paul D. N. Hebert Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3657–3662. Published online 2006 February 27. doi: 10.1073/pnas.0511318103.PMCID: PMC1383497 Evolution Clonal population structure and genetic diversity of Candida albicans in AIDS patients from Abidjan (Côte d’Ivoire) François Nébavi, Francisco J. Ayala, François Renaud, Sébastien Bertout, Serge Eholié, Koné Moussa, Michèle Mallié, and Thierry de Meeûs Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3663–3668. Published online 2006 February 24. doi: 10.1073/pnas.0511328103.PMCID: PMC1450139 Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain Patrick Forterre Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3669–3674. Published online 2006 February 27. doi: 10.1073/pnas.0510333103.PMCID: PMC1450140 Sodium channel genes and the evolution of diversity in communication signals of electric fishes: Convergent molecular evolution Harold H. Zakon, Ying Lu, Derrick J. Zwickl, and David M. Hillis Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3675–3680. Published online 2006 February 27. doi: 10.1073/pnas.0600160103.PMCID: PMC1450141 From the Cover: New insights into myosin evolution and classification Bernardo J. Foth, Marc C. Goedecke, and Dominique Soldati Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3681–3686. Published online 2006 February 27. doi: 10.1073/pnas.0506307103.PMCID: PMC1533776 Genetics INAUGURAL ARTICLE by a Recently Elected Academy Member: Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia Dvora Shmulewitz, Simon C. Heath, Maude L. Blundell, Zhihua Han, Ratnendra Sharma, Jacqueline Salit, Steven B. Auerbach, Stefano Signorini, Jan L. Breslow, Markus Stoffel, and Jeffrey M. Friedman Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3502–3509. Published online 2006 February 28. doi: 10.1073/pnas.0510156103.PMCID: PMC1533774 The colorectal microRNAome Jordan M. Cummins, Yiping He, Rebecca J. Leary, Ray Pagliarini, Luis A. Diaz, Jr., Tobias Sjoblom, Omer Barad, Zvi Bentwich, Anna E. Szafranska, Emmanuel Labourier, Christopher K. Raymond, Brian S. Roberts, Hartmut Juhl, Kenneth W. Kinzler, Bert Vogelstein, and Victor E. Velculescu Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3687–3692. Published online 2006 February 27. doi: 10.1073/pnas.0511155103.PMCID: PMC1450142 Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice Hiroko Koike, P. Alexander Arguello, Mirna Kvajo, Maria Karayiorgou, and Joseph A. Gogos Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3693–3697. Published online 2006 February 16. doi: 10.1073/pnas.0511189103.PMCID: PMC1450143 Functional mapping of disease susceptibility loci using cell biology Peter A. Antinozzi, Alejandro Garcia-Diaz, Chuan Hu, and James E. Rothman Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3698–3703. Published online 2006 February 28. doi: 10.1073/pnas.0510521103.PMCID: PMC1533777 Genomic anatomy of the Tyrp1 (brown) deletion complex Ian M. Smyth, Laurens Wilming, Angela W. Lee, Martin S. Taylor, Phillipe Gautier, Karen Barlow, Justine Wallis, Sancha Martin, Rebecca Glithero, Ben Phillimore, Sarah Pelan, Rob Andrew, Karen Holt, Ruth Taylor, Stuart McLaren, John Burton, Jonathon Bailey, Sarah Sims, Jan Squares, Bob Plumb, Ann Joy, Richard Gibson, James Gilbert, Elizabeth Hart, Gavin Laird, Jane Loveland, Jonathan Mudge, Charlie Steward, David Swarbreck, Jennifer Harrow, Philip North, Nicholas Leaves, John Greystrong, Maria Coppola, Shilpa Manjunath, Mark Campbell, Mark Smith, Gregory Strachan, Calli Tofts, Esther Boal, Victoria Cobley, Giselle Hunter, Christopher Kimberley, Daniel Thomas, Lee Cave-Berry, Paul Weston, Marc R. M. Botcherby, Sharon White, Ruth Edgar, Sally H. Cross, Marjan Irvani, Holger Hummerich, Eleanor H. Simpson, Dabney Johnson, Patricia R. Hunsicker, Peter F. R. Little, Tim Hubbard, R. Duncan Campbell, Jane Rogers, and Ian J. Jackson Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3704–3709. Published online 2006 February 27. doi: 10.1073/pnas.0600199103.PMCID: PMC1450144 Checkpoint functions are required for normal S-phase progression in Saccharomyces cerevisiae RCAF- and CAF-I-defective mutants Ellen S. Kats, Claudio P. Albuquerque, Huilin Zhou, and Richard D. Kolodner Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3710–3715. Published online 2006 February 24. doi: 10.1073/pnas.0511102103.PMCID: PMC1533778 Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms Rika Numano, Shin Yamazaki, Nanae Umeda, Tomonori Samura, Mitsugu Sujino, Ri-ichi Takahashi, Masatsugu Ueda, Akiko Mori, Kazunori Yamada, Yoshiyuki Sakaki, Shin-Ichi T. Inouye, Michael Menaker, and Hajime Tei Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3716–3721. Published online 2006 February 28. doi: 10.1073/pnas.0600060103.PMCID: PMC1450145 Immunology Mucosal and systemic adjuvant activity of alphavirus replicon particles Joseph M. Thompson, Alan C. Whitmore, Jennifer L. Konopka, Martha L. Collier, Erin M. B. Richmond, Nancy L. Davis, Herman F. Staats, and Robert E. Johnston Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3722–3727. Published online 2006 February 27. doi: 10.1073/pnas.0600287103.PMCID: PMC1383499 An ancient evolutionary origin of the Rag1/2 gene locus Sebastian D. Fugmann, Cynthia Messier, Laura A. Novack, R. Andrew Cameron, and Jonathan P. Rast Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3728–3733. Published online 2006 February 27. doi: 10.1073/pnas.0509720103.PMCID: PMC1450146 Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen Haochu Huang, John F. Kearney, Michael J. Grusby, Christophe Benoist, and Diane Mathis Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3734–3739. Published online 2006 February 27. doi: 10.1073/pnas.0600214103.PMCID: PMC1450147 Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment Takanori So, Jianxun Song, Katsuji Sugie, Amnon Altman, and Michael Croft Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3740–3745. Published online 2006 February 24. doi: 10.1073/pnas.0600205103.PMCID: PMC1450148 R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells Claudia Cicala, James Arthos, Elena Martinelli, Nina Censoplano, Catherine C. Cruz, Eva Chung, Sara M. Selig, Donald Van Ryk, Jun Yang, Shyla Jagannatha, Tae Wook Chun, Ping Ren, Richard A. Lempicki, and Anthony S. Fauci Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3746–3751. Published online 2006 February 27. doi: 10.1073/pnas.0511237103.PMCID: PMC1533779 Medical Sciences Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment Paul M. Kulesa, Jennifer C. Kasemeier-Kulesa, Jessica M. Teddy, Naira V. Margaryan, Elisabeth A. Seftor, Richard E. B. Seftor, and Mary J. C. Hendrix Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3752–3757. Published online 2006 February 27. doi: 10.1073/pnas.0506977103.PMCID: PMC1450149 Body-wide gene therapy of Duchenne muscular dystrophy in the mdx mouse model Michela Alessandra Denti, Alessandro Rosa, Giuseppe D’Antona, Olga Sthandier, Fernanda Gabriella De Angelis, Carmine Nicoletti, Mariacarmela Allocca, Orietta Pansarasa, Valeria Parente, Antonio Musarò, Alberto Auricchio, Roberto Bottinelli, and Irene Bozzoni Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3758–3763. Published online 2006 February 24. doi: 10.1073/pnas.0508917103.PMCID: PMC1450150 Conserved oligomeric Golgi complex subunit 1 deficiency reveals a previously uncharacterized congenital disorder of glycosylation type II François Foulquier, Eliza Vasile, Els Schollen, Nico Callewaert, Tim Raemaekers, Dulce Quelhas, Jaak Jaeken, Philippa Mills, Bryan Winchester, Monty Krieger, Wim Annaert, and Gert Matthijs Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3764–3769. Published online 2006 February 28. doi: 10.1073/pnas.0507685103.PMCID: PMC1450151 Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population Sharon Simchoni, Eitan Friedman, Bella Kaufman, Ruth Gershoni-Baruch, Avi Orr-Urtreger, Inbal Kedar-Barnes, Ronit Shiri-Sverdlov, Efrat Dagan, Sigal Tsabari, Mordechai Shohat, Raphael Catane, Mary-Claire King, Amnon Lahad, and Ephrat Levy-Lahad Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3770–3774. Published online 2006 February 28. doi: 10.1073/pnas.0511301103.PMCID: PMC1450152 A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase Cynthia S. Collins, Jiyong Hong, Lisa Sapinoso, Yingyao Zhou, Zheng Liu, Kenneth Micklash, Peter G. Schultz, and Garret M. Hampton Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3775–3780. Published online 2006 February 28. doi: 10.1073/pnas.0600040103.PMCID: PMC1383649 Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice Eugene Trogan, Jonathan E. Feig, Snjezana Dogan, George H. Rothblat, Véronique Angeli, Frank Tacke, Gwendalyn J. Randolph, and Edward A. Fisher Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3781–3786. Published online 2006 March 1. doi: 10.1073/pnas.0511043103.PMCID: PMC1450154 Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells Bradley W. Schuller, Peter J. Binns, Kent J. Riley, Ling Ma, M. Frederick Hawthorne, and Jeffrey A. Coderre Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3787–3792. Published online 2006 February 27. doi: 10.1073/pnas.0600133103.PMCID: PMC1383492 Delayed testicular aging in pituitary adenylate cyclase-activating peptide (PACAP) null mice Arnaud Lacombe, Vincent Lelievre, Charles E. Roselli, Wael Salameh, Yan-he Lue, Gregory Lawson, Jean-Marc Muller, James A. Waschek, and Eric Vilain Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3793–3798. Published online 2006 February 27. doi: 10.1073/pnas.0505827103.PMCID: PMC1450155 Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism Ayyakannu Ayyanan, Gianluca Civenni, Laura Ciarloni, Catherine Morel, Nathalie Mueller, Karine Lefort, Anna Mandinova, Wassim Raffoul, Maryse Fiche, Gian Paolo Dotto, and Cathrin Brisken Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3799–3804. Published online 2006 February 24. doi: 10.1073/pnas.0600065103.PMCID: PMC1450156 From the Cover: Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro Brett D. Lindenbach, Philip Meuleman, Alexander Ploss, Thomas Vanwolleghem, Andrew J. Syder, Jane A. McKeating, Robert E. Lanford, Stephen M. Feinstone, Marian E. Major, Geert Leroux-Roels, and Charles M. Rice Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3805–3809. Published online 2006 February 16. doi: 10.1073/pnas.0511218103.PMCID: PMC1533780 Microbiology Dissecting toxin immunity in virus-infected killer yeast uncovers an intrinsic strategy of self-protection Frank Breinig, Tanja Sendzik, Katrin Eisfeld, and Manfred J. Schmitt Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3810–3815. Published online 2006 February 27. doi: 10.1073/pnas.0510070103.PMCID: PMC1533781 Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays Rodolphe Barrangou, M. Andrea Azcarate-Peril, Tri Duong, Shannon B. Conners, Robert M. Kelly, and Todd R. Klaenhammer Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3816–3821. Published online 2006 February 27. doi: 10.1073/pnas.0511287103.PMCID: PMC1533782 Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response Mark R. Pett, M. Trent Herdman, Roger D. Palmer, Giles S. H. Yeo, Mahmud K. Shivji, Margaret A. Stanley, and Nicholas Coleman Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3822–3827. Published online 2006 February 27. doi: 10.1073/pnas.0600078103.PMCID: PMC1383496 Quorum sensing and motility mediate interactions between Pseudomonas aeruginosa and Agrobacterium tumefaciens in biofilm cocultures Dingding An, Thomas Danhorn, Clay Fuqua, and Matthew R. Parsek Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3828–3833. Published online 2006 February 28. doi: 10.1073/pnas.0511323103.PMCID: PMC1533783 The partitioned Rhizobium etli genome: Genetic and metabolic redundancy in seven interacting replicons Víctor González, Rosa I. Santamaría, Patricia Bustos, Ismael Hernández-González, Arturo Medrano-Soto, Gabriel Moreno-Hagelsieb, Sarath Chandra Janga, Miguel A. Ramírez, Verónica Jiménez-Jacinto, Julio Collado-Vides, and Guillermo Dávila Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3834–3839. Published online 2006 February 27. doi: 10.1073/pnas.0508502103.PMCID: PMC1383491 A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling Christina Paulus, Steffen Krauss, and Michael Nevels Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3840–3845. Published online 2006 February 23. doi: 10.1073/pnas.0600007103.PMCID: PMC1533784 Heterotrophic Archaea dominate sedimentary subsurface ecosystems off Peru Jennifer F. Biddle, Julius S. Lipp, Mark A. Lever, Karen G. Lloyd, Ketil B. Sørensen, Rika Anderson, Helen F. Fredricks, Marcus Elvert, Timothy J. Kelly, Daniel P. Schrag, Mitchell L. Sogin, Jean E. Brenchley, Andreas Teske, Christopher H. House, and Kai-Uwe Hinrichs Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3846–3851. Published online 2006 February 27. doi: 10.1073/pnas.0600035103.PMCID: PMC1533785 Neuroscience Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring Anika Bick-Sander, Barbara Steiner, Susanne A. Wolf, Harish Babu, and Gerd Kempermann Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3852–3857. Published online 2006 March 6. doi: 10.1073/pnas.0502644103.PMCID: PMC1389702 Between-subject transfer of emotional information evokes specific pattern of amygdala activation Ewelina Knapska, Evgeni Nikolaev, Pawel Boguszewski, Grazyna Walasek, Janusz Blaszczyk, Leszek Kaczmarek, and Tomasz Werka Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3858–3862. Published online 2006 February 23. doi: 10.1073/pnas.0511302103.PMCID: PMC1533786 Information-based functional brain mapping Nikolaus Kriegeskorte, Rainer Goebel, and Peter Bandettini Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3863–3868. Published online 2006 February 28. doi: 10.1073/pnas.0600244103.PMCID: PMC1383651 Brain cholesterol turnover required for geranylgeraniol production and learning in mice Tiina J. Kotti, Denise M. O. Ramirez, Brad E. Pfeiffer, Kimberly M. Huber, and David W. Russell Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3869–3874. Published online 2006 February 27. doi: 10.1073/pnas.0600316103.PMCID: PMC1450160 Prion infection of mouse neurospheres Ranjit K. Giri, Rebecca Young, Rose Pitstick, Stephen J. DeArmond, Stanley B. Prusiner, and George A. Carlson Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3875–3880. Published online 2006 February 22. doi: 10.1073/pnas.0510902103.PMCID: PMC1533787 Elevated cholecystokininergic tone constitutes an important molecular/neuronal mechanism for the expression of anxiety in the mouse Qian Chen, Akira Nakajima, Corbin Meacham, and Ya-Ping Tang Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3881–3886. Published online 2006 February 28. doi: 10.1073/pnas.0505407103.PMCID: PMC1383652 Neuroprotection by pharmacologic blockade of the GAPDH death cascade Makoto R. Hara, Bobby Thomas, Matthew B. Cascio, Byoung-Il Bae, Lynda D. Hester, Valina L. Dawson, Ted M. Dawson, Akira Sawa, and Solomon H. Snyder Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3887–3889. Published online 2006 February 27. doi: 10.1073/pnas.0511321103.PMCID: PMC1450161 From the Cover: Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors Masayuki Akimoto, Hong Cheng, Dongxiao Zhu, Joseph A. Brzezinski, Ritu Khanna, Elena Filippova, Edwin C. T. Oh, Yuezhou Jing, Jose-Luis Linares, Matthew Brooks, Sepideh Zareparsi, Alan J. Mears, Alfred Hero, Tom Glaser, and Anand Swaroop Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3890–3895. Published online 2006 February 27. doi: 10.1073/pnas.0508214103.PMCID: PMC1383502 Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants Paul A. Sieving, Rafael C. Caruso, Weng Tao, Hanna R. Coleman, Darby J. S. Thompson, Keri R. Fullmer, and Ronald A. Bush Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3896–3901. Published online 2006 February 27. doi: 10.1073/pnas.0600236103.PMCID: PMC1383495 Retinoic acid is required early during adult neurogenesis in the dentate gyrus Sharoni Jacobs, D. Chichung Lie, Kathleen L. DeCicco, Yanhong Shi, Luigi M. DeLuca, Fred H. Gage, and Ronald M. Evans Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3902–3907. Published online 2006 February 27. doi: 10.1073/pnas.0511294103.PMCID: PMC1450163 Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action Kyoung-Shim Kim, Ko-Woon Lee, Kang-Woo Lee, Joo-Young Im, Ji Yeoun Yoo, Seung-Woo Kim, Ja-Kyeong Lee, Eric J. Nestler, and Pyung-Lim Han Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3908–3913. Published online 2006 February 28. doi: 10.1073/pnas.0508812103.PMCID: PMC1533788 Pharmacology Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin Anna Bratasz, Nathan M. Weir, Narasimham L. Parinandi, Jay L. Zweier, Rajagopalan Sridhar, Louis J. Ignarro, and Periannan Kuppusamy Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3914–3919. Published online 2006 February 23. doi: 10.1073/pnas.0511250103.PMCID: PMC1450164 Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor Takeshi Inagaki, Antonio Moschetta, Youn-Kyoung Lee, Li Peng, Guixiang Zhao, Michael Downes, Ruth T. Yu, John M. Shelton, James A. Richardson, Joyce J. Repa, David J. Mangelsdorf, and Steven A. Kliewer Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3920–3925. Published online 2006 February 10. doi: 10.1073/pnas.0509592103.PMCID: PMC1450165 Physiology cAMP regulates plasma membrane vacuolar-type H+-ATPase assembly and activity in blowfly salivary glands Petra Dames, Bernhard Zimmermann, Ruth Schmidt, Julia Rein, Martin Voss, Bettina Schewe, Bernd Walz, and Otto Baumann Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3926–3931. Published online 2006 February 28. doi: 10.1073/pnas.0600011103.PMCID: PMC1450166 Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices Christian Erxleben, Yanhong Liao, Saverio Gentile, David Chin, Claudio Gomez-Alegria, Yasuo Mori, Lutz Birnbaumer, and David L. Armstrong Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3932–3937. Published online 2006 February 28. doi: 10.1073/pnas.0511322103.PMCID: PMC1533789 Cortisol levels and very early pregnancy loss in humans Pablo A. Nepomnaschy, Kathleen B. Welch, Daniel S. McConnell, Bobbi S. Low, Beverly I. Strassmann, and Barry G. England Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3938–3942. Published online 2006 February 22. doi: 10.1073/pnas.0511183103.PMCID: PMC1533790 Social Sciences Anthropology Body size, body proportions, and encephalization in a Middle Pleistocene archaic human from northern China Karen R. Rosenberg, Lü Zuné, and Christopher B. Ruff Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3552–3556. Published online 2006 February 27. doi: 10.1073/pnas.0508681103.PMCID: PMC1450121 Cortisol levels and very early pregnancy loss in humans Pablo A. Nepomnaschy, Kathleen B. Welch, Daniel S. McConnell, Bobbi S. Low, Beverly I. Strassmann, and Barry G. England Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3938–3942. Published online 2006 February 22. doi: 10.1073/pnas.0511183103.PMCID: PMC1533790 Sustainability Science INAUGURAL ARTICLE by a Recently Elected Academy Member: Geography and macroeconomics: New data and new findings William D. Nordhaus Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3510–3517. Published online 2006 February 10. doi: 10.1073/pnas.0509842103.PMCID: PMC1363683 Pharmacology Correction for Robert et al., The antimalarial drug artemisinin alkylates heme in infected mice Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3943. doi: 10.1073/pnas.0600629103.PMCID: PMC1533791 Corrects: Anne Robert, et al. The antimalarial drug artemisinin alkylates heme in infected mice. Proc Natl Acad Sci U S A. 2005 September 20; 102(38): 13676–13680. |