| | This journal provides immediate access to some articles. Inaugural Article INAUGURAL ARTICLE by a Recently Elected Academy Member: Retinoic acid regulates sex-specific timing of meiotic initiation in mice Jana Koubova, Douglas B. Menke, Qing Zhou, Blanche Capel, Michael D. Griswold, and David C. Page Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2474–2479. Published online 2006 February 6. doi: 10.1073/pnas.0510813103.PMCID: PMC1413806 This Week in PNAS Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2467–2468. doi: 10.1073/pnas.iti0806103.PMCID: PMC1413863 Commentary A globin in every cell? Austen F. Riggs and Thomas A. Gorr Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2469–2470. Published online 2006 February 15. doi: 10.1073/pnas.0600290103.PMCID: PMC1413860 Profile Profile of David C. Page Bijal Trivedi Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2471–2473. Published online 2006 February 15. doi: 10.1073/pnas.0600615103.PMCID: PMC1413862 Tissue Engineering Special Feature Research Articles In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation Néha Datta, Quynh P. Pham, Upma Sharma, Vassilios I. Sikavitsas, John A. Jansen, and Antonios G. Mikos Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2488–2493. Published online 2006 February 13. doi: 10.1073/pnas.0505661103.PMCID: PMC1413766 Regulating activation of transplanted cells controls tissue regeneration Elliott Hill, Tanyarut Boontheekul, and David J. Mooney Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2494–2499. Published online 2006 February 13. doi: 10.1073/pnas.0506004103.PMCID: PMC1413770 Relevance and safety of telomerase for human tissue engineering Rebecca Y. Klinger, Juliana L. Blum, Bevin Hearn, Benjamin Lebow, and Laura E. Niklason Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2500–2505. Published online 2006 February 13. doi: 10.1073/pnas.0508184103.PMCID: PMC1413782 Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1α variant for local induction of angiogenesis Diana Trentin, Heike Hall, Sandra Wechsler, and Jeffrey A. Hubbell Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2506–2511. Published online 2006 February 13. doi: 10.1073/pnas.0505964102.PMCID: PMC1413769 From the Cover: A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo Millicent C. Ford, James P. Bertram, Sara Royce Hynes, Michael Michaud, Qi Li, Michael Young, Steven S. Segal, Joseph A. Madri, and Erin B. Lavik Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2512–2517. Published online 2006 February 10. doi: 10.1073/pnas.0506020102.PMCID: PMC1413771 Perspective Microscale technologies for tissue engineering and biology Ali Khademhosseini, Robert Langer, Jeffrey Borenstein, and Joseph P. Vacanti Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2480–2487. Published online 2006 February 13. doi: 10.1073/pnas.0507681102.PMCID: PMC1413775 Physical Sciences Chemistry Principles of self-assembly of helical pores from dendritic dipeptides Virgil Percec, Andrés E. Dulcey, Mihai Peterca, Monica Ilies, Sami Nummelin, Monika J. Sienkowska, and Paul A. Heiney Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2518–2523. Published online 2006 February 9. doi: 10.1073/pnas.0509676103.PMCID: PMC1413792 Flexible bilayers with spontaneous curvature lead to lamellar gels and spontaneous vesicles Bret A. Coldren, Heidi Warriner, Ryan van Zanten, Joseph A. Zasadzinski, and Eric B. Sirota Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2524–2529. Published online 2006 February 8. doi: 10.1073/pnas.0507024103.PMCID: PMC1413774 From the Cover: Self-fulfilling cavitands: Packing alkyl chains into small spaces Byron W. Purse and Julius Rebek, Jr. Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2530–2534. Published online 2006 February 13. doi: 10.1073/pnas.0511149103.PMCID: PMC1413836 Mathematics Conformal invariants associated to a measure Sun-Yung A. Chang, Matthew J. Gursky, and Paul Yang Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2535–2540. Published online 2006 February 10. doi: 10.1073/pnas.0510814103.PMCID: PMC1413807 Physics Direct structural observation of a molecular junction by high-energy x-ray reflectometry Michael Lefenfeld, Julian Baumert, Eli Sloutskin, Ivan Kuzmenko, Peter Pershan, Moshe Deutsch, Colin Nuckolls, and Benjamin M. Ocko Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2541–2545. Published online 2006 February 8. doi: 10.1073/pnas.0508070103.PMCID: PMC1413780 Biological Sciences Applied Biological Sciences In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation Néha Datta, Quynh P. Pham, Upma Sharma, Vassilios I. Sikavitsas, John A. Jansen, and Antonios G. Mikos Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2488–2493. Published online 2006 February 13. doi: 10.1073/pnas.0505661103.PMCID: PMC1413766 Regulating activation of transplanted cells controls tissue regeneration Elliott Hill, Tanyarut Boontheekul, and David J. Mooney Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2494–2499. Published online 2006 February 13. doi: 10.1073/pnas.0506004103.PMCID: PMC1413770 Relevance and safety of telomerase for human tissue engineering Rebecca Y. Klinger, Juliana L. Blum, Bevin Hearn, Benjamin Lebow, and Laura E. Niklason Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2500–2505. Published online 2006 February 13. doi: 10.1073/pnas.0508184103.PMCID: PMC1413782 Biochemistry The structure of a ring-opened proliferating cell nuclear antigen–replication factor C complex revealed by fluorescence energy transfer Zhihao Zhuang, Bonita L. Yoder, Peter M. J. Burgers, and Stephen J. Benkovic Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2546–2551. Published online 2006 February 13. doi: 10.1073/pnas.0511263103.PMCID: PMC1413853 The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function Ming-Hong Chuang, Ming-Shiang Wu, Wan-Lin Lo, Jaw-Town Lin, Chi-Huey Wong, and Shyh-Horng Chiou Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2552–2557. Published online 2006 February 15. doi: 10.1073/pnas.0510770103.PMCID: PMC1413804 Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis Luke J. Alderwick, Virginie Molle, Laurent Kremer, Alain J. Cozzone, Timothy R. Dafforn, Gurdyal S. Besra, and Klaus Fütterer Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2558–2563. Published online 2006 February 13. doi: 10.1073/pnas.0507766103.PMCID: PMC1413777 Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles Alexander A. Ishchenko, Eric Deprez, Andrei Maksimenko, Jean-Claude Brochon, Patrick Tauc, and Murat K. Saparbaev Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2564–2569. Published online 2006 February 10. doi: 10.1073/pnas.0508582103.PMCID: PMC1413785 Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state Zhi-Jie Liu, Galina A. Stepanyuk, Eugene S. Vysotski, John Lee, Svetlana V. Markova, Natalia P. Malikova, and Bi-Cheng Wang Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2570–2575. Published online 2006 February 8. doi: 10.1073/pnas.0511142103.PMCID: PMC1413834 Structure and mechanism of the Propionibacterium acnes polyunsaturated fatty acid isomerase Alena Liavonchanka, Ellen Hornung, Ivo Feussner, and Markus Georg Rudolph Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2576–2581. Published online 2006 February 13. doi: 10.1073/pnas.0510144103.PMCID: PMC1413795 Agrobacterium tumefaciens VirB8 structure reveals potential protein–protein interaction sites Susan Bailey, Doyle Ward, Rebecca Middleton, J. Gunter Grossmann, and Patricia C. Zambryski Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2582–2587. Published online 2006 February 15. doi: 10.1073/pnas.0511216103.PMCID: PMC1413848 The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites Maria G. Kapetanaki, Jennifer Guerrero-Santoro, Dawn C. Bisi, Ching L. Hsieh, Vesna Rapić-Otrin, and Arthur S. Levine Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2588–2593. Published online 2006 February 10. doi: 10.1073/pnas.0511160103.PMCID: PMC1413840 Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks Kenneth G. Geles, Richard N. Freiman, Wei-Li Liu, Shuang Zheng, Ekaterina Voronina, and Robert Tjian Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2594–2599. Published online 2006 February 10. doi: 10.1073/pnas.0510764103.PMCID: PMC1413803 Biophysics Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold Min Wang, Thomas E. Wales, and Michael C. Fitzgerald Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2600–2604. Published online 2006 February 10. doi: 10.1073/pnas.0508121103.PMCID: PMC1413781 On the origin and highly likely completeness of single-domain protein structures Yang Zhang, Isaac A. Hubner, Adrian K. Arakaki, Eugene Shakhnovich, and Jeffrey Skolnick Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2605–2610. Published online 2006 February 14. doi: 10.1073/pnas.0509379103.PMCID: PMC1413790 Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O2 incorporation by a heme-containing dioxygenase Hiroshi Sugimoto, Shun-ichiro Oda, Takashi Otsuki, Tomoya Hino, Tadashi Yoshida, and Yoshitsugu Shiro Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2611–2616. Published online 2006 February 13. doi: 10.1073/pnas.0508996103.PMCID: PMC1413787 Mitochondrial carriers in the cytoplasmic state have a common substrate binding site Alan J. Robinson and Edmund R. S. Kunji Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2617–2622. Published online 2006 February 9. doi: 10.1073/pnas.0509994103.PMCID: PMC1413793 DNA conformation on surfaces measured by fluorescence self-interference Lev Moiseev, M. Selim Ünlü, Anna K. Swan, Bennett B. Goldberg, and Charles R. Cantor Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2623–2628. Published online 2006 February 13. doi: 10.1073/pnas.0511214103.PMCID: PMC1413847 Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications Elena Olkhova, Carola Hunte, Emanuela Screpanti, Etana Padan, and Hartmut Michel Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2629–2634. Published online 2006 February 13. doi: 10.1073/pnas.0510914103.PMCID: PMC1413810 Cell Biology Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake Xiaoyan Shen, Kai-Feng Xu, Qingyuan Fan, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2635–2640. Published online 2006 February 13. doi: 10.1073/pnas.0510599103.PMCID: PMC1413799 The HIV lipidome: A raft with an unusual composition Britta Brügger, Bärbel Glass, Per Haberkant, Iris Leibrecht, Felix T. Wieland, and Hans-Georg Kräusslich Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2641–2646. Published online 2006 February 15. doi: 10.1073/pnas.0511136103.PMCID: PMC1413831 The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components Noora Kotaja, Suvendra N. Bhattacharyya, Lukasz Jaskiewicz, Sarah Kimmins, Martti Parvinen, Witold Filipowicz, and Paolo Sassone-Corsi Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2647–2652. Published online 2006 February 13. doi: 10.1073/pnas.0509333103.PMCID: PMC1413789 Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology Tianzheng Yu, James L. Robotham, and Yisang Yoon Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2653–2658. Published online 2006 February 13. doi: 10.1073/pnas.0511154103.PMCID: PMC1413838 RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells Janet Kalesnikoff, Eon J. Rios, Ching-Cheng Chen, Susumu Nakae, Brian A. Zabel, Eugene C. Butcher, Mindy Tsai, See-Ying Tam, and Stephen J. Galli Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2659–2664. Published online 2006 February 21. doi: 10.1073/pnas.0511191103.PMCID: PMC1413845 Synergistic roles of platelet-derived growth factor-BB and interleukin-1β in phenotypic modulation of human aortic smooth muscle cells Cheng-Nan Chen, Yi-Shuan J. Li, Yi-Ting Yeh, Pei-Ling Lee, Shunichi Usami, Shu Chien, and Jeng-Jiann Chiu Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2665–2670. Published online 2006 February 13. doi: 10.1073/pnas.0510973103.PMCID: PMC1413813 Regulation of apoptosis by the p8/prothymosin α complex Cédric Malicet, Valentin Giroux, Sophie Vasseur, Jean Charles Dagorn, José Luis Neira, and Juan L. Iovanna Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2671–2676. Published online 2006 February 14. doi: 10.1073/pnas.0508955103.PMCID: PMC1413786 Z-DNA-forming sequences generate large-scale deletions in mammalian cells Guliang Wang, Laura A. Christensen, and Karen M. Vasquez Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2677–2682. Published online 2006 February 10. doi: 10.1073/pnas.0511084103.PMCID: PMC1413824 Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei Carmen Citterio, Heather D. Jones, Gustavo Pacheco-Rodriguez, Aminul Islam, Joel Moss, and Martha Vaughan Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2683–2688. Published online 2006 February 8. doi: 10.1073/pnas.0510571103.PMCID: PMC1413798 IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-κB activation Yoon-Jae Song, Kai-Yu Jen, Vishal Soni, Elliott Kieff, and Ellen Cahir-McFarland Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2689–2694. Published online 2006 February 13. doi: 10.1073/pnas.0511096103.PMCID: PMC1413826 Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition Tulsiram Prathapam, Sarah Tegen, Thordur Oskarsson, Andreas Trumpp, and G. Steven Martin Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2695–2700. Published online 2006 February 13. doi: 10.1073/pnas.0511186103.PMCID: PMC1413844 Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity Dorothea Brandhorst, Daniel Zwilling, Silvio O. Rizzoli, Undine Lippert, Thorsten Lang, and Reinhard Jahn Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2701–2706. Published online 2006 February 9. doi: 10.1073/pnas.0511138103.PMCID: PMC1413832 Developmental Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: Retinoic acid regulates sex-specific timing of meiotic initiation in mice Jana Koubova, Douglas B. Menke, Qing Zhou, Blanche Capel, Michael D. Griswold, and David C. Page Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2474–2479. Published online 2006 February 6. doi: 10.1073/pnas.0510813103.PMCID: PMC1413806 Automated cell lineage tracing in Caenorhabditis elegans Zhirong Bao, John I. Murray, Thomas Boyle, Siew Loon Ooi, Matthew J. Sandel, and Robert H. Waterston Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2707–2712. Published online 2006 February 13. doi: 10.1073/pnas.0511111103.PMCID: PMC1413828 SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos Xungang Tan, Josep Rotllant, Huiqing Li, Patrick DeDeyne, and Shao Jun Du Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2713–2718. Published online 2006 February 13. doi: 10.1073/pnas.0509503103.PMCID: PMC1531647 In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development Ren-Shan Ge, Qiang Dong, Chantal M. Sottas, Vassilios Papadopoulos, Barry R. Zirkin, and Matthew P. Hardy Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2719–2724. Published online 2006 February 8. doi: 10.1073/pnas.0507692103.PMCID: PMC1413776 Testicular germ cells can colonize sexually undifferentiated embryonic gonad and produce functional eggs in fish Tomoyuki Okutsu, Kensuke Suzuki, Yutaka Takeuchi, Toshio Takeuchi, and Goro Yoshizaki Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2725–2729. Published online 2006 February 10. doi: 10.1073/pnas.0509218103.PMCID: PMC1413788 Evolution Buffering of crucial functions by paleologous duplicated genes may contribute cyclicality to angiosperm genome duplication Brad A. Chapman, John E. Bowers, Frank A. Feltus, and Andrew H. Paterson Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2730–2735. Published online 2006 February 8. doi: 10.1073/pnas.0507782103.PMCID: PMC1413778 Phanerozoic marine biodiversity dynamics in light of the incompleteness of the fossil record Peter J. Lu, Motohiro Yogo, and Charles R. Marshall Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2736–2739. Published online 2006 February 13. doi: 10.1073/pnas.0511083103.PMCID: PMC1413823 Genetics A large family of ancient repeat elements in the human genome is under strong selection Michael Kamal, Xiaohui Xie, and Eric S. Lander Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2740–2745. Published online 2006 February 13. doi: 10.1073/pnas.0511238103.PMCID: PMC1413850 Cell-type-specific signatures of microRNAs on target mRNA expression Pranidhi Sood, Azra Krek, Mihaela Zavolan, Giuseppe Macino, and Nikolaus Rajewsky Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2746–2751. Published online 2006 February 13. doi: 10.1073/pnas.0511045103.PMCID: PMC1413820 Immunology Negative regulation of activation-induced cytidine deaminase in B cells Taro Muto, Il-mi Okazaki, Shuichi Yamada, Yoshimasa Tanaka, Kazuo Kinoshita, Masamichi Muramatsu, Hitoshi Nagaoka, and Tasuku Honjo Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2752–2757. Published online 2006 February 13. doi: 10.1073/pnas.0510970103.PMCID: PMC1413812 Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction Sayuri Yamazaki, Munjal Patel, Alice Harper, Anthony Bonito, Hidehiro Fukuyama, Maggi Pack, Kristin V. Tarbell, Mia Talmor, Jeffrey V. Ravetch, Kayo Inaba, and Ralph M. Steinman Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2758–2763. Published online 2006 February 10. doi: 10.1073/pnas.0510606103.PMCID: PMC1413800 An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses Paul G. Thomas, Scott A. Brown, Wen Yue, Jenny So, Richard J. Webby, and Peter C. Doherty Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2764–2769. Published online 2006 February 10. doi: 10.1073/pnas.0511185103.PMCID: PMC1413843 Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren’s syndrome Jacques-Eric Gottenberg, Nicolas Cagnard, Carlo Lucchesi, Franck Letourneur, Sylvie Mistou, Thierry Lazure, Sebastien Jacques, Nathalie Ba, Marc Ittah, Christine Lepajolec, Marc Labetoulle, Marc Ardizzone, Jean Sibilia, Catherine Fournier, Gilles Chiocchia, and Xavier Mariette Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2770–2775. Published online 2006 February 13. doi: 10.1073/pnas.0510837103.PMCID: PMC1413808 Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling Krista M. Heinonen, Nadia Dubé, Annie Bourdeau, Wayne S. Lapp, and Michel L. Tremblay Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2776–2781. Published online 2006 February 13. doi: 10.1073/pnas.0508563103.PMCID: PMC1413784 Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells Everett H. Meyer, Sho Goya, Omid Akbari, Gerald J. Berry, Paul B. Savage, Mitchell Kronenberg, Toshinori Nakayama, Rosemarie H. DeKruyff, and Dale T. Umetsu Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2782–2787. Published online 2006 February 14. doi: 10.1073/pnas.0510282103.PMCID: PMC1413796 Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor Deborah J. Stauber, Erik W. Debler, Patricia A. Horton, Kendall A. Smith, and Ian A. Wilson Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2788–2793. Published online 2006 February 13. doi: 10.1073/pnas.0511161103.PMCID: PMC1413841 Medical Sciences Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1α variant for local induction of angiogenesis Diana Trentin, Heike Hall, Sandra Wechsler, and Jeffrey A. Hubbell Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2506–2511. Published online 2006 February 13. doi: 10.1073/pnas.0505964102.PMCID: PMC1413769 From the Cover: A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo Millicent C. Ford, James P. Bertram, Sara Royce Hynes, Michael Michaud, Qi Li, Michael Young, Steven S. Segal, Joseph A. Madri, and Erin B. Lavik Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2512–2517. Published online 2006 February 10. doi: 10.1073/pnas.0506020102.PMCID: PMC1413771 Gene expression changes associated with progression and response in chronic myeloid leukemia Jerald P. Radich, Hongyue Dai, Mao Mao, Vivian Oehler, Jan Schelter, Brian Druker, Charles Sawyers, Neil Shah, Wendy Stock, Cheryl L. Willman, Stephen Friend, and Peter S. Linsley Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2794–2799. Published online 2006 February 13. doi: 10.1073/pnas.0510423103.PMCID: PMC1413797 Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds Jan Pilch, Darren M. Brown, Masanobu Komatsu, Tero A. H. Järvinen, Meng Yang, David Peters, Robert M. Hoffman, and Erkki Ruoslahti Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2800–2804. Published online 2006 February 13. doi: 10.1073/pnas.0511219103.PMCID: PMC1413849 Liddle’s syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage Kristin K. Knight, Diane R. Olson, Ruifeng Zhou, and Peter M. Snyder Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2805–2808. Published online 2006 February 13. doi: 10.1073/pnas.0511184103.PMCID: PMC1413842 Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury Béatrice Bailly-Maitre, Constantino Fondevila, Fady Kaldas, Nathalie Droin, Fréderic Luciano, Jean-Ehrland Ricci, Rhonda Croxton, Maryla Krajewska, Juan M. Zapata, Jerzy W. Kupiec-Weglinski, Douglas Farmer, and John C. Reed Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2809–2814. Published online 2006 February 14. doi: 10.1073/pnas.0506854103.PMCID: PMC1413773 Microbiology Biogeographical distribution and diversity of microbes in methane hydrate-bearing deep marine sediments on the Pacific Ocean Margin Fumio Inagaki, Takuro Nunoura, Satoshi Nakagawa, Andreas Teske, Mark Lever, Antje Lauer, Masae Suzuki, Ken Takai, Mark Delwiche, Frederick S. Colwell, Kenneth H. Nealson, Koki Horikoshi, Steven D’Hondt, and Bo B. Jørgensen Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2815–2820. Published online 2006 February 13. doi: 10.1073/pnas.0511033103.PMCID: PMC1413818 Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins Miguel Gaspar and Thomas Shenk Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2821–2826. Published online 2006 February 13. doi: 10.1073/pnas.0511148103.PMCID: PMC1413835 The UL41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins Brunella Taddeo, Weiran Zhang, and Bernard Roizman Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2827–2832. Published online 2006 February 13. doi: 10.1073/pnas.0510712103.PMCID: PMC1413801 An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants Nicole T. Liberati, Jonathan M. Urbach, Sachiko Miyata, Daniel G. Lee, Eliana Drenkard, Gang Wu, Jacinto Villanueva, Tao Wei, and Frederick M. Ausubel Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2833–2838. Published online 2006 February 13. doi: 10.1073/pnas.0511100103.PMCID: PMC1413827 Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence Hemantha Kulesekara, Vincent Lee, Anja Brencic, Nicole Liberati, Jonathan Urbach, Sachiko Miyata, Daniel G. Lee, Alice N. Neely, Mamoru Hyodo, Yoshihiro Hayakawa, Frederick M. Ausubel, and Stephen Lory Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2839–2844. Published online 2006 February 13. doi: 10.1073/pnas.0511090103.PMCID: PMC1413825 Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control H. Chen, G. J. D. Smith, K. S. Li, J. Wang, X. H. Fan, J. M. Rayner, D. Vijaykrishna, J. X. Zhang, L. J. Zhang, C. T. Guo, C. L. Cheung, K. M. Xu, L. Duan, K. Huang, K. Qin, Y. H. C. Leung, W. L. Wu, H. R. Lu, Y. Chen, N. S. Xia, T. S. P. Naipospos, K. Y. Yuen, S. S. Hassan, S. Bahri, T. D. Nguyen, R. G. Webster, J. S. M. Peiris, and Y. Guan Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2845–2850. Published online 2006 February 10. doi: 10.1073/pnas.0511120103.PMCID: PMC1413830 Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity Robert B. Abramovitch, Radmila Janjusevic, C. Erec Stebbins, and Gregory B. Martin Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2851–2856. Published online 2006 February 13. doi: 10.1073/pnas.0507892103.PMCID: PMC1413779 A pneumococcal pilus influences virulence and host inflammatory responses M. A. Barocchi, J. Ries, X. Zogaj, C. Hemsley, B. Albiger, A. Kanth, S. Dahlberg, J. Fernebro, M. Moschioni, V. Masignani, K. Hultenby, A. R. Taddei, K. Beiter, F. Wartha, A. von Euler, A. Covacci, D. W. Holden, S. Normark, R. Rappuoli, and B. Henriques-Normark Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2857–2862. Published online 2006 February 15. doi: 10.1073/pnas.0511017103.PMCID: PMC1368962 An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection Christina Nilsson, Anna Skoglund, Anthony P. Moran, Heidi Annuk, Lars Engstrand, and Staffan Normark Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2863–2868. Published online 2006 February 13. doi: 10.1073/pnas.0511119103.PMCID: PMC1413829 Variable host–pathogen compatibility in Mycobacterium tuberculosis Sebastien Gagneux, Kathryn DeRiemer, Tran Van, Midori Kato-Maeda, Bouke C. de Jong, Sujatha Narayanan, Mark Nicol, Stefan Niemann, Kristin Kremer, M. Cristina Gutierrez, Markus Hilty, Philip C. Hopewell, and Peter M. Small Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2869–2873. Published online 2006 February 13. doi: 10.1073/pnas.0511240103.PMCID: PMC1413851 Neuroscience Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype Cecile Martinat, Jean-Jacques Bacci, Thomas Leete, Jongpil Kim, William B. Vanti, Amy H. Newman, Joo H. Cha, Ulrik Gether, Honggang Wang, and Asa Abeliovich Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2874–2879. Published online 2006 February 13. doi: 10.1073/pnas.0511153103.PMCID: PMC1413837 Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway Jianyuan Sun, Peter Bronk, Xinran Liu, Weiping Han, and Thomas C. Südhof Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2880–2885. Published online 2006 February 15. doi: 10.1073/pnas.0511300103.PMCID: PMC1413856 A voltage-driven switch for ion-independent signaling by ether-à-go-go K+ channels Andrew P. Hegle, Daniel D. Marble, and Gisela F. Wilson Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2886–2891. Published online 2006 February 13. doi: 10.1073/pnas.0505909103.PMCID: PMC1413768 From the Cover: NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation Giuseppina Amadoro, Maria Teresa Ciotti, Marco Costanzi, Vincenzo Cestari, Pietro Calissano, and Nadia Canu Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2892–2897. Published online 2006 February 13. doi: 10.1073/pnas.0511065103.PMCID: PMC1413822 Frequency selectivity of synaptic exocytosis in frog saccular hair cells Mark A. Rutherford and William M. Roberts Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2898–2903. Published online 2006 February 10. doi: 10.1073/pnas.0511005103.PMCID: PMC1413814 Ceramide mediates the rapid phase of febrile response to IL-1β Manuel Sanchez-Alavez, Iustin V. Tabarean, M. Margarita Behrens, and Tamas Bartfai Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2904–2908. Published online 2006 February 13. doi: 10.1073/pnas.0510960103.PMCID: PMC1413811 Partial tuning of motor cortex neurons to final posture in a free-moving paradigm Tyson N. Aflalo and Michael S. A. Graziano Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2909–2914. Published online 2006 February 10. doi: 10.1073/pnas.0511139103.PMCID: PMC1413833 Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission John D. Slonimsky, Mark D. Mattaliano, Jung-il Moon, Leslie C. Griffith, and Susan J. Birren Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2915–2919. Published online 2006 February 13. doi: 10.1073/pnas.0511276103.PMCID: PMC1413855 Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells Maria Carmen Inda, Javier DeFelipe, and Alberto Muñoz Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2920–2925. Published online 2006 February 10. doi: 10.1073/pnas.0511197103.PMCID: PMC1413846 CSPα-deficiency causes massive and rapid photoreceptor degeneration Frank Schmitz, Lucia Tabares, Darina Khimich, Nicola Strenzke, Pedro de la Villa-Polo, Manuel Castellano-Muñoz, Anna Bulankina, Tobias Moser, Rafael Fernández-Chacón, and Thomas C. Südhof Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2926–2931. Published online 2006 February 13. doi: 10.1073/pnas.0510060103.PMCID: PMC1413794 Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference Emmanuel Valjent, Anne-Gaëlle Corbillé, Jesus Bertran-Gonzalez, Denis Hervé, and Jean-Antoine Girault Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2932–2937. Published online 2006 February 10. doi: 10.1073/pnas.0511030103.PMCID: PMC1413817 κ opioids selectively control dopaminergic neurons projecting to the prefrontal cortex Elyssa B. Margolis, Hagar Lock, Vladimir I. Chefer, Toni S. Shippenberg, Gregory O. Hjelmstad, and Howard L. Fields Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2938–2942. Published online 2006 February 13. doi: 10.1073/pnas.0511159103.PMCID: PMC1413839 Effects of cyclothiazide on GluR1/AMPA receptors Sergio Fucile, Ricardo Miledi, and Fabrizio Eusebi Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2943–2947. Published online 2006 February 10. doi: 10.1073/pnas.0511063103.PMCID: PMC1413821 Posterior α activity is not phase-reset by visual stimuli Ali Mazaheri and Ole Jensen Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2948–2952. Published online 2006 February 10. doi: 10.1073/pnas.0505785103.PMCID: PMC1413767 Pharmacology MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics Christopher N. Davis, Enrique Mann, M. Margarita Behrens, Svetlana Gaidarova, Mitra Rebek, Julius Rebek, Jr., and Tamas Bartfai Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2953–2958. Published online 2006 February 13. doi: 10.1073/pnas.0510802103.PMCID: PMC1413805 Physiology Role of estrogen receptor β in colonic epithelium Osamu Wada-Hiraike, Otabek Imamov, Haruko Hiraike, Kjell Hultenby, Thomas Schwend, Yoko Omoto, Margaret Warner, and Jan-Åke Gustafsson Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2959–2964. Published online 2006 February 13. doi: 10.1073/pnas.0511271103.PMCID: PMC1413854 Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation Emanuela M. Bruscia, Joanna E. Price, Ee-Chun Cheng, Scott Weiner, Christina Caputo, Elisa C. Ferreira, Marie E. Egan, and Diane S. Krause Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2965–2970. Published online 2006 February 15. doi: 10.1073/pnas.0510758103.PMCID: PMC1413802 Directly observed reversible shape changes and hemoglobin stratification during centrifugation of human and Amphiuma red blood cells Joseph F. Hoffman and Shinya Inoué Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2971–2976. Published online 2006 February 13. doi: 10.1073/pnas.0510884103.PMCID: PMC1413809 From The Cover: Hypoxia-inducible myoglobin expression in nonmuscle tissues Jane Fraser, Luciane Vieira de Mello, Deborah Ward, Huw H. Rees, Daryl R. Williams, Yongchang Fang, Andrew Brass, Andrew Y. Gracey, and Andrew R. Cossins Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2977–2981. Published online 2006 February 9. doi: 10.1073/pnas.0508270103.PMCID: PMC1413783 Depletion “skraps” and dynamic buffering inside the cellular calcium store Bradley S. Launikonis, Jingsong Zhou, Leandro Royer, Thomas R. Shannon, Gustavo Brum, and Eduardo Ríos Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2982–2987. Published online 2006 February 10. doi: 10.1073/pnas.0511252103.PMCID: PMC1413852 Plant Biology A complete ferredoxin/thioredoxin system regulates fundamental processes in amyloplasts Yves Balmer, William H. Vensel, Nick Cai, Wanda Manieri, Peter Schürmann, William J. Hurkman, and Bob B. Buchanan Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2988–2993. Published online 2006 February 15. doi: 10.1073/pnas.0511040103.PMCID: PMC1413819 Vacuolar invertase regulates elongation of Arabidopsis thaliana roots as revealed by QTL and mutant analysis Lidiya I. Sergeeva, Joost J. B. Keurentjes, Leónie Bentsink, Jenneke Vonk, Linus H. W. van der Plas, Maarten Koornneef, and Dick Vreugdenhil Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2994–2999. Published online 2006 February 15. doi: 10.1073/pnas.0511015103.PMCID: PMC1413815 Psychology Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates Karen J. Parker, Christine L. Buckmaster, Karan Sundlass, Alan F. Schatzberg, and David M. Lyons Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3000–3005. Published online 2006 February 10. doi: 10.1073/pnas.0506571103.PMCID: PMC1413772 Corrections Correction for Hal Alper et al., Tuning genetic control through promoter engineering Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3006. Published online 2006 February 2. doi: 10.1073/pnas.0511314103.PMCID: PMC1413857 Corrects: Hal Alper, et al. Tuning genetic control through promoter engineering. Proc Natl Acad Sci U S A. 2005 September 6; 102(36): 12678–12683. Correction for Joseph DeMasi et al., Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3007. Published online 2006 February 8. doi: 10.1073/pnas.0600157103.PMCID: PMC1413858 Corrects: Joseph DeMasi, et al. Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding. Proc Natl Acad Sci U S A. 2005 August 9; 102(32): 11486–11491. Correction for Satoshi Nagata et al., Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3007. Published online 2006 February 8. doi: 10.1073/pnas.0600274103.PMCID: PMC1413859 Corrects: Satoshi Nagata, et al. Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy. Proc Natl Acad Sci U S A. 2005 May 31; 102(22): 7946–7951. Correction for M. Bar et al., Top-down facilitation of visual recognition M. Bar, K.S. Kassam, A.S. Ghuman, J. Boshyan, A.M. Schmid, A.M. Dale, M.S. Hämäläinen, K. Marinkovic, D.L. Schacter, B.R. Rosen, and E. Halgren Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3007. Published online 2006 February 8. doi: 10.1073/pnas.0600325103.PMCID: PMC1413861 Corrects: M. Bar, et al. Top-down facilitation of visual recognition. Proc Natl Acad Sci U S A. 2006 January 10; 103(2): 449–454. |