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Volume 101(22);  June 1, 2004
Commentaries
T4 replication: What does “processivity” really mean?
Catherine M. Joyce
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8255–8256. Published online 2004 May 24. doi: 10.1073/pnas.0402850101.
PMCID: PMC420379
Environmental signatures in proteome properties
Luciano Brocchieri
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8257–8258. Published online 2004 May 24. doi: 10.1073/pnas.0402797101.
PMCID: PMC420380
Biography
Biography of Pietro De Camilli
Liza Bundesen
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8259–8261. Published online 2004 May 24. doi: 10.1073/pnas.0403132101.
PMCID: PMC420381
Physical Sciences
Chemistry
Dynamers: Polyacylhydrazone reversible covalent polymers, component exchange, and constitutional diversity
Williams G. Skene and Jean-Marie P. Lehn
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8270–8275. Published online 2004 May 18. doi: 10.1073/pnas.0401885101.
PMCID: PMC420383
Molecular sorting by stochastic resonance
Damien Alcor, Vincent Croquette, Ludovic Jullien, and Annie Lemarchand
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8276–8280. Published online 2004 May 20. doi: 10.1073/pnas.0400663101.
PMCID: PMC420384
Geology
Magnetic tests for magnetosome chains in Martian meteorite ALH84001
Benjamin P. Weiss, Soon Sam Kim, Joseph L. Kirschvink, Robert E. Kopp, Mohan Sankaran, Atsuko Kobayashi, and Arash Komeili
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8281–8284. Published online 2004 May 20. doi: 10.1073/pnas.0402292101.
PMCID: PMC420385
Biological Sciences
Applied Biological Sciences
Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria
Miro Smriga, Shibani Ghosh, Youssef Mouneimne, Peter L. Pellett, and Nevin S. Scrimshaw
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8285–8288. Published online 2004 May 24. doi: 10.1073/pnas.0402550101.
PMCID: PMC420386
Biochemistry
From the Cover:
The dynamic processivity of the T4 DNA polymerase during replication
Jingsong Yang, Zhihao Zhuang, Rosa Maria Roccasecca, Michael A. Trakselis, and Stephen J. Benkovic
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8289–8294. Published online 2004 May 17. doi: 10.1073/pnas.0402625101.
PMCID: PMC420387
Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis
Nayden Koon, Christopher J. Squire, and Edward N. Baker
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8295–8300. Published online 2004 May 24. doi: 10.1073/pnas.0400820101.
PMCID: PMC420388
Structural basis for the attachment of a paramyxoviral polymerase to its template
Richard L. Kingston, Damon J. Hamel, Leslie S. Gay, Frederick W. Dahlquist, and Brian W. Matthews
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8301–8306. Published online 2004 May 24. doi: 10.1073/pnas.0402690101.
PMCID: PMC420389
Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III
Haihong Wu, Anthony Henras, Guillaume Chanfreau, and Juli Feigon
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8307–8312. Published online 2004 May 18. doi: 10.1073/pnas.0402627101.
PMCID: PMC420390
Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells
Masanari Matsumoto, Takashi Miki, Tadao Shibasaki, Miho Kawaguchi, Hidehiro Shinozaki, Junko Nio, Atsunori Saraya, Haruhiko Koseki, Masaru Miyazaki, Toshihiko Iwanaga, and Susumu Seino
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8313–8318. Published online 2004 May 24. doi: 10.1073/pnas.0306709101.
PMCID: PMC420391
Involvement of Per–Arnt–Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose
Gabriela da Silva Xavier, Jared Rutter, and Guy A. Rutter
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8319–8324. Published online 2004 May 17. doi: 10.1073/pnas.0307737101.
PMCID: PMC420392
A high-affinity interaction between NusA and the rrn nut site in Mycobacterium tuberculosis
Kristine B. Arnvig, S. Pennell, B. Gopal, and M. J. Colston
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8325–8330. Published online 2004 May 24. doi: 10.1073/pnas.0401287101.
PMCID: PMC420393
Biophysics
From the Cover:
Structure of membrane-bound α-synuclein studied by site-directed spin labeling
Christine C. Jao, Ani Der-Sarkissian, Jeannie Chen, and Ralf Langen
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8331–8336. Published online 2004 May 20. doi: 10.1073/pnas.0400553101.
PMCID: PMC420394
Predicting indirect readout effects in protein–DNA interactions
Yongli Zhang, Zhiqun Xi, Rashmi S. Hegde, Zippora Shakked, and Donald M. Crothers
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8337–8341. Published online 2004 May 17. doi: 10.1073/pnas.0402319101.
PMCID: PMC420395
Evidence for assembly of prions with left-handed β-helices into trimers
Cédric Govaerts, Holger Wille, Stanley B. Prusiner, and Fred E. Cohen
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8342–8347. Published online 2004 May 21. doi: 10.1073/pnas.0402254101.
PMCID: PMC420396
3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
Beili Wu, Pengyun Li, Yiwei Liu, Zhiyong Lou, Yi Ding, Cuiling Shu, Sheng Ye, Mark Bartlam, Beifen Shen, and Zihe Rao
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8348–8353. Published online 2004 May 24. doi: 10.1073/pnas.0305969101.
PMCID: PMC420397
Simulation, experiment, and evolution: Understanding nucleation in protein S6 folding
Isaac A. Hubner, Mikael Oliveberg, and Eugene I. Shakhnovich
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8354–8359. Published online 2004 May 18. doi: 10.1073/pnas.0401672101.
PMCID: PMC420398
Cell Biology
Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals
Markus R. Wenk and Pietro De Camilli
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8262–8269. Published online 2004 May 14. doi: 10.1073/pnas.0401874101.
PMCID: PMC420382
Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes
Hélène Strick-Marchand, Serban Morosan, Pierre Charneau, Dina Kremsdorf, and Mary C. Weiss
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8360–8365. Published online 2004 May 20. doi: 10.1073/pnas.0401092101.
PMCID: PMC420399
XLαs, the extra-long form of the α-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex
Joel Abramowitz, Dagoberto Grenet, Mariel Birnbaumer, Hector N. Torres, and Lutz Birnbaumer
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8366–8371. Published online 2004 May 17. doi: 10.1073/pnas.0308758101.
PMCID: PMC420400
Trafficking of ODV-E66 is mediated via a sorting motif and other viral proteins: Facilitated trafficking to the inner nuclear membrane
Sharon C. Braunagel, Shawn T. Williamson, Suraj Saksena, Zhenping Zhong, William K. Russell, David H. Russell, and Max D. Summers
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8372–8377. Published online 2004 May 18. doi: 10.1073/pnas.0402727101.
PMCID: PMC420401
Developmental Biology
phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development
Haiwei Pi, Shao-Kuei Huang, Chiou-Yang Tang, Y. Henry Sun, and Cheng-Ting Chien
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8378–8383. Published online 2004 May 17. doi: 10.1073/pnas.0306010101.
PMCID: PMC420402
Molecular diversity of astrocytes with implications for neurological disorders
Robert M. Bachoo, Ryung S. Kim, Keith L. Ligon, Elizabeth A. Maher, Cameron Brennan, Nathan Billings, Suzanne Chan, Cheng Li, David H. Rowitch, Wing H. Wong, and Ronald A. DePinho
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8384–8389. Published online 2004 May 21. doi: 10.1073/pnas.0402140101.
PMCID: PMC420403
Evolution
From the Cover:
Global analysis of predicted proteomes: Functional adaptation of physical properties
Christopher G. Knight, Rees Kassen, Holger Hebestreit, and Paul B. Rainey
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8390–8395. Published online 2004 May 18. doi: 10.1073/pnas.0307270101.
PMCID: PMC420404
The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus
Rafael Sanjuán, Andrés Moya, and Santiago F. Elena
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8396–8401. Published online 2004 May 24. doi: 10.1073/pnas.0400146101.
PMCID: PMC420405
Genetics
Deletion of the Parkin coregulated gene causes male sterility in the quakingviable mouse mutant
Diego Lorenzetti, Colin E. Bishop, and Monica J. Justice
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8402–8407. Published online 2004 May 17. doi: 10.1073/pnas.0401832101.
PMCID: PMC420406
From the Cover:
Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales
Jessica M. Girard, David M. Wagner, Amy J. Vogler, Christine Keys, Christopher J. Allender, Lee C. Drickamer, and Paul Keim
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8408–8413. Published online 2004 May 20. doi: 10.1073/pnas.0401561101.
PMCID: PMC420407
Programmable cells: Interfacing natural and engineered gene networks
Hideki Kobayashi, Mads Kærn, Michihiro Araki, Kristy Chung, Timothy S. Gardner, Charles R. Cantor, and James J. Collins
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8414–8419. Published online 2004 May 24. doi: 10.1073/pnas.0402940101.
PMCID: PMC420408
Immunology
Cytokine detection by antibody-based proximity ligation
Mats Gullberg, Sigrún M. Gústafsdóttir, Edith Schallmeiner, Jonas Jarvius, Mattias Bjarnegård, Christer Betsholtz, Ulf Landegren, and Simon Fredriksson
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8420–8424. Published online 2004 May 21. doi: 10.1073/pnas.0400552101.
PMCID: PMC420409
Medical Sciences
Deletion of macrophage-inflammatory protein 1α retards neurodegeneration in Sandhoff disease mice
Yun-Ping Wu and Richard L. Proia
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8425–8430. Published online 2004 May 20. doi: 10.1073/pnas.0400625101.
PMCID: PMC420410
Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes
Jennifer Pittman, Erich Huang, Holly Dressman, Cheng-Fang Horng, Skye H. Cheng, Mei-Hua Tsou, Chii-Ming Chen, Andrea Bild, Edwin S. Iversen, Andrew T. Huang, Joseph R. Nevins, and Mike West
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8431–8436. Published online 2004 May 19. doi: 10.1073/pnas.0401736101.
PMCID: PMC420411
Nuclear receptor corepressor RIP140 regulates fat accumulation
Göran Leonardsson, Jenny H. Steel, Mark Christian, Victoria Pocock, Stuart Milligan, Jimmy Bell, Po-Wah So, Gema Medina-Gomez, Antonio Vidal-Puig, Roger White, and Malcolm G. Parker
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8437–8442. Published online 2004 May 20. doi: 10.1073/pnas.0401013101.
PMCID: PMC420412
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice
Shinobu Tsuzuki, Masao Seto, Mel Greaves, and Tariq Enver
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8443–8448. Published online 2004 May 20. doi: 10.1073/pnas.0402063101.
PMCID: PMC420413
Microbiology
Magnetic tests for magnetosome chains in Martian meteorite ALH84001
Benjamin P. Weiss, Soon Sam Kim, Joseph L. Kirschvink, Robert E. Kopp, Mohan Sankaran, Atsuko Kobayashi, and Arash Komeili
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8281–8284. Published online 2004 May 20. doi: 10.1073/pnas.0402292101.
PMCID: PMC420385
Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax
Alex R. Hoffmaster, Jacques Ravel, David A. Rasko, Gail D. Chapman, Michael D. Chute, Chung K. Marston, Barun K. De, Claudio T. Sacchi, Collette Fitzgerald, Leonard W. Mayer, Martin C. J. Maiden, Fergus G. Priest, Margaret Barker, Lingxia Jiang, Regina Z. Cer, Jennifer Rilstone, Scott N. Peterson, Robbin S. Weyant, Darrell R. Galloway, Timothy D. Read, Tanja Popovic, and Claire M. Fraser
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8449–8454. Published online 2004 May 21. doi: 10.1073/pnas.0402414101.
PMCID: PMC420414
Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides
Berend Jan Bosch, Byron E. E. Martina, Ruurd van der Zee, Jean Lepault, Bert Jan Haijema, Cees Versluis, Albert J. R. Heck, Raoul de Groot, Albert D. M. E. Osterhaus, and Peter J. M. Rottier
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8455–8460. Published online 2004 May 18. doi: 10.1073/pnas.0400576101.
PMCID: PMC420415
Neuroscience
Functional photoreceptor loss revealed with adaptive optics: An alternate cause of color blindness
Joseph Carroll, Maureen Neitz, Heidi Hofer, Jay Neitz, and David R. Williams
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8461–8466. Published online 2004 May 17. doi: 10.1073/pnas.0401440101.
PMCID: PMC420416
NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex
Mark E. Jackson, Houman Homayoun, and Bita Moghaddam
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8467–8472. Published online 2004 May 24. doi: 10.1073/pnas.0308455101.
PMCID: PMC420417
Voluntary exercise increases axonal regeneration from sensory neurons
Raffaella Molteni, Jun-Qi Zheng, Zhe Ying, Fernando Gómez-Pinilla, and Jeffery L. Twiss
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8473–8478. Published online 2004 May 24. doi: 10.1073/pnas.0401443101.
PMCID: PMC420418
Completion of neuronal migration regulated by loss of Ca2+ transients
Tatsuro Kumada and Hitoshi Komuro
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8479–8484. Published online 2004 May 18. doi: 10.1073/pnas.0401000101.
PMCID: PMC420419
Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype
Guochuan Tsai, Rebecca J. Ralph-Williams, Marzia Martina, Richard Bergeron, Joanne Berger-Sweeney, Kevin S. Dunham, Zhichun Jiang, S. Barak Caine, and Joseph T. Coyle
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8485–8490. Published online 2004 May 24. doi: 10.1073/pnas.0402662101.
PMCID: PMC420420
From the Cover:
Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
Pranab K. Mukherjee, Victor L. Marcheselli, Charles N. Serhan, and Nicolas G. Bazan
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8491–8496. Published online 2004 May 19. doi: 10.1073/pnas.0402531101.
PMCID: PMC420421
Pharmacology
Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties
Ennio Ongini, Francesco Impagnatiello, Albino Bonazzi, Massimiliano Guzzetta, Mirco Govoni, Angela Monopoli, Piero Del Soldato, and Louis J. Ignarro
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8497–8502. doi: 10.1073/pnas.0401996101.
PMCID: PMC420422
Physiology
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation
Pauline M. Anton, Jerome Gay, Andreas Mykoniatis, Amy Pan, Michael O'Brien, Daniel Brown, Katia Karalis, and Charalabos Pothoulakis
Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8503–8508. Published online 2004 May 24. doi: 10.1073/pnas.0402693101.
PMCID: PMC420423
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