| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17253–17254. doi: 10.1073/iti4805102.PMCID: PMC1297702 Commentary Transgenic rice for allergy immunotherapy Shengwu Ma and Anthony M. Jevnikar Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17255–17256. Published online 2005 November 21. doi: 10.1073/pnas.0509018102.PMCID: PMC1297701 Physical Sciences Chemistry Charting biologically relevant chemical space: A structural classification of natural products (SCONP) Marcus A. Koch, Ansgar Schuffenhauer, Michael Scheck, Stefan Wetzel, Marco Casaulta, Alex Odermatt, Peter Ertl, and Herbert Waldmann Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17272–17277. Published online 2005 November 21. doi: 10.1073/pnas.0503647102.PMCID: PMC1297657 Light-switching excimer probes for rapid protein monitoring in complex biological fluids Chaoyong James Yang, Steffen Jockusch, Marie Vicens, Nicholas J. Turro, and Weihong Tan Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17278–17283. Published online 2005 November 21. doi: 10.1073/pnas.0508821102.PMCID: PMC1297691 Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure Adam M. Hawkridge, Denise M. Heublein, H. Robert Bergen, III, Alessandro Cataliotti, John C. Burnett, Jr., and David C. Muddiman Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17442–17447. Published online 2005 November 17. doi: 10.1073/pnas.0508782102.PMCID: PMC1297688 Geophysics INAUGURAL ARTICLE by a Recently Elected Academy Member: Deep mantle structure and the postperovskite phase transition D. Helmberger, T. Lay, S. Ni, and M. Gurnis Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17257–17263. Published online 2005 October 10. doi: 10.1073/pnas.0502504102.PMCID: PMC1297654 Physics Cooperative cargo transport by several molecular motors Stefan Klumpp and Reinhard Lipowsky Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17284–17289. Published online 2005 November 15. doi: 10.1073/pnas.0507363102.PMCID: PMC1283533 Biological Sciences Agricultural Sciences Glyphosate inhibits rust diseases in glyphosate-resistant wheat and soybean Paul C. C. Feng, G. James Baley, William P. Clinton, Greg J. Bunkers, Murtaza F. Alibhai, Timothy C. Paulitz, and Kimberlee K. Kidwell Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17290–17295. Published online 2005 November 17. doi: 10.1073/pnas.0508873102.PMCID: PMC1297694 Applied Biological Sciences A data integration methodology for systems biology Daehee Hwang, Alistair G. Rust, Stephen Ramsey, Jennifer J. Smith, Deena M. Leslie, Andrea D. Weston, Pedro de Atauri, John D. Aitchison, Leroy Hood, Andrew F. Siegel, and Hamid Bolouri Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17296–17301. Published online 2005 November 21. doi: 10.1073/pnas.0508647102.PMCID: PMC1297682 A data integration methodology for systems biology: Experimental verification Daehee Hwang, Jennifer J. Smith, Deena M. Leslie, Andrea D. Weston, Alistair G. Rust, Stephen Ramsey, Pedro de Atauri, Andrew F. Siegel, Hamid Bolouri, John D. Aitchison, and Leroy Hood Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17302–17307. Published online 2005 November 21. doi: 10.1073/pnas.0508649102.PMCID: PMC1297683 Biochemistry From the Cover: Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75 Peter Cherepanov, Andre L. B. Ambrosio, Shaila Rahman, Tom Ellenberger, and Alan Engelman Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17308–17313. Published online 2005 October 31. doi: 10.1073/pnas.0506924102.PMCID: PMC1297672 Fcp1 directly recognizes the C-terminal domain (CTD) and interacts with a site on RNA polymerase II distinct from the CTD Man-Hee Suh, Ping Ye, Mincheng Zhang, Stéphane Hausmann, Stewart Shuman, Averell L. Gnatt, and Jianhua Fu Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17314–17319. Published online 2005 November 21. doi: 10.1073/pnas.0507987102.PMCID: PMC1297677 Structure of a nonheme globin in environmental stress signaling James W. Murray, Olivier Delumeau, and Richard J. Lewis Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17320–17325. Published online 2005 November 21. doi: 10.1073/pnas.0506599102.PMCID: PMC1297668 Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae Mohammed A. S. Khan, P. Boon Chock, and Earl R. Stadtman Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17326–17331. Published online 2005 November 21. doi: 10.1073/pnas.0508120102.PMCID: PMC1287485 Cell-free cloning using 29 DNA polymerase Clyde A. Hutchison, III, Hamilton O. Smith, Cynthia Pfannkoch, and J. Craig Venter Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17332–17336. Published online 2005 November 14. doi: 10.1073/pnas.0508809102.PMCID: PMC1283157 Oxygen isotopes indicate most intracellular water in log-phase Escherichia coli is derived from metabolism Helen W. Kreuzer-Martin, James R. Ehleringer, and Eric L. Hegg Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17337–17341. Published online 2005 November 21. doi: 10.1073/pnas.0506531102.PMCID: PMC1297667 Biophysics 3D structure of Alzheimer's amyloid-β(1–42) fibrils Thorsten Lührs, Christiane Ritter, Marc Adrian, Dominique Riek-Loher, Bernd Bohrmann, Heinz Döbeli, David Schubert, and Roland Riek Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17342–17347. Published online 2005 November 17. doi: 10.1073/pnas.0506723102.PMCID: PMC1297669 Probing structural heterogeneities and fluctuations of nucleic acids and denatured proteins Ted A. Laurence, Xiangxu Kong, Marcus Jäger, and Shimon Weiss Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17348–17353. Published online 2005 November 15. doi: 10.1073/pnas.0508584102.PMCID: PMC1297681 An allosteric model for heterogeneous receptor complexes: Understanding bacterial chemotaxis responses to multiple stimuli Bernardo A. Mello and Yuhai Tu Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17354–17359. Published online 2005 November 17. doi: 10.1073/pnas.0506961102.PMCID: PMC1297673 Cell Biology Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes Alla Grishok and Phillip A. Sharp Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17360–17365. Published online 2005 November 15. doi: 10.1073/pnas.0508989102.PMCID: PMC1297700 The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8 Haitong Hou, Kanagaraj Subramanian, Tracy J. LaGrassa, Daniel Markgraf, Lars E. P. Dietrich, Jörg Urban, Nadine Decker, and Christian Ungermann Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17366–17371. Published online 2005 November 21. doi: 10.1073/pnas.0508885102.PMCID: PMC1297695 Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins Karl B. Shpargel and A. Gregory Matera Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17372–17377. Published online 2005 November 21. doi: 10.1073/pnas.0508947102.PMCID: PMC1297697 Developmental Biology β-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells Weijun Pan, Yingying Jia, Jiyong Wang, Donglei Tao, Xiaoqing Gan, Leonidas Tsiokas, Naihe Jing, Dianqing Wu, and Lin Li Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17378–17383. Published online 2005 November 21. doi: 10.1073/pnas.0505922102.PMCID: PMC1297664 Environmental Sciences Climatic unpredictability and parasitism of caterpillars: Implications of global warming J. O. Stireman, III, L. A. Dyer, D. H. Janzen, M. S. Singer, J. T. Lill, R. J. Marquis, R. E. Ricklefs, G. L. Gentry, W. Hallwachs, P. D. Coley, J. A. Barone, H. F. Greeney, H. Connahs, P. Barbosa, H. C. Morais, and I. R. Diniz Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17384–17387. Published online 2005 November 17. doi: 10.1073/pnas.0508839102.PMCID: PMC1283988 Evolution “Clonal” population structure of the malaria agent Plasmodium falciparum in high-infection regions F. G. Razakandrainibe, P. Durand, J. C. Koella, T. De Meeüs, F. Rousset, F. J. Ayala, and F. Renaud Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17388–17393. Published online 2005 November 21. doi: 10.1073/pnas.0508871102.PMCID: PMC1297693 Coevolution of generalist feeding ecologies and gyrencephalic mushroom bodies in insects Sarah M. Farris and Nathan S. Roberts Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17394–17399. Published online 2005 November 17. doi: 10.1073/pnas.0508430102.PMCID: PMC1297680 Genetics Identifying the conserved network of cis-regulatory sites of a eukaryotic genome Ting Wang and Gary D. Stormo Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17400–17405. Published online 2005 November 21. doi: 10.1073/pnas.0505147102.PMCID: PMC1297658 Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice Philippe Clément-Lacroix, Minrong Ai, Frederic Morvan, Sergio Roman-Roman, Béatrice Vayssière, Cecille Belleville, Kenneth Estrera, Matthew L. Warman, Roland Baron, and Georges Rawadi Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17406–17411. Published online 2005 November 17. doi: 10.1073/pnas.0505259102.PMCID: PMC1297659 Immunology Visualization of a primary anti-tumor immune response by positron emission tomography Chengyi J. Shu, Shuling Guo, Young J. Kim, Stephanie M. Shelly, Amar Nijagal, Pritha Ray, Sanjiv S. Gambhir, Caius G. Radu, and Owen N. Witte Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17412–17417. Published online 2005 November 17. doi: 10.1073/pnas.0508698102.PMCID: PMC1283986 CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity Leigh A. Stephens, David Gray, and Stephen M. Anderton Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17418–17423. Published online 2005 November 15. doi: 10.1073/pnas.0507454102.PMCID: PMC1297676 Medical Sciences The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues Alexandre Havt, Andrew V. Schally, Gabor Halmos, Jozsef L. Varga, Gabor L. Toller, Judit E. Horvath, Karoly Szepeshazi, Frank Köster, Kevin Kovitz, Kate Groot, Marta Zarandi, and Celia A. Kanashiro Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17424–17429. Published online 2005 November 18. doi: 10.1073/pnas.0506844102.PMCID: PMC1297670 Self renewal, expansion, and transfection of rat spermatogonial stem cells in culture F. Kent Hamra, Karen M. Chapman, Derek M. Nguyen, Ashley A. Williams-Stephens, Robert E. Hammer, and David L. Garbers Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17430–17435. Published online 2005 November 17. doi: 10.1073/pnas.0508780102.PMCID: PMC1283987 Transformation of breast cells by truncated neurokinin-1 receptor is secondary to activation by preprotachykinin-A peptides Hiral J. Patel, Shakti H. Ramkissoon, Prem S. Patel, and Pranela Rameshwar Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17436–17441. Published online 2005 November 16. doi: 10.1073/pnas.0506351102.PMCID: PMC1297665 Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure Adam M. Hawkridge, Denise M. Heublein, H. Robert Bergen, III, Alessandro Cataliotti, John C. Burnett, Jr., and David C. Muddiman Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17442–17447. Published online 2005 November 17. doi: 10.1073/pnas.0508782102.PMCID: PMC1297688 Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors Katerina V. Gurova, Jason E. Hill, Canhui Guo, Anatoly Prokvolit, Lyudmila G. Burdelya, Eugenia Samoylova, Anna V. Khodyakova, Ram Ganapathi, Mahrukh Ganapathi, Natalia D. Tararova, Dmitry Bosykh, Dmitriy Lvovskiy, Thomas R. Webb, George R. Stark, and Andrei V. Gudkov Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17448–17453. Published online 2005 November 15. doi: 10.1073/pnas.0508888102.PMCID: PMC1297696 Microbiology Transcriptome profiling of bacterial responses to root exudates identifies genes involved in microbe-plant interactions G. Louise Mark, J. Maxwell Dow, Patrick D. Kiely, Hazel Higgins, Jill Haynes, Christine Baysse, Abdelhamid Abbas, Tara Foley, Ashley Franks, John Morrissey, and Fergal O'Gara Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17454–17459. Published online 2005 November 21. doi: 10.1073/pnas.0506407102.PMCID: PMC1297666 Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid Brian K. Coombes, Mark E. Wickham, Michael J. Lowden, Nat F. Brown, and B. Brett Finlay Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17460–17465. Published online 2005 November 21. doi: 10.1073/pnas.0505401102.PMCID: PMC1297660 Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2 Adnan Hasona, Paula J. Crowley, Celine M. Levesque, Richard W. Mair, Dennis G. Cvitkovitch, Arnold S. Bleiweis, and L. Jeannine Brady Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17466–17471. Published online 2005 November 17. doi: 10.1073/pnas.0508778102.PMCID: PMC1297686 The genome sequence of Clostridium botulinum type C neurotoxin-converting phage and the molecular mechanisms of unstable lysogeny Yoshihiko Sakaguchi, Tetsuya Hayashi, Ken Kurokawa, Keisuke Nakayama, Kenshiro Oshima, Yukako Fujinaga, Makoto Ohnishi, Eiichi Ohtsubo, Masahira Hattori, and Keiji Oguma Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17472–17477. Published online 2005 November 15. doi: 10.1073/pnas.0505503102.PMCID: PMC1283531 Neuroscience Experience induces structural and biochemical changes in the adult primate brain Yevgenia Kozorovitskiy, Charles G. Gross, Catherine Kopil, Lisa Battaglia, Meghan McBreen, Alexis M. Stranahan, and Elizabeth Gould Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17478–17482. Published online 2005 November 18. doi: 10.1073/pnas.0508817102.PMCID: PMC1297690 Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor Ana Ledo, Rui M. Barbosa, Greg A. Gerhardt, Enrique Cadenas, and João Laranjinha Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17483–17488. Published online 2005 November 17. doi: 10.1073/pnas.0503624102.PMCID: PMC1297656 From the Cover: Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299 Chad J. Swanson, Thomas P. Blackburn, Xuexiang Zhang, Kang Zheng, Zhi-Qing David Xu, Tomas Hökfelt, Toni D. Wolinsky, Michael J. Konkel, Heidi Chen, Huailing Zhong, Mary W. Walker, Douglas A. Craig, Christophe P. G. Gerald, and Theresa A. Branchek Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17489–17494. Published online 2005 November 15. doi: 10.1073/pnas.0508970102.PMCID: PMC1283534 Pharmacology From the Cover: Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation Wen Guo, Lei Shi, Marta Filizola, Harel Weinstein, and Jonathan A. Javitch Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17495–17500. Published online 2005 November 21. doi: 10.1073/pnas.0508950102.PMCID: PMC1287488 Leukotriene B4 signaling through NF-κB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia Magnus Bäck, De-xiu Bu, Robert Bränström, Yuri Sheikine, Zhong-Qun Yan, and Göran K. Hansson Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17501–17506. Published online 2005 November 17. doi: 10.1073/pnas.0505845102.PMCID: PMC1297663 Physiology The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption Bram C. J. van der Eerden, Joost G. J. Hoenderop, Teun J. de Vries, Ton Schoenmaker, Cok J. Buurman, André G. Uitterlinden, Huibert A. P. Pols, René J. M. Bindels, and Johannes P. T. M. van Leeuwen Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17507–17512. Published online 2005 November 16. doi: 10.1073/pnas.0505789102.PMCID: PMC1297662 Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation Celso Caruso-Neves, Sang-Ho Kwon, and William B. Guggino Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17513–17518. Published online 2005 November 17. doi: 10.1073/pnas.0507255102.PMCID: PMC1297674 Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction Gang Zhi, Jeffrey W. Ryder, Jian Huang, Peiguo Ding, Yue Chen, Yingming Zhao, Kristine E. Kamm, and James T. Stull Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17519–17524. Published online 2005 November 18. doi: 10.1073/pnas.0506846102.PMCID: PMC1297671 Plant Biology From the Cover: A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses Hidenori Takagi, Takachika Hiroi, Lijun Yang, Yoshifumi Tada, Yoshikazu Yuki, Kaoru Takamura, Ryotaro Ishimitsu, Hideyuki Kawauchi, Hiroshi Kiyono, and Fumio Takaiwa Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17525–17530. Published online 2005 November 8. doi: 10.1073/pnas.0503428102.PMCID: PMC1297655 MINISEED3 (MINI3), a WRKY family gene, and HAIKU2 (IKU2), a leucine-rich repeat (LRR) KINASE gene, are regulators of seed size in Arabidopsis Ming Luo, Elizabeth S. Dennis, Frederic Berger, William James Peacock, and Abed Chaudhury Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17531–17536. Published online 2005 November 17. doi: 10.1073/pnas.0508418102.PMCID: PMC1297679 Social Sciences Anthropology From the Cover: INAUGURAL ARTICLE by a Recently Elected Academy Member: Burning down the brewery: Establishing and evacuating an ancient imperial colony at Cerro Baúl, Peru Michael E. Moseley, Donna J. Nash, Patrick Ryan Williams, Susan D. deFrance, Ana Miranda, and Mario Ruales Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17264–17271. Published online 2005 November 17. doi: 10.1073/pnas.0508673102.PMCID: PMC1297684 |