| | This journal provides immediate access to some articles. Commentaries Closing the gaps in kinetoplast DNA network replication Michele M. Klingbeil and Paul T. Englund Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4333–4334. Published online 2004 March 22. doi: 10.1073/pnas.0401400101.PMCID: PMC384744 Unzipping the mysteries of amyloid fiber formation Andrew D. Miranker Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4335–4336. Published online 2004 March 22. doi: 10.1073/pnas.0401163101.PMCID: PMC384745 Extending molecular modeling methodology to study insertion of membrane nanopores Aleksij Aksimentiev and Klaus Schulten Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4337–4338. Published online 2004 March 22. doi: 10.1073/pnas.0400739101.PMCID: PMC384746 Unraveling the mystery of Nod factor signaling by a genomic approach in Medicago trunactula Douglas R. Cook Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4339–4340. Published online 2004 March 22. doi: 10.1073/pnas.0400961101.PMCID: PMC384747 Physical Sciences Applied Mathematics Response of complex networks to stimuli Yaneer Bar-Yam and Irving R. Epstein Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4341–4345. Published online 2004 March 18. doi: 10.1073/pnas.0400673101.PMCID: PMC384748 Chemistry The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: A potent sodium-channel blocker Mari Yotsu-Yamashita, Yong H. Kim, Samuel C. Dudley, Jr., Gaurav Choudhary, Arnold Pfahnl, Yasukatsu Oshima, and John W. Daly Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4346–4351. Published online 2004 March 22. doi: 10.1073/pnas.0400368101.PMCID: PMC384749 Mathematics The strong Nagata conjecture Ualbai U. Umirbaev and Jie-Tai Yu Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4352–4355. Published online 2004 March 16. doi: 10.1073/pnas.0308157101.PMCID: PMC384750 Biological Sciences Anthropology Morphometrics and hominoid phylogeny: Support for a chimpanzee–human clade and differentiation among great ape subspecies Charles A. Lockwood, William H. Kimbel, and John M. Lynch Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4356–4360. Published online 2004 March 22. doi: 10.1073/pnas.0306235101.PMCID: PMC384751 Biochemistry From the Cover: Mitochondrial DNA ligase in Crithidia fasciculata Krishna Murari Sinha, Jane C. Hines, Nicholas Downey, and Dan S. Ray Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4361–4366. Published online 2004 March 2. doi: 10.1073/pnas.0305705101.PMCID: PMC384752 Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin Victor F. Lundin, Peter C. Stirling, Juan Gomez-Reino, Jill C. Mwenifumbo, Jennifer M. Obst, José M. Valpuesta, and Michel R. Leroux Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4367–4372. Published online 2004 March 19. doi: 10.1073/pnas.0306276101.PMCID: PMC384753 The arginine finger of bacteriophage T7 gene 4 helicase: Role in energy coupling Donald J. Crampton, Shenyuan Guo, Donald E. Johnson, and Charles C. Richardson Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4373–4378. doi: 10.1073/pnas.0400968101.PMCID: PMC384754 Purification and architecture of the ubiquitous Wave complex Alexis Gautreau, Hsin-yi H. Ho, Jiaxu Li, Hanno Steen, Steven P. Gygi, and Marc W. Kirschner Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4379–4383. Published online 2004 March 19. doi: 10.1073/pnas.0400628101.PMCID: PMC384755 Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum Puran S. Sijwali and Philip J. Rosenthal Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4384–4389. Published online 2004 March 15. doi: 10.1073/pnas.0307720101.PMCID: PMC384756 Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin Wei Lu, Markus Oberthür, Catherine Leimkuhler, Junhua Tao, Daniel Kahne, and Christopher T. Walsh Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4390–4395. Published online 2004 March 18. doi: 10.1073/pnas.0400277101.PMCID: PMC384757 The role of RNA polymerase σ subunit in promoter-independent initiation of transcription Nikolay Zenkin and Konstantin Severinov Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4396–4400. Published online 2004 March 15. doi: 10.1073/pnas.0400886101.PMCID: PMC384758 Functional association between Wwox tumor suppressor protein and p73, a p53 homolog Rami I. Aqeilan, Yuri Pekarsky, Juan J. Herrero, Alexey Palamarchuk, Jean Letofsky, Teresa Druck, Francesco Trapasso, Shuang-Yin Han, Gerry Melino, Kay Huebner, and Carlo M. Croce Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4401–4406. doi: 10.1073/pnas.0400805101.PMCID: PMC384759 Mammalian GLD-2 homologs are poly(A) polymerases Jae Eun Kwak, Liaoteng Wang, Scott Ballantyne, Judith Kimble, and Marvin Wickens Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4407–4412. doi: 10.1073/pnas.0400779101.PMCID: PMC384760 Isoprenoid biosynthesis in the diatoms Rhizosolenia setigera (Brightwell) and Haslea ostrearia (Simonsen) Guillaume Massé, Simon T. Belt, Steven J. Rowland, and Michel Rohmer Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4413–4418. Published online 2004 March 22. doi: 10.1073/pnas.0400902101.PMCID: PMC384761 M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP Nobumoto Watanabe, Harumi Arai, Yoshifumi Nishihara, Makoto Taniguchi, Naoko Watanabe, Tony Hunter, and Hiroyuki Osada Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4419–4424. Published online 2004 March 22. doi: 10.1073/pnas.0307700101.PMCID: PMC384762 Biophysics The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation Kyung H. Choi, James M. Groarke, Dorothy C. Young, Richard J. Kuhn, Janet L. Smith, Daniel C. Pevear, and Michael G. Rossmann Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4425–4430. Published online 2004 March 19. doi: 10.1073/pnas.0400660101.PMCID: PMC384763 From the Cover: Understanding nature's design for a nanosyringe Carlos F. Lopez, Steve O. Nielsen, Preston B. Moore, and Michael L. Klein Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4431–4434. Published online 2004 March 12. doi: 10.1073/pnas.0400352101.PMCID: PMC384764 Exploring amyloid formation by a de novo design Richard A. Kammerer, Dirk Kostrewa, Jesús Zurdo, Andreas Detken, Carlos García-Echeverría, Janelle D. Green, Shirley A. Müller, Beat H. Meier, Fritz K. Winkler, Christopher M. Dobson, and Michel O. Steinmetz Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4435–4440. Published online 2004 February 26. doi: 10.1073/pnas.0306786101.PMCID: PMC384765 Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity Delphine Bichet, Yu-Fung Lin, Christian A. Ibarra, Cindy Shen Huang, B. Alexander Yi, Yuh Nung Jan, and Lily Yeh Jan Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4441–4446. Published online 2004 March 22. doi: 10.1073/pnas.0401195101.PMCID: PMC384766 Percolation and criticality in a mitochondrial network Miguel A. Aon, Sonia Cortassa, and Brian O'Rourke Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4447–4452. Published online 2004 March 18. doi: 10.1073/pnas.0307156101.PMCID: PMC384767 Cell Biology Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction Manuel Mark, Hiromi Yoshida-Komiya, Martine Gehin, Lan Liao, Ming-Jer Tsai, Bert W. O'Malley, Pierre Chambon, and Jianming Xu Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4453–4458. doi: 10.1073/pnas.0400234101.PMCID: PMC384768 Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells Loren Michel, Elena Diaz-Rodriguez, Gopeshwar Narayan, Eva Hernando, Vundavalli V. V. S. Murty, and Robert Benezra Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4459–4464. Published online 2004 March 15. doi: 10.1073/pnas.0306069101.PMCID: PMC384769 Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107 Taku Chibazakura, Seth G. McGrew, Jonathan A. Cooper, Hirofumi Yoshikawa, and James M. Roberts Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4465–4470. Published online 2004 March 15. doi: 10.1073/pnas.0400655101.PMCID: PMC384770 A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype Andrew J. Syder, Sherif M. Karam, Jason C. Mills, Joseph E. Ippolito, Habib R. Ansari, Vidya Farook, and Jeffrey I. Gordon Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4471–4476. doi: 10.1073/pnas.0307983101.PMCID: PMC384771 Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair Chang-Goo Huh, Valentina M. Factor, Aránzazu Sánchez, Koichi Uchida, Elizabeth A. Conner, and Snorri S. Thorgeirsson Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4477–4482. doi: 10.1073/pnas.0306068101.PMCID: PMC384772 Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis Sebastian Treusch, Sarah Knuth, Susan A. Slaugenhaupt, Ehud Goldin, Barth D. Grant, and Hanna Fares Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4483–4488. Published online 2004 March 15. doi: 10.1073/pnas.0400709101.PMCID: PMC384773 Developmental Biology Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling Wei Liu, Jennifer Selever, Degang Wang, Mei-Fang Lu, Kelvin A. Moses, Robert J. Schwartz, and James F. Martin Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4489–4494. Published online 2004 March 19. doi: 10.1073/pnas.0308466101.PMCID: PMC384774 Self-renewal capacity is a widespread property of various types of neural crest precursor cells Andréa Trentin, Corinne Glavieux-Pardanaud, Nicole M. Le Douarin, and Elisabeth Dupin Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4495–4500. Published online 2004 March 15. doi: 10.1073/pnas.0400629101.PMCID: PMC384775 Ecology The ecological and evolutionary consequences of sperm chemoattraction Jeffrey A. Riffell, Patrick J. Krug, and Richard K. Zimmer Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4501–4506. Published online 2004 March 22. doi: 10.1073/pnas.0304594101.PMCID: PMC384776 Evolution Body plan evolution of ascomycetes, as inferred from an RNA polymerase II phylogeny Yajuan J. Liu and Benjamin D. Hall Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4507–4512. Published online 2004 March 19. doi: 10.1073/pnas.0400938101.PMCID: PMC384777 Evolutionary stability of DNA uptake signal sequences in the Pasteurellaceae M. Bakkali, T.-Y. Chen, H. C. Lee, and R. J. Redfield Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4513–4518. Published online 2004 March 19. doi: 10.1073/pnas.0306366101.PMCID: PMC384778 Genetics Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks Kiersten A. Henderson and Scott Keeney Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4519–4524. Published online 2004 March 18. doi: 10.1073/pnas.0400843101.PMCID: PMC384779 Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action Kristin Baetz, Lianne McHardy, Ken Gable, Tamsin Tarling, Delphine Rebérioux, Jenny Bryan, Raymond J. Andersen, Teresa Dunn, Phil Hieter, and Michel Roberge Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4525–4530. Published online 2004 March 15. doi: 10.1073/pnas.0307122101.PMCID: PMC384780 Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults Julio Licinio, Sinan Caglayan, Metin Ozata, Bulent O. Yildiz, Patricia B. de Miranda, Fiona O'Kirwan, Robert Whitby, Liyin Liang, Pinchas Cohen, Shalender Bhasin, Ronald M. Krauss, Johannes D. Veldhuis, Anthony J. Wagner, Alex M. DePaoli, Samuel M. McCann, and Ma-Li Wong Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4531–4536. Published online 2004 March 9. doi: 10.1073/pnas.0308767101.PMCID: PMC384781 Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries Peter J. Sabo, Richard Humbert, Michael Hawrylycz, James C. Wallace, Michael O. Dorschner, Michael McArthur, and John A. Stamatoyannopoulos Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4537–4542. Published online 2004 March 19. doi: 10.1073/pnas.0400678101.PMCID: PMC384782 Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse Takeshi Imai, Reiko Takakuwa, Sandra Marchand, Emilie Dentz, Jean-Marc Bornert, Nadia Messaddeq, Olivia Wendling, Manuel Mark, Béatrice Desvergne, Walter Wahli, Pierre Chambon, and Daniel Metzger Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4543–4547. Published online 2004 March 16. doi: 10.1073/pnas.0400356101.PMCID: PMC384783 Circle-to-circle amplification for precise and sensitive DNA analysis Fredrik Dahl, Johan Banér, Mats Gullberg, Maritha Mendel-Hartvig, Ulf Landegren, and Mats Nilsson Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4548–4553. Published online 2004 March 15. doi: 10.1073/pnas.0400834101.PMCID: PMC384784 A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme B. D. Gregory, B. E. Nickels, S. J. Garrity, E. Severinova, L. Minakhin, R. J. Bieber Urbauer, J. L. Urbauer, T. Heyduk, K. Severinov, and A. Hochschild Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4554–4559. Published online 2004 March 22. doi: 10.1073/pnas.0400923101.PMCID: PMC384785 Immunology Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria Frank A. W. Verreck, Tjitske de Boer, Dennis M. L. Langenberg, Marieke A. Hoeve, Matthijs Kramer, Elena Vaisberg, Robert Kastelein, Arend Kolk, René de Waal-Malefyt, and Tom H. M. Ottenhoff Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4560–4565. Published online 2004 March 19. doi: 10.1073/pnas.0400983101.PMCID: PMC384786 Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation Marc Schmidt-Supprian, Jane Tian, Ethan P. Grant, Manolis Pasparakis, René Maehr, Huib Ovaa, Hidde L. Ploegh, Anthony J. Coyle, and Klaus Rajewsky Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4566–4571. Published online 2004 March 16. doi: 10.1073/pnas.0400885101.PMCID: PMC384787 TGF-β regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes Yufeng Peng, Yasmina Laouar, Ming O. Li, E. Allison Green, and Richard A. Flavell Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4572–4577. Published online 2004 March 18. doi: 10.1073/pnas.0400810101.PMCID: PMC384788 Medical Sciences Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells Wen-Chien Chou, Chunfa Jie, Andrew A. Kenedy, Richard J. Jones, Michael A. Trush, and Chi V. Dang Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4578–4583. Published online 2004 March 15. doi: 10.1073/pnas.0306687101.PMCID: PMC384789 A zebrafish model for pyruvate dehydrogenase deficiency: Rescue of neurological dysfunction and embryonic lethality using a ketogenic diet Michael R. Taylor, James B. Hurley, Heather A. Van Epps, and Susan E. Brockerhoff Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4584–4589. Published online 2004 March 15. doi: 10.1073/pnas.0307074101.PMCID: PMC384790 Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge Linda S. Wyatt, Patricia L. Earl, Leigh Anne Eller, and Bernard Moss Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4590–4595. Published online 2004 March 11. doi: 10.1073/pnas.0401165101.PMCID: PMC384791 Microbiology From the Cover: Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota John F. Rawls, Buck S. Samuel, and Jeffrey I. Gordon Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4596–4601. Published online 2004 March 19. doi: 10.1073/pnas.0400706101.PMCID: PMC384792 The temporal expression profile of Mycobacterium tuberculosis infection in mice Adel M. Talaat, Rick Lyons, Susan T. Howard, and Stephen Albert Johnston Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4602–4607. Published online 2004 March 18. doi: 10.1073/pnas.0306023101.PMCID: PMC384793 Mycobacterial polyketide-associated proteins are acyltransferases: Proof of principle with Mycobacterium tuberculosis PapA5 Kenolisa C. Onwueme, Julian A. Ferreras, John Buglino, Christopher D. Lima, and Luis E. N. Quadri Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4608–4613. Published online 2004 March 18. doi: 10.1073/pnas.0306928101.PMCID: PMC384794 Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway Erik Haghjoo and Jorge E. Galán Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4614–4619. doi: 10.1073/pnas.0400932101.PMCID: PMC384795 Human and avian influenza viruses target different cell types in cultures of human airway epithelium Mikhail N. Matrosovich, Tatyana Y. Matrosovich, Thomas Gray, Noel A. Roberts, and Hans-Dieter Klenk Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4620–4624. Published online 2004 March 15. doi: 10.1073/pnas.0308001101.PMCID: PMC384796 Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide Christopher J. Farrell, Jae Myun Lee, Eui-Cheol Shin, Marek Cebrat, Philip A. Cole, and S. Diane Hayward Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4625–4630. Published online 2004 March 19. doi: 10.1073/pnas.0306482101.PMCID: PMC384797 Temperature dependence of metabolic rates for microbial growth, maintenance, and survival P. Buford Price and Todd Sowers Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4631–4636. doi: 10.1073/pnas.0400522101.PMCID: PMC384798 Neuroscience Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI Michael D. Greicius, Gaurav Srivastava, Allan L. Reiss, and Vinod Menon Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4637–4642. Published online 2004 March 15. doi: 10.1073/pnas.0308627101.PMCID: PMC384799 Proteomic mapping provides powerful insights into functional myelin biology Christopher M. Taylor, Cecilia B. Marta, Robert J. Claycomb, David K. Han, Matthew N. Rasband, Timothy Coetzee, and Steven E. Pfeiffer Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4643–4648. Published online 2004 March 19. doi: 10.1073/pnas.0400922101.PMCID: PMC384800 From the Cover: Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice Michihiro Mieda, Jon T. Willie, Junko Hara, Christopher M. Sinton, Takeshi Sakurai, and Masashi Yanagisawa Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4649–4654. Published online 2004 March 16. doi: 10.1073/pnas.0400590101.PMCID: PMC384801 Chaos may enhance information transmission in the inferior olive Nicolas Schweighofer, Kenji Doya, Hidekazu Fukai, Jean Vianney Chiron, Tetsuya Furukawa, and Mitsuo Kawato Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4655–4660. Published online 2004 March 22. doi: 10.1073/pnas.0305966101.PMCID: PMC384802 Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation Qian Gao, Michael J. Wolfgang, Susanne Neschen, Katsutaro Morino, Tamas L. Horvath, Gerald I. Shulman, and Xin-Yuan Fu Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4661–4666. Published online 2004 March 22. doi: 10.1073/pnas.0303992101.PMCID: PMC384803 Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time K. Matthew Lattal and Ted Abel Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4667–4672. Published online 2004 March 19. doi: 10.1073/pnas.0306546101.PMCID: PMC384804 Pharmacology The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: A potent sodium-channel blocker Mari Yotsu-Yamashita, Yong H. Kim, Samuel C. Dudley, Jr., Gaurav Choudhary, Arnold Pfahnl, Yasukatsu Oshima, and John W. Daly Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4346–4351. Published online 2004 March 22. doi: 10.1073/pnas.0400368101.PMCID: PMC384749 Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells S. J. Briddon, R. J. Middleton, Y. Cordeaux, F. M. Flavin, J. A. Weinstein, M. W. George, B. Kellam, and S. J. Hill Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4673–4678. Published online 2004 March 16. doi: 10.1073/pnas.0400420101.PMCID: PMC384805 Physiology Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Yuxiang Sun, Pei Wang, Hui Zheng, and Roy G. Smith Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4679–4684. Published online 2004 March 18. doi: 10.1073/pnas.0305930101.PMCID: PMC384806 Relaxin regulation of endometrial structure and function in the rhesus monkey Laura T. Goldsmith, Gerson Weiss, Smita Palejwala, Tony M. Plant, Andrea Wojtczuk, W. Clark Lambert, Nael Ammur, Debra Heller, Joan H. Skurnick, Dean Edwards, and Donna M. Cole Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4685–4689. Published online 2004 March 19. doi: 10.1073/pnas.0400776101.PMCID: PMC384807 Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins Kozue Yamauchi, Tatemitsu Rai, Katsuki Kobayashi, Eisei Sohara, Tatsunori Suzuki, Tomohiro Itoh, Shin Suda, Atsushi Hayama, Sei Sasaki, and Shinichi Uchida Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4690–4694. Published online 2004 March 19. doi: 10.1073/pnas.0306924101.PMCID: PMC384808 Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36 B. G. Challis, A. P. Coll, G. S. H. Yeo, S. B. Pinnock, S. L. Dickson, R. R. Thresher, J. Dixon, D. Zahn, J. J. Rochford, A. White, R. L. Oliver, G. Millington, S. A. Aparicio, W. H. Colledge, A. P. Russ, M. B. Carlton, and S. O'Rahilly Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4695–4700. Published online 2004 March 15. doi: 10.1073/pnas.0306931101.PMCID: PMC384809 Plant Biology From the Cover: A Ca2+/calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning Raka M. Mitra, Cynthia A. Gleason, Anne Edwards, James Hadfield, J. Allan Downie, Giles E. D. Oldroyd, and Sharon R. Long Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4701–4705. Published online 2004 March 1. doi: 10.1073/pnas.0400595101.PMCID: PMC384810 WIN1, a transcriptional activator of epidermal wax accumulation in Arabidopsis Pierre Broun, Patricia Poindexter, Erin Osborne, Cai-Zhong Jiang, and José Luis Riechmann Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4706–4711. Published online 2004 March 22. doi: 10.1073/pnas.0305574101.PMCID: PMC384811 A latitudinal cline in flowering time in Arabidopsis thaliana modulated by the flowering time gene FRIGIDA John R. Stinchcombe, Cynthia Weinig, Mark Ungerer, Kenneth M. Olsen, Charlotte Mays, Solveig S. Halldorsdottir, Michael D. Purugganan, and Johanna Schmitt Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4712–4717. Published online 2004 March 19. doi: 10.1073/pnas.0306401101.PMCID: PMC384812 Corrections Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4718. doi: 10.1073/pnas.0401128101.PMCID: PMC384813 Corrects: Teresa Laragione, et al. Redox regulation of surface protein thiols: Identification of integrin α-4 as a molecular target by using redox proteomics. Proc Natl Acad Sci U S A. 2003 December 9; 100(25): 14737–14741. Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4718. doi: 10.1073/pnas.0400811101.PMCID: PMC384814 Corrects: Joseph Ziegelbauer, et al. Myc-interacting protein 1 target gene profile: A link to microtubules, extracellular signal-regulated kinase, and cell growth. Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 458–463. Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4718. doi: 10.1073/pnas.0401134101.PMCID: PMC384815 Corrects: Elizabeth M. Boon, et al. DNA-mediated charge transport for DNA repair. Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12543–12547. Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4718–4719. doi: 10.1073/pnas.0400841101.PMCID: PMC384816 Corrects: Vaishali Parikh, et al. A strabismus susceptibility locus on chromosome 7p. Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12283–12288. |