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Volume 173(5);  November 2008
Biological Perspectives
Physiological, Pathological, and Therapeutic Implications of Zonulin-Mediated Intestinal Barrier Modulation : Living Life on the Edge of the Wall
Alessio Fasano
Am J Pathol. 2008 November; 173(5): 1243–1252. doi: 10.2353/ajpath.2008.080192.
PMCID: PMC2570116
Review
Inflammation at the Molecular Interface of Atherogenesis : An Anthropological Journey
Brian D. Lamon and David P. Hajjar
Am J Pathol. 2008 November; 173(5): 1253–1264. doi: 10.2353/ajpath.2008.080442.
PMCID: PMC2570117
Regular Articles
Cardiovascular, Pulmonary and Renal Pathology
A Mutation in Rab38 Small GTPase Causes Abnormal Lung Surfactant Homeostasis and Aberrant Alveolar Structure in Mice
Kazuhiro Osanai, Rieko Oikawa, Junko Higuchi, Makoto Kobayashi, Katsuma Tsuchihara, Masaharu Iguchi, Huang Jongsu, Hirohisa Toga, and Dennis R. Voelker
Am J Pathol. 2008 November; 173(5): 1265–1274. doi: 10.2353/ajpath.2008.080056.
PMCID: PMC2570118
Transforming Growth Factor-β Regulates in Vitro Heart Valve Repair by Activated Valve Interstitial Cells
Amber C. Liu and Avrum I. Gotlieb
Am J Pathol. 2008 November; 173(5): 1275–1285. doi: 10.2353/ajpath.2008.080365.
PMCID: PMC2570119
Lipid Droplet-Associated Proteins Protect Renal Tubular Cells from Fatty Acid-Induced Apoptosis
Yoshimichi Urahama, Yuki Ohsaki, Yutaka Fujita, Shoichi Maruyama, Yukio Yuzawa, Seiichi Matsuo, and Toyoshi Fujimoto
Am J Pathol. 2008 November; 173(5): 1286–1294. doi: 10.2353/ajpath.2008.080137.
PMCID: PMC2570120
Cell Injury, Repair, Aging and Apoptosis
Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice
Ekaterina Semenova, Heidi Koegel, Sybille Hasse, Jennifer E. Klatte, Esfir Slonimsky, Daniel Bilbao, Ralf Paus, Sabine Werner, and Nadia Rosenthal
Am J Pathol. 2008 November; 173(5): 1295–1310. doi: 10.2353/ajpath.2008.071177.
PMCID: PMC2570121
Adenoviral Overexpression and Small Interfering RNA Suppression Demonstrate That Plasminogen Activator Inhibitor-1 Produces Elevated Collagen Accumulation in Normal and Keloid Fibroblasts
Tai-Lan Tuan, Paul Hwu, Wendy Ho, Peter Yiu, Richard Chang, Annette Wysocki, and Paul D. Benya
Am J Pathol. 2008 November; 173(5): 1311–1325. doi: 10.2353/ajpath.2008.080272.
PMCID: PMC2570122
Inhibition of Nuclear Translocation of Apoptosis-Inducing Factor Is an Essential Mechanism of the Neuroprotective Activity of Pigment Epithelium-Derived Factor in a Rat Model of Retinal Degeneration
Yusuke Murakami, Yasuhiro Ikeda, Yoshikazu Yonemitsu, Mitsuho Onimaru, Kazunori Nakagawa, Ri-ichiro Kohno, Masanori Miyazaki, Toshio Hisatomi, Makoto Nakamura, Takeshi Yabe, Mamoru Hasegawa, Tatsuro Ishibashi, and Katsuo Sueishi
Am J Pathol. 2008 November; 173(5): 1326–1338. doi: 10.2353/ajpath.2008.080466.
PMCID: PMC2570123
Epithelial and Mesenchymal Cell Biology
Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface
Julie Ann Mayer, John Foley, Damon De La Cruz, Cheng-Ming Chuong, and Randall Widelitz
Am J Pathol. 2008 November; 173(5): 1339–1348. doi: 10.2353/ajpath.2008.070920.
PMCID: PMC2570124
CGI-58 Is an α/β-Hydrolase within Lipid Transporting Lamellar Granules of Differentiated Keratinocytes
Masashi Akiyama, Kaori Sakai, Chitoshi Takayama, Teruki Yanagi, Yasuko Yamanaka, James R. McMillan, and Hiroshi Shimizu
Am J Pathol. 2008 November; 173(5): 1349–1360. doi: 10.2353/ajpath.2008.080005.
PMCID: PMC2570125
Hyaluronan-Mediated Leukocyte Adhesion and Dextran Sulfate Sodium-Induced Colitis Are Attenuated in the Absence of Signal Transducer and Activator of Transcription 1
Sudip K. Bandyopadhyay, Carol A. de la Motte, Sean P. Kessler, Vincent C. Hascall, David R. Hill, and Scott A. Strong
Am J Pathol. 2008 November; 173(5): 1361–1368. doi: 10.2353/ajpath.2008.080444.
PMCID: PMC2570126
Immunopathology and Infectious Diseases
CD34+ Cord Blood Cell-Transplanted Rag2−/− γc−/− Mice as a Model for Epstein-Barr Virus Infection
Mario Cocco, Cristiana Bellan, Roxane Tussiwand, Davide Corti, Elisabetta Traggiai, Stefano Lazzi, Susanna Mannucci, Lucio Bronz, Nazzareno Palummo, Chiara Ginanneschi, Piero Tosi, Antonio Lanzavecchia, Markus G. Manz, and Lorenzo Leoncini
Am J Pathol. 2008 November; 173(5): 1369–1378. doi: 10.2353/ajpath.2008.071186.
PMCID: PMC2570127
Stress-Induced Neurogenic Inflammation in Murine Skin Skews Dendritic Cells Towards Maturation and Migration : Key Role of Intercellular Adhesion Molecule-1/Leukocyte Function-Associated Antigen Interactions
Ricarda Alcira Joachim, Bori Handjiski, Sandra Maria Blois, Evelin Hagen, Ralf Paus, and Petra Clara Arck
Am J Pathol. 2008 November; 173(5): 1379–1388. doi: 10.2353/ajpath.2008.080105.
PMCID: PMC2570128
Foxp3+ T-Regulatory Cells in Sjögren’s Syndrome : Correlation with the Grade of the Autoimmune Lesion and Certain Adverse Prognostic Factors
Maria I. Christodoulou, Efstathia K. Kapsogeorgou, Niki M. Moutsopoulos, and Haralampos M. Moutsopoulos
Am J Pathol. 2008 November; 173(5): 1389–1396. doi: 10.2353/ajpath.2008.080246.
PMCID: PMC2570129
Up-Regulation of Activating Transcription Factor-5 Suppresses SAP Expression to Activate T Cells in Hemophagocytic Syndrome Associated with Epstein-Barr Virus Infection and Immune Disorders
Huai-Chia Chuang, Ju-Ming Wang, Wen-Chuan Hsieh, Yao Chang, and Ih-Jen Su
Am J Pathol. 2008 November; 173(5): 1397–1405. doi: 10.2353/ajpath.2008.080440.
PMCID: PMC2570130
Human Autoantibodies Specific for Neurotrophin Receptors TrkA, TrkB, and TrkC Protect against Lethal Trypanosoma cruzi Infection in Mice
Bo Lu, Joseph Alroy, Alejandro O. Luquetti, and Mercio PereiraPerrin
Am J Pathol. 2008 November; 173(5): 1406–1414. doi: 10.2353/ajpath.2008.080514.
PMCID: PMC2570131
Interaction of the Lyme Disease Spirochete Borrelia burgdorferi with Brain Parenchyma Elicits Inflammatory Mediators from Glial Cells as Well as Glial and Neuronal Apoptosis
Geeta Ramesh, Juan T. Borda, Jason Dufour, Deepak Kaushal, Ramesh Ramamoorthy, Andrew A. Lackner, and Mario T. Philipp
Am J Pathol. 2008 November; 173(5): 1415–1427. doi: 10.2353/ajpath.2008.080483.
PMCID: PMC2570132
Shiga Toxin-Mediated Disease in MyD88-Deficient Mice Infected with Escherichia coli O157:H7
Carla Calderon Toledo, Trisha Jayne Rogers, Majlis Svensson, Ramesh Tati, Hans Fischer, Catharina Svanborg, and Diana Karpman
Am J Pathol. 2008 November; 173(5): 1428–1439. doi: 10.2353/ajpath.2008.071218.
PMCID: PMC2570133
Tolerance to Melanin-Associated Antigen in Autoimmune Uveitis Is Mediated by CD4+CD25+ T-Regulatory Cells
Bharati Matta, Purushottam Jha, Puran S. Bora, and Nalini S. Bora
Am J Pathol. 2008 November; 173(5): 1440–1454. doi: 10.2353/ajpath.2008.080150.
PMCID: PMC2570134
Molecular Pathogenesis of Genetic and Inherited Diseases
Sall1, Sall2, and Sall4 Are Required for Neural Tube Closure in Mice
Johann Böhm, Anja Buck, Wiktor Borozdin, Ashraf U. Mannan, Uta Matysiak-Scholze, Ibrahim Adham, Walter Schulz-Schaeffer, Thomas Floss, Wolfgang Wurst, Jürgen Kohlhase, and Francisco Barrionuevo
Am J Pathol. 2008 November; 173(5): 1455–1463. doi: 10.2353/ajpath.2008.071039.
PMCID: PMC2570135
Defect of Hepatocyte Growth Factor Activator Inhibitor Type 1/Serine Protease Inhibitor, Kunitz Type 1 (Hai-1/Spint1) Leads to Ichthyosis-Like Condition and Abnormal Hair Development in Mice
Koki Nagaike, Makiko Kawaguchi, Naoki Takeda, Tsuyoshi Fukushima, Akira Sawaguchi, Kazuyo Kohama, Mitsuru Setoyama, and Hiroaki Kataoka
Am J Pathol. 2008 November; 173(5): 1464–1475. doi: 10.2353/ajpath.2008.071142.
PMCID: PMC2570136
Dysferlin Deficiency Shows Compensatory Induction of Rab27A/Slp2a That May Contribute to Inflammatory Onset
Akanchha Kesari, Mitsunori Fukuda, Susan Knoblach, Rumaisa Bashir, Gustavo A. Nader, Deepak Rao, Kanneboyina Nagaraju, and Eric P. Hoffman
Am J Pathol. 2008 November; 173(5): 1476–1487. doi: 10.2353/ajpath.2008.080098.
PMCID: PMC2570137
Neurobiology
Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer’s Disease
Natalia Louneva, Julia W. Cohen, Li-Ying Han, Konrad Talbot, Robert S. Wilson, David A. Bennett, John Q. Trojanowski, and Steven E. Arnold
Am J Pathol. 2008 November; 173(5): 1488–1495. doi: 10.2353/ajpath.2008.080434.
PMCID: PMC2570138
Flupirtine as Neuroprotective Add-On Therapy in Autoimmune Optic Neuritis
Muriel B. Sättler, Sarah K. Williams, Clemens Neusch, Markus Otto, Jens R. Pehlke, Mathias Bähr, and Ricarda Diem
Am J Pathol. 2008 November; 173(5): 1496–1507. doi: 10.2353/ajpath.2008.080491.
PMCID: PMC2570139
Enhanced Integrated Stress Response Promotes Myelinating Oligodendrocyte Survival in Response to Interferon-γ
Wensheng Lin, Phillip E. Kunkler, Heather P. Harding, David Ron, Richard P. Kraig, and Brian Popko
Am J Pathol. 2008 November; 173(5): 1508–1517. doi: 10.2353/ajpath.2008.080449.
PMCID: PMC2570140
Tumorigenesis and Neoplastic Progression
Specific Mutations in the β-Catenin Gene (CTNNB1) Correlate with Local Recurrence in Sporadic Desmoid Tumors
Alexander J.F. Lazar, Daniel Tuvin, Shohrae Hajibashi, Sultan Habeeb, Svetlana Bolshakov, Empar Mayordomo-Aranda, Carla L. Warneke, Dolores Lopez-Terrada, Raphael E. Pollock, and Dina Lev
Am J Pathol. 2008 November; 173(5): 1518–1527. doi: 10.2353/ajpath.2008.080475.
PMCID: PMC2570141
Keratinocyte Expression of MMP3 Enhances Differentiation and Prevents Tumor Establishment
Lisa J. McCawley, Jane Wright, Bonnie J. LaFleur, Howard C. Crawford, and Lynn M. Matrisian
Am J Pathol. 2008 November; 173(5): 1528–1539. doi: 10.2353/ajpath.2008.080132.
PMCID: PMC2570142
Focal Adhesion Kinase-Related Proline-Rich Tyrosine Kinase 2 and Focal Adhesion Kinase Are Co-Overexpressed in Early-Stage and Invasive ErbB-2-Positive Breast Cancer and Cooperate for Breast Cancer Cell Tumorigenesis and Invasiveness
Emy Behmoaram, Krikor Bijian, Su Jie, Yingjie Xu, Andrew Darnel, Tarek A. Bismar, and Moulay A. Alaoui-Jamali
Am J Pathol. 2008 November; 173(5): 1540–1550. doi: 10.2353/ajpath.2008.080292.
PMCID: PMC2570143
Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer
Paolo P. Provenzano, David R. Inman, Kevin W. Eliceiri, Hilary E. Beggs, and Patricia J. Keely
Am J Pathol. 2008 November; 173(5): 1551–1565. doi: 10.2353/ajpath.2008.080308.
PMCID: PMC2570144
Vascular Biology, Atherosclerosis and Endothelium Biology
Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions
Tae Nakasaki, Toshiyuki Tanaka, Shinichi Okudaira, Michi Hirosawa, Eiji Umemoto, Kazuhiro Otani, Soojung Jin, Zhongbin Bai, Haruko Hayasaka, Yoshinori Fukui, Katsuyuki Aozasa, Naoya Fujita, Takashi Tsuruo, Keiichi Ozono, Junken Aoki, and Masayuki Miyasaka
Am J Pathol. 2008 November; 173(5): 1566–1576. doi: 10.2353/ajpath.2008.071153.
PMCID: PMC2570145
Regulation of the Atheroma-Enriched Protein, SPRR3, in Vascular Smooth Muscle Cells through Cyclic Strain is Dependent on Integrin α1β1/Collagen Interaction
Amy L. Pyle, James B. Atkinson, Ambra Pozzi, Jeff Reese, Beate Eckes, Jeffrey M. Davidson, Dan L. Crimmins, and Pampee P. Young
Am J Pathol. 2008 November; 173(5): 1577–1588. doi: 10.2353/ajpath.2008.080042.
PMCID: PMC2570146
Correspondence
Vitamin D May Reduce Prostate Cancer Metastasis by Several Mechanisms Including Blocking Stat3
Am J Pathol. 2008 November; 173(5): 1589–1590. doi: 10.2353/ajpath.2008.080579.
PMCID: PMC2570147
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