Screening for Colorectal Cancer: A Targeted, Updated Systematic Review for the U.S. Preventive Services Task Force

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Table 3. Efficient and Near-Efficient Strategies for Colonoscopy Screening

Test, Age Begin–Age Stop, Interval^a	Outcomes per 1000 Persons (COL)	Outcomes per 1000 Persons (LYG)	Outcomes per 1000 Persons (ΔCOL)	Outcomes per 1000 Persons (ΔLYG)	Outcomes per 1000 Persons (ΔCOL/ΔLYG)
MISCAN
COL, 60–75, 20	2175	156	–	–	–
COL, 50–75, 20	3325	203	1150	47	24.7
COL, 50–75, 10	4136	230	811	27	29.6
COL, 50–85, 10	4534	236	398	5	72.9
COL, 50–75, 5	5895	254	1362	18	74.8
COL, 50–85, 5	6460	257	565	4	156.1
SimCRC
COL, 60–75, 20	1780	165	–	–	–
COL, 50–75, 20	2885	246	1106	82	13.5
COL, 50–75, 10	3756	271	871	25	34.7
COL, 50–85, 10	4114	273	358	2	Near-efficient^b
COL, 50–75, 5	5572	281.6	1816	10	178.8
COL, 50–85, 5	6031	282.1	459	0.5	975.7

COL = colonoscopy; ΔCOL = incremental number of colonoscopies compared with the next-best nondominated strategy; LYG = life-years gained compared with no screening;
ΔLYG = incremental number of life-years gained compared with the next-best nondominated strategy; MISCAN = Microsimulation Screening Analysis;
SimCRC = Simulation Model of Colorectal Cancer.
^a. Bold indicates recommendable strategy. Age and intervals expressed as years.
^b. Strategy yields life-years gained within 98% of the efficient frontier.

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