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| Sponsored by: |
National Taiwan University Hospital |
|---|---|
| Information provided by: | National Taiwan University Hospital |
| ClinicalTrials.gov Identifier: | NCT00155129 |
Purpose
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.
| Condition |
|---|
|
Migraine Headache |
| Study Type: | Observational |
| Study Design: | Screening, Cross-Sectional, Defined Population, Prospective Study |
| Official Title: | The Role of Calcitonin Gene-Related Peptide(CGRP)and Nociceptin in the Pathogenesis of Migraine |
| Estimated Enrollment: | 200 |
| Study Start Date: | January 2005 |
| Estimated Study Completion Date: | June 2005 |
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.
Eligibility| Ages Eligible for Study: | 3 Years to 50 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria: patients with headache -
Exclusion Criteria: fever, congenital anomaly, CNS organic lesions
-
Contacts and Locations| Contact: Pi-Chuan Fan, MD | pcfan@ntumc.org | |
| Contact: Li-Chu Chiou, PhD |
| Taiwan | |
| Department of Pediatrics | Recruiting |
| Taipei, Taiwan | |
| Contact: Pi-Chuan Fan, MD 886-2-23123456 ext 5135 pcfan@ntumc.org | |
| Principal Investigator: Pi-Chuan Fan, MD | |
| Principal Investigator: | Pi-Chuan Fan | Department of Pediatric, NTUH |
More Information
| Study ID Numbers: | 9361701099, 9361701099 |
| Study First Received: | September 9, 2005 |
| Last Updated: | September 9, 2005 |
| ClinicalTrials.gov Identifier: | NCT00155129 History of Changes |
| Health Authority: | Taiwan: Department of Health |
|
migraine CGRP nociceptin |
|
Calcitonin Gene-Related Peptide Calcitonin Vasodilator Agents Migraine Disorders Nociceptin Headache |
Central Nervous System Diseases Headache Disorders, Primary Cardiovascular Agents Brain Diseases Salmon calcitonin Headache Disorders |
|
Calcitonin Gene-Related Peptide Vasodilator Agents Migraine Disorders Therapeutic Uses Nociceptin Nervous System Diseases |
Central Nervous System Diseases Headache Disorders, Primary Cardiovascular Agents Brain Diseases Pharmacologic Actions Headache Disorders |
