is responsible for overall coordination of CDC′s preparedness, assessment, response, recovery, and evaluation prior to and during public health emergencies. DEO is also responsible for the CDC Director´s Emergency Operations Center, which maintains situational awareness of potential health threats 24/7/365 and is the centralized location for event management when activated.

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administers the Public Health Emergency Preparedness (PHEP) Cooperative Agreement, which supports preparedness nationwide in state, local, tribal, and territorial public health departments. As of 2007, the cooperative agreement has provided more than $5 billion to these public health departments to upgrade their ability to effectively respond to the public health consequences of all hazards, including infectious diseases, natural disasters, and biological, chemical, nuclear, and radiological events. The cooperative agreement currently funds 62 grantees including all 50 states, eight U.S. territories and freely associated states, and four localities.

DSLR also administers a cooperative agreement for the Centers for Public Health Preparedness (CPHP) program. The CPHP program is a national network of colleges and universities that collaborates with state and local public health departments and other community partners to provide preparedness education and training resources to the public health workforce, healthcare providers, students, and others based on community need.

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has the mission to deliver critical medical assets to the site of a national emergency. DSNS manages the Strategic National Stockpile (SNS), a national repository of antibiotics, chemical antidotes, antitoxins, life-support medications, and medical supplies that can be used to supplement state and local resources during a large-scale public health emergency.