The Registry of Toxic Effects of Chemical Substances
Plumbane, tetraethyl - |
UPDATE: May 2008 | MW: 323.47 | MF: C8H20Pb |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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morphological transform
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hamster
embryo
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12,500 µg/L
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AETODY 1,241,1980
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
intraperitoneal | rat
lowest published toxic dose: 3 mg/kg (14 day pregnant)
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Reproductive: Effects on newborn: Biochemical and metabolic
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BNEOBV 58,41,1990
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intraperitoneal | rat
lowest published toxic dose: 1,499 µg/kg (13 day pregnant)
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Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Specific developmental abnormalities: Hepatobiliary system
VHTODE 34,510,1992
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intraperitoneal | rat
lowest published toxic dose: 3 mg/kg (19 day pregnant)
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Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system
VHTODE 34,510,1992
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oral | mouse
lowest published toxic dose: 11 mg/kg (5-15 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
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FCTXAV 13,629,1975
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oral | rat
lowest published toxic dose: 11 mg/kg (6-16 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
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FCTXAV 13,629,1975
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oral | rat
lowest published toxic dose: 7,500 µg/kg (12-14 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 21,265,1972
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
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subcutaneous | mouse
lowest published toxic dose: 100 mg/kg/21 day- intermittent
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Tumorigenic: Carcinogenic by RTECS criteria | Liver: Tumors Blood: Lymphoma including Hodgkin's disease
EXPEAM 24,580,1968
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | human
lowest published toxic concentration: 1,749 gm/m3/30 minute
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Olfaction: Other olfaction effects | Eye: Lacrimation Gastrointestinal: Nausea or vomiting
SAIGBL 17,223,1975
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inhalation | mouse
lowest published lethal concentration: 650 mg/m3/7 hour
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N/R
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SAIGBL 15,3,1973
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inhalation | mouse
lethal concentration (50 percent kill): 48.52 mg/m3/2 hour
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N/R
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TPKVAL 9,7,1967
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inhalation | mouse
lethal concentration (50 percent kill): 3.5 ppm/2 hour
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N/R
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TPKVAL 9,7,1967
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inhalation | rat
lethal concentration (50 percent kill): 850 mg/m3/1 hour
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Behavioral: Excitement | Lung, Thorax, or Respiration: Cyanosis
BJIMAG 18,277,1961
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intraperitoneal | rat
lethal dose (50 percent kill): 15 mg/kg
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N/R
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MELAAD 54,486,1963
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intravenous | rat
lethal dose (50 percent kill): 14,400 µg/kg
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N/R
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MELAAD 54,486,1963
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intravenous | rabbit
lowest published lethal dose: 22 mg/kg
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N/R
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EQSSDX 1,1,1975
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oral | rat
lethal dose (50 percent kill): 12,300 µg/kg
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Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Convulsions or effect on seizure threshold Behavioral: Aggression
EXPEAM 28,923,1972
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oral | rabbit
lowest published lethal dose: 30 mg/kg
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N/R
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SAIGBL 15,3,1973
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parenteral | rat
lethal dose (50 percent kill): 15 mg/kg
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N/R
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AOHYA3 3,226,1961
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subcutaneous | mouse
lethal dose (50 percent kill): 13,020 µg/kg
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Behavioral: Tremor | Behavioral: Convulsions or effect on seizure threshold Behavioral: Convulsions or effect on seizure threshold
FKIZA4 49,2779,1958
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subcutaneous | rabbit
lowest published lethal dose: 32 mg/kg
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N/R
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EQSSDX 1,1,1975
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skin | dog
lowest published lethal dose: 547 mg/kg
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N/R
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SAIGBL 15,3,1973
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skin | guinea pig
lowest published lethal dose: 995 mg/kg
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N/R
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SAIGBL 15,3,1973
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skin | rabbit
lowest published lethal dose: 830 mg/kg
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N/R
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SAIGBL 15,3,1973
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unreported route | man
lowest published lethal dose: 1,470 µg/kg
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N/R
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85DCAI 2,73,1970
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 1,100 mg/m3/1 hour/5 day- intermittent
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Brain and Coverings: Other degenerative changes | Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0533656-1
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intravenous | monkey
lowest published toxic dose: 42 mg/kg/7 day- intermittent
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Behavioral: Food intake (animal) | Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 2,187,1978
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oral | mouse
lowest published toxic dose: 10 mg/kg/5 day- intermittent
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Behavioral: Tremor
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NTPTR* NTR-IMM-20009
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oral | mouse
lowest published toxic dose: 14 mg/kg/14 day- intermittent
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Blood: Normocytic anemia | Blood: Luekopenia Blood: Changes in erythrocyte (RBC) count
NTPTR* IMM-20009
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oral | mouse
lowest published toxic dose: 14 mg/kg/14 day- intermittent
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Liver: Hepatitis (hepatocellular necrosis), diffuse | Kidney, Ureter, and Bladder: Renal function tests depressed Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-20009
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oral | mouse
lowest published toxic dose: 14 mg/kg/14 day- intermittent
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Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Immunological Including Allergic: Decreased immune response
NTPTR* IMM-20009
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oral | rat
lowest published toxic dose: 2,520 µg/kg/6 week- continuous
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Endocrine: Other changes
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JANSY* 8,287,1983
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skin | dog
lowest published toxic dose: 504 µL/kg/21 day- intermittent
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Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
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FKIZA4 49,2779,1958
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REVIEWS:
ORGANIZATION
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STANDARD
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| REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 0.1 mg(Pb)/m3 (skin)
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DTLVS* TLV/BEI,2007
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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Not classifiable as human carcinogen
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DTLVS* TLV/BEI,2007
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International Agency for Research on Cancer (IARC) Cancer Review
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Human Inadequate Evidence
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IMSUDL 7,230,1987
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal Inadequate Evidence
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IMEMDT 23,325,1980
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 3
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IMSUDL 7,230,1987
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TOXICOLOGY REVIEW
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JORCAI 76,265,1974
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TOXICOLOGY REVIEW
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JAMAAP 105,578,1935
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TOXICOLOGY REVIEW
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FCTXAV 9,105,1971
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TOXICOLOGY REVIEW
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AJMEAZ 38,409,1965
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TOXICOLOGY REVIEW
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85DHAX Pb,255,1972
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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| REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air
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time-weighted average 0.1 mg(Pb)/m3 (skin)
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DTLVS* 3,251,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 0.075 mg(Pb)/m3 (skin)
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 0.1 mg(Pb)/m3 (skin)
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 0.1 mg(Pb)/m3 (skin)
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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8 hour time-weighted average 0.075 mg(Pb)/m3
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - ARAB Republic of Egypt
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time-weighted average 0.1 mg/m3, JAN1993
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 0.1 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - BELGIUM
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time-weighted average 0.1 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 0.007 ppm (0.05 mg(Pb)/m3), OCT 2002
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Occupational Exposure Limit - FRANCE
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VME 0.1 mg(Pb)/m3, Skin, FEB2006
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Occupational Exposure Limit - GERMANY
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MAK 0.05 mg(Pb)/m3, 2005
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Occupational Exposure Limit - HUNGARY
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time-weighted average 0.005 mg/m3, short term exposure limit 0.01 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - JAPAN
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Occupational Exposure Limit 0.075 mg(Pb)/m3, skin, APR2007
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Occupational Exposure Limit - KOREA
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time-weighted average 0.075 mg/m3, skin, 2006
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Occupational Exposure Limit - MEXICO
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time-weighted average 0.1 mg(Pb)/m3; | short term exposure limit 0.3 mg(Pb)/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 0.05 mg/m3, Skin, 2003
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Occupational Exposure Limit - NEW ZEALAND
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time-weighted average 0.1 mg(Pb)/m3, skin, JAN2002
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Occupational Exposure Limit - NORWAY
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time-weighted average 0.001 ppm (0.075 mg/m3), JAN1999
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Occupational Exposure Limit - THE PHILIPPINES
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time-weighted average 0.075 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - POLAND
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MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
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Occupational Exposure Limit - RUSSIA
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short term exposure limit 0.005 mg/m3, Skin, JUN2003
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Occupational Exposure Limit - SWEDEN
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time-weighted average 0.05 mg(Pb)/m3; | short term exposure limit 0.2 mg(Pb)/m3, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.05 mg(Pb)/m3; | KZG- week 0.1 mg(Pb)/m3, DEC2006
Occupational Exposure Limit - THAILAND
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time-weighted average 0.075 mg/m3, JAN1993
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not classifiable as human carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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| REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAETHYLLEAD (as Pb)-air
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10 hour time-weighted average 0.075 mg/m3 (Sk)
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NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 71640; | Number of Industries 1; Total Number of Facilities 85; Number of Occupations 6; Total Number of Employees Exposed 799
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 71640 |
![]() Number of Industries 6; Total Number of Facilities 729; Number of Occupations 15; Total Number of Employees Exposed 36,802; Total Number of Female Employees Exposed 1,099 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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| REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as component of anti-knock mixes for gas and as intermediate in making fungicides
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Tetraethyl lead (as Pb), 2533
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NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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REFERENCES:
CODEN
|
| REFERENCE
85DCAI
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"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C.
Thomas, 1970
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85DHAX
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"Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National
Academy of Sciences, 1972-77
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AETODY
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Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton
Junction, NJ 08550) V.1- 1980-
|
AJMEAZ
|
American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1-
1946-
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AOHYA3
|
Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford,
NY 10523) V.1- 1958-
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BJIMAG
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British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME
04046) V.1- 1944-
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BNEOBV
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Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15-
1970-
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CFRGBR
|
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
|
EQSSDX
|
Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76.
Discontinued.
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EXPEAM
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Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
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FCTXAV
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Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see
FCTOD7.
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FKIZA4
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Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu, Fukuoka-shi, Fukuoka, Japan)
V.33- 1940-
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IMEMDT
|
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
|
IMSUDL
|
IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210) No.1- 1979-
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JAMAAP
|
JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.1- 1883-
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JANSY*
|
Journal of the autonomic nervous system (Amsterdam, Elsevier/North Holland Biomedical Press)
V.1-81 1979-2000.
|
JORCAI
|
Journal of Organometallic Chemistry. (Elsevier Sequoia SA, POB 851, CH-1001 Lausanne l,
Switzerland) V.1- 1963-
|
MELAAD
|
Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16-
1925-
|
NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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NTPTR*
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National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709)
No.206-
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SAIGBL
|
Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu
Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
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TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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TPKVAL
|
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial
Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow,
USSR) No.1- 1961-
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TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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VHTODE
|
Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology,
Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
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