The Registry of Toxic Effects of Chemical Substances
Arsenic trioxide |
UPDATE: August 2008 | MW: 197.84 | MF: As2O3 |
SYNONYMS:
|
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
|
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
cytogenetic analysis
|
human
leukocyte
|
1,200 nmol/L
|
MUREAV 88,73,1981
|
cytogenetic analysis
|
oral | mouse
3,696 mg/kg
|
CYTOAN 52,445,1987
|
cytogenetic analysis
|
mouse
other cell types
|
28,500 µg/m3
|
JJATDK 5,61,1985
|
cytogenetic analysis
|
mouse
other cell types
|
7 µmol/L/4 hour
|
MUREAV 634,40,2007
|
cytogenetic analysis
|
intraperitoneal | rat
25 mg/kg/5 day- intermittent
|
MUREAV 587,126,2005
|
cytogenetic analysis
|
intraperitoneal | rat
25 mg/kg/5 day
|
TOXID9 78,390,2004
|
DNA damage
|
human
fibroblast
|
5 µg/L/30 minute
|
TOXID9 66,123,2002
|
DNA damage
|
human
other cell types
|
5 µg/L/30 minute
|
TOXID9 66,123,2002
|
DNA damage
|
oral | mouse
0.13 mg/kg
|
TXCYAC 162,171,2001
|
DNA inhibition
|
human
HeLa cell
|
500 µmol/L
|
MUREAV 92,427,1982
|
DNA inhibition
|
oral | mouse
20 mL/kg
|
ARGEAR 51,605,1981
|
DNA repair
|
Bacillus subtilis
|
50 mmol/L
|
MUREAV 77,109,1980
|
unscheduled DNA synthesis
|
human
lung
|
1 µmol/L
|
MUREAV 315,11,1994
|
micronucleus test
|
hamster
lung
|
250 nmol/L
|
MUREAV 412,213,1998
|
micronucleus test
|
human
liver
|
5 µmol/L/24 hour
|
TXCYAC 198,315,2004
|
micronucleus test
|
intraperitoneal | mouse
1 mg/kg
|
GNKAA5 20,365,1984
|
micronucleus test
|
intraperitoneal | rat
50 mg/kg/5 day- intermittent
|
MUREAV 587,126,2005
|
micronucleus test
|
intraperitoneal | rat
50 mg/kg/5 day
|
MUREAV 577S,1,2005
|
morphological transform
|
mouse
other cell types
|
0.4 mg/L/12 day
|
MUREAV 557,191,2004
|
sister chromatid exchange
|
human
lymphocyte
|
2 µg/cm3
|
BCTKAG 19,255,1986
|
specific locus test
|
intraperitoneal | mouse
38 mg/kg/5 day
|
MUREAV 513,205,2002
|
specific locus test
|
mouse
other cell types
|
7 µmol/L/4 hour
|
MUREAV 634,40,2007
|
|
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mouse
lowest published toxic concentration: 28,500 µg/m3/4 hour (9-12 day pregnant)
|
Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) | Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 5,61,1985
|
inhalation | mouse
lowest published toxic concentration: 260 µg/m3/4 hour (9-12 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
JJATDK 5,61,1985
|
intraperitoneal | rat
lowest published toxic dose: 10 mg/kg (9 day pregnant)
|
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Eye, ear
TJADAB 60,283,1999
|
intratracheal | rat
lowest published toxic dose: 20,800 µg/kg (8 week male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
|
NEZAAQ 50,135,1995
|
oral | mouse
lowest published toxic dose: 224 mg/kg (multigenerations)
|
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
|
AEHLAU 23,102,1971
|
oral | mouse
lowest published toxic dose: 3,636 mg/kg (1-18 day pregnant)
|
Reproductive: Effects on fertility: Abortion
|
52GUAX -,91,1983
|
oral | mouse
lowest published toxic dose: 8,250 µg/kg (7-17 day pregnant)
|
Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system | Reproductive: Effects on newborn: Behavioral
CHYCDW 28,20,1994
|
oral | mouse
lowest published toxic dose: 1,650 µg/kg (7-17 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system
|
CHYCDW 28,20,1994
|
oral | mouse
lowest published toxic dose: 315 mg/kg (1-21 day pregnant)
|
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 72,35,2003
|
oral | rat
lowest published toxic dose: 30 mg/kg (9 day pregnant)
|
Reproductive: Other effects on female | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TJADAB 60,283,1999
|
oral | rat
lowest published toxic dose: 330 mg/kg (14 day prior to copulation/1-19 day pregnant)
|
Reproductive: Other effects on female | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 38,459,2000
|
oral | rat
lowest published toxic dose: 0.756 mg/kg (1-18 day pregnant)
|
Reproductive: Effects on newborn: Biochemical and metabolic
|
TOXID9 44,30,2005
|
oral | woman
lowest published toxic dose: 600 mg/kg (30 week pregnant)
|
Reproductive: Effects on newborn: Apgar score (human only) | Reproductive: Effects on newborn: Other neonatal measures or effects
AJDCAI 117,328,1969
|
|
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | human
lowest published toxic concentration: 50 µg/m3/24 year- continuous
|
Tumorigenic: Carcinogenic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
HBPTO* 2,1398,2001
|
intratracheal | hamster
lowest published toxic dose: 45 mg/kg/15 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
ATSUDG 7,403,1984
|
intratracheal | hamster
toxic dose : 40 mg/kg/15 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors
CALEDQ 21,141,1983
|
intratracheal | hamster
toxic dose : 55,450 µg/kg/15 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
CALEDQ 21,141,1983
|
intratracheal | hamster
toxic dose : 39,608 µg/kg/24 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors
JOUOD4 5(Suppl),109,1983
|
intratracheal | hamster
toxic dose : 55,456 µg/kg/24 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors
JOUOD4 5(Suppl),109,1983
|
intratracheal | hamster
toxic dose : 30 mg/kg/15 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
SAIGBL 24,523,1982
|
intratracheal | rat
lowest published toxic dose: 16 mg/kg/15 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors
EVHPAZ 19,191,1977
|
intratracheal | rat
toxic dose : 75 mg/kg/15 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors
FKIZA4 71,19,1980
|
intratracheal | rat
toxic dose : 167 mg/kg/15 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors
SAIGBL 20,230,1978
|
|
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intradermal | chicken
lowest published lethal dose: 13 mg/kg
|
N/R
|
HBAMAK 4,1306,1935
|
intradermal | dog
lowest published lethal dose: 2 mg/kg
|
N/R
|
HBAMAK 4,1306,1935
|
intradermal | pigeon
lowest published lethal dose: 100 mg/kg
|
N/R
|
HBAMAK 4,1306,1935
|
intraperitoneal | mouse
lethal dose (50 percent kill): 10 mg/kg
|
N/R
|
VCVN5* -,88,1993
|
intraperitoneal | rat
lethal dose (50 percent kill): 871 mg/kg
|
N/R
|
GTPZAB 19(3),30,1975
|
intravenous | guinea pig
lowest published toxic dose: 0.8 mg/kg
|
Cardiac: EKG changes not diagnostic of above | Cardiac: Change in resting or action potential
BCLPT* 98,381,2006
|
intravenous | mouse
lethal dose (50 percent kill): 10,700 µg/kg
|
N/R
|
PSEBAA 78,392,1951
|
intravenous | rat
lowest published toxic dose: 3.96 mg/kg
|
Liver: Other changes | Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 66,83,2002
|
intravenous | rabbit
lowest published lethal dose: 10,560 µg/kg
|
Lung, Thorax, or Respiration: Other changes | Gastrointestinal: Hypermotility, diarrhea Blood: Other changes
BIZEA2 70,144,1915
|
oral | cattle
lowest published lethal dose: 30 mg/kg
|
N/R
|
HBAMAK 4,1306,1935
|
oral | dog
lowest published lethal dose: 10 mg/kg
|
N/R
|
HBAMAK 4,1306,1935
|
oral | human
lowest published lethal dose: 1,429 µg/kg
|
N/R
|
YKYUA6 31,1247,1980
|
oral | human
lowest published lethal dose: 1.1 mg/kg
|
Gastrointestinal: Nausea or vomiting | Behavioral: Headache Vascular: BP lowering not characterized in autonomic section
BJDEAZ 149,757,2003
|
oral | man
lowest published lethal dose: 114 mg/kg
|
Behavioral: Muscle weakness | Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Urine volume decreased or anuria
HETOEA 18,640,1999
|
oral | man
lowest published lethal dose: 29 mg/kg
|
Behavioral: Sleep | Behavioral: Muscle weakness Gastrointestinal: Hypermotility, diarrhea
AEMED3 16,702,1987
|
oral | man
lowest published lethal dose: 286 mg/kg
|
Cardiac: Arrythmias (indlucing changes in conduction) | Liver: Liver function tests impaired Musculoskeletal: Other changes
JTCTDW 29,45,1991
|
oral | man
lowest published toxic dose: 14,857 µg/kg
|
Eye: Visual field changes | Gastrointestinal: Hypermotility, diarrhea Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTCTDW 36,27,1998
|
oral | man
lowest published lethal dose: 2,857 mg/kg
|
Behavioral: Coma | Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Renal function tests depressed
JTCTDW 29,131,1991
|
oral | man
lowest published lethal dose: 123 mg/kg
|
Brain and Coverings: Other degenerative changes | Gastrointestinal: Nausea or vomiting Liver: Other changes
JFSCAS 36,1163,1992
|
oral | man
lowest published toxic dose: 2 mg/kg
|
Behavioral: Headache | Cardiac: Pulse rate decreased with fall in BP Gastrointestinal: Nausea or vomiting
JTCTDW 39,13,2001
|
oral | man
lowest published toxic dose: 8.6 mg/kg
|
Cardiac: Pulse rate increased without fall in BP | Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting
ARTODN 77,63,2003
|
oral | man
lowest published toxic dose: 143 mg/kg
|
Cardiac: Change in rate | Gastrointestinal: Nausea or vomiting
HETOEA 23,359,2004
|
oral | man
lowest published lethal dose: 142.8 mg/kg
|
Brain and Coverings: Changes in circulation | Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Renal function tests depressed
JTCTDW 41,1,2003
|
oral | mouse
lethal dose (50 percent kill): 20 mg/kg
|
N/R
|
VCVN5* -,88,1993
|
oral | rat
lethal dose (50 percent kill): 10 mg/kg
|
N/R
|
VCVN5* -,88,1993
|
oral | rabbit
lethal dose (50 percent kill): 20,190 µg/kg
|
N/R
|
CHYCDW 22,284,1988
|
oral | woman
lowest published toxic dose: 100 mg/kg
|
Cardiac: EKG changes not diagnostic of above | Vascular: BP lowering not characterized in autonomic section Gastrointestinal: Nausea or vomiting
JTCTDW 38,471,2000
|
oral | woman
lowest published toxic dose: 549 mg/kg
|
Lung, Thorax, or Respiration: Other changes | Gastrointestinal: Nausea or vomiting Blood: Changes in bone marrow not included in above
JJAMA* 20,1557,1996
|
oral | woman
lowest published toxic dose: 20 mg/kg
|
Gastrointestinal: Nausea or vomiting | Gastrointestinal: Other changes Liver: Other changes
IAEHDW 68,342,1996
|
oral | woman
lowest published toxic dose: 100 mg/kg
|
Cardiac: Pulse rate decreased with fall in BP | Gastrointestinal: Nausea or vomiting Gastrointestinal: Other changes
JTCTDW 38,471,2000
|
oral | woman
lowest published toxic dose: 0.1 gm/kg
|
Cardiac: Change in rate | Vascular: BP lowering not characterized in autonomic section Gastrointestinal: Nausea or vomiting
JTCTDW 38,471,2000
|
oral | woman
lowest published toxic dose: 180 mg/kg
|
Peripheral Nerve and Sensation: Paresthesia | Cardiac: EKG changes not diagnostic of above Liver: Liver function tests impaired
JTCTDW 42,889,2004
|
subcutaneous | mouse
lethal dose (50 percent kill): 9,800 µg/kg
|
N/R
|
PSEBAA 78,392,1951
|
subcutaneous | rat
lowest published lethal dose: 8 mg/kg
|
Skin: After topical application: Corrosive
|
JPETAB 19,337,1922
|
unreported route | human
lowest published lethal dose: 0.29 mg/kg
|
N/R
|
VCVN5* -,92,1993
|
unreported route | man
lowest published lethal dose: 2,941 µg/kg
|
N/R
|
85DCAI 2,73,1970
|
unreported route | rat
lowest published lethal dose: 8 mg/kg
|
N/R
|
BIZEA2 184,360,1927
|
|
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lowest published toxic concentration: 31 µg/m3/24 hour/22 week- continuous
|
Brain and Coverings: Recordings from specific areas of CNS | Blood: Other changes
GISAAA 47(1),6,1982
|
inhalation | rat
lowest published toxic concentration: 500 µg/m3/24 hour/33 day- continuous
|
Brain and Coverings: Recordings from specific areas of CNS | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 47(11),74,1982
|
inhalation | rabbit
lowest published toxic concentration: 0.22 mg/m3/8 week- continuous
|
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
|
TOXID9 66,83,2002
|
intraperitoneal | rat
lowest published toxic dose: 25 mg/kg/5 day- intermittent
|
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 44,379,2005
|
intratracheal | hamster
lowest published toxic dose: 20,800 µg/kg/8 week- intermittent
|
Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight
FKIZA4 91,21,2000
|
intratracheal | rat
lowest published toxic dose: 20,800 µg/kg/8 week- intermittent
|
Liver: Changes in liver weight
|
NEZAAQ 50,133,1995
|
intravenous | rabbit
lowest published toxic dose: 6 mg/kg/30 day- intermittent
|
Cardiac: Arrythmias (indlucing changes in conduction)
|
TXAPA9 189,214,2003
|
oral | human
lowest published toxic dose: 37.8 µg/kg/3 week- continuous
|
Kidney, Ureter, and Bladder: Other changes in urine composition
|
TOXID9 72,242,2003
|
oral | mouse
lowest published toxic dose: 15 mg/kg/30 day- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 191,19,2003
|
oral | mouse
lowest published toxic dose: 27 mg/kg/9 day- intermittent
|
Kidney, Ureter, and Bladder: Other changes in urine composition
|
TOXID9 72,242,2003
|
oral | mouse
lowest published toxic dose: 0.35 µg/kg/5 week- continuous
|
Vascular: Structural changes in vessels | Vascular: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
|
oral | mouse
lowest published toxic dose: 0.7 µg/kg/10 week- continuous
|
Vascular: Structural changes in vessels | Vascular: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
|
oral | mouse
lowest published toxic dose: 0.14 µg/kg/20 week- continuous
|
Vascular: Structural changes in vessels | Vascular: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
|
oral | mouse
lowest published toxic dose: 0.14 mg/kg/10 week- continuous
|
Vascular: Other changes | Tumorigenic: Facilitates action of known carcinogens Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,236,2004
|
oral | mouse
lowest published toxic dose: 87.5 mg/kg/5 week- continuous
|
Gastrointestinal: Changes in structure or function of exocrine pancreas | Endocrine: Other changes
TOLED5 172,91,2007
|
oral | rat
lowest published toxic dose: 1,820 mg/kg/26 week- continuous
|
Behavioral: Somnolence (general depressed activity) | Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain
WDZAEK 8,95,1994
|
oral | rat
lowest published toxic dose: 180 mg/kg/4 day- intermittent
|
Liver: Hepatitis (hepatocellular necrosis), diffuse | Liver: Fatty liver degeneration Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
WDZAEK 4,4,1990
|
oral | rat
lowest published toxic dose: 900 mg/kg/15 week- intermittent
|
Behavioral: Change in motor activity (specific assay) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTOTDY 5,91,1983
|
oral | rat
lowest published toxic dose: 350 µg/kg/30 day- intermittent
|
Kidney, Ureter, and Bladder: Other changes in urine composition | Nutritional and Gross Metabolic: Changes in: Na Nutritional and Gross Metabolic: Changes in: K
GISAAA 52(1),21,1987
|
oral | rat
lowest published toxic dose: 25.2 mg/kg/3 week- intermittent
|
Kidney, Ureter, and Bladder: Other changes in urine composition
|
TOXID9 72,242,2003
|
oral | rat
lowest published toxic dose: 22.4 mg/kg/8 week- continuous
|
Gastrointestinal: Other changes | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 135,193,2002
|
unreported route | mouse
lowest published toxic dose: 150 mg/kg/30 day- intermittent
|
Cardiac: Cardiomyopathy including infarction | Cardiac: EKG changes not diagnostic of above
TOXID9 72,167,2003
|
|
REVIEWS:
ORGANIZATION
|
STANDARD
|
| REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
time-weighted average 0.01 mg(As)/m3
|
DTLVS* TLV/BEI,2007
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
Confirmed human carcinogen
|
DTLVS* TLV/BEI,2007
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Limited Evidence
|
IMEMDT 2,48,1973
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Sufficient Evidence
|
IMEMDT 23,39,1980
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Limited Evidence
|
IMSUDL 7,100,1987
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Inadequate Evidence
|
IMEMDT 2,48,1973
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Inadequate Evidence
|
IMEMDT 23,39,1980
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Group 1
|
IMSUDL 7,100,1987
|
TOXICOLOGY REVIEW
|
|
AMIHAB 21,132,1960
|
TOXICOLOGY REVIEW
|
|
ADTEAS 5,51,1972
|
TOXICOLOGY REVIEW
|
|
PTPAD4 1,189,1976
|
TOXICOLOGY REVIEW
|
|
85DHAX As,-,1977
|
TOXICOLOGY REVIEW
|
|
DRDTO* 7,156,2002
|
TOXICOLOGY REVIEW
|
|
TOLED5 133,1,2002
|
TOXICOLOGY REVIEW
|
|
TOLED5 133,17,2002
|
TOXICOLOGY REVIEW
|
|
TOLED5 145,1,2003
|
TOXICOLOGY REVIEW
|
|
MUTAEX 14,5,1999
|
TOXICOLOGY REVIEW
|
|
CRTXB2 33,215,2003
|
TOXICOLOGY REVIEW
|
|
CREOH* 50,197,2004
|
TOXICOLOGY REVIEW
|
|
ENTOX* -,384,2005
|
TOXICOLOGY REVIEW
|
|
JJATDK 26,191,2006
|
TOXICOLOGY REVIEW
|
|
CRTOEC 19,1,2006
|
TOXICOLOGY REVIEW
|
|
MUREAV 533,65,2003
|
TOXICOLOGY REVIEW
|
|
MUREAV 651,131,2008
|
TOXICOLOGY REVIEW
|
|
MUREAV 533,173,2003
|
TOXICOLOGY REVIEW
|
|
MUREAV 533,183,2003
|
|
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
| REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
|
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
|
FEREAC 54,7740,1989
|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
|
PESTICIDES: Supported
|
RBREV* -,100,1998
|
Occupational Safety and Health Administration (OSHA)
|
cancer hazard
|
CFRGBR 29,1910.1018,1987
|
Occupational Exposure Limit - AUSTRALIA
|
Carcinogen, JAN1993
|
Occupational Exposure Limit - AUSTRIA
|
TRK 0.1 mg/m3 (inhalable), JAN 2006
|
Occupational Exposure Limit - BELGIUM
|
Carcinogen, JAN1993
|
Occupational Exposure Limit - DENMARK
|
time-weighted average 0.01 mg(As)/m3, OCT 2002
|
Occupational Exposure Limit - FINLAND
|
Carcinogen, JAN1993
|
Occupational Exposure Limit - FRANCE
|
VME 0.2 mg/m3, continuous1 Carcinogen, FEB2006
|
Occupational Exposure Limit - KOREA
|
time-weighted average 0.2 mg(As)/m3, 2006
|
Occupational Exposure Limit - MEXICO
|
time-weighted average 0.5 mg/m3 (production), 2004
|
Occupational Exposure Limit - MEXICO
|
time-weighted average 0.2 mg(As)/m3, 2004
|
Occupational Exposure Limit - NEW ZEALAND
|
time-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
|
Occupational Exposure Limit - NORWAY
|
time-weighted average 0.01 mg(As)/m3, JAN1999
|
Occupational Exposure Limit - THE PHILIPPINES
|
time-weighted average 0.1 mg/m3, Carcinogen, JAN1993
|
Occupational Exposure Limit - POLAND
|
time-weighted average 0.01 mg(As)/m3, JAN1999
|
Occupational Exposure Limit - SWEDEN
|
time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
|
Occupational Exposure Limit - SWITZERLAND
|
MAK- week 0.1 mg(As)/m3, Carcinogen, DEC2006
|
Occupational Exposure Limit - UNITED KINGDOM
|
time-weighted average 0.1 mg(As)/m3, 2005
|
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Confirmed human carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
| REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air
|
Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute
|
NIOSH* DHHS #92-100,1992
|
National Occupational Hazard Survey 1974
|
National Occupational Hazard Survey 1974: Hazard Code: 07570; | Number of Industries 6; Total Number of Facilities 1,284; Number of Occupations 6; Total Number of Employees Exposed 3,980
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: 07570 |
![]() Number of Industries 8; Total Number of Facilities 107; Number of Occupations 16; Total Number of Employees Exposed 4,657; Total Number of Female Employees Exposed 2,001 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
| REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
|
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
Used in manufacture of pesticides, glass, industrial chemicals and drugs
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
|
NIOSH Analytical Method, 1994: Arsenic trioxide as As, 7901
|
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
|
NTP Carcinogenesis studies; selected, October 2000
|
|
REFERENCES:
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85DCAI
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