The Registry of Toxic Effects of Chemical Substances
Styrene |
UPDATE: August 2008 | MW: 104.16 | MF: C8H8 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
eye | human
50 ppm
|
mild
|
ENTOX* -,105,2005
|
eye | rabbit
100 mg
|
severe
|
AJOPAA 29,1363,1946
|
eye | rabbit
100 mg/24 hour
|
moderate
|
85JCAE -,32,1986
|
skin | human
500 mg rinse
|
moderate
|
INMEAF 17,199,1948
|
skin | rabbit
500 mg open irritation test
|
mild
|
UCDS** 12/13/1963
|
skin | rabbit
1,00%
|
moderate
|
AMIHAB 14,387,1956
|
|
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
body fluid assay
|
human
| lymphocyte
300 mg/kg
|
EMMUEG 17,27,1991
|
cytogenetic analysis
|
hamster
lung
|
100 mg/L
|
ATSUDG 4,41,1980
|
cytogenetic analysis
|
inhalation | human
7,500 ppb/8 hour/5 day- intermittent
|
HEREAY 100,87,1984
|
cytogenetic analysis
|
human
lymphocyte
|
300 ppm/72 hour
|
MUREAV 58,277,1978
|
cytogenetic analysis
|
multiple | human
20 ppm/8 year- intermittent
|
MUREAV 537,131,2003
|
cytogenetic analysis
|
inhalation | rat
300 ppm/8 week- intermittent
|
TOLED5 1,315,1978
|
DNA adduct
|
inhalation | mouse
1,500 µg/L/21 day- intermittent
|
TXAPA9 210,1,2006
|
DNA damage
|
human
leukocyte
|
5 mmol/L/30 minute
|
TXCYAC 186,131,2003
|
DNA damage
|
inhalation | human
36.8 ppm/8.5 year- intermittent
|
EMMUEG 41,243,2003
|
DNA damage
|
intraperitoneal | mouse
10 mmol/kg
|
CALEDQ 21,9,1983
|
DNA damage
|
inhalation | mouse
1,500 mg/m3/7 day- intermittent
|
CBINA8 137,213,2001
|
DNA damage
|
rat
liver
|
3 mmol/L
|
SinJF# 26OCT1982
|
DNA inhibition
|
human
HeLa cell
|
28 mmol/L
|
MUREAV 93,447,1982
|
unscheduled DNA synthesis
|
human
lymphocyte
|
100 µmol/L
|
CRNGDP 3,681,1982
|
unscheduled DNA synthesis
|
rat
liver
|
3,800 µmol/L
|
MUREAV 221,263,1989
|
host-mediated assay
|
mouse
| Saccharomyes cerevisiae
1 gm/kg
|
MUREAV 40,317,1976
|
host-mediated assay
|
mouse
| Schizosaccharomyces pombe
1 gm/kg
|
MUREAV 40,317,1976
|
mutation in microorganisms
|
hamster
lung
|
240 µmol/plate (+enzymatic activation step)
|
CBINA8 39,57,1982
|
mutation in microorganisms
|
Salmonella typhimurium
|
1 µmol/plate (-enzymatic activation step)
|
MUREAV 56,147,1977
|
mutation in microorganisms
|
Saccharomyes cerevisiae
|
1 mmol/L (-enzymatic activation step)
|
BSIBAC 59,233,1983
|
micronucleus test
|
intraperitoneal | mouse
250 mg/kg
|
TOLED5 8,247,1981
|
micronucleus test
|
inhalation | mouse
1,500 mg/m3/7 day- intermittent
|
CBINA8 137,213,2001
|
gene conversion and mitotic recombination
|
Saccharomyes cerevisiae
|
1 mmol/L
|
BSIBAC 59,233,1983
|
morphological transform
|
rat
embryo
|
145 µg/plate
|
JJATDK 1,190,1981
|
sister chromatid exchange
|
inhalation | human
1,204 mg/m3/5 year- intermittent
|
MUREAV 73,387,1980
|
sister chromatid exchange
|
human
lymphocyte
|
10 µmol/L
|
EMMUEG 22,85,1993
|
sister chromatid exchange
|
intraperitoneal | mouse
450 mg/kg
|
MUREAV 271,49,1992
|
sister chromatid exchange
|
inhalation | mouse
125 ppm/4 day- intermittent
|
APTOD9 19,A34,1980
|
sister chromatid exchange
|
intraperitoneal | rat
750 mg/kg
|
MUREAV 271,49,1992
|
sperm morphology
|
intraperitoneal | mouse
3,500 mg/kg/7 week- intermittent
|
MUREAV 271,49,1992
|
sperm morphology
|
intraperitoneal | rat
40 gm/kg/8 week- intermittent
|
MUREAV 271,49,1992
|
|
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | hamster
lowest published toxic concentration: 1,000 ppm/6 hour (6-18 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
|
APTOA6 47,127,1980
|
inhalation | mouse
lowest published toxic concentration: 500 ppm/6 hour (6-16 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
|
APTOA6 47,127,1980
|
inhalation | rat
lowest published toxic concentration: 293 ppm/6 hour (7-21 day pregnant)
|
Reproductive: Effects on newborn: Behavioral
|
NETEEC 17,121,1995
|
inhalation | rat
lowest published toxic concentration: 1,500 µg/m3/24 hour (1-22 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 39(11),65,1974
|
inhalation | rat
lowest published toxic concentration: 5 mg/m3/24 hour (1-22 day pregnant)
|
Reproductive: Effects on newborn: Stillbirth | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
GISAAA 39(11),65,1974
|
inhalation | rat
lowest published toxic concentration: 1,500 µg/m3/24 hour (1-7 day pregnant)
|
Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
GISAAA 39(11),65,1974
|
inhalation | rat
lowest published toxic concentration: 50 ppm/6 hour (7-12 day pregnant)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
|
NEZAAQ 47,227,1992
|
oral | rat
lowest published toxic dose: 8,600 mg/kg (1-22 day pregnant/21 day after birth)
|
Reproductive: Effects on newborn: Behavioral
|
NTOTDY 7,23,1985
|
oral | rat
lowest published toxic dose: 5,575 mg/kg (multigenerations)
|
Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
FAATDF 5,855,1985
|
oral | rat
lowest published toxic dose: 4 gm/kg (6-15 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
JEBIDP 11,73,1990
|
oral | rat
lowest published toxic dose: 11,470 mg/kg (6-15 day pregnant)
|
Reproductive: Specific developmental abnormalities: Urogenital system
|
TJADAB 42,651,1990
|
|
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mouse
lowest published toxic concentration: 160 ppm/6 hour/2 year- intermittent
|
Tumorigenic: Carcinogenic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
NTIS** OTS0558579-2
|
inhalation | mouse
lowest published toxic concentration: 160 ppm/6 hour/98 week- intermittent
|
Tumorigenic: Carcinogenic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
JAPTO* 21,185,2001
|
inhalation | mouse
lowest published toxic concentration: 20 ppm/6 hour/98 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
JAPTO* 21,185,2001
|
inhalation | mouse
lowest published toxic concentration: 40 ppm/6 hour/104 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
JAPTO* 21,185,2001
|
inhalation | rat
lowest published toxic concentration: 100 ppm/4 hour/5 day/1 year- intermittent
|
Tumorigenic: Carcinogenic by RTECS criteria | Skin and Appendages: Tumors Blood: Leukemia
ANYAA9 534,203,1988
|
oral | rat
lowest published toxic dose: 1,520 mg/kg/43 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Skin and Appendages: Tumors
KHZDAN 25,464,1982
|
|
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | guinea pig
lowest published lethal concentration: 12 gm/m3/14 hour
|
Eye: Lacrimation | Behavioral: Muscle weakness Behavioral: Antipsychotic
JIHTAB 24,295,1942
|
inhalation | guinea pig
lowest published toxic concentration: 3 gm/m3
|
N/R
|
TPKVAL 4,52,1962
|
inhalation | human
lowest published lethal concentration: 10,000 ppm/30 minute
|
N/R
|
29ZWAE -,77,1968
|
inhalation | human
lowest published toxic concentration: 600 ppm
|
Olfaction: Other olfaction effects | Eye: Other eye effects
AMIHAB 14,387,1956
|
inhalation | human
lowest published toxic concentration: 20 µg/m3
|
Eye: Other eye effects
|
GISAAA 26(8),11,1961
|
inhalation | human
lowest published toxic concentration: 376 ppm/1 hour
|
Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) | Behavioral: Change in motor activity (specific assay)
AEHLAU 16,656,1968
|
inhalation | human
lowest published toxic concentration: 100 ppm/1 hour
|
Eye: Conjunctiva irritation
|
VCVGH* -,193,1990
|
inhalation | human
lowest published toxic concentration: 376 ppm/25 minute
|
Behavioral: Change in psychophysiological tests
|
VCVGH* -,193,1990
|
inhalation | human
lowest published toxic concentration: 376 ppm/50 minute
|
Gastrointestinal: Nausea or vomiting | Behavioral: Ataxia
VCVGH* -,193,1990
|
inhalation | human
lowest published toxic concentration: 376 ppm/60 minute
|
Behavioral: Headache
|
VCVGH* -,193,1990
|
inhalation | human
lowest published toxic concentration: 800 ppm/4 hour
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Muscle weakness Behavioral: Ataxia
VCVGH* -,193,1990
|
inhalation | human
lowest published toxic concentration: 3.4 gm/m3/3 hour
|
N/R
|
TPKVAL 4,52,1962
|
inhalation | human
lowest published toxic concentration: 2 gm/m3/8 hour
|
N/R
|
TPKVAL 4,52,1962
|
inhalation | man
lowest published toxic concentration: 50 mg/m3/8 hour
|
Kidney, Ureter, and Bladder: Other changes in urine composition
|
TXAPA9 189,160,2003
|
inhalation | mouse
lowest published toxic concentration: 300 ppm/6 minute
|
Lung, Thorax, or Respiration: Respiratory depression
|
TOLED5 9,137,1981
|
inhalation | mouse
lethal concentration (50 percent kill): 21,000 mg/m3/2 hour
|
N/R
|
VCVGH* -,192,1990
|
inhalation | mouse
lethal concentration (50 percent kill): 9,500 mg/m3/4 hour
|
N/R
|
VCVGH* -,192,1990
|
inhalation | mouse
lowest published toxic concentration: 40 ppm/6 hour
|
Lung, Thorax, or Respiration: Other changes | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FCTOD7 42,1655,2004
|
inhalation | mouse
lowest published toxic concentration: 3 gm/m3
|
Eye: Conjunctiva irritation | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 4,52,1962
|
inhalation | mouse
lethal concentration (50 percent kill): 4,940 ppm/2 hour
|
N/R
|
ENTOX* ,105,2005
|
inhalation | rat
lethal concentration (50 percent kill): 11,800 mg/m3/4 hour
|
N/R
|
VCVGH* -,192,1990
|
inhalation | rat
lowest published toxic concentration: 5,460 mg/m3/1 hour
|
Eye: Lacrimation | Gastrointestinal: Changes in structure or function of salivary glands
VCVGH* -,192,1990
|
inhalation | rat
lowest published toxic concentration: 40,000 mg/m3/2 hour
|
Endocrine: Changes in thymus weight | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in leukocyte (WBC) count
VCVGH* -,192,1990
|
inhalation | rat
lowest published toxic concentration: 500 ppm/6 hour
|
Lung, Thorax, or Respiration: Changes in lung weight | Gastrointestinal: Changes in structure or function of salivary glands
FCTOD7 42,1655,2004
|
inhalation | rat
lowest published toxic dose: 6,450 mg/m3/5 hour
|
Gastrointestinal: Changes in structure or function of salivary glands
|
INHTE5 16,209,2004
|
inhalation | rat
lowest published toxic concentration: 3 gm/m3
|
Lung, Thorax, or Respiration: Cough
|
TPKVAL 4,52,1962
|
inhalation | rat
lowest published toxic concentration: 6,450 mg/m3/5 hour
|
Gastrointestinal: Changes in structure or function of salivary glands
|
INHTE5 16,209,2004
|
inhalation | rat
lethal concentration (50 percent kill): 2,770 ppm/4 hour
|
N/R
|
ENTOX* ,105,2005
|
inhalation | rabbit
lowest published lethal concentration: 4,000 ppm/4 hour
|
N/R
|
UCDS** 12/13/1963
|
inhalation | rabbit
lowest published toxic concentration: 40,000 mg/m3/2 hour
|
Endocrine: Changes in thymus weight | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in leukocyte (WBC) count
VCVGH* -,192,1990
|
intraperitoneal | mouse
lethal dose (50 percent kill): 660 mg/kg
|
N/R
|
ARZNAD 19,617,1969
|
intraperitoneal | mouse
lowest published toxic dose: 600 mg/kg
|
Lung, Thorax, or Respiration: Other changes | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 150,335,2004
|
intraperitoneal | mouse
lowest published toxic dose: 600 mg/kg
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | Biochemical: Metabolism (intermediary): Other
TOXID9 227,217,2006
|
intraperitoneal | rat
lethal dose (50 percent kill): 898 mg/kg
|
N/R
|
ENVRAL 40,411,1986
|
intravenous | mouse
lethal dose (50 percent kill): 90 mg/kg
|
N/R
|
ARZNAD 19,617,1969
|
oral | mammal (species unspecified)
lethal dose (50 percent kill): >1,500 mg/kg
|
N/R
|
GISAAA 39(4),86,1974
|
oral | mouse
lethal dose (50 percent kill): 316 mg/kg
|
N/R
|
NCILB* NCI-E-C-72-3252,1973
|
oral | rat
lethal dose (50 percent kill): 2,650 mg/kg
|
Behavioral: Somnolence (general depressed activity) | Liver: Other changes
SRTCAC 36(1-4),10,1989
|
oral | rat
lethal dose (10 percent kill): 5 mL/kg
|
N/R
|
VCVGH* -,192,1990
|
oral | rat
lethal dose (50 percent kill): 5,000 mg/kg
|
N/R
|
ENTOX* ,105,2005
|
|
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | guinea pig
lowest published toxic concentration: 6 gm/m3/8 hour/26 week- intermittent
|
Olfaction: Other olfaction effects | Lung, Thorax, or Respiration: Acute pulmonary edema Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 24,295,1942
|
inhalation | mouse
lowest published toxic concentration: 500 ppm/90 day- intermittent
|
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Liver: Hepatitis (hepatocellular necrosis), zonal Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,397,1992
|
inhalation | mouse
lowest published toxic concentration: 250 ppm/6 hour/14 day- intermittent
|
Liver: Hepatitis (hepatocellular necrosis), zonal | Liver: Changes in liver weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 20,325,1993
|
inhalation | mouse
lowest published toxic concentration: 250 ppm/6 hour/5 day- intermittent
|
Liver: Changes in liver weight | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 20,325,1993
|
inhalation | mouse
lowest published toxic concentration: 500 ppm/6 hour/22 day- intermittent
|
Liver: Hepatitis (hepatocellular necrosis), diffuse | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOSCF2 48,123,1999
|
inhalation | mouse
lowest published toxic dose: 40 ppm/6 hour/3 day- intermittent
|
Olfaction: Other olfaction effects
|
CBINA8 137,185,2001
|
inhalation | mouse
lowest published toxic concentration: 80 ppm/6 hour/104 week- intermittent
|
Behavioral: Food intake (animal) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 21,185,2001
|
inhalation | mouse
lowest published toxic concentration: 160 ppm/6 hour/98 week- intermittent
|
Behavioral: Food intake (animal) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 21,185,2001
|
inhalation | mouse
lowest published toxic concentration: 20 ppm/6 hour/52 week- intermittent
|
Lung, Thorax, or Respiration: Other changes
|
JAPTO* 21,185,2001
|
inhalation | mouse
lowest published toxic concentration: 40 ppm/6 hour/78 week- intermittent
|
Olfaction: Change in olfactory nerve
|
JAPTO* 21,185,2001
|
inhalation | mouse
lowest published toxic concentration: 1,500 mg/m3/3 day- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
|
ARTODN 77,56,2003
|
inhalation | mouse
lowest published toxic concentration: 1,500 mg/m3/6 day- intermittent
|
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
|
ARTODN 77,56,2003
|
inhalation | mouse
lowest published toxic concentration: 40 ppm/6 hour/5 day- intermittent
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
|
FCTOD7 42,1655,2004
|
inhalation | mouse
lowest published toxic concentration: 160 ppm/6 hour/5 day- intermittent
|
Behavioral: Alteration of classical conditioning | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 42,1655,2004
|
inhalation | mouse
lowest published toxic concentration: 40 ppm/6 hour/4 week- intermittent
|
Lung, Thorax, or Respiration: Other changes | Blood: Other changes
FCTOD7 42,1655,2004
|
inhalation | mouse
lowest published toxic concentration: 160 ppm/6 hour/4 week- intermittent
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FCTOD7 42,1655,2004
|
inhalation | rat
lowest published toxic concentration: 50 mg/m3/24 hour/70 day- continuous
|
Blood: Changes in erythrocyte (RBC) count | Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 26(8),11,1961
|
inhalation | rat
lowest published toxic concentration: 2,000 ppm/8 hour/32 week- intermittent
|
Peripheral Nerve and Sensation: Sensory change involving peripheral nerve | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ENVRAL 62,148,1993
|
inhalation | rat
lowest published toxic concentration: 6 gm/m3/8 hour/26 week- intermittent
|
Olfaction: Other olfaction effects | Eye: Other eye effects
JIHTAB 24,295,1942
|
inhalation | rat
lowest published toxic concentration: 1,500 ppm/6 hour/13 week- intermittent
|
Olfaction: Other olfaction effects | Behavioral: Fluid intake
FAATDF 35,152,1997
|
inhalation | rat
lowest published toxic concentration: 300 ppm/6 hour/2 week- intermittent
|
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Lung, Thorax, or Respiration: Other changes Liver: Other changes
JTEHD6 52,63,1997
|
inhalation | rat
lowest published toxic concentration: 1,000 ppm/6 hour/20 day- intermittent
|
Ear: Change in cochlear structure or function | Ear: Tumors
NETEEC 23,71,2001
|
inhalation | rat
lowest published toxic concentration: 2,000 mg/m3/4 hour/20 day- intermittent
|
Endocrine: Adrenal cortex hyperplasia
|
VCVGH* -,195,1990
|
inhalation | rat
lowest published toxic concentration: 2,000 mg/m3/4 hour/6 week- intermittent
|
Biochemical: Metabolism (intermediary): Lipids including transport
|
VCVGH* -,195,1990
|
inhalation | rat
lowest published toxic concentration: 1,000 ppm/6 hour/5 day- intermittent
|
Ear: Change in acuity | Ear: Change in cochlear structure or function
NETEEC 25,39,2003
|
inhalation | rat
lowest published toxic concentration: 160 ppm/6 hour/4 day- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
|
FCTOD7 42,1655,2004
|
inhalation | rat
lowest published toxic concentration: 500 ppm/6 hour/2 day- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
|
FCTOD7 42,1655,2004
|
inhalation | rat
lowest published toxic concentration: 500 ppm/6 hour/3 day- intermittent
|
Eye: Ptosis | Behavioral: Somnolence (general depressed activity)
FCTOD7 42,1655,2004
|
inhalation | rat
lowest published toxic concentration: 600 ppm/4 week- intermittent
|
Ear: Change in acuity | Ear: Change in cochlear structure or function
ARTODN 76,40,2002
|
inhalation | rat
lowest published toxic concentration: 2,150 mg/m3/5 day- intermittent
|
Brain and Coverings: Other degenerative changes | Endocrine: Change in LH Endocrine: Androgenic
INHTE5 16,209,2004
|
inhalation | rat
lowest published toxic concentration: 150 ppm/8 hour/10 day- intermittent
|
Endocrine: Other changes
|
ARTODN 79,653,2006
|
inhalation | rat
lowest published toxic concentration: 1,000 ppm/6 hour/4 week- intermittent
|
Brain and Coverings: Other degenerative changes | Biochemical: Metabolism (intermediary): Other
ARTODN 80,703,2006
|
inhalation | rat
lowest published toxic concentration: 140.2 ppm/8 hour/10 day- intermittent
|
Endocrine: Change in gonadotropins
|
ARTODN 79,653,2005
|
inhalation | rabbit
lowest published toxic concentration: 50 mg/m3/4 hour/17 week- intermittent
|
Blood: Changes in bone marrow not included in above | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins
GISAAA 35(8),112,1970
|
inhalation | rabbit
lowest published toxic concentration: 2,000 mg/m3/4 hour/20 day- intermittent
|
Endocrine: Adrenal cortex hyperplasia
|
VCVGH* -,195,1990
|
inhalation | rabbit
lowest published toxic concentration: 1 gm/m3/60 day- intermittent
|
Blood: Changes in other cell count (unspecified) | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count
TPKVAL 4,52,1962
|
intraperitoneal | rat
lowest published toxic dose: 8,400 mg/kg/7 week- intermittent
|
Liver: Other changes | Biochemical: Metabolism (intermediary): Lipids including transport
JTSCDR 14,1,1989
|
intraperitoneal | rat
lowest published toxic dose: 10 gm/kg/10 day- intermittent
|
Kidney, Ureter, and Bladder: Other changes in urine composition
|
TOLED5 45,271,1989
|
oral | dog
lowest published toxic dose: 337 gm/kg/76 week- continuous
|
Liver: Other changes | Blood: Other changes Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0546563
|
oral | guinea pig
lowest published toxic dose: 3,200 mg/kg/4 week- intermittent
|
Gastrointestinal: Changes in structure or function of exocrine pancreas | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
IJEBA6 32,68,1994
|
oral | mouse
lowest published toxic dose: 500 mg/kg/4 week- intermittent
|
Gastrointestinal: Changes in structure or function of exocrine pancreas | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
IJEBA6 32,68,1994
|
oral | rat
lowest published toxic dose: 17,200 mg/kg/14 week- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
JJATDK 2,219,1982
|
oral | rat
lowest published toxic dose: 3,200 mg/kg/4 week- intermittent
|
Gastrointestinal: Changes in structure or function of exocrine pancreas | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
IJEBA6 32,68,1994
|
oral | rat
lowest published toxic dose: 23,190 mg/kg/15 day- intermittent
|
Brain and Coverings: Other degenerative changes | Vascular: Regional or general arteriolar constriction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase
TOLED5 7,47,1980
|
oral | rat
lowest published toxic dose: 40 gm/kg/2 year- continuous
|
Brain and Coverings: Changes in brain weight | Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 5,855,1985
|
oral | rat
lowest published toxic dose: 3,150 mg/kg/7 day- intermittent
|
Kidney, Ureter, and Bladder: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
APTOA6 52,47,1983
|
oral | rat
lowest published toxic dose: 12,000 mg/kg/60 day- intermittent
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Changes in testicular weight
IJEBA6 30,399,1992
|
oral | rat
lowest published toxic dose: 20,400 mg/kg/60 day- intermittent
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 63,43,1989
|
oral | rat
lowest published toxic dose: 8,822 mg/kg/2 week- intermittent
|
Ear: Change in cochlear structure or function | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 79,346,2005
|
skin | rat
lowest published toxic dose: 3,500 mg/kg/7 day- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
RCOCB8 19,109,1978
|
|
REVIEWS:
ORGANIZATION
|
STANDARD
|
| REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
time-weighted average 20 ppm;short term exposure limit 40 ppm
|
DTLVS* TLV/BEI,2007
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
Not classifiable as human carcinogen
|
DTLVS* TLV/BEI,2007
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Limited Evidence
|
IMEMDT 19,231,1979
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Limited Evidence
|
IMEMDT 60,233,1994
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Limited Evidence
|
IMEMDT 82,437,2002
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Inadequate Evidence
|
IMEMDT 19,231,1979
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Inadequate Evidence
|
IMEMDT 60,233,1994
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Limited Evidence
|
IMEMDT 82,437,2002
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Group 2B
|
IMEMDT 60,233,1994
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Group 2B
|
IMEMDT 82,437,2002
|
TOXICOLOGY REVIEW
|
|
MUREAV 566,21,2004
|
TOXICOLOGY REVIEW
|
|
EVHPAZ 11,163,1975
|
TOXICOLOGY REVIEW
|
|
CMTVAS 10(3),49,1973
|
TOXICOLOGY REVIEW
|
|
CBINA8 22,117,1978
|
TOXICOLOGY REVIEW
|
|
IGAYAY 106,105,1978
|
TOXICOLOGY REVIEW
|
|
TOLED5 134,3,2002
|
TOXICOLOGY REVIEW
|
|
TOLED5 138,1,2003
|
TOXICOLOGY REVIEW
|
|
MUREAV 543,201,2003
|
TOXICOLOGY REVIEW
|
|
EMMUEG 39,69,2002
|
TOXICOLOGY REVIEW
|
|
TOLED5 138,75,2003
|
TOXICOLOGY REVIEW
|
|
MUREAV 567,227,2004
|
TOXICOLOGY REVIEW
|
|
MUREAV 567,109,2004
|
TOXICOLOGY REVIEW
|
|
MUREAV 567,151,2004
|
TOXICOLOGY REVIEW
|
|
MUREAV 567,347,2004
|
TOXICOLOGY REVIEW
|
|
RTOPDW 35,308,2002
|
TOXICOLOGY REVIEW
|
|
MUREAV 589,158,2005
|
TOXICOLOGY REVIEW
|
|
MUREAV 589,67,2005
|
TOXICOLOGY REVIEW
|
|
EMMUEG 45,271,2005
|
TOXICOLOGY REVIEW
|
|
MUREAV 566,209,2004
|
TOXICOLOGY REVIEW
|
|
BCLPT* 96,131,2005
|
TOXICOLOGY REVIEW
|
|
ENTOX* -,105,2005
|
TOXICOLOGY REVIEW
|
|
MUREAV 584,1,2005
|
TOXICOLOGY REVIEW
|
|
JTEHD6 5,1,2002
|
TOXICOLOGY REVIEW
|
|
JTEHD6 7,1,2004
|
TOXICOLOGY REVIEW
|
|
JTEHD6 8,95,2005
|
|
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
| REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air
|
time-weighted average 100 ppm (420 mg/m3)
|
DTLVS* 3,235,1971
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
|
8 hour time-weighted average 100 ppm; | ceiling concentration 200; peak concentration 600/5 minute/3 hour
CFRGBR 29,1910.1000,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
|
8 hour time-weighted average 100 ppm (420 mg/m3)
|
CFRGBR 29,1926.55,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
|
8 hour time-weighted average 100 ppm (420 mg/m3)
|
CFRGBR 29,1915.1000,1993
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
|
8 hour time-weighted average 100 ppm (420 mg/m3)
|
CFRGBR 41,50-204.50,1994
|
Occupational Exposure Limit - AUSTRALIA
|
time-weighted average 50 ppm (215 mg/m3), short term exposure limit 100 ppm, JAN1993
|
Occupational Exposure Limit - DENMARK
|
ceiling concentration 25 ppm (105 mg/m3), OCT 2002
|
Occupational Exposure Limit - FINLAND
|
time-weighted average 20 ppm (85 mg/m3), short term exposure limit 100 ppm (420 mg/m3), JAN1999
|
Occupational Exposure Limit - FRANCE
|
VME 50 ppm (215 mg/m3), FEB2006
|
Occupational Exposure Limit - GERMANY
|
MAK 86 mg/m3 (20 mL/m3), 2005
|
Occupational Exposure Limit - HUNGARY
|
short term exposure limit 50 mg/m3, Carcinogen, JAN1993
|
Occupational Exposure Limit - JAPAN
|
Occupational Exposure Limit 20 ppm (85 mg/m3), skin, 2B carcinogen, APR2007
|
Occupational Exposure Limit - KOREA
|
time-weighted average 50 ppm (215 mg/m3), short term exposure limit 100 ppm (425 mg/m3), skin, 2006
|
Occupational Exposure Limit - MEXICO
|
time-weighted average 50 ppm (215 mg/m3); | short term exposure limit 100 ppm (425 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS
|
MAC-TGG 107 mg/m3, 2003
|
Occupational Exposure Limit - NEW ZEALAND
|
time-weighted average 50 ppm (213 mg/m3), short term exposure limit 100 ppm (426 mg/m3), skin, JAN2002
|
Occupational Exposure Limit - NORWAY
|
time-weighted average 25 ppm (105 mg/m3), JAN1999
|
Occupational Exposure Limit - THE PHILIPPINES
|
time-weighted average 100 ppm (420 mg/m3), JAN1993
|
Occupational Exposure Limit - POLAND
|
MAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 200 mg/m3, JAN1999
|
Occupational Exposure Limit - RUSSIA
|
time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
|
Occupational Exposure Limit - SWEDEN
|
time-weighted average 20 ppm (90 mg/m3); | short term exposure limit 50 ppm (200 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND
|
MAK- week 20 ppm (85 mg/m3),KZG- week 40 ppm (170 mg/m3), DEC2006
|
Occupational Exposure Limit - THAILAND
|
time-weighted average 100 ppm, short term exposure limit 200 ppm, JAN1993
|
Occupational Exposure Limit - TURKEY
|
time-weighted average 100 ppm (420 mg/m3), JAN1993
|
Occupational Exposure Limit - UNITED KINGDOM
|
time-weighted average 100 ppm (430 mg/m3); | short term exposure limit 250 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not classifiable as human carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
| REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO STYRENE-air
|
10 hour time-weighted average 50 ppm; | short term exposure limit 100 ppm
NIOSH* DHHS #92-100,1992
|
National Occupational Hazard Survey 1974
|
National Occupational Hazard Survey 1974: Hazard Code: 70130; | Number of Industries 137; Total Number of Facilities 16,394; Number of Occupations 117; Total Number of Employees Exposed 292,018
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: 70130 |
![]() Number of Industries 154; Total Number of Facilities 24,702; Number of Occupations 115; Total Number of Employees Exposed 333,212; Total Number of Female Employees Exposed 86,902 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
| REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110849/AS)
|
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-human lymphocyte; Host-mediated assay
|
EPA GENETOX PROGRAM 1988, Positive: In vitro human lymphocyte micronucleus
|
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
|
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
|
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
|
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
|
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; In vitro UDS-human fibroblast
|
EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
|
EPA GENETOX PROGRAM 1988, Inconclusive: S pombe-forward mutation
|
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
|
FEREAC 47,26992,82
|
Used in the production of plastics and polystyrene resins
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0393-8756;8EHQ-0294-8756
|
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8996
|
On EPA IRIS database
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
|
NCI Carcinogenesis Bioassay (gavage);inadequate studies:mouse,rat
|
NCITR* NCI-TR-185,1979
|
NCI Carcinogenesis Bioassay (gavage);inadequate studies:mouse,rat
|
NCITR* NCI-TR-170,1979
|
OSHA ANALYTICAL METHOD #89
|
|
REFERENCES:
CODEN
|
| REFERENCE
29ZWAE
|
"Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968
|
85JCAE
|
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
|
AEHLAU
|
Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC
20016) V.1- 1960-
|
AJOPAA
|
American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415,
Chicago, IL 60611) Series 3: V.1- 1918-
|
AMIHAB
|
AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher
information, see AEHLAU.
|
ANYAA9
|
Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New
York, NY 10021) V.1- 1877-
|
APTOA6
|
Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher
information, see PHTOEH
|
APTOD9
|
Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802)
|
ARTODN
|
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974-
|
ARZNAD
|
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951-
|
ATSUDG
|
Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz
Way, Secaucus, NJ 07094) No.1- 1978-
|
BCLPT*
|
Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological
Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
|
BSIBAC
|
Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de
Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
|
CALEDQ
|
Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick,
Ireland) V.1- 1975-
|
CBINA8
|
Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick,
Ireland) V.1- 1969-
|
CFRGBR
|
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
|
CMTVAS
|
Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail,
rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
|
CRNGDP
|
Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford
OX8 1JJ, UK) V.1- 1980-
|
DTLVS*
|
The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
|
EMMUEG
|
Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.10- 1987-
|
ENTOX*
|
Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
|
ENVRAL
|
Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-
1967-
|
EVHPAZ
|
EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents,
Washington, DC 20402) No.1- 1972-
|
FAATDF
|
Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
|
FCTOD7
|
Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford,
NY 10523) V.20- 1982-
|
FEREAC
|
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
|
GISAAA
|
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
|
HEREAY
|
Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947-
|
IGAYAY
|
Igaku No Ayumi. Progress in Medicine. (Ishiyaku Shuppan K.K., 1-7-10, Honkomagom, Bunkyo-ku,
Tokyo, Japan) V.1- 1946-
|
IJEBA6
|
Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR,
Hillside Rd., New Delhi 110 012, India) V.1- 1963-
|
IMEMDT
|
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
|
INHTE5
|
Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P
4EE) V.1- 1989-
|
INMEAF
|
Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
|
JAPTO*
|
Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex,
PO22 9SA England) V.1- 1981-
|
JEBIDP
|
Journal of Environmental Biology. (Academy of Environmental Biology, India, 657/5, Civil
Lines (South), Muzaffarnagar, 251001, India) V.1- 1980-
|
JIHTAB
|
Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For
publisher information, see AEHLAU.
|
JJATDK
|
JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W.
Sussex PO19 1UD, UK) V.1- 1981-
|
JTEHD6
|
Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
|
JTSCDR
|
Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor,
Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
|
KHZDAN
|
Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria)
V.9- 1966-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
NCILB*
|
Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer
Institute by Litton Bionetics, Inc. (Bethesda, MD)
|
NCITR*
|
National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205.
For publisher information, see NTPTR*.
|
NETEEC
|
Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford,
NY 10523) V.9- 1987-
|
NEZAAQ
|
Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto
Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
|
NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
|
NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
|
NTOTDY
|
Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher
information, see NETEEC.
|
RCOCB8
|
Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966,
Westbury, NY 11590) V.1- 1970-
|
RTOPDW
|
Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1981-
|
SRTCAC
|
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku
University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan)
V.1- 1949-
|
SinJF#
|
Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point,
PA 19486, Oct. 26, 1982
|
TJADAB
|
Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.1- 1968-
|
TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TOSCF2
|
Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 )
V. 41, Jan. 1998-
|
TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
|
TPKVAL
|
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial
Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow,
USSR) No.1- 1961-
|
TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
|
TXCYAC
|
Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
|
UCDS**
|
Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
|
VCVGH*
|
"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances:
Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
|
|