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Safety and Health Topics: |
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| Hydrazine |
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General Description
Synonyms: Hydrazine, anhydrous
OSHA IMIS Code Number: 1390
Chemical Abstracts Service (CAS) Registry Number: 302-01-2
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: MU7175000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2029 132 (anhydrous); 3293 152 (≤37% solution); 2030 153 (37-64% solution); 2029 132 (>64% solution)
NIOSH Pocket Guide to Chemical Hazards, Hydrazine: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 1 ppm, 1.3 mg/m3; Skin
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 1 ppm, 1.3 mg/m3; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.01 ppm TWA; Skin; Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans)
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.03 ppm, 0.04 mg/m3 Ceiling (120 Minutes); Appendix A - Potential Occupational Carcinogen
Health Factors
National Toxicology Program (NTP) carcinogenic classification: Reasonably Anticipated to be Human Carcinogen
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 50 ppm
Potential symptoms: Eye, nose, throat irritation; temporary blindness; dizziness; nausea; dermatitis; skin, eye burns; malar rash, photosensitivity, antinuclear antibody, antibody to nDNA (one case); coma (one case); (carcinogenic); In animals: bronchitis, pulmonary edema; liver, kidney damage; convulsions
Health Effects: Irritation-Respiratory tract---Marked (HE14); Cumulative organ damage (HE3); Mutagen (HE2)
Affected organs: CNS, respiratory system, skin, eyes
Date Last Revised: 05/29/03
Literature Basis:
- (coma and other symptoms)
U.S. Environmental Protection Agency, Technology Transfer Network Air Toxics Website, Hydrazine.
- (malar rash, photosensitivity, antinuclear antibody, antibody to nDNA)
Reidenberg, M.M., Durant, P.J., Harris, R.A., De Boccardo, G., Lahita, R. and Stenzel, K.H.: Lupus erythematosus-like disease due to hydrazine. Am. J. Med. 75: 365-370, 1983.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
sampling media: Two Coated Glass Fiber Filters (37 mm) in 3 piece cassette. Coating is Sulfuric Acid.
maximum volume: 240 Liters maximum flow rate: 1.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Manual of Analytical Methods (OSHA 108)
method classification: Fully Validated
note: The two filters are separated by the ring section of the 3 piece cassette, thereby, providing a backup portion to the sampling train.
On-Site Sampling Techniques/Methods:
device: Detector Tube
manufacturer: AUER/MSA
model/type: Hydrazine-0.5, AUER P/N 5086-832
sampling information: follow manufacturer’s instructions
upper measurement limit: 3200 ppm
detection limit: approx. 20 ppm
overall uncertainty: unknown
method reference: on-site air secondary (manufacturer)
device: Detector Tube
manufacturer: Dräger
model/type: Hydrazine 0.2/a, order no. 67 33121
sampling information: 10 or 20 strokes
upper measurement limit: 10 ppm
detection limit: approx. 0.1 ppm
overall uncertainty: 25%
method reference: on-site air secondary (manufacturer)
device: Detector Tube
manufacturer: Dräger
model/type: Hydrazine 0.25/a, order no. CH 31801
sampling information: 10 or 20 strokes
upper measurement limit: 5 ppm
detection limit: approx. 0.05 ppm
overall uncertainty: 16%
method reference: on-site air secondary (manufacturer)
device: Detector Tube
manufacturer: Gastec
model/type: 185
sampling information: 5 or 10 strokes
upper measurement limit: 2.0 ppm
detection limit: 0.01 ppm
overall uncertainty: 16% for 0.1 to 0.5 ppm, 8% for 0.5 to 2 ppm
method reference: on-site air secondary (manufacturer)
device: Detector Tube
manufacturer: Matheson-Kitagawa
model/type: 8014-219S
sampling information: follow manufacturer’s instructions
upper measurement limit: 10 ppm
detection limit: approx. 0.1 ppm
overall uncertainty: unknown
method reference: on-site air secondary (manufacturer)
Bulk sampling: Limit the amount of bulk submitted to one gram or one mL.
* All Trademarks are the property of their respective owners.
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| Revised: 14 October 2003 |
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