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Sponsors and Collaborators: |
National Heart, Lung, and Blood Institute (NHLBI) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Cancer Institute (NCI) National Institute on Aging (NIA) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00000611 |
To address cardiovascular disease, cancer, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women. The three major components of the WHI are: a randomized controlled clinical trial of hormone replacement therapy (HRT), dietary modification (DM), and calcium/vitamin D supplementation (CaD); an observational study (OS); and a community prevention study (CPS). On October 1, 1997, administration of the WHI was transferred to the NHLBI where it is conducted as a consortium effort led by the NHLBI in cooperation with the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Cancer Institute (NCI), and the National Institute on Aging (NIA).
Condition | Intervention | Phase |
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Bone Diseases Breast Neoplasms Cardiovascular Diseases Colonic Neoplasms Coronary Disease Heart Diseases Myocardial Ischemia Osteoporosis Postmenopause |
Drug: hormone replacement therapy Drug: estrogens Drug: progestins Drug: estrogen replacement therapy Behavioral: diet, fat-restricted Drug: calcium Drug: vitamin D Behavioral: dietary supplements |
Phase III |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Placebo Control |
Ages Eligible for Study: | 50 Years to 79 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Postmenopausal women ages 50 to 79.
Study ID Numbers: | 114 |
Study First Received: | October 27, 1999 |
Last Updated: | November 27, 2006 |
ClinicalTrials.gov Identifier: | NCT00000611 History of Changes |
Health Authority: | United States: Federal Government |
Gastrointestinal Diseases Hormone Antagonists Myocardial Ischemia Colonic Diseases Hormones, Hormone Substitutes, and Hormone Antagonists Arteriosclerosis Hormones Bone Diseases Musculoskeletal Diseases Progestins Vitamins Breast Diseases Arterial Occlusive Diseases Estrogens Heart Diseases |
Digestive System Neoplasms Skin Diseases Vascular Diseases Osteoporosis Breast Neoplasms Bone Diseases, Metabolic Ischemia Intestinal Diseases Intestinal Neoplasms Coronary Disease Calcium, Dietary Vitamin D Digestive System Diseases Gastrointestinal Neoplasms Colonic Neoplasms |
Gastrointestinal Diseases Myocardial Ischemia Physiological Effects of Drugs Colonic Diseases Hormones, Hormone Substitutes, and Hormone Antagonists Arteriosclerosis Hormones Bone Diseases Pathologic Processes Neoplasms by Site Musculoskeletal Diseases Progestins Cardiovascular Diseases Breast Diseases Arterial Occlusive Diseases |
Estrogens Heart Diseases Digestive System Neoplasms Skin Diseases Vascular Diseases Osteoporosis Breast Neoplasms Bone Diseases, Metabolic Ischemia Intestinal Diseases Pharmacologic Actions Intestinal Neoplasms Coronary Disease Neoplasms Digestive System Diseases |