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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institute of Neurological Disorders and Stroke (NINDS) |
ClinicalTrials.gov Identifier: | NCT00004728 |
The purpose of this study is to determine whether aspirin or warfarin is more effective in preventing stroke in patients with intracranial stenosis.
Condition | Intervention | Phase |
---|---|---|
Stroke Cerebral Infarction Atherosclerosis Constriction, Pathologic |
Drug: Warfarin Drug: Aspirin |
Phase III |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind |
Official Title: | Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Study |
Estimated Study Completion Date: | July 2003 |
Prevention of stroke in patients with narrowing of one of the arteries in the brain typically consists of using medications to prevent blood clots from forming. Currently, the best medication to use in this situation is unknown. The purpose of this study is to compare the effectiveness of two different medications, warfarin or aspirin, for the prevention of stroke due to narrowing of one of the large arteries in the brain. Patients must have experienced a recent transient ischemic attack (TIA) or mild stroke. Stroke of this type is thought to occur more often in minorities.
Ages Eligible for Study: | 40 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | R01NS36643 |
Study First Received: | February 25, 2000 |
Last Updated: | June 5, 2006 |
ClinicalTrials.gov Identifier: | NCT00004728 History of Changes |
Health Authority: | United States: Federal Government |
stroke cerebral infarction warfarin coumadin aspirin ASA acetysalicylic acid atherosclerosis |
stenosis intracranial artery arteries transient ischemic attack TIA minorities |
Atherosclerosis Pathological Conditions, Anatomical Anti-Inflammatory Agents Cerebral Infarction Fibrinolytic Agents Constriction, Pathologic Arteriosclerosis Brain Diseases Cerebrovascular Disorders Fibrin Modulating Agents Necrosis Aspirin Brain Ischemia Anti-Inflammatory Agents, Non-Steroidal Analgesics |
Arterial Occlusive Diseases Ischemic Attack, Transient Anticoagulants Cyclooxygenase Inhibitors Stroke Vascular Diseases Central Nervous System Diseases Cardiovascular Agents Ischemia Warfarin Analgesics, Non-Narcotic Platelet Aggregation Inhibitors Brain Infarction Peripheral Nervous System Agents Infarction |
Anti-Inflammatory Agents Atherosclerosis Pathological Conditions, Anatomical Molecular Mechanisms of Pharmacological Action Cerebral Infarction Hematologic Agents Physiological Effects of Drugs Fibrinolytic Agents Constriction, Pathologic Arteriosclerosis Brain Diseases Cerebrovascular Disorders Fibrin Modulating Agents Necrosis Pathologic Processes |
Aspirin Sensory System Agents Therapeutic Uses Brain Ischemia Cardiovascular Diseases Anti-Inflammatory Agents, Non-Steroidal Analgesics Arterial Occlusive Diseases Anticoagulants Cyclooxygenase Inhibitors Stroke Nervous System Diseases Vascular Diseases Central Nervous System Diseases Enzyme Inhibitors |