Investigation on the Role of Corticosteroids and Beta-Agonists on Cytokine Production in COPD Patients

This study is currently recruiting participants.

Verified by St. Antonius Hospital, July 2005

First Received: December 7, 2005 Last Updated: September 8, 2006 History of Changes

Sponsored by:	St. Antonius Hospital
Information provided by:	St. Antonius Hospital
ClinicalTrials.gov Identifier:	NCT00263380

Purpose

Research on the synergistic effect of corticosteroids and beta-agonists on the cytokine production in COPD patients. Blood will be obtained from healthy volunteers and COPD patients and blood monocytes will be stimulated to produce cytokines with or without the prementioned drugs.

Condition
COPD

Drug Information available for: Corticosteroids

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Longitudinal, Case Control, Prospective Study
Official Title:	Experimental Study on the Role of Corticosteroids and Beta-Agonists on Cytokine Production in COPD Patients

Further study details as provided by St. Antonius Hospital:

Estimated Enrollment:	90
Study Start Date:	October 2005

Eligibility

Ages Eligible for Study:	40 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

clinical COPD
smoking
age > 40 years

Exclusion Criteria:

age < 40 years
use of antibiotics, corticosteroids or beta-agonists

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00263380

Locations

Netherlands, Utrecht
St Antonius Hospital	Recruiting
Nieuwegein, Utrecht, Netherlands, 3435 CM
Contact: Robert Ten Broeke, Dr + 31 30 609111 r.broeke@kf-antoniusmesosgroep.nl
Principal Investigator: Robert Ten Broeke, Dr
St Antonius Hospital	Recruiting
Nieuwegein, Utrecht, Netherlands, 3435 CM
Contact: Robert Ten Broeke, Dr + 31 30 6091111 r.broeke@kf-antoniusmesosgroep.nl

Sponsors and Collaborators

St. Antonius Hospital

Investigators

Principal Investigator:

Robert Ten Broeke, Dr

St. Antonius Hospital

More Information

No publications provided

Study ID Numbers:	COPD IL8
Study First Received:	December 7, 2005
Last Updated:	September 8, 2006
ClinicalTrials.gov Identifier:	NCT00263380 History of Changes
Health Authority:	Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by St. Antonius Hospital:

COPD
cytokines
corticosteroids
beta agonists
synergistic effect

Study placed in the following topic categories:

Lung Diseases, Obstructive
Respiratory Tract Diseases
Lung Diseases
Pulmonary Disease, Chronic Obstructive

Additional relevant MeSH terms:

Lung Diseases, Obstructive
Respiratory Tract Diseases
Lung Diseases
Pulmonary Disease, Chronic Obstructive

ClinicalTrials.gov processed this record on May 07, 2009