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| Sponsors and Collaborators: |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) University Hospitals of Cleveland Case Western Reserve University The Cleveland Clinic Department of Veterans Affairs Creighton University Medical Center Fred Hutchinson Cancer Research Center University of Washington Mercy Medical Center |
|---|---|
| Information provided by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| ClinicalTrials.gov Identifier: | NCT00288119 |
Purpose
This is a multi-center study whose aim is to define the epidemiology and genetics of Barrett's esophagus and adenocarcinoma. The researchers have studied families affected with Barrett's esophagus and esophageal adenocarcinoma, a specific type of cancer of the esophagus. They have found that Barrett's and esophageal cancer occur at a younger age in these families suggesting that familial Barrett's esophagus is a genetically inherited disease.
| Condition |
|---|
|
Barrett's Esophagus Esophageal Neoplasm |
| Study Type: | Observational |
| Study Design: | Family-Based, Cross-Sectional |
| Official Title: | Familial Barrett's Esophagus |
Blood Samples are required to be sent to our NIH approved Biorepository and this repository is designed to help all researchers performing studies on the genetic basis of diseases.
| Estimated Enrollment: | 1000 |
| Study Start Date: | October 2005 |
| Estimated Study Completion Date: | September 2010 |
This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland and the Cleveland Clinic are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Individuals with Barrett's esophagus or adenocarcenoma of the esophagus whose medical care is at the participating institutions, are referred from outside institutions, or who contact the participating institutions.
Eligible cases will be defined as those patients and their family members who meet the following criteria:
Contacts and Locations| Contact: Amitabh Chak, MD | 216-844-5385 | axc22@po.cwru.edu |
| Contact: Wendy Brock, RN | 216-844-3853 | wendy.brock@UHhospitals.org |
| United States, Nebraska | |
| Creighton University Medical Center | Recruiting |
| Omaha, Nebraska, United States, 68131 | |
| Contact: Sumeet Mittal, MD 402-280-4161 SumeetMittal@creighton.edu | |
| Contact: Shannon Staton, PA-C (402) 280-4526 ShannonStaton@creighton.edu | |
| Principal Investigator: Sumeet Mittal, MD | |
| United States, Ohio | |
| University Hospitals of Cleveland | Recruiting |
| Cleveland, Ohio, United States, 44106-8066 | |
| Contact: Amitabh Chak, MD 216-844-5386 axc22@po.cwru.edu | |
| Contact: Wendy Brock, RN 216-844-3853 wendy.brock@UHhospitals.org | |
| Principal Investigator: Amitabh Chak, MD | |
| The Cleveland Clinic Foundation | Recruiting |
| Cleveland, Ohio, United States, 44195 | |
| Contact: Gary W. Falk, MD 216-444-1762 falkg@ccf.org | |
| Contact: Mary Oldenburgh, RN 216-444-8562 oldenbm@ccf.org | |
| Principal Investigator: Gary W. Falk, MD | |
| Northeastern Ohio University College of Medicine, Mercy Medical Center | Recruiting |
| Canton, Ohio, United States, 44718 | |
| Contact: James King, MD 330-305-2020 ext 465 jfjk@aol.com | |
| Contact: Linda Chessler 330-936-5815 craigo16@juno.com | |
| Principal Investigator: James King, MD | |
| Cleveland Veterans Administration Medical Center - Wade Park | Recruiting |
| Cleveland, Ohio, United States, 44106 | |
| Contact: Margaret Kinnard, MD 216-791-3800 ext 3769 Margaret.kinnard@med.va.gov | |
| Contact: Anna Haas, RN 216-791-3800 ext 3695 anna.haas@va.gov | |
| Principal Investigator: Margaret Kinnard, MD | |
| United States, Washington | |
| Fred Hutchinson Cancer Research Center, UWMC | Recruiting |
| Seattle, Washington, United States, 98109 | |
| Contact: William Grady, MD 206-667-1107 wgrady@fhcrc.org | |
| Contact: Kasey Orlowski 206-667-1997 Korlowsk@fhcrc.org | |
| Principal Investigator: William Grady, MD | |
| Principal Investigator: Brain Reid, MD | |
| Principal Investigator: | Amitabh Chak, MD | University Hospitals of Cleveland, CWRU, Cleveland, OH |
| Principal Investigator: | Gary W Falk, MD, MS | The Cleveland Clinic Foundation, Cleveland, OH |
| Principal Investigator: | William Grady, MD | Fred Hutchinson Cancer Research Center, UWMC, Seattle, WA |
| Principal Investigator: | James King, MD | Northeastern Ohio University College of Medicine, Mercy Medical Center, Canton, OH |
| Principal Investigator: | Margaret Kinnard, MD | VA Medical Center - Wade Park |
| Principal Investigator: | Sumeet Mittal, M.D. | Creighton University Medical Center |
More Information
| Responsible Party: | Familial Barrett's Esophagus Consortium ( Dr. Amitabh Chak, M.D., Prinicipal Investigator Dr. Gary Falk, M.D. , MS Principal Investigator ) |
| Study ID Numbers: | DK61426, NIH IK24DK02800 |
| Study First Received: | February 6, 2006 |
| Last Updated: | December 1, 2008 |
| ClinicalTrials.gov Identifier: | NCT00288119 History of Changes |
| Health Authority: | United States: Federal Government |
|
Barrett's Esophagus |
|
Digestive System Neoplasms Gastrointestinal Diseases Esophageal Neoplasms Esophageal Cancer Digestive System Abnormalities Digestive System Diseases Esophageal Disorder |
Barrett Syndrome Head and Neck Neoplasms Gastrointestinal Neoplasms Barrett Esophagus Esophageal Diseases Congenital Abnormalities |
|
Neoplasms Neoplasms by Site Digestive System Neoplasms Digestive System Diseases Digestive System Abnormalities Gastrointestinal Diseases |
Head and Neck Neoplasms Esophageal Neoplasms Gastrointestinal Neoplasms Barrett Esophagus Esophageal Diseases |
