12-Month Stability of Diurnal IOP Control on Cosopt - Full Text View

Sponsored by:	West Virginia University
Information provided by:	West Virginia University
ClinicalTrials.gov Identifier:	NCT00379834

Purpose

To determine the stability of diurnal intraocular pressure in eyes with glaucoma treated with Cosopt

Condition	Intervention	Phase
Glaucoma	Drug: Cosopt	Phase IV

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma

Drug Information available for: Cosopt

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study
Official Title:	12-Month Stability of Diurnal IOP Control on Cosopt

Further study details as provided by West Virginia University:

Primary Outcome Measures:

Diurnal IOP control
Adverse events

Estimated Enrollment:	10
Study Start Date:	September 2006
Estimated Study Completion Date:	March 2008

Detailed Description:

Glaucoma is a potentially-blinding but treatable eye disease. A major risk factor for glaucoma is elevated intraocular pressure (IOP). IOP is a dynamic variable (like blood pressure)—it changes over time. The more it changes, the more likely patients are to get worse. Glaucoma is treated by lowering IOP.

Cosopt is a medication that lowers IOP. Little is known about how well Cosopt reduces IOP fluctuations. In this study, we plan to measure the IOP in both eyes of 10 glaucoma patients treated with Cosopt, every 2 hours from 8am to 8pm, on five separate days over a one-year period. Untreated baseline IOP will be measured on a similar long day before beginning treatment with Cosopt. This methodology will allow us to compare IOP fluctuations with and without Cosopt, and also to learn about long-term control of IOP fluctuations in eyes treated with Cosopt.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

bilateral OAG

Exclusion Criteria:

contraindications to Cosopt
pathology affecting tonometry

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00379834

Sponsors and Collaborators

West Virginia University

Investigators

Principal Investigator:

Anthony D Realini, MD

West Virginia University

More Information

No publications provided

Study ID Numbers:	31861
Study First Received:	September 21, 2006
Last Updated:	March 28, 2007
ClinicalTrials.gov Identifier:	NCT00379834 History of Changes
Health Authority:	United States: Institutional Review Board

Keywords provided by West Virginia University:

glaucoma
diurnal
intraocular pressure

Study placed in the following topic categories:

Glaucoma
Eye Diseases
Hypertension
Ocular Hypertension

Additional relevant MeSH terms:

Glaucoma
Eye Diseases
Ocular Hypertension

ClinicalTrials.gov processed this record on May 07, 2009