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Sponsored by: |
Rennes University Hospital |
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Information provided by: | Rennes University Hospital |
ClinicalTrials.gov Identifier: | NCT00378469 |
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be collected regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.
Condition | Intervention |
---|---|
Iron Overload Iron Deficiency |
Behavioral: 45 minute exercise on ergocycle |
Study Type: | Interventional |
Study Design: | Randomized, Open Label, Placebo Control, Crossover Assignment, Pharmacokinetics/Dynamics Study |
Official Title: | Study of the Effects of Muscular Activity on Iron Metabolism: A Pilot Study on Healthy Volunteers |
Estimated Enrollment: | 14 |
Study Start Date: | September 2006 |
Hemojuvelin has been described as interfering with hepcidin, a key regulator of iron homeostasis. Hemojuvelin is mainly produced by muscle, and the relationship between exercise and iron metabolism can be questioned about.
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will be investigated at two periods according to a cross-over design after:
Urine and blood samples will be collected at both periods regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Pierre Brissot, MD | 33-2-9928-4297 | pierre.brissot@univ-rennes1.fr |
Contact: Fabrice Lainé, MD | 33-2-9928-3715 | fabrice.laine@chu-rennes.fr |
France | |
Service des Maladies du Foie - Hôpital de Pontchaillou | Recruiting |
Rennes, France, 35033 | |
Contact: Pierre Brissot, MD 33-2-9928-4297 pierre.brissot@univ-rennes1.fr | |
Principal Investigator: Pierre Brissot, MD | |
Sub-Investigator: Yves Deugnier, MD | |
Sub-Investigator: Fabrice Lainé, MD | |
Unité de Biologie et Médecine du Sport - Hôpital de Pontchaillou | Recruiting |
Rennes, France, 35033 | |
Contact: Pierre Rochcongar, MD 33-2-9928-9323 pierre.rochcongar@chu-rennes.fr | |
Principal Investigator: Pierre Rochcongar, MD | |
Sub-Investigator: Jocelyne Beillot, MD |
Principal Investigator: | Pierre Brissot, MD | Rennes University Hospital |
Study Chair: | Bruno Laviolle, MD | Rennes University Hospital |
Study ID Numbers: | DGS 2006/0415, LOC/05-07, CIC0203/061 |
Study First Received: | September 19, 2006 |
Last Updated: | July 11, 2007 |
ClinicalTrials.gov Identifier: | NCT00378469 History of Changes |
Health Authority: | France: DGS - Direction Générale de la Santé |
Hepcidin Hemojuvelin Iron Healthy volunteers |
Metabolic Diseases Hematologic Diseases Anemia Healthy Iron Metabolism Disorders |
Iron Overload Iron Metabolic Disorder Anemia, Iron-Deficiency |
Metabolic Diseases Hematologic Diseases Anemia Anemia, Hypochromic |
Iron Metabolism Disorders Iron Overload Anemia, Iron-Deficiency |