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Sponsored by: |
Centre Hospitalier Universitaire de Saint Etienne |
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Information provided by: | Centre Hospitalier Universitaire de Saint Etienne |
ClinicalTrials.gov Identifier: | NCT00475059 |
Among the different creatinine-based GFR predicting equations, the MDRD equation gives the best prediction in renal transplantation but does not provide the level of accuracy usually seen in renal patients with native kidneys. Blocking the tubular secretion of creatinine with an oral administration of cimetidine is likely to make creatinine a more accurate marker of GFR.
We will test the hypothesis that the accuracy of the MDRD equation will be improved in renal transplant patients by incorporating into the equation a cimetidine-corrected serum creatinine value.
Condition | Intervention |
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Kidney Transplantation |
Drug: cimetidine arrow |
Study Type: | Interventional |
Study Design: | Diagnostic, Open Label, Uncontrolled, Single Group Assignment |
Official Title: | Performance of Cimetidine-Corrected MDRD Equation in Renal Transplant Patients |
Estimated Enrollment: | 60 |
Study Start Date: | March 2007 |
Study Completion Date: | March 2008 |
Primary Completion Date: | March 2007 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental
patients who received cimétidine
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Drug: cimetidine arrow
patients who received cimétidine
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
France | |
Nephrology unit, CHU Saint-Etienne | |
Saint-Etienne, France, 42055 |
Principal Investigator: | Christophe Mariat, MD PhD | CHU-Saint-Etienne |
Responsible Party: | Centre Hospitalier Universitaire de Saint Etienne ( Dr Mariat Christophe ) |
Study ID Numbers: | 0608090, 2006-005294-22 |
Study First Received: | May 16, 2007 |
Last Updated: | June 4, 2008 |
ClinicalTrials.gov Identifier: | NCT00475059 History of Changes |
Health Authority: | France: Afssaps - French Health Products Safety Agency |
kidney transplantation Glomerular filtration rate inulin clearance |
MDRD equation cystatin C cimetidine |
Neurotransmitter Agents Histamine Antagonists Histamine phosphate Cystatins |
Cimetidine Histamine H2 Antagonists Histamine |
Neurotransmitter Agents Histamine Antagonists Molecular Mechanisms of Pharmacological Action Therapeutic Uses Anti-Ulcer Agents Physiological Effects of Drugs |
Gastrointestinal Agents Histamine Agents Enzyme Inhibitors Cimetidine Histamine H2 Antagonists Pharmacologic Actions |