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Sponsored by: |
Samsung Medical Center |
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Information provided by: | Samsung Medical Center |
ClinicalTrials.gov Identifier: | NCT00474643 |
Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability and early death within the first 3 decades of life.To assess the significance of risk factors for future disabilities, carotid artery intima-media thickness (IMT) was measured and correlated with known atherosclerotic risk factors in 27 children with PWS and 24 age-, sex-, and body mass index (BMI)-adjusted controls.
Condition |
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Prader Willi Syndrome Obesity |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Case Control, Prospective Study |
Enrollment: | 51 |
Study Start Date: | August 2006 |
Study Completion Date: | December 2006 |
Main outcome measures: Correlation of IMT with age, standard deviation score of BMI (BMI-SDS), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), C-reactive protein, HOMA-IR and ghrelin.
Ages Eligible for Study: | 1 Year to 18 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | 2006-06-043 |
Study First Received: | May 10, 2007 |
Last Updated: | May 15, 2007 |
ClinicalTrials.gov Identifier: | NCT00474643 History of Changes |
Health Authority: | South Korea: Institutional Review Board |
Obesity Chromosome Disorders Overweight Body Weight Mental Retardation Signs and Symptoms Genetic Diseases, Inborn |
Abnormalities, Multiple Nutrition Disorders Neurologic Manifestations Overnutrition Prader-Willi Syndrome Congenital Abnormalities Neurobehavioral Manifestations |
Obesity Disease Nervous System Diseases Chromosome Disorders Overweight Body Weight Mental Retardation Signs and Symptoms Pathologic Processes |
Genetic Diseases, Inborn Syndrome Abnormalities, Multiple Nutrition Disorders Neurologic Manifestations Overnutrition Prader-Willi Syndrome Congenital Abnormalities Neurobehavioral Manifestations |