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Sponsors and Collaborators: |
Institute of Food Research University of East Anglia The Coca-Cola Company |
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Information provided by: | Institute of Food Research |
ClinicalTrials.gov Identifier: | NCT00474500 |
The aim of this project is to measure the effect of Coca-Cola and Diet Coke, relative to mineral water, on non-haem iron absorption. The results from this study will quantify any enhancing effect of Coca-Cola or Diet Coke on non-haem iron absorption and will be of use to the Coca-Cola Company and the scientific and nutrition community in evaluating the nutritional value of these products.
Condition | Intervention |
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Iron Deficiency |
Drug: Coca, Cola, Diet Coke |
Study Type: | Interventional |
Study Design: | Basic Science, Open Label, Active Control, Crossover Assignment, Bio-availability Study |
Official Title: | Effect of Coca-Cola on Iron Absorption |
Estimated Enrollment: | 16 |
Study Start Date: | May 2007 |
Previous studies have suggested that Coca-Cola may enhance absorption of non-haem iron. A randomized cross-over trial will be undertaken to compare the absorption of iron added to a pizza meal consumed with either Coca-Cola, Diet Coke or mineral water. Pizza containing added iron, labelled with an iron stable isotope (Fe-58), will be consumed for lunch on two consecutive days with either a Coca-Cola, Diet Coke or mineral water drink. Iron absorption from the pizza will be determined using the erythrocyte incorporation technique.
A baseline blood sample will be taken prior to consuming the first test meal (pizza + drink 1) and after approximately 15 days, a second fasting blood sample will be taken prior to consumption of a second set of test meals (pizza + drink 2). Iron isotope enrichment of the blood sample will be used as a baseline for the second set of test meals and to calculate absorption from the first set of test meals. A third blood sample will be taken after approximately 30 days and the iron isotope enrichment will be used as a baseline for the third set of test meals (pizza + drink 3) and to determine absorption from the second set of test meals. At about 45 days a final blood sample will be taken to determine absorption from the third set of test meals. Iron absorption will be calculated from the isotopic enrichment in blood, assuming that 80% of absorbed iron is incorporated into red blood cells.
Absorption of iron consumed with Coca-Cola and Diet Coke will be compared with iron absorption when consumed with mineral water. The order in which the volunteers will be given the drinks will be randomised.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United Kingdom, Norfolk | |
Institute of Food Research | |
Norwich, Norfolk, United Kingdom, NR4 6JF |
Principal Investigator: | Susan J Fairweather-Tait | University of East Anglia |
Study ID Numbers: | IFR13/2006 |
Study First Received: | May 16, 2007 |
Last Updated: | January 29, 2009 |
ClinicalTrials.gov Identifier: | NCT00474500 History of Changes |
Health Authority: | United Kingdom: Research Ethics Committee |
Iron absorption Coca-Cola |
Metabolic Diseases Hematologic Diseases Anemia Iron Metabolism Disorders |
Cocaine Iron Metabolic Disorder Anemia, Iron-Deficiency |
Metabolic Diseases Hematologic Diseases Anemia |
Anemia, Hypochromic Iron Metabolism Disorders Anemia, Iron-Deficiency |