|
|
Home
Search
Study Topics
Glossary
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||||||||||
| Sponsors and Collaborators: |
Canadian Critical Care Trials Group Kingston General Hospital Canadian Institutes of Health Research (CIHR) AstraZeneca Bayer |
|---|---|
| Information provided by: | Canadian Critical Care Trials Group |
| ClinicalTrials.gov Identifier: | NCT00434460 |
Purpose
The purpose of this prospective, multicentre, time-series study is to develop, implement, refine, and evaluate a sustainable behaviour change strategy in the intensive care unit (ICU).
| Condition | Intervention |
|---|---|
|
Ventilator Associated Pneumonia |
Behavioral: Education |
| Study Type: | Observational |
| Study Design: | Cohort, Prospective |
| Official Title: | Active Observational Study of the Adoption and Transfer of Clinical Practice Guidelines Through Education, for Ventilator Associated Pneumonia (ABATE VAP Study) |
| Estimated Enrollment: | 1650 |
| Study Start Date: | April 2007 |
| Estimated Study Completion Date: | January 2010 |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
1
Patients receiving invasive mechanical ventilation > 48 hours.
|
Behavioral: Education
Implementation of clinical practice guideline for ventilator associated pneumonia through education.
|
Background:
In order to improve the care of our patients, it is necessary for research evidence to be translated into clinical practice. There are gaps in our understanding of knowledge translation (KT) and this is evident in the Intensive Care Unit (ICU), specifically as it applies to the prevention, diagnosis and treatment of ventilator-associated pneumonia (VAP). VAP is associated with a high burden of illness in the critically ill and there is an extensive amount of research evidence on this disease. It has been demonstrated that best practice as defined by research evidence is not uniformly applied to VAP. In addition, recent advances in VAP knowledge need be disseminated and implemented in order to improve patient safety and outcomes from VAP. A systematic process of knowledge transfer is crucial to translate this research into evidence-based bedside practice and the development and implementation of evidence based Clinical Practice Guidelines (CPGs) may facilitate VAP knowledge uptake. In addition, there is a need to study knowledge translation (KT) in the ICU since there is little information about optimal KT and CPG implementation strategies in this environment and efforts that are effective in other clinical areas may not result in meaningful change in the ICU.
Research Question:
What is the effect of VAP CPGs implemented by a multidisciplinary behaviour change strategy (consisting of multifaceted educational strategies led by local opinion leaders and augmented with reminders) on VAP guideline concordance and on clinical VAP outcomes in the ICU?
Research Plan:
Data will only be collected on consecutive patients mechanically ventilated for at least 48 hours. The following health care professionals will be studied to assess the behaviour change strategy for the VAP CPGs: physicians (intensivists, ICU fellows, ICU rotating residents), nurses, respiratory therapists, dieticians, physiotherapists and ICU administrators.
The study will be conducted in 3 phases:
Development of a behaviour change strategy consisting of three components:
Prospective evaluation of the behaviour change strategy over a 24 month period
Eligibility| Ages Eligible for Study: | 17 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Patients invasively mechanically ventilated > 48 hours in the critical care setting.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: John Muscedere, MD | 613-549-6666 ext 4847 | muscedej@kgh.kari.net |
| Contact: Tasmin Sinuff, MD, PhD | 416-480-6100 | tazsinuff@sunnybrook.ca |
| United States, Pennsylvania | |
| Geisinger Health Centre, Temple University | Recruiting |
| Danville, Pennsylvania, United States, 17821-4400 | |
| Principal Investigator: Marilyn Haupt, MD | |
| Canada, British Columbia | |
| St. Paul Hospital, University of British Columbia | Recruiting |
| Vancouver, British Columbia, Canada, V6Z 1Y6 | |
| Principal Investigator: Peter Dodek, MD | |
| Royal Columbian Hospital, University of British Columbia | Recruiting |
| New Westminister, British Columbia, Canada, V3L 3W4 | |
| Principal Investigator: Sean Keenan, MD | |
| Vancouver Island Health Research Centre | Recruiting |
| Victoria, British Columbia, Canada, V8R 1J8 | |
| Principal Investigator: Gordon Wood, MD | |
| Canada, Ontario | |
| Kingston General Hospital, Queen's University | Recruiting |
| Kingston, Ontario, Canada, K7L 2V7 | |
| Principal Investigator: John Muscedere, MD | |
| Thunder Bay Regional Health Sciences Centre | Recruiting |
| Thunder Bay, Ontario, Canada, P7B 6V4 | |
| Principal Investigator: Will Anderson, MD | |
| St. Joseph's Healthcare, McMaster University | Recruiting |
| Hamilton, Ontario, Canada, L8N 4A6 | |
| Principal Investigator: Deborah Cook, MD | |
| The Ottawa Hospital, University of Ottawa | Recruiting |
| Ottawa, Ontario, Canada, K1H 8L7 | |
| Principal Investigator: Redouane Bouali, MD | |
| William Osler Health Centre | Recruiting |
| Toronto, Ontario, Canada | |
| Principal Investigator: Michael Miletin, MD | |
| Hotel Dieu Grace Hospital | Not yet recruiting |
| Windsor, Ontario, Canada, N4A 1E1 | |
| Principal Investigator: Richard Tan, MD | |
| Sunnybrook Health Sciences Centre, University of Toronto | Recruiting |
| Toronto, Ontario, Canada, M4N 3M5 | |
| Principal Investigator: Tasmin Sinuff, MD, PhD | |
| Study Chair: | John Muscedere, MD | Kingston General Hospital, Queen's University |
| Study Chair: | Tasmin Sinuff, MD, PhD | Sunnybrook Health Sciences Centre, University of Toronto |
| Principal Investigator: | Daren Heyland, MD | Kingston General Hospital, Queen's University |
| Principal Investigator: | Deborah Cook, MD | St. Joseph's Healthcare, McMaster University |
| Principal Investigator: | Peter Dodek, MD | St. Paul's University, University of British Columbia |
| Principal Investigator: | Redouane Bouali, MD | The Ottawa Hospital, University of Ottawa |
| Principal Investigator: | Sean Keenan, MD | Royal Columbian Hospital, University of British Columbia |
| Principal Investigator: | Kevin Eva, PhD | McMaster University |
| Principal Investigator: | Brenda Morgan, RN | London Health Sciences Centre, University of Western Ontario |
| Principal Investigator: | Lori Hand, RRT | Hamilton Health Sciences Centre, McMaster University |
More Information
| Responsible Party: | Kingston General Hospital, Queen's University ( Dr. John Muscedere ) |
| Study ID Numbers: | ABATE VAP |
| Study First Received: | February 12, 2007 |
| Last Updated: | September 15, 2008 |
| ClinicalTrials.gov Identifier: | NCT00434460 History of Changes |
| Health Authority: | Canada: Canadian Institutes of Health Research; Canada: Ethics Review Committees |
|
Ventilator Associated Pneumonia Knowledge Translation Clinical Practice Guidelines Education Behaviour Change |
|
Respiratory Tract Infections Respiratory Tract Diseases Lung Diseases |
Pneumonia, Ventilator-Associated Cross Infection Pneumonia |
|
Respiratory Tract Infections Respiratory Tract Diseases Lung Diseases Infection |
Pneumonia, Ventilator-Associated Cross Infection Pneumonia |
