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Sponsored by: |
Hadassah Medical Organization |
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Information provided by: | Hadassah Medical Organization |
ClinicalTrials.gov Identifier: | NCT00431587 |
The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern It has been shown that weight loss after bariatric surgery is followed by metabolic improvements.
The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments, and their effect on the improvement of the metabolic profile. In this study we define the absolute and relative changes in the different adipose tissue compartment after weight loss surgery
Condition |
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Morbid Obesity Metabolic Syndrome Visceral Obesity |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Changes in Different Fat Compartments During Weight Loss and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures. |
Estimated Enrollment: | 1000 |
Study Start Date: | June 2007 |
The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern.
The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments.
Rapid and preferential reduction of visceral fat mass could occur in morbid obese with visceral obesity. It has been previously shown, and it was also partially confirmed in this study, that a reduction in visceral fat was associated with metabolic improvements that included improved glucose tolerance and reduced plasma insulin and lipid levels. This again suggests a threshold of proportional visceral fat loss, above which there is an improvement in insulin sensitivity and other component of metabolic syndrom. We will quantify the different fat compartments changes after bariatric surgery by means of CT scan.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Andrei Keidar, MD | 00 972 2 6777384 | andreik@hadassah.org.il |
Israel | |
Hadassah Medical Organization, | Recruiting |
Jerusalem, Israel | |
Contact: Arik Tzukert, DMD 00 972 2 6776095 arik@hadassah.org.il | |
Contact: Hadas Lemberg, PhD 00 972 2 6777572 |
Principal Investigator: | Andrei Keidar, MD | Hadassah Medical Organization |
Study ID Numbers: | metabo-HMO-CTIL |
Study First Received: | February 5, 2007 |
Last Updated: | April 16, 2008 |
ClinicalTrials.gov Identifier: | NCT00431587 History of Changes |
Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
morbid obesity metabolic syndrome visceral fat peripheral fat |
Body Weight Signs and Symptoms Obesity Weight Loss |
Nutrition Disorders Overweight Overnutrition Obesity, Morbid |
Body Weight Signs and Symptoms Obesity Pathologic Processes Disease |
Syndrome Nutrition Disorders Overweight Overnutrition Obesity, Morbid |