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| Sponsored by: |
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
|---|---|
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00341640 |
Purpose
This study will provide information regarding the optimal dose and duration of nicotine replacement using the nicotine patch for a smoking cessation study of pregnant African-American women. Previous studies have shown that pregnancy, race and ethnicity can affect the way people metabolize nicotine.
The information from this study may help scientists develop ways to help pregnant African-American women quit smoking and not start smoking again after delivery.
African-American women 18-30years of age who are in the second trimester of a healthy pregnancy, who are carrying only one baby and who smoke 10 or more cigarettes a day may be eligible for this study. Candidates are screened with a medical history, physical examination and urine test. They receive counseling to help them quit smoking. Those who cannot quit smoking within 7 to 10 days after receiving counseling may be invited to join the study.
Participants are admitted to a private room in the Pediatric Clinical Research Center at Children's National Medical Center in Washington, D.C., for 48 hours, during which time they are not permitted to smoke. After a "wash out" period, a nicotine patch will be applied according to these doses and schedules:
An intravenous (IV) line is placed in the subject's arm and 12 blood samples are drawn through the line at intervals during the 48 hours. Twleve urine and saliva samples are also collected. Blood, urine, and saliva samples are analyzed for nicotine and cotinine (a product of nicotine metabolism) levels, and DNA will be collected studied for genes that are associated with nicotine and cotinine metabolism. Participants are interviewed about their urges to smoke, quality of sleep, etc.
| Condition | Intervention | Phase |
|---|---|---|
|
Pregnancy Smokers |
Procedure: Blood testing |
Phase I |
| Study Type: | Interventional |
| Study Design: | Treatment |
| Official Title: | Pharmacokinetics of Nicotine and Cotinine in Pregnant African-American Women and Implications for Pharmacological Interventions |
| Estimated Enrollment: | 50 |
| Study Start Date: | January 2005 |
| Estimated Study Completion Date: | December 2006 |
This is a two-part protocol. This protocol is for Part A, the specific aims of which are to:
Additional aims are to:
1. Collect DNA for exploratory analyses regarding genetic causes of differences in metabolism of nicotine and cotinine.
Latina/Hispanic women will not be included in this study because a) few smoke, and b) few are seen in the clinical sites from which participants will be recruited.
Eligibility| Ages Eligible for Study: | 18 Years to 30 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
English-speaking, self-identified African-American women smokers, age 18 to 30 years, with singleton, uncomplicated pregnancies in the second trimester will be eligible.
Only women receiving routine prenatal care, begun by 16 weeks gestation, will be included.
Women will be asked to release records of their pregnancy to study staff for review prior to enrollment.
All participating women will receive clearance from their obstetrician before enrollment.
EXCLUSION CRITERIA:
Women who report use of any other substance of abuse besides nicotine will be ineligible.
Contacts and Locations More Information
| Study ID Numbers: | 999905074, 05-CH-N074 |
| Study First Received: | June 19, 2006 |
| Last Updated: | February 24, 2007 |
| ClinicalTrials.gov Identifier: | NCT00341640 History of Changes |
| Health Authority: | United States: Federal Government |
|
Teen Pregnancy |
|
Nicotine polacrilex Nicotine |
