A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study

This study has been completed.

First Received: June 19, 2006 Last Updated: March 3, 2009 History of Changes

Sponsored by:	National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00340509

Purpose

Studies have shown that there is a significant association between serum bilirubin concentrations and risk of coronary artery disease (CAD). So far, no linkage analysis in humans between serum bilirubin and DNA markers has been reported. The purpose of this protocol is to identify chromosome regions that contain quantitative trait loci (QTL) involved in serum bilirubin metabolism and bilirubin concentration. In the Framingham Study, a 10cM genome scan (about 400 markers) has been conducted in more than three hundred families. Serum bilirubin was measured in the first and second exams of the Framingham Offspring. These data provide us the opportunity to undertake linkage analyses to map QTL of serum bilirubin.

Condition
Genetics

MedlinePlus related topics: Nuclear Scans

U.S. FDA Resources

Study Type:	Observational
Official Title:	A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	330
Study Start Date:	October 2001

Detailed Description:

Many studies showed that there is a significant relationship between serum bilirubin levels and risk of coronary artery disease (CAD). We carried out a genome-wide scan for quantitative trait loci of serum bilirubin through the 330 extended Framingham families and found significant evidence of linkage of serum bilirubin to chromosome 2q telomere where an important candidate gene, Uridine diphosphate glycosyltransferase 1 gene (UGT1A1), resides. The purposes of this protocol are to confirm linkage between serum bilirubin and UGT1A1, mathematical modeling and association studies between the genotypes of UGT1A1 and CAD.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

INCLUSION CRITERIA:

The study population will include the members of the 330 Framingham Study families with genome scan.

The Original Cohort will also be included.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00340509

Locations

United States, Maryland
National Heart, Lung and Blood Institute (NHLBI), 9000 Rockville Pike
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

More Information

No publications provided

Study ID Numbers:	999902016, 02-H-N016
Study First Received:	June 19, 2006
Last Updated:	March 3, 2009
ClinicalTrials.gov Identifier:	NCT00340509 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Genetics
Population
CHD Risk
Epidemiology
Gene Mapping

Study placed in the following topic categories:

Antioxidants
Bilirubin

Additional relevant MeSH terms:

Antioxidants
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs

Bilirubin
Protective Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on May 07, 2009