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Sponsored by: |
Clinic and Research Center in Human Reproduction Roger Abdelmassih |
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Information provided by: | Clinic and Research Center in Human Reproduction Roger Abdelmassih |
ClinicalTrials.gov Identifier: | NCT00484081 |
We evaluated the application of surgical testicular exploration with the aid of a microscope (MictoTESE) to increase the chances of obtaining sperm in men with impaired sperm production, a condition known as non-obstructive azoospermia.
We also evaluated the outcomes of these couples when the sperm obtained were used in ICSI (Intracytoplasmic Sperm Injection) during assisted reproductive technology treatment. We believe that excellent results may be obtained with the use of the following techniques in the treatment of couples where non-obstructive azoospermia is a significant cause.
Condition | Intervention |
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Azoospermia Infertility |
Procedure: Microdissection Testicular Sperm Extraction Procedure: ICSI |
Study Type: | Interventional |
Study Design: | Treatment, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study |
Official Title: | Prospective Evaluation of Microdissection Testicular Sperm Extraction in Non-Obstructive Azoospermic Men and Their IVF-ICSI Related Outcomes at ART Treatment. |
Enrollment: | 53 |
Study Start Date: | June 2005 |
Study Completion Date: | October 2006 |
Men diagnosed with non-obstructive azoospermia and seeking assisted reproductive technology treatment (ART) are candidates for surgical sperm retrieval with the aid of microdissection. We believe that this approach may currently be the best option for these subjects.
We evaluated our surgical sperm retrieval rate associated to their serum LH, FSH, TOTAL TESTOTERONE and PROLACTIN levels, pre-operative testicular volume and also compared to the post-operative histological analysis of fixed testicular tissue specimens collected during the procedure, stained with haematoxylin and eosin. We also evaluated the outcomes using ICSI based ART for these couples observing mean ICSI and fertilized oocytes, number and quality of embryos transferred, implantation and pregnancy rates.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Brazil, SP | |
Clinic and Research Center in Human Reproduction Roger Abdelmassih | |
São Paulo, SP, Brazil, 01431-000 |
Principal Investigator: | Pedro Ravizzini, Dr. | Clinic and Research Center in Human Reproduction Roger Abdelmassih |
Study ID Numbers: | RA9969 |
Study First Received: | June 6, 2007 |
Last Updated: | June 7, 2007 |
ClinicalTrials.gov Identifier: | NCT00484081 History of Changes |
Health Authority: | Brazil: Ministry of Health |
TESE NON-OBSTRUCTIVE MICRODISSECTION AZOOSPERMIA ICSI |
Genital Diseases, Female Infertility Azoospermia |
Infertility, Male Genital Diseases, Male Spastic Paraplegia Epilepsy Mental Retardation |
Genital Diseases, Female Infertility Azoospermia Infertility, Male Genital Diseases, Male |