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Sponsored by: |
Imperial College London |
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Information provided by: | Imperial College London |
ClinicalTrials.gov Identifier: | NCT00733655 |
Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels. We propose to obtain small skin samples from patients with HHT in order to analyze the samples using histological methods, and study the properties of vascular endothelial cells derived from patients. We hypothesize that these cells will show altered growth, migration, and protein synthetic differences when compared to normal endothelial cells, which may be confirmed in single time point analyses in histological samples. We anticipate that that these findings may help to explain aspects of the HHT disease phenotype.
Condition |
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Telangiectasia, Hereditary Hemorrhagic |
Study Type: | Observational |
Study Design: | Prospective |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | IC/CLS5 |
Study First Received: | August 12, 2008 |
Last Updated: | August 12, 2008 |
ClinicalTrials.gov Identifier: | NCT00733655 History of Changes |
Health Authority: | United Kingdom: Research Ethics Committee |
Hemorrhagic Disorders Cardiovascular Abnormalities Hematologic Diseases Telangiectasia, Hereditary Hemorrhagic Blood Coagulation Disorders Vascular Malformations |
Telangiectasis Vascular Diseases Hereditary Hemorrhagic Telangiectasia Congenital Abnormalities Hemostatic Disorders |
Hemorrhagic Disorders Cardiovascular Abnormalities Hematologic Diseases Telangiectasia, Hereditary Hemorrhagic Vascular Malformations |
Telangiectasis Vascular Diseases Cardiovascular Diseases Congenital Abnormalities Hemostatic Disorders |