![]() |
Home
Search
Study Topics
Glossary
|
![]() |
![]() |
|
![]() |
|
![]() |
|
![]() |
![]() |
![]() |
|
![]() |
![]() |
Sponsored by: |
Imperial College London |
---|---|
Information provided by: | Imperial College London |
ClinicalTrials.gov Identifier: | NCT00733629 |
Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels. We propose to culture endothelial cells from patients with HHT, to culture cells that express the proteins mutated in HHT, namely endoglin and ALK-1. We will study the properties of these cells which will involve their growth in different conditions and anticipate that DNA, mRNA and proteins will be extracted from these cells for study of cell responses and association with expression levels of endoglin and ALK-1. We hypothesize that these cells which express "half-normal" endoglin or ALK-1 will show altered protein synthetic differences when compared to normal white blood cells.
We anticipate that that these findings may help to explain aspects of the HHT disease phenotype.
Condition |
---|
Telangiectasia, Hereditary Hemorrhagic |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | In Vitro Studies pf Endothelial Cells Derived From HHT Patients |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | IC/CLS4 |
Study First Received: | August 12, 2008 |
Last Updated: | August 12, 2008 |
ClinicalTrials.gov Identifier: | NCT00733629 History of Changes |
Health Authority: | United Kingdom: Research Ethics Committee |
Hemorrhagic Disorders Cardiovascular Abnormalities Hematologic Diseases Telangiectasia, Hereditary Hemorrhagic Blood Coagulation Disorders Vascular Malformations |
Telangiectasis Vascular Diseases Hereditary Hemorrhagic Telangiectasia Congenital Abnormalities Hemostatic Disorders |
Hemorrhagic Disorders Cardiovascular Abnormalities Hematologic Diseases Telangiectasia, Hereditary Hemorrhagic Vascular Malformations |
Telangiectasis Vascular Diseases Cardiovascular Diseases Congenital Abnormalities Hemostatic Disorders |