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Sponsors and Collaborators: |
Xijing Hospital Fourth Military Medical University |
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Information provided by: | Xijing Hospital |
ClinicalTrials.gov Identifier: | NCT00732459 |
The purpose of this study is to investigate the protective effect of electro-acupuncture preconditioning in patients underwent cardiac surgery.
Condition | Intervention |
---|---|
Rheumatic Valve Disease |
Device: Electro-acupuncture preconditioning |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Clinical Trial of The Myocardial Protective Effects of Repeated Electroacupuncture Preconditioning in Heart Valve Replacement Surgery |
Estimated Enrollment: | 60 |
Study Start Date: | January 2007 |
Estimated Study Completion Date: | December 2008 |
Primary Completion Date: | July 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
---|---|
1
electro-acupuncture preconditioning group
|
Device: Electro-acupuncture preconditioning
electro-acupuncture
|
2
control group
|
Heart valve replacement surgery has been proved to be an effective method in treating both regenerative and rheumatic valve disease. Current studies showed that cardiopulmonary bypass (CPB) and operation related myocardial injury, as indicated by the release of perioperative cardiac enzymes, is associated with worse patient morbidity and mortality after elective valve replacement surgery. Although the actual mechanism is still unclear, it has been shown that ischemic preconditioning is one potential strategy for reduction of myocardial injury in open heart surgery. Recently, Electro- acupuncture (EA) was proved to produced cerebral protective and antiarrhythmic effects by mimicking ischemic preconditioning. This study aims to assess whether electroacupuncture preconditioning is also effective in reducing myocardial injury in adults with acquired heart valve disease undergoing elective valve replacement surgery.
Ages Eligible for Study: | 40 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
This study enrolls a group of 40-65years patients who have heart valve disease who need valve replacement.
Inclusion Criteria:
Exclusion Criteria:
China, Shaanxi | |
Department of Anesthesiology of Xijing Hospital, Fourth Military Medical University | |
Xi'an, Shaanxi, China, 710032 |
Study Chair: | Lize Xiong, M.D. | Director of Department of Anasthesiology of Xijing Hospital, Fourth Military Medical University |
Responsible Party: | Xijing Hospital of Fourth Military Military Medical University ( Lize Xiong / Director of Department of Anasthesiology of Xijing Hospital ) |
Study ID Numbers: | XJ-20080808 |
Study First Received: | August 9, 2008 |
Last Updated: | August 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00732459 History of Changes |
Health Authority: | China: State Food and Drug Administration |
myocardial protection cardiac surgery heart valve replacement |
Rheumatic Diseases |