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Sponsored by: |
Glaxo Wellcome |
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Information provided by: | NIH AIDS Clinical Trials Information Service |
ClinicalTrials.gov Identifier: | NCT00002404 |
The purpose of this study is to see if valacyclovir affects the detection of HIV in genital herpes lesions in HIV-infected patients. Valacyclovir is used to treat recurrent genital herpes.
Condition | Intervention |
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Herpes Simplex HIV Infections |
Drug: Valacyclovir hydrochloride |
Study Type: | Interventional |
Study Design: | Treatment, Double-Blind, Efficacy Study |
Official Title: | The Effect of Treatment With Valacyclovir 500 mg BID on the Detection of HIV From Genital HSV Lesions in HIV-Infected Patients: A Double-Blind Crossover Study |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria
Patients must have:
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms or conditions are excluded:
Patients with the following prior conditions are excluded:
History of hypersensitivity to acyclovir or valacyclovir.
Prior Medication:
Excluded:
Systemic anti-HSV therapy within 7 days prior to start of study drug.
1. Probenecid.
Required:
- Stable antiretroviral therapy or no therapy for at least 1 month.
Study ID Numbers: | 291A |
Study First Received: | November 2, 1999 |
Last Updated: | January 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00002404 History of Changes |
Health Authority: | United States: Food and Drug Administration |
HIV-1 Antiviral Agents Herpes Genitalis Recurrence |
DNA, Viral RNA, Viral valacyclovir Herpesvirus 2, Human |
Herpes Simplex Sexually Transmitted Diseases, Viral Skin Diseases Herpes Genitalis Acquired Immunodeficiency Syndrome Antiviral Agents Recurrence Immunologic Deficiency Syndromes Herpesviridae Infections |
Valacyclovir Virus Diseases Skin Diseases, Infectious Acyclovir HIV Infections Sexually Transmitted Diseases DNA Virus Infections Retroviridae Infections |
Herpes Simplex Anti-Infective Agents RNA Virus Infections Sexually Transmitted Diseases, Viral Slow Virus Diseases Skin Diseases Immune System Diseases Acquired Immunodeficiency Syndrome Infection Antiviral Agents Pharmacologic Actions Immunologic Deficiency Syndromes |
Herpesviridae Infections Valacyclovir Skin Diseases, Viral Virus Diseases Skin Diseases, Infectious Acyclovir HIV Infections Therapeutic Uses Sexually Transmitted Diseases Lentivirus Infections DNA Virus Infections Retroviridae Infections |