|
|
Home
Search
Study Topics
Glossary
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||||||||||
| Sponsored by: |
Hadassah Medical Organization |
|---|---|
| Information provided by: | Hadassah Medical Organization |
| ClinicalTrials.gov Identifier: | NCT00226551 |
Purpose
Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2 adrenergic receptor (ß2AR) modify its pharmacological properties and may alter the response to ß2AR agonists. The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo.
Internal mammary leftover segments were collected from 96 patients undergoing coronary artery bypass graft operation. Four rings that were prepared from each specimen were allowed to reach equilibrium with physiological Krebs solution prior to precontraction with U46619. Using the organ bath technique, cumulative dose response curve of isoproterenol was constructed and mean EC50 calculated for each patient.
| Condition | Intervention |
|---|---|
|
Coronary Disease |
Drug: Isoproterenol |
| Study Type: | Interventional |
| Study Design: | Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Pharmacodynamics Study |
| Official Title: | ß2 Adrenergic Receptor Polymorphisms and Vasodilation of Internal Mammary Artery Induced by Isoproterenol |
Eligibility| Ages Eligible for Study: | 20 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations More Information
| Study ID Numbers: | yc19558-HMO-CTIL |
| Study First Received: | September 12, 2005 |
| Last Updated: | October 28, 2008 |
| ClinicalTrials.gov Identifier: | NCT00226551 History of Changes |
| Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
|
Arterial Occlusive Diseases Neurotransmitter Agents Heart Diseases Adrenergic Agents Adrenergic beta-Agonists Myocardial Ischemia Vascular Diseases Anti-Asthmatic Agents Cardiovascular Agents |
Ischemia Arteriosclerosis Isoproterenol Adrenergic Agonists Coronary Disease Peripheral Nervous System Agents Bronchodilator Agents Coronary Artery Disease |
|
Respiratory System Agents Neurotransmitter Agents Adrenergic Agents Molecular Mechanisms of Pharmacological Action Cardiotonic Agents Myocardial Ischemia Physiological Effects of Drugs Arteriosclerosis Adrenergic Agonists Therapeutic Uses Cardiovascular Diseases Arterial Occlusive Diseases Heart Diseases |
Adrenergic beta-Agonists Sympathomimetics Vascular Diseases Anti-Asthmatic Agents Cardiovascular Agents Protective Agents Isoproterenol Pharmacologic Actions Coronary Disease Autonomic Agents Peripheral Nervous System Agents Bronchodilator Agents Coronary Artery Disease |
