The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

This study has been completed.

First Received: March 3, 2008 Last Updated: March 10, 2008 History of Changes

Sponsored by:	Far Eastern Memorial Hospital
Information provided by:	Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier:	NCT00632892

Purpose

Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists. The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP). The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).

Condition
Kidney Diseases

MedlinePlus related topics: Urine and Urination

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case-Only, Prospective
Official Title:	The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

Further study details as provided by Far Eastern Memorial Hospital:

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

The urine samples are collected just before and 30 minutes after IVP.The samples are immediately frozen at -80'C until analyzed.

Estimated Enrollment:	80
Study Start Date:	December 2007
Primary Completion Date:	January 2008 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Adult patients (> 18 years old)
Undergoing IVP with an appropriate medical indication
Signing informed consent

Criteria

Inclusion Criteria:

Adult patients (> 18 years old)
Undergoing IVP with an appropriate medical indication
Signing informed consent

Exclusion Criteria:

1. Without signing informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00632892

Locations

Taiwan
Far Eastern Memorial Hospital
Pan Chiao, Taipei, Taiwan, 220

Sponsors and Collaborators

Far Eastern Memorial Hospital

More Information

No publications provided

Study ID Numbers:	96013
Study First Received:	March 3, 2008
Last Updated:	March 10, 2008
ClinicalTrials.gov Identifier:	NCT00632892 History of Changes
Health Authority:	Taiwan: Institutional Review Board

Keywords provided by Far Eastern Memorial Hospital:

oxidative stress markers in urine
urine norepinephrine
renal tubular enzyme markers

Study placed in the following topic categories:

Urologic Diseases
Norepinephrine
Stress
Kidney Diseases

Additional relevant MeSH terms:

Urologic Diseases
Kidney Diseases

ClinicalTrials.gov processed this record on May 07, 2009