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Sponsors and Collaborators: |
Ball Memorial Hospital St. Jude Medical |
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Information provided by: | Ball Memorial Hospital |
ClinicalTrials.gov Identifier: | NCT00589992 |
To test the hypothesis that localized functional reentry maintains Afib in humans, ibutilide will be administered intravenously in patients undergoing an Afib ablation. The hypothesis of this study is that ibutilide will decrease the high frequency signals observed in Afib suggesting the presence of micro reentrant circuits as the basic mechanism of Afib, especially for the paroxysmal Afib group. The potential difference in response to the ibutilide in patients with paroxysmal versus persistent Afib may show the difference in the underlying mechanism of Afib between these two groups.
Condition | Intervention |
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Atrial Fibrillation Pulmonary Vein Ablation |
Drug: Ibutilide fumarate |
Study Type: | Interventional |
Study Design: | Basic Science, Open Label, Single Group Assignment |
Official Title: | Atrial Fibrillation Mechanism Analysis Through Ibutilide Administration During Pulmonary Vein Ablation. |
Estimated Enrollment: | 50 |
Study Start Date: | October 2007 |
Estimated Study Completion Date: | December 2011 |
Estimated Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Antonio Navarrete, MD | 765-281-2000 | annavarr@mac.com |
Contact: Julie Foster, RN | 765-747-8457 | Jfoster@chsmail.org |
United States, Indiana | |
Ball Memorial Hospital | Recruiting |
Muncie, Indiana, United States, 47303 | |
Contact: Julie Foster, RN 765-747-8457 JFoster@chsmail.org | |
Principal Investigator: Antonio Navarrete, MD |
Principal Investigator: | Antonio Navarrete, MD | Staff Physician, Ball Memorial Hospital |
Responsible Party: | Medical Consultants, P.C. ( Antonio Navarrete, MD ) |
Study ID Numbers: | BMH study #762 |
Study First Received: | December 26, 2007 |
Last Updated: | January 29, 2009 |
ClinicalTrials.gov Identifier: | NCT00589992 History of Changes |
Health Authority: | United States: Institutional Review Board; United States: Food and Drug Administration |
Heart Diseases Cardiovascular Agents Anti-Arrhythmia Agents |
Atrial Fibrillation Ibutilide Arrhythmias, Cardiac |
Pathologic Processes Heart Diseases Therapeutic Uses Cardiovascular Diseases Cardiovascular Agents |
Anti-Arrhythmia Agents Atrial Fibrillation Pharmacologic Actions Ibutilide Arrhythmias, Cardiac |