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| Sponsored by: |
The Cleveland Clinic |
|---|---|
| Information provided by: | The Cleveland Clinic |
| ClinicalTrials.gov Identifier: | NCT00589836 |
Purpose
The purpose of this study is to learn about the twisting or wringing motion of the heartbeat called torsion which can be seen on ultrasound. This study will help figure out if there is a difference in the how a heart twists at rest and with exercise in people with normal hearts compared to people with HCM (abnormally thickened heart muscle). Volunteers will have an echocardiogram (ultrasound of the heart) while lying on a bed both at rest and while peddling a wheel located at at the foot of the bed. The patients will take about 1 to 1 1/2 hours total and the study will be complete after this procedure.
| Condition |
|---|
|
Hypertrophic Cardiomyopathy |
| Study Type: | Observational |
| Study Design: | Case Control, Cross-Sectional |
| Official Title: | Assessment of LV Torsion by Tissue Doppler Echocardiography |
| Estimated Enrollment: | 40 |
| Study Start Date: | June 2005 |
| Estimated Study Completion Date: | December 2008 |
| Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Normal
Patients with structurally normal hearts
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HCM
Patients with hypertrophic cardiomyopathy
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Left ventricular myocardial torsion (myocardial wringing motion) will be investigated by the use of tissue Doppler echocardiography in both normal and HCM (hypertrophic cardiomyopathy) patients. The objective of this study is to characterize the myocardial torsional behavior in normal and in HCM patients both at rest and while undergoing moderate physiological exercise.
After a routine echocardiographic study, tissue Doppler echocardiogram will be performed before and during supine bicycle exercise. Stress EchoTM Bed with ergometer (supine bicycle) is used during exercise testing. Standard electrocardiogram and blood pressure will be monitored throughout the exercise testing. This procedure will take about 1 to 1 1/2 hours and will not involve any follow-up.
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Patients undergoing cardiac echocardiography testing in the outpatient department
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, Ohio | |
| The Cleveland Clinic Foundation | |
| Cleveland, Ohio, United States, 44195 | |
| Principal Investigator: | Zoran Popovic, M.D. | The Cleveland Clinic |
More Information
| Responsible Party: | Cleveland Clinic ( Zoran Popovic, PhD ) |
| Study ID Numbers: | IRB 05-023 |
| Study First Received: | December 26, 2007 |
| Last Updated: | October 22, 2008 |
| ClinicalTrials.gov Identifier: | NCT00589836 History of Changes |
| Health Authority: | United States: Institutional Review Board |
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HCM HOCM hypertrophic cardiomyopathy tissue doppler echocardiography myocardial torsion |
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Pathological Conditions, Anatomical Hypertrophy Heart Diseases Cardiomyopathy, Hypertrophic |
Constriction, Pathologic Aortic Valve Stenosis Cardiomyopathies Heart Valve Diseases |
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Pathological Conditions, Anatomical Hypertrophy Aortic Stenosis, Subvalvular Heart Diseases Cardiomyopathy, Hypertrophic |
Cardiovascular Diseases Aortic Valve Stenosis Cardiomyopathies Heart Valve Diseases |
