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Sponsors and Collaborators: |
University of Cincinnati National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | University of Cincinnati |
ClinicalTrials.gov Identifier: | NCT00682695 |
The purpose of this study is to find risk factors for hemorrhagic stroke.
Condition |
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Stroke |
Study Type: | Observational |
Study Design: | Ecologic or Community, Prospective |
Official Title: | Genetic and Environmental Risk Factors for Hemorrhagic Stroke |
whole blood or buccal DNA
Enrollment: | 3187 |
Study Start Date: | September 1997 |
Study Completion Date: | June 2007 |
Primary Completion Date: | June 2007 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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Healthy volunteers and people who have had a hemorrhagic stroke and live within a 50 mile radius of Cincinnati, Ohio.
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Hemorrhagic stroke—specifically intracranial hemorrhage (ICH) and subarachnoid hemorrhage (SAH)—affects 50,000 to 60,000 individuals in the United States each year. The consequences of this type of stroke are devastating with 40 percent of cases ending in death within 30 days. Identifying the genetic and environmental risk factors for hemorrhagic stroke is beneficial and may lead to better treatments and possible preventions.
The purpose of this research study is to determine the significant environmental and genetic risk factors for intracerebral hemorrhage (bleeding in the brain tissue) and subarachnoid hemorrhage (bleeding around the brain). The researchers will look for the presence of several stroke-related genes and any environmental risk factors hat may contribute to stroke in people who have suffered a hemorrhagic stroke. Because environmental risk factors vary within different areas, this study will be limited to physician-reviewed cases of people who have had a hemorrhagic stroke and who live within a 50-mile radius of Cincinnati, Ohio.
There are two primary hypotheses in this study:
The investigators also will look for environmental risk factors (e.g., smoking, obesity, diabetes, etc.) that are prevalent in the participants with hemorrhagic stroke.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
This study will be limited to physician-reviewed cases of people who have had a hemorrhagic stroke and who live within a 50-mile radius of Cincinnati, Ohio.
Inclusion Criteria:
Exclusion Criteria:
United States, Ohio | |
University of Cincinnati Academic Health Center, Department of Neurology, 260 Stetson St. Room # 2300, P.O. Box 670525 | |
Cincinnati, Ohio, United States, 45267-0525 |
Principal Investigator: | Daniel Woo, MD | University of Cincinnati |
Responsible Party: | University of Cincinnati College of Medicine ( Daniel Woo, MD ) |
Study ID Numbers: | R01NS36695 |
Study First Received: | May 20, 2008 |
Last Updated: | May 6, 2009 |
ClinicalTrials.gov Identifier: | NCT00682695 History of Changes |
Health Authority: | United States: Federal Government |
stroke brain attack hemorrhagic stroke risk factors |
Cerebral Infarction Stroke Vascular Diseases Brain Ischemia Central Nervous System Diseases Ischemia |
Brain Infarction Intracranial Hemorrhages Brain Diseases Hemorrhage Infarction Cerebrovascular Disorders |
Cerebral Infarction Stroke Nervous System Diseases Vascular Diseases Central Nervous System Diseases Intracranial Hemorrhages Brain Diseases |
Hemorrhage Cerebrovascular Disorders Pathologic Processes Brain Ischemia Cardiovascular Diseases Brain Infarction |