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Sponsored by: |
University of Cambridge Cancer Research UK |
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Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00757211 |
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with breast cancer.
Condition | Intervention |
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Breast Cancer |
Genetic: polymorphism analysis Other: laboratory biomarker analysis Other: questionnaire administration |
Study Type: | Observational |
Official Title: | A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Breast Cancer in East Anglia |
Estimated Enrollment: | 6000 |
Study Start Date: | February 2008 |
OBJECTIVES:
OUTLINE: This is a multicenter study.
Patients complete an epidemiological questionnaire that covers standard known breast cancer risk factors including reproductive history, oral contraceptive use, hormone replacement therapy use, family history, and alcohol consumption. The questionnaire will also request identifying information on the patient's first-degree relatives.
Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the breast cancer patients recruited for this study, patients with malignant melanoma and lymphoma, colorectal, ovarian, prostate, colorectal, bladder, kidney, pancreatic, and esophageal cancer, and brain tumors are recruited for the following related clinical trials: MREC-SEARCH-COLORECTAL, MREC-SEARCH-OVARIAN, MREC-SEARCH-PROSTATE, MREC-SEARCH-ENDOMETRIAL, and MREC-SEARCH-CANCER.
Ages Eligible for Study: | 18 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
United Kingdom, England | |
University of Cambridge Cancer Research UK | Recruiting |
Cambridge, England, United Kingdom, CB1 8RN | |
Contact: Contact Person 44-122-374-0166 paul.pharoah@srl.cam.ac.uk |
Study Chair: | Paul Pharoah, MD | University of Cambridge Cancer Research UK |
Study ID Numbers: | CDR0000598878, MREC-SEARCH-BREAST, MREC-07/MRE05/17 |
Study First Received: | September 22, 2008 |
Last Updated: | February 6, 2009 |
ClinicalTrials.gov Identifier: | NCT00757211 History of Changes |
Health Authority: | Unspecified |
breast cancer male breast cancer |
Skin Diseases Disease Susceptibility Breast Neoplasms, Male Breast Neoplasms |
Breast Cancer, Male Genetic Predisposition to Disease Breast Diseases |
Neoplasms Neoplasms by Site Skin Diseases Breast Neoplasms Breast Diseases |