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Sponsors and Collaborators: |
National Taiwan University Hospital National Science Council, Taiwan |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00756158 |
The ultimate goal of this study is to find specific polymorphism of candidate genes associated with endophenotypes and/or phenomenological phenotypes of ADHD. We propose to replicate the analysis of the candidate genes identified by previous genetic studies on ADHD using the candidate gene association study design (family-based case control study using parental controls) to validate the findings from other research groups. These results will lead our team: (1) to resolve controversies over inconsistent findings in previous genetic studies and contribute to the literature on the validity of ASD using clinical and genetic data; (2) to study the pathogenetic process of abnormal genes in abnormal neuropsychological and neurobiological functions of ADHD; (3) to delineate the nature and the effect of gene-gene interaction in the etiology of ADHD.
Condition |
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Attention Deficit Hyperactivity Disorder |
Study Type: | Observational |
Study Design: | Family-Based |
Official Title: | Molecular Studies on the Candidate Genes of Dopaminergic and Noradrenergic Systems in Attention-Deficit Hyperactivity Disorder |
The subjects will receive blood withdrawal. The blood sample will be used for establishing lymphoblastoid cell lines, which will be used for molecular genetic experiments
Estimated Enrollment: | 100 |
Study Start Date: | August 2008 |
Estimated Study Completion Date: | July 2011 |
Attention deficit hyperactivity disorder (ADHD), characterized by inattention, hyperactivity and impulsivity, is an early onset, highly heritable, clinically heterogeneous, long-term impairing disorder with tremendous impact on individuals, families, and societies. It affects 5-10% of school-aged children worldwide (7.5% in Taiwan) and 2-4% of adults. Neuropsychological deficits related to executive functions, state regulation, and delay aversion show heritability, replicated association with ADHD, and familial-genetic overlap with ADHD, are suitable for biomarkers for ADHD. Despite the abundance of molecular genetic studies on ADHD, the genetic etiologies of ADHD have been non-conclusive, and there is limited information about the expressions, neuropsychological deficits, and genetic variants for ADHD in Chinese population. This present study, a family-based parental control association study, aims to identify the genetic markers of dopaminergic and noradrenergic systems for ADHD using the dichotomous categorization of affected and non-affected, quantitative phenotypes (symptom dimension and severity of ADHD) and endophenotype (neuropsychological measures) as well.
Specific Aims:
In addition to a sample of 200 ADHD families (200 probands, 400 parents, and 150 siblings) being recruited in a parallel study (NSC96-2628-B-002-069
We anticipate the establishment of clinical, neuropsychological, and genetic database of 300 ADHD families (200 in NSC96-2628-B-002-069-MY3 and 100 in this project), completion of the screening of several candidate genes, and identification of potential genetic variants for ADHD, and determination of their association with ADHD diagnosis and symptoms and its endophenotype in a Taiwanese sample. The long-term objectives are to identify the behavioral phenotypes and endophenotypes that are close to the biological expression of genes underlying ADHD. The findings of different approaches to identify the genetic etiologies for ADHD in this pilot study should help us to determine the most promising approach for future molecular genetic and pharmacogenetic study on ADHD.
Ages Eligible for Study: | 7 Years to 18 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
The sample will consist of 100 probands with ADHD, aged 7-18. Their biological parents (n = 200) and siblings (estimated number = 75) born to the same biological parents will be recruited as the parent controls and sibling controls, respectively, for the family-based case control study.
Inclusion Criteria:
Exclusion Criteria:
DSM-IV:
Organic Psychosis, or Pervasive Developmental Disorder.
Contact: Chi-Yung Shang, MD | +886-2-23123456 ext 66965 | cyshang@ntu.edu.tw |
Taiwan | |
National Taiwan University Hospital | Recruiting |
Taipei, Taiwan | |
Contact: Chi-Yung Shang, MD +886-2-23123456 ext 66965 cyshang@ntu.edu.tw | |
Principal Investigator: Chi-Yung Shang, MD | |
Sub-Investigator: Susan Shur-Fen Gau, MD, PhD | |
Sub-Investigator: Chih-Min Liu, MD |
Principal Investigator: | Chi-Yung Shang, MD | Dept of Psychiatry, National Taiwan University Hospital |
Responsible Party: | National Taiwan University Hospital ( Chi-Yung Shang, MD ) |
Study ID Numbers: | 200712085R |
Study First Received: | September 18, 2008 |
Last Updated: | September 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00756158 History of Changes |
Health Authority: | Taiwan: Department of Health |
Attention Deficit Hyperactivity Disorder dopaminergic noradrenergic endophenotype |
molecular genetics candidate gene Family-based Association study |
Neurotransmitter Agents Attention Deficit and Disruptive Behavior Disorders Cardiovascular Agents Dopamine Agonists Dyskinesias Signs and Symptoms Dopamine |
Attention Deficit Disorder with Hyperactivity Mental Disorders Mental Disorders Diagnosed in Childhood Hyperkinesis Neurologic Manifestations Dopamine Agents Peripheral Nervous System Agents |
Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Cardiotonic Agents Physiological Effects of Drugs Dopamine Agonists Signs and Symptoms Dopamine Pathologic Processes Attention Deficit Disorder with Hyperactivity Mental Disorders Therapeutic Uses Mental Disorders Diagnosed in Childhood Hyperkinesis |
Disease Sympathomimetics Nervous System Diseases Attention Deficit and Disruptive Behavior Disorders Cardiovascular Agents Dyskinesias Protective Agents Pharmacologic Actions Autonomic Agents Neurologic Manifestations Dopamine Agents Peripheral Nervous System Agents |