Coronary Atherosclerosis Evaluation by Arterial Wall MRI

This study is currently recruiting participants.

Verified by Johns Hopkins University, July 2006

First Received: July 18, 2006 No Changes Posted

Sponsors and Collaborators:	Johns Hopkins University Northwestern University
Information provided by:	Johns Hopkins University
ClinicalTrials.gov Identifier:	NCT00353795

Purpose

The overall goal of this study is to use MRI to:

Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;
Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,
Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.

Condition	Intervention
Coronary Arteriosclerosis Arteriosclerosis, Coronary Atherosclerosis, Coronary Coronary Artery Disease Coronary Atherosclerosis	Procedure: MR Imaging of the Coronary Arteries

MedlinePlus related topics: Coronary Artery Disease

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Diagnostic, Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Official Title:	Coronary Atherosclerosis Evaluation by Arterial Wall MRI

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:

Coronary artery wall thickness

Estimated Enrollment:	300
Study Start Date:	July 2005
Estimated Study Completion Date:	April 2007

Detailed Description:

Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes

Eligibility

Ages Eligible for Study:	45 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
Male or Female adult equal to or older than 45 years of age
Willing/able to provide informed consent

Exclusion Criteria:

Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
Metal in the eyes

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00353795

Contacts

Contact: Tracy McCracken, RN BSN

410-955-4924

tborman@jhmi.edu

Locations

United States, Illinois
Northwestern University MESA Field Center	Recruiting
Chicago, Illinois, United States, 60611
Contact: Fran Horn 312-908-7914 f-horn@northwestern.edu
Principal Investigator: Kiang Liu, PhD
United States, Maryland
Johns Hopkins MESA Field Center	Recruiting
Baltimore, Maryland, United States, 21244
Contact: Carol Christman 410-944-6780 cchrist3@jhmi.edu
Principal Investigator: David A Bluemke, MD PhD

Sponsors and Collaborators

Johns Hopkins University

Northwestern University

Investigators

Principal Investigator:

David A Bluemke, MD PhD

Johns Hopkins University

More Information

Additional Information:

Multi-Ethnic Study of Atherosclerosis webpage This link exits the ClinicalTrials.gov site

No publications provided

Study ID Numbers:	05-05-23-01, 5R01HL078909
Study First Received:	July 18, 2006
Last Updated:	July 18, 2006
ClinicalTrials.gov Identifier:	NCT00353795 History of Changes
Health Authority:	United States: Institutional Review Board

Keywords provided by Johns Hopkins University:

MESA
MRI
Cardiovascular

Cardiac
Coronary
Atherosclerosis

Study placed in the following topic categories:

Arterial Occlusive Diseases
Coronary Disease
Atherosclerosis
Heart Diseases
Myocardial Ischemia

Vascular Diseases
Ischemia
Arteriosclerosis
Coronary Artery Disease

Additional relevant MeSH terms:

Arterial Occlusive Diseases
Coronary Disease
Atherosclerosis
Heart Diseases
Myocardial Ischemia

Vascular Diseases
Cardiovascular Diseases
Arteriosclerosis
Coronary Artery Disease

ClinicalTrials.gov processed this record on May 07, 2009